DK0621862T3 - Organiske salte af N,N-diacetylcystin - Google Patents

Organiske salte af N,N-diacetylcystin

Info

Publication number
DK0621862T3
DK0621862T3 DK92924975.3T DK92924975T DK0621862T3 DK 0621862 T3 DK0621862 T3 DK 0621862T3 DK 92924975 T DK92924975 T DK 92924975T DK 0621862 T3 DK0621862 T3 DK 0621862T3
Authority
DK
Denmark
Prior art keywords
diacetylcystine
organic salts
salts
organic
Prior art date
Application number
DK92924975.3T
Other languages
Danish (da)
English (en)
Inventor
Edib Jakupovic
Carl-Magnus Andersson
Hakan Bergstrand
Bo-Goeran Josefsson
Magnus Lindvall
Bengt Saernstrand
Eric Teneberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of DK0621862T3 publication Critical patent/DK0621862T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92924975.3T 1991-11-29 1992-11-25 Organiske salte af N,N-diacetylcystin DK0621862T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (1)

Publication Number Publication Date
DK0621862T3 true DK0621862T3 (da) 1996-09-16

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92924975.3T DK0621862T3 (da) 1991-11-29 1992-11-25 Organiske salte af N,N-diacetylcystin

Country Status (38)

Country Link
US (5) US5385904A (cs)
EP (1) EP0621862B1 (cs)
JP (1) JP3302018B2 (cs)
KR (1) KR100256185B1 (cs)
CN (1) CN1039586C (cs)
AP (1) AP350A (cs)
AT (1) ATE141913T1 (cs)
AU (1) AU657827B2 (cs)
CA (1) CA2123516A1 (cs)
CZ (1) CZ282085B6 (cs)
DE (1) DE69213256T2 (cs)
DK (1) DK0621862T3 (cs)
DZ (1) DZ1637A1 (cs)
EE (1) EE03025B1 (cs)
ES (1) ES2090713T3 (cs)
FI (1) FI942504L (cs)
GR (1) GR3021546T3 (cs)
HK (1) HK62297A (cs)
HR (1) HRP921322B1 (cs)
HU (1) HU215390B (cs)
IL (1) IL103778A (cs)
IS (1) IS1645B (cs)
LV (1) LV11949B (cs)
MA (1) MA22716A1 (cs)
MX (1) MX9206851A (cs)
MY (1) MY110523A (cs)
NO (1) NO301325B1 (cs)
NZ (1) NZ245077A (cs)
PL (2) PL170787B1 (cs)
RU (1) RU2135468C1 (cs)
SE (1) SE9103572D0 (cs)
SG (1) SG73962A1 (cs)
SI (1) SI9200351A (cs)
SK (1) SK281697B6 (cs)
TN (1) TNSN92108A1 (cs)
WO (1) WO1993011104A1 (cs)
YU (1) YU48594B (cs)
ZA (1) ZA928739B (cs)

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SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
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US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (en) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
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EP2322180B1 (en) 2004-08-23 2015-05-27 MannKind Corporation Diketopiperazine salts for drug delivery
US7799344B2 (en) 2005-09-14 2010-09-21 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN101389348A (zh) 2006-02-22 2009-03-18 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
KR101672684B1 (ko) 2008-06-13 2016-11-03 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN102065942B (zh) * 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
IN2014DN03093A (cs) 2011-10-24 2015-05-15 Mannkind Corp
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
RU2650035C2 (ru) 2012-07-12 2018-04-06 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
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BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
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Also Published As

Publication number Publication date
HRP921322B1 (en) 1998-12-31
SK281697B6 (sk) 2001-06-11
EP0621862A1 (en) 1994-11-02
PL171336B1 (en) 1997-04-30
CZ129794A3 (en) 1995-01-18
LV11949A (lv) 1998-01-20
HU9401473D0 (en) 1994-08-29
CN1073683A (zh) 1993-06-30
AU3099692A (en) 1993-06-28
SG73962A1 (en) 2000-07-18
SK63294A3 (en) 1995-02-08
NO301325B1 (no) 1997-10-13
FI942504A0 (fi) 1994-05-27
AP9200448A0 (en) 1993-01-31
US5650538A (en) 1997-07-22
HRP921322A2 (en) 1996-10-31
AP350A (en) 1994-08-09
GR3021546T3 (en) 1997-02-28
IS1645B (is) 1997-03-25
HU215390B (hu) 1998-12-28
ATE141913T1 (de) 1996-09-15
YU48594B (sh) 1998-12-23
PL170787B1 (en) 1997-01-31
CZ282085B6 (cs) 1997-05-14
JPH07501539A (ja) 1995-02-16
ES2090713T3 (es) 1996-10-16
CN1039586C (zh) 1998-08-26
NO941968D0 (no) 1994-05-26
IS3949A (is) 1993-05-30
MA22716A1 (fr) 1993-07-01
KR100256185B1 (ko) 2000-05-15
EP0621862B1 (en) 1996-08-28
US5824681A (en) 1998-10-20
LV11949B (en) 1998-07-20
FI942504A7 (fi) 1994-05-27
IL103778A0 (en) 1993-04-04
US5693858A (en) 1997-12-02
IL103778A (en) 1997-08-14
MX9206851A (es) 1993-05-01
US5804582A (en) 1998-09-08
CA2123516A1 (en) 1993-06-10
DE69213256D1 (de) 1996-10-02
HUT70851A (en) 1995-11-28
MY110523A (en) 1998-07-31
FI942504L (fi) 1994-05-27
EE03025B1 (et) 1997-08-15
TNSN92108A1 (fr) 1993-06-08
WO1993011104A1 (en) 1993-06-10
NO941968L (no) 1994-05-26
US5385904A (en) 1995-01-31
JP3302018B2 (ja) 2002-07-15
YU99092A (sh) 1995-12-04
SI9200351A (en) 1993-06-30
NZ245077A (en) 1995-04-27
ZA928739B (en) 1993-06-09
AU657827B2 (en) 1995-03-23
HK62297A (en) 1997-05-16
RU2135468C1 (ru) 1999-08-27
DE69213256T2 (de) 1997-01-23
SE9103572D0 (sv) 1991-11-29
DZ1637A1 (fr) 2002-02-17

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