PL173978B1 - Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej - Google Patents

Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej

Info

Publication number
PL173978B1
PL173978B1 PL92295273A PL29527392A PL173978B1 PL 173978 B1 PL173978 B1 PL 173978B1 PL 92295273 A PL92295273 A PL 92295273A PL 29527392 A PL29527392 A PL 29527392A PL 173978 B1 PL173978 B1 PL 173978B1
Authority
PL
Poland
Prior art keywords
lysozyme
culture
peripheral blood
cytokines
lysozyme dimer
Prior art date
Application number
PL92295273A
Other languages
English (en)
Polish (pl)
Other versions
PL295273A1 (en
Inventor
Witold Kiczka
Original Assignee
Nika Health Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nika Health Products Ltd filed Critical Nika Health Products Ltd
Priority to PL92295273A priority Critical patent/PL173978B1/pl
Priority to DE69333258T priority patent/DE69333258T2/de
Priority to RO95-00041A priority patent/RO112580B1/ro
Priority to CA002140140A priority patent/CA2140140A1/en
Priority to JP6502985A priority patent/JPH07508744A/ja
Priority to CZ199585A priority patent/CZ286725B6/cs
Priority to MX9304197A priority patent/MX9304197A/es
Priority to PT93915903T priority patent/PT651654E/pt
Priority to DE0651654T priority patent/DE651654T1/de
Priority to RU95105517A priority patent/RU2145875C1/ru
Priority to NZ254135A priority patent/NZ254135A/en
Priority to AU45686/93A priority patent/AU677786B2/en
Priority to EP93915903A priority patent/EP0651654B1/en
Priority to ZA935046A priority patent/ZA935046B/xx
Priority to CN93116771A priority patent/CN1057937C/zh
Priority to KR1019940704649A priority patent/KR100289841B1/ko
Priority to ES93915903T priority patent/ES2074037T3/es
Priority to PCT/EP1993/001841 priority patent/WO1994001127A1/en
Priority to UA95018021A priority patent/UA49789C2/uk
Priority to BR9306722A priority patent/BR9306722A/pt
Priority to HU9500098A priority patent/HU218151B/hu
Priority to SG1996008336A priority patent/SG52727A1/en
Priority to FI950144A priority patent/FI950144A0/fi
Priority to GEAP19932466A priority patent/GEP20012466B/en
Priority to DK93915903T priority patent/DK0651654T3/da
Priority to AT93915903T priority patent/ATE252392T1/de
Priority to SK40-95A priority patent/SK282377B6/sk
Priority to TW082106180A priority patent/TW259710B/zh
Publication of PL295273A1 publication Critical patent/PL295273A1/xx
Priority to BG99287A priority patent/BG63331B1/bg
Priority to NO950076A priority patent/NO950076L/no
Priority to OA60604A priority patent/OA10125A/en
Priority to US08/476,561 priority patent/US6132715A/en
Priority to GR950300039T priority patent/GR950300039T1/el
Priority to NZ299377A priority patent/NZ299377A/en
Publication of PL173978B1 publication Critical patent/PL173978B1/pl
Priority to US09/348,822 priority patent/US6183742B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL92295273A 1992-04-08 1992-07-13 Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej PL173978B1 (pl)

Priority Applications (35)

Application Number Priority Date Filing Date Title
PL92295273A PL173978B1 (pl) 1992-07-13 1992-07-13 Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej
UA95018021A UA49789C2 (uk) 1992-07-13 1993-07-13 Застосування димеру лізоциму як лікарського засобу для інгібування біосинтезу фактора некрозу пухлини, спосіб лікування та профілактики захворювань (варіанти), фармацевтична композиція (варіанти), застосування димеру лізоциму як лікарського засобу для профілактики або лікування сніду
RO95-00041A RO112580B1 (ro) 1992-07-13 1993-07-13 Metoda pentru profilaxia si/sau tratamentul bolii asociate cu un nivel nedorit al factorului de necrozare tumorala (tnf)
CA002140140A CA2140140A1 (en) 1992-07-13 1993-07-13 Lysozyme dimer and compositions containing the same
JP6502985A JPH07508744A (ja) 1992-07-13 1993-07-13 リゾチーム二量体の新しい使用と該二量体を含む配合品
CZ199585A CZ286725B6 (en) 1992-07-13 1993-07-13 Medicinal preparation for modulating natural protective mechanisms and pharmaceutical preparation for this purpose
MX9304197A MX9304197A (es) 1992-07-13 1993-07-13 Nuevo uso de dimero de lisozina y composiciones que lo contienen.
PT93915903T PT651654E (pt) 1992-07-13 1993-07-13 Utilizacao de um dimero de lisozima para a preparacao de um medicamento para modular os mecanismos natutais de defesa
DE0651654T DE651654T1 (de) 1992-07-13 1993-07-13 Lysozym-dimer und zubereitungen die ihn enthalten.
RU95105517A RU2145875C1 (ru) 1992-07-13 1993-07-13 Применение димера лизоцима в качестве лекарственного средства и содержащие его композиции
NZ254135A NZ254135A (en) 1992-07-13 1993-07-13 Inhibition of biosynthesis of tumour necrosis factor (tnf) by administering the dimerised from of lysozyme; formulations containing lysozyme and an antibiotic
AU45686/93A AU677786B2 (en) 1992-07-13 1993-07-13 Lysozyme dimer and compositions containing the same
EP93915903A EP0651654B1 (en) 1992-07-13 1993-07-13 Use of lysozyme dimer for the manufacture of a medicament for modulating natural defensive mechanisms
ZA935046A ZA935046B (en) 1992-07-13 1993-07-13 Use of lysozyme dimer and compositions containing the same
CN93116771A CN1057937C (zh) 1992-07-13 1993-07-13 溶菌酵素二聚体的新用途及其含有溶菌酵素二聚体的制剂
KR1019940704649A KR100289841B1 (ko) 1992-07-13 1993-07-13 라이소자임 이량체와 이를 포함하는 조성물
ES93915903T ES2074037T3 (es) 1992-07-13 1993-07-13 Uso del dimero de lisozima para la fabricacion de un medicamento para modular los mecanismos de defensa naturales.
DE69333258T DE69333258T2 (de) 1992-07-13 1993-07-13 Verwendung von lysozymdimer zur herstellung eines arzneimittels zur modulation der natürlichen abwehrvorgänge
PCT/EP1993/001841 WO1994001127A1 (en) 1992-07-13 1993-07-13 Lysozyme dimer and compositions containing the same
BR9306722A BR9306722A (pt) 1992-07-13 1993-07-13 Dímero de lisozima e composições contendo o mesmo
HU9500098A HU218151B (hu) 1992-07-13 1993-07-13 Eljárás lizozim dimert tartalmazó gyógyászati készítmények előállítására
SG1996008336A SG52727A1 (en) 1992-07-13 1993-07-13 Lysozyme dimer and compositions containing the same
FI950144A FI950144A0 (fi) 1992-07-13 1993-07-13 Lysotsyymidimeeri ja sitä sisältävät koostumukset
GEAP19932466A GEP20012466B (en) 1992-07-13 1993-07-13 Lysozyme Dimer and Compositions Containing the Same
DK93915903T DK0651654T3 (da) 1992-07-13 1993-07-13 Anvendelse af lysozymdimer til fremstilling af et lægemiddel til styrkelse af de naturlige forsvarsmekanismer
AT93915903T ATE252392T1 (de) 1992-07-13 1993-07-13 Verwendung des lysozym-dimers zur herrstellung eines arzneimittels zur modulation der naturlichen abwehrvorgänge.
SK40-95A SK282377B6 (sk) 1992-07-13 1993-07-13 Použitie dimerizovanej formy lyzozýmu a farmaceutický prostriedok s jeho obsahom
TW082106180A TW259710B (https=) 1992-07-13 1993-08-03
BG99287A BG63331B1 (bg) 1992-07-13 1994-12-22 Лизозимен димер и състави, които го съдържат
NO950076A NO950076L (no) 1992-07-13 1995-01-09 Lysozymdimer og materialer inneholdende samme
OA60604A OA10125A (en) 1992-07-13 1995-01-13 Lysozyme dimer and compositions containing the same
US08/476,561 US6132715A (en) 1992-04-08 1995-06-07 Method of inhibiting biosynthesis of tumor necrosis factor
GR950300039T GR950300039T1 (en) 1992-07-13 1995-07-31 Lysozyme dimer and compositions containing the same.
NZ299377A NZ299377A (en) 1992-07-13 1996-09-13 Inhibiting TNF biosynthesis using lysozyme in dimerized form
US09/348,822 US6183742B1 (en) 1992-07-13 1999-07-08 Applications of lysozyme dimer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL92295273A PL173978B1 (pl) 1992-07-13 1992-07-13 Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej

Publications (2)

Publication Number Publication Date
PL295273A1 PL295273A1 (en) 1994-01-24
PL173978B1 true PL173978B1 (pl) 1998-05-29

Family

ID=20058087

Family Applications (1)

Application Number Title Priority Date Filing Date
PL92295273A PL173978B1 (pl) 1992-04-08 1992-07-13 Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej

Country Status (31)

Country Link
US (1) US6132715A (https=)
EP (1) EP0651654B1 (https=)
JP (1) JPH07508744A (https=)
KR (1) KR100289841B1 (https=)
CN (1) CN1057937C (https=)
AT (1) ATE252392T1 (https=)
AU (1) AU677786B2 (https=)
BG (1) BG63331B1 (https=)
BR (1) BR9306722A (https=)
CA (1) CA2140140A1 (https=)
CZ (1) CZ286725B6 (https=)
DE (2) DE69333258T2 (https=)
DK (1) DK0651654T3 (https=)
ES (1) ES2074037T3 (https=)
FI (1) FI950144A0 (https=)
GE (1) GEP20012466B (https=)
GR (1) GR950300039T1 (https=)
HU (1) HU218151B (https=)
MX (1) MX9304197A (https=)
NZ (2) NZ254135A (https=)
OA (1) OA10125A (https=)
PL (1) PL173978B1 (https=)
PT (1) PT651654E (https=)
RO (1) RO112580B1 (https=)
RU (1) RU2145875C1 (https=)
SG (1) SG52727A1 (https=)
SK (1) SK282377B6 (https=)
TW (1) TW259710B (https=)
UA (1) UA49789C2 (https=)
WO (1) WO1994001127A1 (https=)
ZA (1) ZA935046B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183742B1 (en) 1992-07-13 2001-02-06 Nika Health Products, Limited Applications of lysozyme dimer
DZ1964A1 (fr) * 1995-01-13 2002-10-15 Nika Health Products Ltd Nouvelle applications d'un dimère de lysozyme.
AU5884096A (en) * 1995-05-30 1996-12-18 Lectin Biopharma, Inc. Method of using lectins for agglutination and collection of menstrual flow
US6123937A (en) * 1997-03-14 2000-09-26 Nika Health Products, Limited Applications of lysozyme dimer
ITMI981148A1 (it) * 1998-05-22 1999-11-22 Therapicon Srl Utilizzo di lisozima c modificato per preparare composizioni medicinali per il trattamento di alcune gravi malattie
EP1174147A1 (en) * 2000-06-27 2002-01-23 Nika Health Products Limited Reversal of antibiotic resistance with lysozyme dimer
US20050244402A1 (en) * 2004-04-30 2005-11-03 Villanueva Julie M Absorption of pain-causing agents
RU2320367C1 (ru) * 2006-08-22 2008-03-27 Государственное образовательное учреждение дополнительного профессионального образования Российская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию (ГОУ ДПО РМАПО Росздрава) Способ сопроводительного лечения острого лимфобластного лейкоза
RU2351351C1 (ru) * 2007-08-08 2009-04-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Средство, повышающее неспецифическую сопротивляемость организма к бактериальным эндотоксинам
RU2472467C2 (ru) * 2011-04-13 2013-01-20 Государственное научное учреждение Краснодарский научно-исследовательский ветеринарный институт (ГНУ КНИВИ) Способ профилактики и лечения гастроэнтеритов, обусловленных бактериозами, у телят
CN105106626A (zh) * 2015-09-30 2015-12-02 成都倍加特生物科技有限公司 一种治疗月经期感染的汤剂药物及其制备方法

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EP0380484B1 (en) * 1988-05-26 1993-08-18 Nika Health Products Limited Use of a lysozyme dimer and/or a ribonuclease dimer for th emanufacture of an antiviral or antibiotic drug
DE3817955A1 (de) * 1988-05-27 1989-11-30 Hoechst Ag Tnf-inhibitor enthaltendes arzneimittel
AU3765689A (en) * 1988-05-31 1990-01-05 Napp Systems (U.S.A.) Inc. Apparatus and process for processing printing plates
KR920702621A (ko) * 1989-06-13 1992-10-06 스튜어트 알. 슈터 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제
HU214509B (hu) * 1990-01-08 1998-03-30 Nika Health Products Ltd. Eljárás tisztított lizozim dimerek előállítására
US5314816A (en) * 1990-01-08 1994-05-24 Nika Health Products Ltd. Method of preparing lysozyme dimers
WO1992002220A1 (en) * 1990-08-03 1992-02-20 Smithkline Beecham Corporation Tnf inhibitors

Also Published As

Publication number Publication date
SG52727A1 (en) 1998-09-28
CZ8595A3 (en) 1995-09-13
DE69333258T2 (de) 2004-08-26
JPH07508744A (ja) 1995-09-28
EP0651654B1 (en) 2003-10-22
ES2074037T3 (es) 2004-07-01
AU677786B2 (en) 1997-05-08
HUT70973A (en) 1995-11-28
CN1087278A (zh) 1994-06-01
TW259710B (https=) 1995-10-11
MX9304197A (es) 1994-02-28
WO1994001127A1 (en) 1994-01-20
FI950144L (fi) 1995-01-12
HU218151B (hu) 2000-06-28
HU9500098D0 (en) 1995-03-28
ATE252392T1 (de) 2003-11-15
ES2074037T1 (es) 1995-09-01
SK282377B6 (sk) 2002-01-07
BG63331B1 (bg) 2001-10-31
US6132715A (en) 2000-10-17
CZ286725B6 (en) 2000-06-14
DE69333258D1 (de) 2003-11-27
ZA935046B (en) 1994-02-07
DE651654T1 (de) 1996-01-04
KR100289841B1 (ko) 2001-05-15
OA10125A (en) 1996-12-18
RU2145875C1 (ru) 2000-02-27
UA49789C2 (uk) 2002-10-15
KR950702432A (ko) 1995-07-29
PT651654E (pt) 2004-03-31
BG99287A (bg) 1995-08-28
FI950144A7 (fi) 1995-01-12
NZ254135A (en) 1996-11-26
GR950300039T1 (en) 1995-07-31
DK0651654T3 (da) 2004-02-23
EP0651654A1 (en) 1995-05-10
RO112580B1 (ro) 1997-11-28
CN1057937C (zh) 2000-11-01
NZ299377A (en) 2001-02-23
FI950144A0 (fi) 1995-01-12
SK4095A3 (en) 1995-09-13
GEP20012466B (en) 2001-06-25
AU4568693A (en) 1994-01-31
BR9306722A (pt) 1998-12-08
CA2140140A1 (en) 1994-01-20
PL295273A1 (en) 1994-01-24

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