ES2074037T1 - Dimero de la lisozima y composiciones que lo contienen. - Google Patents
Dimero de la lisozima y composiciones que lo contienen.Info
- Publication number
- ES2074037T1 ES2074037T1 ES93915903T ES93915903T ES2074037T1 ES 2074037 T1 ES2074037 T1 ES 2074037T1 ES 93915903 T ES93915903 T ES 93915903T ES 93915903 T ES93915903 T ES 93915903T ES 2074037 T1 ES2074037 T1 ES 2074037T1
- Authority
- ES
- Spain
- Prior art keywords
- necrosis factor
- tumor necrosis
- medicinal product
- lysozyme
- dimerized form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000016943 Muramidase Human genes 0.000 abstract 2
- 108010014251 Muramidase Proteins 0.000 abstract 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 229960000274 lysozyme Drugs 0.000 abstract 2
- 235000010335 lysozyme Nutrition 0.000 abstract 2
- 239000004325 lysozyme Substances 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA INVENCION SE REFIERE A LOS NUEVOS USOS DE LA FORMA DIMERIZADA DE LA LISOCIMA PARA LA FABRICACION DE UN MEDICAMENTO PARA INHIBIR LA BIOSINTESIS DEL FACTOR DE NECROSIS DE TUMOR EN ANIMALES Y HUMANOS. EL DIMERO DE LA LISOZIMA ES, EN PARTICULAR, UTIL PARA EL TRATAMIENTO Y LA PROFILAXIS DE TRASTORNOS ASOCIADOS CON NIVELES EXCESIVAMENTE ALTOS DE FACTOR DE NECROSIS DE TUMOR. LA INVENCION ADEMAS SE REFIERE A FORMULACIONES FARMACEUTICAS DEL MEDICAMENTO SEGUN LA INVENCION, ES DECIR INYECCIONES QUE CONSTAN DE LA FORMA DIMERIZADA DE LA LISOZIMA EN CANTIDADES DE 0,01-10 MG/ML, DE UNA COMPOSICION ESTERIL APIROGENICA QUE CONSTA DE AL MENOS UN SOLVENTE FISIOLOGICAMENTE ACEPTABLE Y AL MENOS UN PRESERVATIVO FARMACEUTICAMENTE APROBADO, TAMBIEN COMO TAMPONES Y VENDAJES ANTISEPTICOS IMPREGNADOS CON EL, Y POMADAS O GELES QUE CONSTAN DE UNA DOSIS EFECTIVA DE LA FORMA DIMERIZADA DE LA LISOZIMA PARA LA PREVENCION Y/O TRATAMIENTO DE SEPSIS Y DE CONMOCION SEPTICA, ESPECIALMENTE DE HERIDAS INFECTADAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL92295273A PL173978B1 (pl) | 1992-07-13 | 1992-07-13 | Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej |
| PL29527392 | 1992-07-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2074037T1 true ES2074037T1 (es) | 1995-09-01 |
| ES2074037T3 ES2074037T3 (es) | 2004-07-01 |
Family
ID=20058087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93915903T Expired - Lifetime ES2074037T3 (es) | 1992-07-13 | 1993-07-13 | Uso del dimero de lisozima para la fabricacion de un medicamento para modular los mecanismos de defensa naturales. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6132715A (es) |
| EP (1) | EP0651654B1 (es) |
| JP (1) | JPH07508744A (es) |
| KR (1) | KR100289841B1 (es) |
| CN (1) | CN1057937C (es) |
| AT (1) | ATE252392T1 (es) |
| AU (1) | AU677786B2 (es) |
| BG (1) | BG63331B1 (es) |
| BR (1) | BR9306722A (es) |
| CA (1) | CA2140140A1 (es) |
| CZ (1) | CZ286725B6 (es) |
| DE (2) | DE651654T1 (es) |
| DK (1) | DK0651654T3 (es) |
| ES (1) | ES2074037T3 (es) |
| FI (1) | FI950144A (es) |
| GE (1) | GEP20012466B (es) |
| GR (1) | GR950300039T1 (es) |
| HU (1) | HU218151B (es) |
| MX (1) | MX9304197A (es) |
| NZ (2) | NZ254135A (es) |
| OA (1) | OA10125A (es) |
| PL (1) | PL173978B1 (es) |
| PT (1) | PT651654E (es) |
| RO (1) | RO112580B1 (es) |
| RU (1) | RU2145875C1 (es) |
| SG (1) | SG52727A1 (es) |
| SK (1) | SK282377B6 (es) |
| TW (1) | TW259710B (es) |
| UA (1) | UA49789C2 (es) |
| WO (1) | WO1994001127A1 (es) |
| ZA (1) | ZA935046B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183742B1 (en) | 1992-07-13 | 2001-02-06 | Nika Health Products, Limited | Applications of lysozyme dimer |
| DZ1964A1 (fr) * | 1995-01-13 | 2002-10-15 | Nika Health Products Ltd | Nouvelle applications d'un dimère de lysozyme. |
| WO1996038115A1 (en) * | 1995-05-30 | 1996-12-05 | Lectin Biopharma, Inc. | Method of using lectins for agglutination and collection of menstrual flow |
| US6123937A (en) * | 1997-03-14 | 2000-09-26 | Nika Health Products, Limited | Applications of lysozyme dimer |
| ITMI981148A1 (it) | 1998-05-22 | 1999-11-22 | Therapicon Srl | Utilizzo di lisozima c modificato per preparare composizioni medicinali per il trattamento di alcune gravi malattie |
| EP1174147A1 (en) * | 2000-06-27 | 2002-01-23 | Nika Health Products Limited | Reversal of antibiotic resistance with lysozyme dimer |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| RU2472467C2 (ru) * | 2011-04-13 | 2013-01-20 | Государственное научное учреждение Краснодарский научно-исследовательский ветеринарный институт (ГНУ КНИВИ) | Способ профилактики и лечения гастроэнтеритов, обусловленных бактериозами, у телят |
| RU2546911C2 (ru) * | 2013-04-11 | 2015-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Донской государственный аграрный университет" | Способ хранения свинины в охлажденном состоянии |
| CN105106626A (zh) * | 2015-09-30 | 2015-12-02 | 成都倍加特生物科技有限公司 | 一种治疗月经期感染的汤剂药物及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR4020M (es) * | 1965-01-29 | 1966-03-21 | ||
| FR2215201A1 (en) * | 1973-01-24 | 1974-08-23 | Theranol Lab | Broad-spectrum antibiotic compsns. - contg. antibiotic resistant lactic bacilli and enzyme diffusing-agent |
| JPS5533409A (en) * | 1978-08-30 | 1980-03-08 | Eisai Co Ltd | Carcinostatic agent |
| JPS5533408A (en) * | 1978-08-30 | 1980-03-08 | Eisai Co Ltd | Immunity-increasing agent |
| JPS5543040A (en) * | 1978-09-25 | 1980-03-26 | Eisai Co Ltd | Immunity raising agent |
| US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
| US4457919A (en) * | 1980-03-14 | 1984-07-03 | Newport Pharmaceutical International, Inc. | Method of imparting immunomodulating, antiviral or antitumor activity |
| US4510144A (en) * | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
| US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| DE3782958D1 (de) * | 1986-02-19 | 1993-01-21 | Imreg Inc | Verfahren und mittel zum pruefen eines immunsystems. |
| US5200182A (en) * | 1988-05-26 | 1993-04-06 | Nika Health Products, Ltd. | Antiviral or antibacterial composition and method of use |
| DE3817955A1 (de) * | 1988-05-27 | 1989-11-30 | Hoechst Ag | Tnf-inhibitor enthaltendes arzneimittel |
| DE68927733T2 (de) * | 1988-05-31 | 1997-06-12 | Napp Systems Inc | Vorrichtung und verfahren zur behandlung von druckplatten |
| KR920702621A (ko) * | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제 |
| DK0509984T3 (da) * | 1990-01-08 | 1999-03-22 | Nika Health Products Ltd | Fremgangsmåde til fremstilling af lysozymdimer |
| US5314816A (en) * | 1990-01-08 | 1994-05-24 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
| ATE161720T1 (de) * | 1990-08-03 | 1998-01-15 | Smithkline Beecham Corp | Tnf-inhibitoren |
-
1992
- 1992-07-13 PL PL92295273A patent/PL173978B1/pl not_active IP Right Cessation
-
1993
- 1993-07-13 KR KR1019940704649A patent/KR100289841B1/ko not_active IP Right Cessation
- 1993-07-13 ZA ZA935046A patent/ZA935046B/xx unknown
- 1993-07-13 RU RU95105517A patent/RU2145875C1/ru not_active IP Right Cessation
- 1993-07-13 AT AT93915903T patent/ATE252392T1/de not_active IP Right Cessation
- 1993-07-13 CA CA002140140A patent/CA2140140A1/en not_active Abandoned
- 1993-07-13 CZ CZ199585A patent/CZ286725B6/cs not_active IP Right Cessation
- 1993-07-13 HU HU9500098A patent/HU218151B/hu not_active IP Right Cessation
- 1993-07-13 DE DE0651654T patent/DE651654T1/de active Pending
- 1993-07-13 EP EP93915903A patent/EP0651654B1/en not_active Expired - Lifetime
- 1993-07-13 GE GEAP19932466A patent/GEP20012466B/en unknown
- 1993-07-13 WO PCT/EP1993/001841 patent/WO1994001127A1/en active IP Right Grant
- 1993-07-13 DK DK93915903T patent/DK0651654T3/da active
- 1993-07-13 BR BR9306722A patent/BR9306722A/pt not_active Application Discontinuation
- 1993-07-13 DE DE69333258T patent/DE69333258T2/de not_active Expired - Lifetime
- 1993-07-13 ES ES93915903T patent/ES2074037T3/es not_active Expired - Lifetime
- 1993-07-13 CN CN93116771A patent/CN1057937C/zh not_active Expired - Fee Related
- 1993-07-13 PT PT93915903T patent/PT651654E/pt unknown
- 1993-07-13 NZ NZ254135A patent/NZ254135A/en not_active IP Right Cessation
- 1993-07-13 JP JP6502985A patent/JPH07508744A/ja active Pending
- 1993-07-13 AU AU45686/93A patent/AU677786B2/en not_active Ceased
- 1993-07-13 SK SK40-95A patent/SK282377B6/sk not_active IP Right Cessation
- 1993-07-13 SG SG1996008336A patent/SG52727A1/en unknown
- 1993-07-13 RO RO95-00041A patent/RO112580B1/ro unknown
- 1993-07-13 MX MX9304197A patent/MX9304197A/es not_active IP Right Cessation
- 1993-07-13 UA UA95018021A patent/UA49789C2/uk unknown
- 1993-08-03 TW TW082106180A patent/TW259710B/zh active
-
1994
- 1994-12-22 BG BG99287A patent/BG63331B1/bg unknown
-
1995
- 1995-01-12 FI FI950144A patent/FI950144A/fi unknown
- 1995-01-13 OA OA60604A patent/OA10125A/en unknown
- 1995-06-07 US US08/476,561 patent/US6132715A/en not_active Expired - Fee Related
- 1995-07-31 GR GR950300039T patent/GR950300039T1/el unknown
-
1996
- 1996-09-13 NZ NZ299377A patent/NZ299377A/en not_active IP Right Cessation
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