KR0165901B1 - 4-[(2-BENZOTHIAZOLYL) METHYLAMINO]-Ñß-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINE ETHANOL - Google Patents

4-[(2-BENZOTHIAZOLYL) METHYLAMINO]-Ñß-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINE ETHANOL Download PDF

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Publication number
KR0165901B1
KR0165901B1 KR1019930702525A KR930702525A KR0165901B1 KR 0165901 B1 KR0165901 B1 KR 0165901B1 KR 1019930702525 A KR1019930702525 A KR 1019930702525A KR 930702525 A KR930702525 A KR 930702525A KR 0165901 B1 KR0165901 B1 KR 0165901B1
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KR
South Korea
Prior art keywords
difluorophenoxy
benzothiazolyl
methylamino
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019930702525A
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English (en)
Korean (ko)
Inventor
Raymond Antoine Stokbroekz
Gilbert Arthur Jules Grawwels
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Janssen Pharmaceutica Nv
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Epoxy Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Paper (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
KR1019930702525A 1991-02-25 1993-08-23 4-[(2-BENZOTHIAZOLYL) METHYLAMINO]-Ñß-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINE ETHANOL Expired - Fee Related KR0165901B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65964591A 1991-02-25 1991-02-25
PCT/EP1992/000356 WO1992014731A1 (en) 1991-02-25 1992-02-14 4-[(2-BENZOTHIAZOLYL)METHYLAMINO]-α-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINEETHANOL

Publications (1)

Publication Number Publication Date
KR0165901B1 true KR0165901B1 (en) 1999-01-15

Family

ID=24646210

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930702525A Expired - Fee Related KR0165901B1 (en) 1991-02-25 1993-08-23 4-[(2-BENZOTHIAZOLYL) METHYLAMINO]-Ñß-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINE ETHANOL

Country Status (36)

Country Link
US (2) US5434168A (enExample)
EP (2) EP0573473B1 (enExample)
JP (1) JP2825652B2 (enExample)
KR (1) KR0165901B1 (enExample)
CN (3) CN1033454C (enExample)
AT (1) ATE131478T1 (enExample)
AU (1) AU649788B2 (enExample)
BG (1) BG62332B1 (enExample)
CA (1) CA2104000A1 (enExample)
CY (1) CY1924A (enExample)
CZ (1) CZ284705B6 (enExample)
DE (1) DE69206787T2 (enExample)
DK (1) DK0573473T3 (enExample)
DZ (1) DZ1560A1 (enExample)
EE (1) EE02983B1 (enExample)
ES (1) ES2083737T3 (enExample)
FI (1) FI933719L (enExample)
GR (1) GR3018692T3 (enExample)
HK (1) HK172296A (enExample)
HU (2) HUT67695A (enExample)
IE (1) IE69567B1 (enExample)
IL (3) IL100952A (enExample)
LV (1) LV11689B (enExample)
MA (1) MA22447A1 (enExample)
MX (1) MX9200777A (enExample)
NO (1) NO300591B1 (enExample)
NZ (2) NZ241592A (enExample)
PL (1) PL168791B1 (enExample)
RO (1) RO112959B1 (enExample)
RU (2) RU2106348C1 (enExample)
SK (1) SK278705B6 (enExample)
TN (1) TNSN92017A1 (enExample)
TW (1) TW218016B (enExample)
WO (1) WO1992014731A1 (enExample)
ZA (1) ZA921341B (enExample)
ZW (1) ZW1992A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (enExample) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
RU2141821C1 (ru) * 1994-10-14 1999-11-27 Жансен Фармасетика Н.В. Водная суспензия сабелюзола для орального применения и способ ее изготовления
FI972204A0 (fi) * 1994-11-24 1997-05-23 Janssen Pharmaceutica Nv Suonensisäisiä lubelutsoliliuoksia
AU693354B2 (en) * 1995-04-10 1998-06-25 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
IL123083A0 (en) * 1995-10-25 1998-09-24 Janssen Pharmaceutica Nv Lubeluzole n-oxides their preparation and pharmaceutical compositions containing them
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
ES2188957T3 (es) * 1996-06-27 2003-07-01 Janssen Pharmaceutica Nv N-(4-(heteroarilmetil)fenil)-heteroarilaminas.
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
IL135176A0 (en) * 1997-11-10 2001-05-20 Bristol Myers Squibb Co Benzothiazole derivatives and pharmaceutical compositions containing the same
GB9815785D0 (en) * 1998-07-20 1998-09-16 Cerebrus Ltd Chemical compounds
DE60020556T2 (de) 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963732A (en) * 1973-05-30 1976-06-15 Tiberio Bruzzese Process for preparing dihydroxydiphenylmethane derivatives
GB1458392A (en) * 1973-11-09 1976-12-15 Ici Ltd Optically-active 1-aryloxy-2,3-epoxypropane derivatives
US4310658A (en) * 1980-06-18 1982-01-12 Allied Corporation Production of polyester thermally stabilized with an oxirane
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4689330A (en) * 1985-04-15 1987-08-25 Janssen Pharmaceutica N.V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4717760A (en) * 1986-07-10 1988-01-05 The Dow Chemical Company Fluorinated tris-epoxides based on triphenyl methane
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol

Also Published As

Publication number Publication date
IL113837A0 (en) 1995-08-31
CN1113437A (zh) 1995-12-20
US5675027A (en) 1997-10-07
PL168791B1 (pl) 1996-04-30
CZ284705B6 (cs) 1999-02-17
NO300591B1 (no) 1997-06-23
RU2094434C1 (ru) 1997-10-27
EP0573473A1 (en) 1993-12-15
AU649788B2 (en) 1994-06-02
MA22447A1 (fr) 1992-10-01
GR3018692T3 (en) 1996-04-30
CN1117048A (zh) 1996-02-21
IE920575A1 (en) 1992-08-26
TW218016B (enExample) 1993-12-21
NZ248437A (en) 1994-07-26
FI933719A0 (fi) 1993-08-24
DZ1560A1 (fr) 2002-02-17
IL113837A (en) 1996-05-14
CS51292A3 (en) 1992-09-16
ES2083737T3 (es) 1996-04-16
LV11689B (en) 1997-08-20
ZW1992A1 (en) 1993-09-22
EP0501552A1 (en) 1992-09-02
LV11689A (lv) 1997-02-20
HK172296A (en) 1996-09-20
US5434168A (en) 1995-07-18
IL100952A (en) 1995-12-31
ZA921341B (en) 1993-08-24
HUT67695A (en) 1995-04-28
IL100952A0 (en) 1992-11-15
DE69206787T2 (de) 1996-06-05
ATE131478T1 (de) 1995-12-15
CN1064865A (zh) 1992-09-30
CA2104000A1 (en) 1992-08-26
NZ241592A (en) 1994-07-26
BG98068A (bg) 1994-06-30
AU1208592A (en) 1992-09-15
SK278705B6 (sk) 1998-01-14
RU95112519A (ru) 1997-04-20
JP2825652B2 (ja) 1998-11-18
IE69567B1 (en) 1996-10-02
RO112959B1 (ro) 1998-02-27
HU211560A9 (en) 1995-12-28
CN1033454C (zh) 1996-12-04
HU9302395D0 (en) 1993-11-29
CN1043609C (zh) 1999-06-16
EE02983B1 (et) 1997-04-15
RU2106348C1 (ru) 1998-03-10
WO1992014731A1 (en) 1992-09-03
EP0573473B1 (en) 1995-12-13
NO933010L (no) 1993-08-24
TNSN92017A1 (fr) 1993-06-08
DE69206787D1 (de) 1996-01-25
FI933719A7 (fi) 1993-08-24
MX9200777A (es) 1992-08-01
BG62332B1 (bg) 1999-08-31
NO933010D0 (no) 1993-08-24
FI933719L (fi) 1993-08-24
JPH06505012A (ja) 1994-06-09
DK0573473T3 (da) 1996-01-29
CY1924A (en) 1997-03-07

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