RU94019424A - Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа - Google Patents

Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа

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Publication number
RU94019424A
RU94019424A RU94019424/04A RU94019424A RU94019424A RU 94019424 A RU94019424 A RU 94019424A RU 94019424/04 A RU94019424/04 A RU 94019424/04A RU 94019424 A RU94019424 A RU 94019424A RU 94019424 A RU94019424 A RU 94019424A
Authority
RU
Russia
Prior art keywords
preparing
crystalline loracarbef
crystalline
dihydrate
monohydrate
Prior art date
Application number
RU94019424/04A
Other languages
English (en)
Other versions
RU2124013C1 (ru
Inventor
Френсис Плохарчик Эдвард
Us]
Экерт Строуз Эрин
Original Assignee
Эли Лилли энд Компани (US)
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли энд Компани (US), Эли Лилли Энд Компани filed Critical Эли Лилли энд Компани (US)
Publication of RU94019424A publication Critical patent/RU94019424A/ru
Application granted granted Critical
Publication of RU2124013C1 publication Critical patent/RU2124013C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Предложен способ получения кристаллической моногидратной формы соединения формулы:Способ включает выдерживание кристаллической дигидратной формы соединения указанной формулы при температуре около 50 - 65С и относительной влажности около 60 - 100%.

Claims (1)

  1. Предложен способ получения кристаллической моногидратной формы соединения формулы:
    Figure 00000001

    Способ включает выдерживание кристаллической дигидратной формы соединения указанной формулы при температуре около 50 - 65 oС и относительной влажности около 60 - 100%.
RU94019424A 1993-06-04 1994-06-03 Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа RU2124013C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/071,550 1993-06-04
US08/071,550 US5374719A (en) 1993-06-04 1993-06-04 Process for converting loracarbef dihydrate to loracarbef monohydrate
US08/071550 1993-06-04

Publications (2)

Publication Number Publication Date
RU94019424A true RU94019424A (ru) 1996-04-20
RU2124013C1 RU2124013C1 (ru) 1998-12-27

Family

ID=22102051

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94019424A RU2124013C1 (ru) 1993-06-04 1994-06-03 Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа

Country Status (29)

Country Link
US (1) US5374719A (ru)
EP (1) EP0627430B1 (ru)
JP (1) JP3442479B2 (ru)
KR (1) KR100311699B1 (ru)
CN (1) CN1042424C (ru)
AT (1) ATE146472T1 (ru)
AU (1) AU678000B2 (ru)
BR (1) BR9402149A (ru)
CA (1) CA2125001C (ru)
CO (1) CO4230100A1 (ru)
CZ (1) CZ283468B6 (ru)
DE (1) DE69401163T2 (ru)
DK (1) DK0627430T3 (ru)
ES (1) ES2097002T3 (ru)
FI (1) FI108132B (ru)
GR (1) GR3022111T3 (ru)
HU (1) HU217066B (ru)
IL (1) IL109871A (ru)
MY (1) MY110724A (ru)
NO (1) NO306302B1 (ru)
NZ (1) NZ260653A (ru)
PE (1) PE13195A1 (ru)
PH (1) PH30304A (ru)
PL (1) PL174539B1 (ru)
RU (1) RU2124013C1 (ru)
TW (1) TW252980B (ru)
UA (1) UA27812C2 (ru)
YU (1) YU33394A (ru)
ZA (1) ZA943827B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
ZA887409B (en) * 1987-10-06 1990-06-27 Lilly Co Eli Crystalline beta-lactam hydrate
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic

Also Published As

Publication number Publication date
RU2124013C1 (ru) 1998-12-27
US5374719A (en) 1994-12-20
CZ283468B6 (cs) 1998-04-15
CA2125001A1 (en) 1994-12-05
HUT67743A (en) 1995-04-28
PL174539B1 (pl) 1998-08-31
HU9401675D0 (en) 1994-09-28
YU33394A (sh) 1996-10-18
PH30304A (en) 1997-02-20
BR9402149A (pt) 1994-12-27
ATE146472T1 (de) 1997-01-15
JPH06345763A (ja) 1994-12-20
PE13195A1 (es) 1995-05-24
AU678000B2 (en) 1997-05-15
NO942048L (no) 1994-12-05
EP0627430A1 (en) 1994-12-07
FI942633A0 (fi) 1994-06-03
EP0627430B1 (en) 1996-12-18
GR3022111T3 (en) 1997-03-31
FI108132B (fi) 2001-11-30
KR950000701A (ko) 1995-01-03
NZ260653A (en) 1995-12-21
CO4230100A1 (es) 1995-10-19
UA27812C2 (uk) 2000-10-16
ES2097002T3 (es) 1997-03-16
PL303676A1 (en) 1994-12-12
CN1042424C (zh) 1999-03-10
ZA943827B (en) 1995-12-01
HU217066B (hu) 1999-11-29
FI942633A (fi) 1994-12-05
AU6451694A (en) 1994-12-08
JP3442479B2 (ja) 2003-09-02
IL109871A0 (en) 1994-10-07
TW252980B (ru) 1995-08-01
KR100311699B1 (ko) 2001-12-28
DE69401163D1 (de) 1997-01-30
CA2125001C (en) 2004-08-03
NO942048D0 (no) 1994-06-02
MY110724A (en) 1999-01-30
IL109871A (en) 1998-08-16
CN1097754A (zh) 1995-01-25
DK0627430T3 (da) 1997-06-02
DE69401163T2 (de) 1997-04-30
NO306302B1 (no) 1999-10-18
CZ134294A3 (en) 1994-12-15

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Effective date: 20050604