PL168791B1 - Sposób wytwarzania 4-[(2-benzotiazolilo)metyloamino] -a -[(3,4-dwufluorofenoksy)mety- lo]-1-piperydynoetanolu PL PL - Google Patents

Sposób wytwarzania 4-[(2-benzotiazolilo)metyloamino] -a -[(3,4-dwufluorofenoksy)mety- lo]-1-piperydynoetanolu PL PL

Info

Publication number
PL168791B1
PL168791B1 PL92300354A PL30035492A PL168791B1 PL 168791 B1 PL168791 B1 PL 168791B1 PL 92300354 A PL92300354 A PL 92300354A PL 30035492 A PL30035492 A PL 30035492A PL 168791 B1 PL168791 B1 PL 168791B1
Authority
PL
Poland
Prior art keywords
formula
compound
optionally
mixture
converted
Prior art date
Application number
PL92300354A
Other languages
English (en)
Polish (pl)
Inventor
Raymond Antoine Stokbroekx
Gilbert Arthur Jules Grauwels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL168791B1 publication Critical patent/PL168791B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Paper (AREA)
PL92300354A 1991-02-25 1992-02-14 Sposób wytwarzania 4-[(2-benzotiazolilo)metyloamino] -a -[(3,4-dwufluorofenoksy)mety- lo]-1-piperydynoetanolu PL PL PL168791B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65964591A 1991-02-25 1991-02-25
PCT/EP1992/000356 WO1992014731A1 (en) 1991-02-25 1992-02-14 4-[(2-BENZOTHIAZOLYL)METHYLAMINO]-α-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINEETHANOL

Publications (1)

Publication Number Publication Date
PL168791B1 true PL168791B1 (pl) 1996-04-30

Family

ID=24646210

Family Applications (1)

Application Number Title Priority Date Filing Date
PL92300354A PL168791B1 (pl) 1991-02-25 1992-02-14 Sposób wytwarzania 4-[(2-benzotiazolilo)metyloamino] -a -[(3,4-dwufluorofenoksy)mety- lo]-1-piperydynoetanolu PL PL

Country Status (36)

Country Link
US (2) US5434168A (enExample)
EP (2) EP0573473B1 (enExample)
JP (1) JP2825652B2 (enExample)
KR (1) KR0165901B1 (enExample)
CN (3) CN1033454C (enExample)
AT (1) ATE131478T1 (enExample)
AU (1) AU649788B2 (enExample)
BG (1) BG62332B1 (enExample)
CA (1) CA2104000A1 (enExample)
CY (1) CY1924A (enExample)
CZ (1) CZ284705B6 (enExample)
DE (1) DE69206787T2 (enExample)
DK (1) DK0573473T3 (enExample)
DZ (1) DZ1560A1 (enExample)
EE (1) EE02983B1 (enExample)
ES (1) ES2083737T3 (enExample)
FI (1) FI933719A7 (enExample)
GR (1) GR3018692T3 (enExample)
HK (1) HK172296A (enExample)
HU (2) HUT67695A (enExample)
IE (1) IE69567B1 (enExample)
IL (3) IL100952A (enExample)
LV (1) LV11689B (enExample)
MA (1) MA22447A1 (enExample)
MX (1) MX9200777A (enExample)
NO (1) NO300591B1 (enExample)
NZ (2) NZ241592A (enExample)
PL (1) PL168791B1 (enExample)
RO (1) RO112959B1 (enExample)
RU (2) RU2106348C1 (enExample)
SK (1) SK278705B6 (enExample)
TN (1) TNSN92017A1 (enExample)
TW (1) TW218016B (enExample)
WO (1) WO1992014731A1 (enExample)
ZA (1) ZA921341B (enExample)
ZW (1) ZW1992A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (enExample) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
FI971534L (fi) * 1994-10-14 1997-04-11 Janssen Pharmaceutica Nv Oraalisia sabelutsolisuspensioita
AU693969B2 (en) * 1994-11-24 1998-07-09 Janssen Pharmaceutica N.V. Lubeluzole intravenous solutions
AU693354B2 (en) * 1995-04-10 1998-06-25 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
AU7298296A (en) * 1995-10-25 1997-05-15 Janssen Pharmaceutica N.V. Lubeluzole n-oxide
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
KR100365312B1 (ko) * 1996-06-27 2003-03-06 얀센 파마슈티카 엔.브이. N-[4-(헤테로아릴메틸)페닐]헤테로아릴아민
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
KR20010031912A (ko) * 1997-11-10 2001-04-16 스티븐 비. 데이비스 벤조티아졸 단백질 티로신 키나제 억제제
GB9815785D0 (en) * 1998-07-20 1998-09-16 Cerebrus Ltd Chemical compounds
DE60020556T2 (de) 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963732A (en) * 1973-05-30 1976-06-15 Tiberio Bruzzese Process for preparing dihydroxydiphenylmethane derivatives
GB1458392A (en) * 1973-11-09 1976-12-15 Ici Ltd Optically-active 1-aryloxy-2,3-epoxypropane derivatives
US4310658A (en) * 1980-06-18 1982-01-12 Allied Corporation Production of polyester thermally stabilized with an oxirane
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
US4689330A (en) * 1985-04-15 1987-08-25 Janssen Pharmaceutica N.V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
US4717760A (en) * 1986-07-10 1988-01-05 The Dow Chemical Company Fluorinated tris-epoxides based on triphenyl methane
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol

Also Published As

Publication number Publication date
JP2825652B2 (ja) 1998-11-18
IL100952A0 (en) 1992-11-15
NZ241592A (en) 1994-07-26
CA2104000A1 (en) 1992-08-26
DZ1560A1 (fr) 2002-02-17
CZ284705B6 (cs) 1999-02-17
ES2083737T3 (es) 1996-04-16
EP0501552A1 (en) 1992-09-02
LV11689A (lv) 1997-02-20
FI933719A0 (fi) 1993-08-24
US5434168A (en) 1995-07-18
AU649788B2 (en) 1994-06-02
CS51292A3 (en) 1992-09-16
IE920575A1 (en) 1992-08-26
CN1113437A (zh) 1995-12-20
NO300591B1 (no) 1997-06-23
CN1043609C (zh) 1999-06-16
IL113837A (en) 1996-05-14
HU9302395D0 (en) 1993-11-29
IL113837A0 (en) 1995-08-31
BG62332B1 (bg) 1999-08-31
BG98068A (bg) 1994-06-30
IE69567B1 (en) 1996-10-02
JPH06505012A (ja) 1994-06-09
CY1924A (en) 1997-03-07
NZ248437A (en) 1994-07-26
LV11689B (en) 1997-08-20
NO933010D0 (no) 1993-08-24
CN1064865A (zh) 1992-09-30
NO933010L (no) 1993-08-24
GR3018692T3 (en) 1996-04-30
HU211560A9 (en) 1995-12-28
TNSN92017A1 (fr) 1993-06-08
RU2106348C1 (ru) 1998-03-10
FI933719L (fi) 1993-08-24
HK172296A (en) 1996-09-20
FI933719A7 (fi) 1993-08-24
ZW1992A1 (en) 1993-09-22
TW218016B (enExample) 1993-12-21
CN1117048A (zh) 1996-02-21
HUT67695A (en) 1995-04-28
RU95112519A (ru) 1997-04-20
US5675027A (en) 1997-10-07
AU1208592A (en) 1992-09-15
ATE131478T1 (de) 1995-12-15
DE69206787T2 (de) 1996-06-05
EP0573473A1 (en) 1993-12-15
MX9200777A (es) 1992-08-01
RO112959B1 (ro) 1998-02-27
DE69206787D1 (de) 1996-01-25
IL100952A (en) 1995-12-31
RU2094434C1 (ru) 1997-10-27
WO1992014731A1 (en) 1992-09-03
MA22447A1 (fr) 1992-10-01
CN1033454C (zh) 1996-12-04
DK0573473T3 (da) 1996-01-29
KR0165901B1 (en) 1999-01-15
ZA921341B (en) 1993-08-24
EE02983B1 (et) 1997-04-15
EP0573473B1 (en) 1995-12-13
SK278705B6 (sk) 1998-01-14

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