BG63331B1 - Лизозимен димер и състави, които го съдържат - Google Patents
Лизозимен димер и състави, които го съдържат Download PDFInfo
- Publication number
- BG63331B1 BG63331B1 BG99287A BG9928794A BG63331B1 BG 63331 B1 BG63331 B1 BG 63331B1 BG 99287 A BG99287 A BG 99287A BG 9928794 A BG9928794 A BG 9928794A BG 63331 B1 BG63331 B1 BG 63331B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- lysozyme
- tnf
- lysozyme dimer
- dimer
- dimerized
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 239000000539 dimer Substances 0.000 title description 98
- 108010014251 Muramidase Proteins 0.000 claims abstract description 107
- 102000016943 Muramidase Human genes 0.000 claims abstract description 107
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 107
- 229960000274 lysozyme Drugs 0.000 claims abstract description 107
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 107
- 239000004325 lysozyme Substances 0.000 claims abstract description 107
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 24
- 238000011282 treatment Methods 0.000 claims abstract description 24
- 206010040070 Septic Shock Diseases 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 19
- 241001465754 Metazoa Species 0.000 claims abstract description 16
- 230000036303 septic shock Effects 0.000 claims abstract description 15
- 206010040047 Sepsis Diseases 0.000 claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
- 230000002265 prevention Effects 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 5
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 3
- 239000002674 ointment Substances 0.000 claims abstract description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 55
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 55
- 208000015181 infectious disease Diseases 0.000 claims description 30
- 208000030507 AIDS Diseases 0.000 claims description 27
- 239000003242 anti bacterial agent Substances 0.000 claims description 17
- 230000003115 biocidal effect Effects 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 230000007246 mechanism Effects 0.000 claims description 11
- 210000000265 leukocyte Anatomy 0.000 claims description 9
- 230000037125 natural defense Effects 0.000 claims description 9
- 102000004889 Interleukin-6 Human genes 0.000 claims description 8
- 108090001005 Interleukin-6 Proteins 0.000 claims description 8
- 206010057249 Phagocytosis Diseases 0.000 claims description 8
- 230000008782 phagocytosis Effects 0.000 claims description 8
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims description 7
- 229960002555 zidovudine Drugs 0.000 claims description 7
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 6
- 102000014150 Interferons Human genes 0.000 claims description 6
- 108010050904 Interferons Proteins 0.000 claims description 6
- 229940079322 interferon Drugs 0.000 claims description 6
- 229940100601 interleukin-6 Drugs 0.000 claims description 6
- 229930182555 Penicillin Natural products 0.000 claims description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 4
- 229940049954 penicillin Drugs 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 3
- 230000008260 defense mechanism Effects 0.000 claims description 3
- 229960003276 erythromycin Drugs 0.000 claims description 3
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 229930186147 Cephalosporin Natural products 0.000 claims description 2
- 229930193140 Neomycin Natural products 0.000 claims description 2
- 229960000723 ampicillin Drugs 0.000 claims description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 2
- 229940124587 cephalosporin Drugs 0.000 claims description 2
- 150000001780 cephalosporins Chemical class 0.000 claims description 2
- 229960004927 neomycin Drugs 0.000 claims description 2
- 229940102223 injectable solution Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 14
- 238000002360 preparation method Methods 0.000 abstract description 11
- 208000027418 Wounds and injury Diseases 0.000 abstract description 5
- 239000003755 preservative agent Substances 0.000 abstract description 5
- 206010028980 Neoplasm Diseases 0.000 abstract description 4
- 206010052428 Wound Diseases 0.000 abstract description 4
- 230000002335 preservative effect Effects 0.000 abstract description 4
- 230000002956 necrotizing effect Effects 0.000 abstract description 2
- 238000006471 dimerization reaction Methods 0.000 abstract 3
- 239000000499 gel Substances 0.000 abstract 1
- 238000011081 inoculation Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 30
- 238000012360 testing method Methods 0.000 description 23
- 210000004698 lymphocyte Anatomy 0.000 description 21
- 102000004127 Cytokines Human genes 0.000 description 19
- 108090000695 Cytokines Proteins 0.000 description 19
- 241000283690 Bos taurus Species 0.000 description 18
- 241000725303 Human immunodeficiency virus Species 0.000 description 16
- 229940088710 antibiotic agent Drugs 0.000 description 16
- 238000000338 in vitro Methods 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 230000000242 pagocytic effect Effects 0.000 description 10
- 108010005627 KLP602 Proteins 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 230000010076 replication Effects 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000000589 Interleukin-1 Human genes 0.000 description 8
- 108010002352 Interleukin-1 Proteins 0.000 description 8
- 102000000588 Interleukin-2 Human genes 0.000 description 8
- 108010002350 Interleukin-2 Proteins 0.000 description 8
- 210000001744 T-lymphocyte Anatomy 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 206010037660 Pyrexia Diseases 0.000 description 7
- 241000282887 Suidae Species 0.000 description 7
- 239000012888 bovine serum Substances 0.000 description 7
- 239000013068 control sample Substances 0.000 description 7
- 230000028993 immune response Effects 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 6
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 6
- 210000002540 macrophage Anatomy 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000031886 HIV Infections Diseases 0.000 description 5
- 208000037357 HIV infectious disease Diseases 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 244000309466 calf Species 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 5
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 210000005075 mammary gland Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000035473 Communicable disease Diseases 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 102000006354 HLA-DR Antigens Human genes 0.000 description 4
- 108010058597 HLA-DR Antigens Proteins 0.000 description 4
- 206010044248 Toxic shock syndrome Diseases 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 239000002158 endotoxin Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 210000001616 monocyte Anatomy 0.000 description 4
- 230000008506 pathogenesis Effects 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 231100000699 Bacterial toxin Toxicity 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 241000283086 Equidae Species 0.000 description 3
- 102000015696 Interleukins Human genes 0.000 description 3
- 108010063738 Interleukins Proteins 0.000 description 3
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 3
- 102000006601 Thymidine Kinase Human genes 0.000 description 3
- 108020004440 Thymidine kinase Proteins 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000036436 anti-hiv Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000003305 autocrine Effects 0.000 description 3
- 239000000688 bacterial toxin Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000003532 endogenous pyrogen Substances 0.000 description 3
- 239000000147 enterotoxin Substances 0.000 description 3
- 231100000655 enterotoxin Toxicity 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 210000003714 granulocyte Anatomy 0.000 description 3
- 230000005965 immune activity Effects 0.000 description 3
- 238000000099 in vitro assay Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 230000003076 paracrine Effects 0.000 description 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000001698 pyrogenic effect Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 206010001513 AIDS related complex Diseases 0.000 description 2
- 208000031729 Bacteremia Diseases 0.000 description 2
- 201000004813 Bronchopneumonia Diseases 0.000 description 2
- 241000701931 Canine parvovirus Species 0.000 description 2
- 208000037487 Endotoxemia Diseases 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000006992 Interferon-alpha Human genes 0.000 description 2
- 108010047761 Interferon-alpha Proteins 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 241000194054 Streptococcus uberis Species 0.000 description 2
- BMQYVXCPAOLZOK-UHFFFAOYSA-N Trihydroxypropylpterisin Natural products OCC(O)C(O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000037006 agalactosis Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- RDLPVSKMFDYCOR-UEKVPHQBSA-N cephradine Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CCC=CC1 RDLPVSKMFDYCOR-UEKVPHQBSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000002095 exotoxin Substances 0.000 description 2
- 231100000776 exotoxin Toxicity 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000021760 high fever Diseases 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000527 lymphocytic effect Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- BMQYVXCPAOLZOK-XINAWCOVSA-N neopterin Chemical compound OC[C@@H](O)[C@@H](O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-XINAWCOVSA-N 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229940115922 streptococcus uberis Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 239000013638 trimer Substances 0.000 description 2
- 230000006433 tumor necrosis factor production Effects 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 101001023095 Anemonia sulcata Delta-actitoxin-Avd1a Proteins 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 101000641989 Araneus ventricosus Kunitz-type U1-aranetoxin-Av1a Proteins 0.000 description 1
- 206010053555 Arthritis bacterial Diseases 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 101001028691 Carybdea rastonii Toxin CrTX-A Proteins 0.000 description 1
- 101000685083 Centruroides infamatus Beta-toxin Cii1 Proteins 0.000 description 1
- 101000685085 Centruroides noxius Toxin Cn1 Proteins 0.000 description 1
- 101001028688 Chironex fleckeri Toxin CfTX-1 Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 241000761389 Copa Species 0.000 description 1
- 101000644407 Cyriopagopus schmidti U6-theraphotoxin-Hs1a Proteins 0.000 description 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
- 206010014824 Endotoxic shock Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 208000031957 HIV carrier Diseases 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 208000003623 Hypoalbuminemia Diseases 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 206010024774 Localised infection Diseases 0.000 description 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- 102000006386 Myelin Proteins Human genes 0.000 description 1
- 108010083674 Myelin Proteins Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 1
- 101000679608 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) Cysteine rich necrotrophic effector Tox1 Proteins 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 208000035109 Pneumococcal Infections Diseases 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000192023 Sarcina Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 206010044250 Toxic shock syndrome staphylococcal Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 206010046793 Uterine inflammation Diseases 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 206010047400 Vibrio infections Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000001729 effect on metabolism Effects 0.000 description 1
- 206010014665 endocarditis Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000010429 evolutionary process Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000007233 immunological mechanism Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004216 mammary stem cell Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 210000002864 mononuclear phagocyte Anatomy 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- 210000004457 myocytus nodalis Anatomy 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000004796 pathophysiological change Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000002399 phagocytotic effect Effects 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 239000012451 post-reaction mixture Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 201000002765 pyometritis Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 238000011268 retreatment Methods 0.000 description 1
- 238000002435 rhinoplasty Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000017756 staphylococcal toxic-shock syndrome Diseases 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL92295273A PL173978B1 (pl) | 1992-07-13 | 1992-07-13 | Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej |
| PCT/EP1993/001841 WO1994001127A1 (en) | 1992-07-13 | 1993-07-13 | Lysozyme dimer and compositions containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG99287A BG99287A (bg) | 1995-08-28 |
| BG63331B1 true BG63331B1 (bg) | 2001-10-31 |
Family
ID=20058087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG99287A BG63331B1 (bg) | 1992-07-13 | 1994-12-22 | Лизозимен димер и състави, които го съдържат |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6132715A (es) |
| EP (1) | EP0651654B1 (es) |
| JP (1) | JPH07508744A (es) |
| KR (1) | KR100289841B1 (es) |
| CN (1) | CN1057937C (es) |
| AT (1) | ATE252392T1 (es) |
| AU (1) | AU677786B2 (es) |
| BG (1) | BG63331B1 (es) |
| BR (1) | BR9306722A (es) |
| CA (1) | CA2140140A1 (es) |
| CZ (1) | CZ286725B6 (es) |
| DE (2) | DE69333258T2 (es) |
| DK (1) | DK0651654T3 (es) |
| ES (1) | ES2074037T3 (es) |
| FI (1) | FI950144A (es) |
| GE (1) | GEP20012466B (es) |
| GR (1) | GR950300039T1 (es) |
| HU (1) | HU218151B (es) |
| MX (1) | MX9304197A (es) |
| NZ (2) | NZ254135A (es) |
| OA (1) | OA10125A (es) |
| PL (1) | PL173978B1 (es) |
| PT (1) | PT651654E (es) |
| RO (1) | RO112580B1 (es) |
| RU (1) | RU2145875C1 (es) |
| SG (1) | SG52727A1 (es) |
| SK (1) | SK282377B6 (es) |
| TW (1) | TW259710B (es) |
| UA (1) | UA49789C2 (es) |
| WO (1) | WO1994001127A1 (es) |
| ZA (1) | ZA935046B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183742B1 (en) | 1992-07-13 | 2001-02-06 | Nika Health Products, Limited | Applications of lysozyme dimer |
| DZ1964A1 (fr) * | 1995-01-13 | 2002-10-15 | Nika Health Products Ltd | Nouvelle applications d'un dimère de lysozyme. |
| AU5884096A (en) * | 1995-05-30 | 1996-12-18 | Lectin Biopharma, Inc. | Method of using lectins for agglutination and collection of menstrual flow |
| US6123937A (en) * | 1997-03-14 | 2000-09-26 | Nika Health Products, Limited | Applications of lysozyme dimer |
| ITMI981148A1 (it) | 1998-05-22 | 1999-11-22 | Therapicon Srl | Utilizzo di lisozima c modificato per preparare composizioni medicinali per il trattamento di alcune gravi malattie |
| EP1174147A1 (en) * | 2000-06-27 | 2002-01-23 | Nika Health Products Limited | Reversal of antibiotic resistance with lysozyme dimer |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| RU2472467C2 (ru) * | 2011-04-13 | 2013-01-20 | Государственное научное учреждение Краснодарский научно-исследовательский ветеринарный институт (ГНУ КНИВИ) | Способ профилактики и лечения гастроэнтеритов, обусловленных бактериозами, у телят |
| RU2546911C2 (ru) * | 2013-04-11 | 2015-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Донской государственный аграрный университет" | Способ хранения свинины в охлажденном состоянии |
| CN105106626A (zh) * | 2015-09-30 | 2015-12-02 | 成都倍加特生物科技有限公司 | 一种治疗月经期感染的汤剂药物及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR4020M (es) * | 1965-01-29 | 1966-03-21 | ||
| FR2215201A1 (en) * | 1973-01-24 | 1974-08-23 | Theranol Lab | Broad-spectrum antibiotic compsns. - contg. antibiotic resistant lactic bacilli and enzyme diffusing-agent |
| JPS5533409A (en) * | 1978-08-30 | 1980-03-08 | Eisai Co Ltd | Carcinostatic agent |
| JPS5533408A (en) * | 1978-08-30 | 1980-03-08 | Eisai Co Ltd | Immunity-increasing agent |
| JPS5543040A (en) * | 1978-09-25 | 1980-03-26 | Eisai Co Ltd | Immunity raising agent |
| US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
| US4457919A (en) * | 1980-03-14 | 1984-07-03 | Newport Pharmaceutical International, Inc. | Method of imparting immunomodulating, antiviral or antitumor activity |
| US4510144A (en) * | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
| US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| EP0238851B1 (en) * | 1986-02-19 | 1992-12-09 | Imreg, Inc. | A method and means of assaying an immune system |
| AU624331B2 (en) * | 1988-05-26 | 1992-06-11 | Nika Health Products Ltd. | A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier |
| DE3817955A1 (de) * | 1988-05-27 | 1989-11-30 | Hoechst Ag | Tnf-inhibitor enthaltendes arzneimittel |
| DE68927733T2 (de) * | 1988-05-31 | 1997-06-12 | Napp Systems Inc., San Marcos, Calif. | Vorrichtung und verfahren zur behandlung von druckplatten |
| AU6355190A (en) * | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
| WO1991010731A1 (en) * | 1990-01-08 | 1991-07-25 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
| US5314816A (en) * | 1990-01-08 | 1994-05-24 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
| DK0542795T5 (da) * | 1990-08-03 | 1998-09-07 | Smithkline Beecham Corp | TNF-inhibitorer |
-
1992
- 1992-07-13 PL PL92295273A patent/PL173978B1/pl not_active IP Right Cessation
-
1993
- 1993-07-13 NZ NZ254135A patent/NZ254135A/en not_active IP Right Cessation
- 1993-07-13 JP JP6502985A patent/JPH07508744A/ja active Pending
- 1993-07-13 AT AT93915903T patent/ATE252392T1/de not_active IP Right Cessation
- 1993-07-13 ES ES93915903T patent/ES2074037T3/es not_active Expired - Lifetime
- 1993-07-13 MX MX9304197A patent/MX9304197A/es not_active IP Right Cessation
- 1993-07-13 UA UA95018021A patent/UA49789C2/uk unknown
- 1993-07-13 DE DE69333258T patent/DE69333258T2/de not_active Expired - Lifetime
- 1993-07-13 DK DK93915903T patent/DK0651654T3/da active
- 1993-07-13 DE DE0651654T patent/DE651654T1/de active Pending
- 1993-07-13 ZA ZA935046A patent/ZA935046B/xx unknown
- 1993-07-13 GE GEAP19932466A patent/GEP20012466B/en unknown
- 1993-07-13 SG SG1996008336A patent/SG52727A1/en unknown
- 1993-07-13 WO PCT/EP1993/001841 patent/WO1994001127A1/en active IP Right Grant
- 1993-07-13 CN CN93116771A patent/CN1057937C/zh not_active Expired - Fee Related
- 1993-07-13 SK SK40-95A patent/SK282377B6/sk not_active IP Right Cessation
- 1993-07-13 RU RU95105517A patent/RU2145875C1/ru not_active IP Right Cessation
- 1993-07-13 PT PT93915903T patent/PT651654E/pt unknown
- 1993-07-13 CZ CZ199585A patent/CZ286725B6/cs not_active IP Right Cessation
- 1993-07-13 RO RO95-00041A patent/RO112580B1/ro unknown
- 1993-07-13 EP EP93915903A patent/EP0651654B1/en not_active Expired - Lifetime
- 1993-07-13 AU AU45686/93A patent/AU677786B2/en not_active Ceased
- 1993-07-13 HU HU9500098A patent/HU218151B/hu not_active IP Right Cessation
- 1993-07-13 KR KR1019940704649A patent/KR100289841B1/ko not_active IP Right Cessation
- 1993-07-13 BR BR9306722A patent/BR9306722A/pt not_active Application Discontinuation
- 1993-07-13 CA CA002140140A patent/CA2140140A1/en not_active Abandoned
- 1993-08-03 TW TW082106180A patent/TW259710B/zh active
-
1994
- 1994-12-22 BG BG99287A patent/BG63331B1/bg unknown
-
1995
- 1995-01-12 FI FI950144A patent/FI950144A/fi unknown
- 1995-01-13 OA OA60604A patent/OA10125A/en unknown
- 1995-06-07 US US08/476,561 patent/US6132715A/en not_active Expired - Fee Related
- 1995-07-31 GR GR950300039T patent/GR950300039T1/el unknown
-
1996
- 1996-09-13 NZ NZ299377A patent/NZ299377A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2092183C1 (ru) | Антивирусный или антибактериальный состав и способ его употребления | |
| EP0520021A1 (en) | PHARMACEUTICAL COMPOSITIONS. | |
| EP0651654B1 (en) | Use of lysozyme dimer for the manufacture of a medicament for modulating natural defensive mechanisms | |
| AP628A (en) | New applications of lysozyme dimer. | |
| HUT63335A (en) | Process for producing pharmaceutical compositions for treating diseases of mammals | |
| KR930004599B1 (ko) | 항바이러스성 또는 항균성 조성물 | |
| PL176407B1 (pl) | Kompozycja farmaceutyczna zawierająca dimer lizozymu | |
| RU2202356C2 (ru) | Способ стимуляции репаративных процессов длительно незаживающих ран и трофических язв | |
| MXPA97005246A (es) | Nuevas aplicaciones de dimero de lisozina |