PL170787B1 - Method of obtaining an organic salt and n,n'-diacetlocystine - Google Patents

Method of obtaining an organic salt and n,n'-diacetlocystine

Info

Publication number
PL170787B1
PL170787B1 PL92303924A PL30392492A PL170787B1 PL 170787 B1 PL170787 B1 PL 170787B1 PL 92303924 A PL92303924 A PL 92303924A PL 30392492 A PL30392492 A PL 30392492A PL 170787 B1 PL170787 B1 PL 170787B1
Authority
PL
Poland
Prior art keywords
water
compound
organic
diacetyl
dose
Prior art date
Application number
PL92303924A
Other languages
English (en)
Polish (pl)
Inventor
Carl-Magnus Andersson
Hakan Bergstrand
Edib Jakupovic
Bo-Goeran Josefsson
Magnus Lindvall
Bengt Saernstrand
Eric Teneberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of PL170787B1 publication Critical patent/PL170787B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL92303924A 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetlocystine PL170787B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine
PCT/SE1992/000807 WO1993011104A1 (en) 1991-11-29 1992-11-25 Organic salts of n, n'-diacetyl cystine

Publications (1)

Publication Number Publication Date
PL170787B1 true PL170787B1 (en) 1997-01-31

Family

ID=20384494

Family Applications (2)

Application Number Title Priority Date Filing Date
PL92303924A PL170787B1 (en) 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetlocystine
PL92314567A PL171336B1 (en) 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetylocystine

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL92314567A PL171336B1 (en) 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetylocystine

Country Status (38)

Country Link
US (5) US5385904A (cs)
EP (1) EP0621862B1 (cs)
JP (1) JP3302018B2 (cs)
KR (1) KR100256185B1 (cs)
CN (1) CN1039586C (cs)
AP (1) AP350A (cs)
AT (1) ATE141913T1 (cs)
AU (1) AU657827B2 (cs)
CA (1) CA2123516A1 (cs)
CZ (1) CZ282085B6 (cs)
DE (1) DE69213256T2 (cs)
DK (1) DK0621862T3 (cs)
DZ (1) DZ1637A1 (cs)
EE (1) EE03025B1 (cs)
ES (1) ES2090713T3 (cs)
FI (1) FI942504L (cs)
GR (1) GR3021546T3 (cs)
HK (1) HK62297A (cs)
HR (1) HRP921322B1 (cs)
HU (1) HU215390B (cs)
IL (1) IL103778A (cs)
IS (1) IS1645B (cs)
LV (1) LV11949B (cs)
MA (1) MA22716A1 (cs)
MX (1) MX9206851A (cs)
MY (1) MY110523A (cs)
NO (1) NO301325B1 (cs)
NZ (1) NZ245077A (cs)
PL (2) PL170787B1 (cs)
RU (1) RU2135468C1 (cs)
SE (1) SE9103572D0 (cs)
SG (1) SG73962A1 (cs)
SI (1) SI9200351A (cs)
SK (1) SK281697B6 (cs)
TN (1) TNSN92108A1 (cs)
WO (1) WO1993011104A1 (cs)
YU (1) YU48594B (cs)
ZA (1) ZA928739B (cs)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865463A (en) * 1973-11-12 1975-02-11 Busch & Co Inc Ag Electrical adapter plug
ATE144142T1 (de) * 1991-01-10 1996-11-15 Transcend Therapeutics Inc Verwendung von thiazolidin-4-carboxylatderivaten zur behandlung von lungenerkrankungen
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (en) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
NO20003591L (no) * 2000-07-13 2002-01-14 Thia Medica As Fettsyreanaloger for behandling av kreft
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
KR20040021589A (ko) * 2001-03-13 2004-03-10 아지노모토 가부시키가이샤 화장품 또는 피부 외용제
RU2317299C2 (ru) * 2001-08-10 2008-02-20 Кабусики Кайся Хаясибара Сеибуцу Кагаку Ассоциат, содержащий трегалозу и хлорид кальция, в форме кристаллического моногидрата или безводного кристалла
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
ES2363001T3 (es) * 2003-03-11 2011-07-18 Pharmacia Corporation Sal cristalina de clorhidrato de maleato de s-[2(1-iminoetil)etil]-2-metil-l-cisteina.
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
PL2322180T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
BRPI0615819B8 (pt) 2005-09-14 2021-05-25 Mannkind Corp processo para preparar uma composição de distribuição de fármaco compreendendo um agente ativo e uma micropartícula fumaril dicetopiperazina cristalina.
MX360812B (es) 2006-02-22 2018-11-16 Mannkind Corp Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo.
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
CA3086027C (en) * 2008-06-13 2022-05-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
KR20210027546A (ko) 2009-06-12 2021-03-10 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
JP6385673B2 (ja) 2010-06-21 2018-09-05 マンカインド コーポレイション 乾燥粉末薬物送達システム
RU2569776C2 (ru) 2011-04-01 2015-11-27 Маннкайнд Корпорейшн Блистерная упаковка для фармацевтических картриджей
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
MX369136B (es) 2013-03-15 2019-10-30 Mannkind Corp Composiciones de dicetopiperazina microcristalina y metodos.
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20230157939A1 (en) * 2020-04-28 2023-05-25 Conopco, Inc., D/B/A Unilever Personal care compositions with enhanced solubility actives
US20230372272A1 (en) * 2020-09-28 2023-11-23 Georgia Tech Research Corporation Use of cystine and derivatives thereof as anti-thrombotic and thrombolytic agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB592631A (en) * 1945-04-04 1947-09-24 Du Pont Cysteine and cystine
GB954268A (en) 1962-02-26 1964-04-02 Mead Johnson & Co Decongestant compositions comprising n-acylated sulphydryl compounds
FR8205M (cs) * 1968-12-20 1970-09-14
US3647834A (en) 1969-08-11 1972-03-07 Mead Johnson & Co Zinc mercaptide n-acetylcysteine carboxylate salts
US3878305A (en) * 1972-05-25 1975-04-15 Procter & Gamble Fortification of foodstuffs with n-acyl derivatives of sulphur-containing l-amino acids
US3952115A (en) * 1975-04-02 1976-04-20 The Procter & Gamble Company Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters
US4141734A (en) * 1975-09-11 1979-02-27 Ciba-Geiby Ag Photographic developing process
US4093739A (en) * 1977-06-15 1978-06-06 Mead Johnson & Company Mercaptoacylamidobenzoyl glycine and mucolytic process
JPS6011888B2 (ja) * 1978-10-11 1985-03-28 参天製薬株式会社 リウマチ疾患治療薬
JPS56155298A (en) 1980-05-02 1981-12-01 Tanabe Seiyaku Co Shampoo composition
GB2097256B (en) * 1981-04-02 1985-05-30 Morelle Jean V Compositions containing n-butyryl alphaaminoacids
FR2503151A1 (fr) * 1981-04-02 1982-10-08 Morelle Jean Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux
JPS58164566A (ja) * 1982-03-09 1983-09-29 Kenji Okawa シスチン類の製造法
US4827016A (en) * 1985-09-16 1989-05-02 Morgan Lee R Method and compounds for reducing dermal inflammations
US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US4708965A (en) 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
JPH0660157B2 (ja) * 1985-11-20 1994-08-10 三井東圧化学株式会社 システインからシスチンを製造する方法
JPS62195356A (ja) * 1986-02-20 1987-08-28 Seiwa Kasei:Kk シスチン誘導体及びその塩
AT402931B (de) * 1986-11-07 1997-09-25 Pharmacia Gmbh Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung
SE8704542D0 (sv) * 1987-11-19 1987-11-19 Draco Ab New derivatives of cysteine
IL98310A (en) * 1990-06-08 1996-08-04 Astra Ab Pharmaceutical compositions comprising cystine derivatives
TW221376B (cs) * 1990-06-28 1994-03-01 Astra Ab
GB9111885D0 (en) * 1991-06-03 1991-07-24 Erba Carlo Spa Nerve growth factor for use in the prevention and treatment of viral infections

Also Published As

Publication number Publication date
DE69213256T2 (de) 1997-01-23
DK0621862T3 (da) 1996-09-16
IS3949A (is) 1993-05-30
ZA928739B (en) 1993-06-09
AP9200448A0 (en) 1993-01-31
AU657827B2 (en) 1995-03-23
HU9401473D0 (en) 1994-08-29
NO941968L (no) 1994-05-26
US5804582A (en) 1998-09-08
SK281697B6 (sk) 2001-06-11
CN1073683A (zh) 1993-06-30
JPH07501539A (ja) 1995-02-16
MY110523A (en) 1998-07-31
ATE141913T1 (de) 1996-09-15
FI942504A7 (fi) 1994-05-27
KR100256185B1 (ko) 2000-05-15
NZ245077A (en) 1995-04-27
US5693858A (en) 1997-12-02
US5385904A (en) 1995-01-31
NO301325B1 (no) 1997-10-13
MX9206851A (es) 1993-05-01
DE69213256D1 (de) 1996-10-02
WO1993011104A1 (en) 1993-06-10
IL103778A0 (en) 1993-04-04
HU215390B (hu) 1998-12-28
PL171336B1 (en) 1997-04-30
HRP921322B1 (en) 1998-12-31
JP3302018B2 (ja) 2002-07-15
FI942504A0 (fi) 1994-05-27
GR3021546T3 (en) 1997-02-28
IS1645B (is) 1997-03-25
AU3099692A (en) 1993-06-28
YU48594B (sh) 1998-12-23
HUT70851A (en) 1995-11-28
CA2123516A1 (en) 1993-06-10
SI9200351A (en) 1993-06-30
US5824681A (en) 1998-10-20
US5650538A (en) 1997-07-22
AP350A (en) 1994-08-09
CN1039586C (zh) 1998-08-26
EE03025B1 (et) 1997-08-15
SK63294A3 (en) 1995-02-08
CZ129794A3 (en) 1995-01-18
LV11949A (lv) 1998-01-20
EP0621862B1 (en) 1996-08-28
SG73962A1 (en) 2000-07-18
TNSN92108A1 (fr) 1993-06-08
EP0621862A1 (en) 1994-11-02
MA22716A1 (fr) 1993-07-01
NO941968D0 (no) 1994-05-26
YU99092A (sh) 1995-12-04
IL103778A (en) 1997-08-14
LV11949B (en) 1998-07-20
CZ282085B6 (cs) 1997-05-14
DZ1637A1 (fr) 2002-02-17
SE9103572D0 (sv) 1991-11-29
RU2135468C1 (ru) 1999-08-27
FI942504L (fi) 1994-05-27
HRP921322A2 (en) 1996-10-31
ES2090713T3 (es) 1996-10-16
HK62297A (en) 1997-05-16

Similar Documents

Publication Publication Date Title
PL170787B1 (en) Method of obtaining an organic salt and n,n'-diacetlocystine
US3995039A (en) Pyrazolo [1,5-a] [1,3,5] triazines
IE49701B1 (en) Amides of acyl-carnitines,process for preparing same and pharmaceutical compositions containing such amides
US5541209A (en) Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
US3639477A (en) Novel propoxyguanidine compounds and means of producing the same
JPH0219363A (ja) イミダゾリジン誘導体
PL135749B1 (en) Method of obtaining novel imidazolilophenylamidines
JP2023509360A (ja) 発毛を促進する化合物の合成
US3452040A (en) 5,5-disubstituted hydantoins
US3201459A (en) Guanidine
US4147805A (en) Alkylthiophenoxyalkylamines and the pharmaceutical use thereof
US3901944A (en) 1,3-bis(substituted benzylideneamino)guanidines
US3953461A (en) Amino derivatives of thiazolo[5,4-b]pyridine-6-carboxylic acids and esters
HU182645B (en) Process for preparing n-cyano-n'-2-//4-methyl-5-imidazolyl/-methyl-thio/-ethyl-n''-alkinyl-guanidine
NL8803092A (nl) Tromethaminezout van 1-methyl-beta-oxo-alfa-(fenylcarbamoyl)-2-pyrroolpropionitril.
CS265211B2 (en) Process for preparing derivatives of thieno- and furo/2,3-c/pyrroles
US4338319A (en) Method for the treatment of chronic obstructive airway or cardiac diseases
SK13902000A3 (sk) Trisulfidy, spôsob ich prípravy a farmaceuticky prijateľná kompozícia, ktorá ich obsahuje
US3452141A (en) Methods of treating pain with n**alpha-phthaloyl-alpha-amino acid amides
EP4232161A1 (en) Covalent inhibitors of creatine kinase (ck) and uses thereof for treating and preventing cancer
IE49930B1 (en) Water-soluble hydrazones of 3-formylrifamycin sv
HU180567B (en) Method for producing derivatives of isooxazole
PL83310B1 (en) Aminopropanol derivatives[gb1377787a]