PL1706403T3 - Związki imidazo[4,5-c]pirydynowe i sposoby leczenia przeciwwirusowego - Google Patents
Związki imidazo[4,5-c]pirydynowe i sposoby leczenia przeciwwirusowegoInfo
- Publication number
- PL1706403T3 PL1706403T3 PL04815224T PL04815224T PL1706403T3 PL 1706403 T3 PL1706403 T3 PL 1706403T3 PL 04815224 T PL04815224 T PL 04815224T PL 04815224 T PL04815224 T PL 04815224T PL 1706403 T3 PL1706403 T3 PL 1706403T3
- Authority
- PL
- Poland
- Prior art keywords
- imidazo
- methods
- pyridine compounds
- antiviral treatment
- treatment
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 3
- UBOOKRVGOBKDMM-UHFFFAOYSA-N 3h-imidazo[4,5-c]pyridine Chemical class C1=NC=C2NC=NC2=C1 UBOOKRVGOBKDMM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53229203P | 2003-12-22 | 2003-12-22 | |
| US53396304P | 2004-01-02 | 2004-01-02 | |
| US59106904P | 2004-07-26 | 2004-07-26 | |
| US59099004P | 2004-07-26 | 2004-07-26 | |
| US59098904P | 2004-07-26 | 2004-07-26 | |
| US59102404P | 2004-07-26 | 2004-07-26 | |
| PCT/US2004/043112 WO2005063744A2 (en) | 2003-12-22 | 2004-12-21 | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT |
| EP04815224A EP1706403B9 (en) | 2003-12-22 | 2004-12-21 | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1706403T3 true PL1706403T3 (pl) | 2012-07-31 |
Family
ID=34744004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04815224T PL1706403T3 (pl) | 2003-12-22 | 2004-12-21 | Związki imidazo[4,5-c]pirydynowe i sposoby leczenia przeciwwirusowego |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7648998B2 (https=) |
| EP (3) | EP2161273B1 (https=) |
| JP (3) | JP4970048B2 (https=) |
| KR (1) | KR101131589B1 (https=) |
| AT (1) | ATE544765T1 (https=) |
| AU (2) | AU2004309390B2 (https=) |
| CA (1) | CA2549606C (https=) |
| CY (1) | CY1112733T1 (https=) |
| DK (2) | DK1706403T3 (https=) |
| ES (1) | ES2381890T3 (https=) |
| IL (1) | IL176298A (https=) |
| NZ (2) | NZ595000A (https=) |
| PL (1) | PL1706403T3 (https=) |
| PT (1) | PT1706403E (https=) |
| SG (1) | SG149067A1 (https=) |
| SI (1) | SI2161273T1 (https=) |
| WO (1) | WO2005063744A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999044880A1 (en) | 1998-03-02 | 1999-09-10 | Ellsworth Anthony S | Bicycle suspension apparatus and related method |
| GB0215293D0 (en) * | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| EP2161273B1 (en) * | 2003-12-22 | 2015-04-15 | K.U.Leuven Research & Development | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
| BRPI0513811A (pt) * | 2004-07-27 | 2008-07-15 | Gilead Sciences Inc | imidazo [4,5-d] pirimidinas, seus usos e processos de preparação |
| NZ556624A (en) * | 2004-12-21 | 2010-06-25 | Gilead Sciences Inc | 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment |
| US20070128625A1 (en) * | 2005-07-25 | 2007-06-07 | Gilead Sciences, Llc | Drug-resistant mutants of hepatitis C virus |
| AU2011253901B2 (en) * | 2006-07-07 | 2013-08-29 | Gilead Sciences, Inc. | Novel pyridazine compound and use thereof |
| KR101143596B1 (ko) * | 2006-07-07 | 2012-05-11 | 길리애드 사이언시즈, 인코포레이티드 | 신규의 피리다진 화합물 및 이의 용도 |
| CN101484444B (zh) * | 2006-07-07 | 2012-11-21 | 吉里德科学公司 | 哒嗪化合物及其用途 |
| WO2008133669A2 (en) * | 2006-12-14 | 2008-11-06 | Gilead Sciences, Inc. | Viral inhibitors |
| UA99466C2 (en) * | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
| EP2178877A1 (en) * | 2007-07-13 | 2010-04-28 | GlaxoSmithKline LLC | Anti-viral compounds, compositions, and methods of use |
| US20090197880A1 (en) * | 2007-07-13 | 2009-08-06 | Genelabs Technologies, Inc. | Anti-viral compounds, compositions, and methods of use |
| UY31685A (es) * | 2008-03-04 | 2009-11-10 | Smithkline Beecham Corp | Compuestos antivirales, composiciones y metodos para usarlos |
| KR101220182B1 (ko) | 2009-02-25 | 2013-01-11 | 에스케이바이오팜 주식회사 | 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법 |
| US10752611B2 (en) | 2009-02-27 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| RU2544010C2 (ru) | 2009-02-27 | 2015-03-10 | Энанта Фармасьютикалс, Инк. | Ингибиторы вируса гепатита с |
| PH12012501216A1 (en) | 2009-12-18 | 2012-11-05 | Boehringer Ingelheim Int | Hcv combination therapy |
| PE20130244A1 (es) | 2010-01-25 | 2013-03-10 | Enanta Pharm Inc | Inhibidores del virus de la hepatitis c |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| KR101799429B1 (ko) * | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
| EP2571882A1 (en) * | 2010-05-21 | 2013-03-27 | Gilead Sciences, Inc. | Heterocyclic flaviviridae virus inhibitors |
| US8778938B2 (en) | 2010-06-04 | 2014-07-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| WO2012021704A1 (en) | 2010-08-12 | 2012-02-16 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
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| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
| DE202012012955U1 (de) | 2011-10-21 | 2014-07-14 | Abbvie Inc. | Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | N4-ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| US12194023B2 (en) | 2018-11-29 | 2025-01-14 | The Research Foundation For The State University Of New York | Compositions and methods for modular control of bioorthogonal ligation |
| US12577242B2 (en) | 2020-02-24 | 2026-03-17 | Katholieke Universiteit Leuven | Pyrrolopyridine and imidazopyridine antiviral compounds |
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-
2004
- 2004-12-21 EP EP09157035.8A patent/EP2161273B1/en not_active Expired - Lifetime
- 2004-12-21 PT PT04815224T patent/PT1706403E/pt unknown
- 2004-12-21 CA CA2549606A patent/CA2549606C/en not_active Expired - Fee Related
- 2004-12-21 PL PL04815224T patent/PL1706403T3/pl unknown
- 2004-12-21 SI SI200432254T patent/SI2161273T1/sl unknown
- 2004-12-21 AU AU2004309390A patent/AU2004309390B2/en not_active Ceased
- 2004-12-21 SG SG200809590-3A patent/SG149067A1/en unknown
- 2004-12-21 WO PCT/US2004/043112 patent/WO2005063744A2/en not_active Ceased
- 2004-12-21 ES ES04815224T patent/ES2381890T3/es not_active Expired - Lifetime
- 2004-12-21 NZ NZ595000A patent/NZ595000A/xx not_active IP Right Cessation
- 2004-12-21 DK DK04815224.3T patent/DK1706403T3/da active
- 2004-12-21 KR KR1020067012554A patent/KR101131589B1/ko not_active Expired - Fee Related
- 2004-12-21 EP EP04815224A patent/EP1706403B9/en not_active Expired - Lifetime
- 2004-12-21 JP JP2006547305A patent/JP4970048B2/ja not_active Expired - Fee Related
- 2004-12-21 US US10/583,814 patent/US7648998B2/en not_active Expired - Lifetime
- 2004-12-21 EP EP12154571A patent/EP2546254A1/en not_active Withdrawn
- 2004-12-21 NZ NZ548074A patent/NZ548074A/en not_active IP Right Cessation
- 2004-12-21 DK DK09157035.8T patent/DK2161273T3/en active
- 2004-12-21 AT AT04815224T patent/ATE544765T1/de active
- 2004-12-21 US US11/019,830 patent/US20050222198A1/en not_active Abandoned
-
2006
- 2006-06-14 IL IL176298A patent/IL176298A/en not_active IP Right Cessation
-
2009
- 2009-10-13 US US12/577,865 patent/US8329727B2/en not_active Expired - Lifetime
-
2011
- 2011-05-02 JP JP2011103307A patent/JP5395844B2/ja not_active Expired - Fee Related
- 2011-05-13 AU AU2011202214A patent/AU2011202214B2/en not_active Ceased
-
2012
- 2012-04-03 CY CY20121100329T patent/CY1112733T1/el unknown
-
2013
- 2013-07-19 JP JP2013150196A patent/JP2013221030A/ja not_active Withdrawn
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