PL147842B1 - Method of obtaining novel pyroisobenzimidazoles - Google Patents
Method of obtaining novel pyroisobenzimidazoles Download PDFInfo
- Publication number
- PL147842B1 PL147842B1 PL1985259261A PL25926185A PL147842B1 PL 147842 B1 PL147842 B1 PL 147842B1 PL 1985259261 A PL1985259261 A PL 1985259261A PL 25926185 A PL25926185 A PL 25926185A PL 147842 B1 PL147842 B1 PL 147842B1
- Authority
- PL
- Poland
- Prior art keywords
- yield
- melting point
- general formula
- group
- ethanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843417643 DE3417643A1 (de) | 1984-05-12 | 1984-05-12 | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE19843446417 DE3446417A1 (de) | 1984-12-20 | 1984-12-20 | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL147842B1 true PL147842B1 (en) | 1989-08-31 |
Family
ID=25821132
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1985259261A PL147842B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyroisobenzimidazoles |
| PL1985253246A PL144822B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyrolobenzimidazoles |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1985253246A PL144822B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyrolobenzimidazoles |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4666923A (browse.php) |
| EP (1) | EP0161632B1 (browse.php) |
| JP (2) | JPH0647593B2 (browse.php) |
| KR (1) | KR870001201B1 (browse.php) |
| AU (1) | AU560349B2 (browse.php) |
| DE (1) | DE3582447D1 (browse.php) |
| DK (1) | DK209585A (browse.php) |
| ES (1) | ES8603178A1 (browse.php) |
| FI (1) | FI81351C (browse.php) |
| GR (1) | GR851085B (browse.php) |
| HU (1) | HU193754B (browse.php) |
| IL (1) | IL75120A (browse.php) |
| NO (1) | NO851862L (browse.php) |
| NZ (1) | NZ212005A (browse.php) |
| PH (1) | PH22863A (browse.php) |
| PL (2) | PL147842B1 (browse.php) |
| PT (1) | PT80425B (browse.php) |
| SU (1) | SU1480770A3 (browse.php) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL147842B1 (en) * | 1984-05-12 | 1989-08-31 | Method of obtaining novel pyroisobenzimidazoles | |
| DE3445669A1 (de) * | 1984-12-14 | 1986-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3524067A1 (de) * | 1985-07-05 | 1987-01-08 | Boehringer Mannheim Gmbh | Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3530825A1 (de) * | 1985-08-29 | 1987-03-05 | Boehringer Mannheim Gmbh | Neue benzodipyrrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3626664A1 (de) * | 1986-08-07 | 1988-02-11 | Boehringer Mannheim Gmbh | Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3639466A1 (de) * | 1986-11-18 | 1988-05-19 | Thomae Gmbh Dr K | Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3642315A1 (de) * | 1986-12-11 | 1988-06-23 | Boehringer Mannheim Gmbh | Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3740985A1 (de) * | 1987-12-03 | 1989-06-15 | Boehringer Mannheim Gmbh | Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation |
| DE3855327D1 (de) * | 1987-12-30 | 1996-07-04 | Orion Yhtymae Oy | Heterocyclische Verbindungen |
| US4963677A (en) * | 1987-12-30 | 1990-10-16 | Orion Corporation Ltd. | Heterocyclic lactam compounds |
| DE3803775A1 (de) * | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US5324911A (en) * | 1990-01-08 | 1994-06-28 | Schroer Manufacturing Company | Heated animal surgery table |
| DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060142247A1 (en) * | 2004-12-17 | 2006-06-29 | Guy Georges | Tricyclic heterocycles |
| EP1885725B1 (en) * | 2005-04-14 | 2008-09-24 | F.Hoffmann-La Roche Ag | Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents |
| EP1879894A1 (en) * | 2005-04-14 | 2008-01-23 | F.Hoffmann-La Roche Ag | Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents |
| JP2009519279A (ja) * | 2005-12-15 | 2009-05-14 | エフ．ホフマン−ラ ロシュ アーゲー | 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用 |
| JP2009530337A (ja) * | 2006-03-23 | 2009-08-27 | エフ．ホフマン−ラ ロシュ アーゲー | 置換インダゾール誘導体、その製造方法、及びその薬剤としての利用法 |
| US8063225B2 (en) | 2006-08-14 | 2011-11-22 | Chembridge Corporation | Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| RU2443704C1 (ru) * | 2010-10-29 | 2012-02-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СУЛЬФАТЫ 2-АРИЛ-4-ДИАЛКИЛАМИНОЭТИЛ-3-ФЕНИЛПИРРОЛО[1,2-a]-БЕНЗИМИДАЗОЛОВ, ОБЛАДАЮЩИЕ АНТИОКСИДАНТНЫМИ И АНТИРАДИКАЛЬНЫМИ СВОЙСТВАМИ |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| BR112015005186A2 (pt) | 2012-09-13 | 2017-07-04 | Hoffmann La Roche | 2-oxo-2,3-di-hidro-indóis para tratamento de distúrbios do snc |
| HK1218629A1 (zh) | 2013-02-25 | 2017-03-03 | Bausch Health Ireland Limited | 用於结肠清洁的鸟苷酸环化酶受体激动剂 |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| MX375926B (es) | 2013-08-09 | 2025-03-07 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
| GB201709456D0 (en) * | 2017-06-14 | 2017-07-26 | Ucb Biopharma Sprl | Therapeutic agents |
| EP3972599A1 (en) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| JP6854953B1 (ja) | 2020-06-16 | 2021-04-07 | 株式会社ソディック | ワイヤ放電加工装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| FR1529901A (fr) * | 1967-05-12 | 1968-06-21 | Centre Nat Rech Scient | Procédé de préparation de lactames se rattachant à l'indolinone et à l'oxo quinoléine |
| BE714717A (browse.php) * | 1967-05-12 | 1968-09-30 | ||
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| PL147842B1 (en) * | 1984-05-12 | 1989-08-31 | Method of obtaining novel pyroisobenzimidazoles |
-
1985
- 1985-05-06 PL PL1985259261A patent/PL147842B1/pl unknown
- 1985-05-06 PL PL1985253246A patent/PL144822B1/pl unknown
- 1985-05-06 GR GR851085A patent/GR851085B/el unknown
- 1985-05-07 US US06/731,500 patent/US4666923A/en not_active Expired - Lifetime
- 1985-05-07 IL IL75120A patent/IL75120A/xx unknown
- 1985-05-07 NZ NZ212005A patent/NZ212005A/xx unknown
- 1985-05-08 PH PH32240A patent/PH22863A/en unknown
- 1985-05-09 PT PT80425A patent/PT80425B/pt not_active IP Right Cessation
- 1985-05-09 EP EP85105675A patent/EP0161632B1/de not_active Expired - Lifetime
- 1985-05-09 AU AU42222/85A patent/AU560349B2/en not_active Ceased
- 1985-05-09 KR KR1019850003144A patent/KR870001201B1/ko not_active Expired
- 1985-05-09 ES ES542976A patent/ES8603178A1/es not_active Expired
- 1985-05-09 DE DE8585105675T patent/DE3582447D1/de not_active Expired - Lifetime
- 1985-05-10 DK DK209585A patent/DK209585A/da not_active Application Discontinuation
- 1985-05-10 FI FI851869A patent/FI81351C/fi not_active Application Discontinuation
- 1985-05-10 NO NO851862A patent/NO851862L/no unknown
- 1985-05-10 SU SU853894709A patent/SU1480770A3/ru active
- 1985-05-10 HU HU851775A patent/HU193754B/hu not_active IP Right Cessation
- 1985-05-13 JP JP60099742A patent/JPH0647593B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-05 US US07/217,143 patent/US4963686A/en not_active Expired - Fee Related
-
1993
- 1993-12-10 JP JP5310823A patent/JPH0772185B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL253246A1 (en) | 1986-08-26 |
| ES542976A0 (es) | 1986-01-01 |
| SU1480770A3 (ru) | 1989-05-15 |
| US4666923A (en) | 1987-05-19 |
| NO851862L (no) | 1985-11-13 |
| FI81351B (fi) | 1990-06-29 |
| KR850008170A (ko) | 1985-12-13 |
| NZ212005A (en) | 1989-07-27 |
| EP0161632A3 (en) | 1986-06-11 |
| FI81351C (fi) | 1990-10-10 |
| PT80425A (de) | 1985-06-01 |
| KR870001201B1 (ko) | 1987-06-20 |
| EP0161632A2 (de) | 1985-11-21 |
| PH22863A (en) | 1989-01-19 |
| US4963686A (en) | 1990-10-16 |
| IL75120A0 (en) | 1985-09-29 |
| EP0161632B1 (de) | 1991-04-10 |
| AU560349B2 (en) | 1987-04-02 |
| JPH0772185B2 (ja) | 1995-08-02 |
| ES8603178A1 (es) | 1986-01-01 |
| FI851869L (fi) | 1985-11-13 |
| AU4222285A (en) | 1985-11-14 |
| GR851085B (browse.php) | 1985-11-25 |
| JPH0647593B2 (ja) | 1994-06-22 |
| PL144822B1 (en) | 1988-07-30 |
| JPS60246386A (ja) | 1985-12-06 |
| HU193754B (en) | 1987-11-30 |
| DK209585D0 (da) | 1985-05-10 |
| HUT37938A (en) | 1986-03-28 |
| PT80425B (de) | 1987-04-16 |
| DE3582447D1 (de) | 1991-05-16 |
| JPH0741474A (ja) | 1995-02-10 |
| DK209585A (da) | 1985-11-13 |
| IL75120A (en) | 1989-02-28 |
| FI851869A0 (fi) | 1985-05-10 |
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