PL147123B1 - Method of obtaining novel derivatives of dihydropyridazinone - Google Patents

Method of obtaining novel derivatives of dihydropyridazinone Download PDF

Info

Publication number
PL147123B1
PL147123B1 PL1985251516A PL25151685A PL147123B1 PL 147123 B1 PL147123 B1 PL 147123B1 PL 1985251516 A PL1985251516 A PL 1985251516A PL 25151685 A PL25151685 A PL 25151685A PL 147123 B1 PL147123 B1 PL 147123B1
Authority
PL
Poland
Prior art keywords
compounds
formula
compound
methyl
pyridazinone
Prior art date
Application number
PL1985251516A
Other languages
English (en)
Polish (pl)
Other versions
PL251516A1 (en
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of PL251516A1 publication Critical patent/PL251516A1/xx
Publication of PL147123B1 publication Critical patent/PL147123B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
PL1985251516A 1984-01-13 1985-01-11 Method of obtaining novel derivatives of dihydropyridazinone PL147123B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848400863A GB8400863D0 (en) 1984-01-13 1984-01-13 Chemical compounds

Publications (2)

Publication Number Publication Date
PL251516A1 PL251516A1 (en) 1985-12-17
PL147123B1 true PL147123B1 (en) 1989-04-29

Family

ID=10554924

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1985251516A PL147123B1 (en) 1984-01-13 1985-01-11 Method of obtaining novel derivatives of dihydropyridazinone

Country Status (31)

Country Link
US (1) US4654342A (forum.php)
EP (1) EP0150937B1 (forum.php)
JP (3) JPS60158181A (forum.php)
KR (1) KR920006781B1 (forum.php)
CN (1) CN85101722A (forum.php)
AT (1) ATE37179T1 (forum.php)
AU (1) AU572252B2 (forum.php)
CA (2) CA1251209A (forum.php)
CS (1) CS248731B2 (forum.php)
DD (1) DD231350A5 (forum.php)
DE (1) DE3564941D1 (forum.php)
DK (1) DK162519C (forum.php)
ES (3) ES8607949A1 (forum.php)
FI (1) FI850140A7 (forum.php)
GB (1) GB8400863D0 (forum.php)
GR (1) GR850068B (forum.php)
HU (1) HU193591B (forum.php)
IE (1) IE57969B1 (forum.php)
IL (1) IL74031A (forum.php)
JO (1) JO1351B1 (forum.php)
MY (1) MY100124A (forum.php)
NO (1) NO850129L (forum.php)
NZ (1) NZ210816A (forum.php)
PH (1) PH22136A (forum.php)
PL (1) PL147123B1 (forum.php)
PT (1) PT79819B (forum.php)
RO (1) RO92607A (forum.php)
SU (1) SU1396963A3 (forum.php)
WO (1) WO1985003076A1 (forum.php)
ZA (1) ZA85251B (forum.php)
ZW (1) ZW385A1 (forum.php)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1251448A (en) * 1985-03-27 1989-03-21 William J. Coates Pyridazinone derivatives
US4946842A (en) * 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
GB8722776D0 (en) * 1987-09-28 1987-11-04 Smith Kline French Lab Chemical compounds
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
AU2002254124A1 (en) 2001-02-27 2002-09-12 Mitokor Aryl-n-cyanoguanidines and methods related thereto
HUP0401747A3 (en) * 2001-11-05 2005-06-28 Merck Patent Gmbh Piridazine derivatives of hydrazono-malonitriles, their use, process for preparation of the compounds and pharmaceutical compositions containing the compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) * 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
AU2006310997B2 (en) * 2005-11-14 2013-01-10 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2702986A1 (en) 2008-11-25 2014-03-05 Boehringer Ingelheim Vetmedica GmbH Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP3167876B1 (en) 2012-03-15 2021-09-08 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
ES2593210T3 (es) 2013-12-04 2016-12-07 Boehringer Ingelheim Vetmedica Gmbh Composiciones farmacéuticas mejoradas de pimobendán
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
BE791539A (fr) * 1971-11-19 1973-05-17 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
EP0030835B1 (en) * 1979-12-05 1983-05-11 Morishita Pharmaceutical Co. Ltd. Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
FI72718C (fi) * 1981-03-04 1987-07-10 Ciba Geigy Ag Foerfarande foer framstaellning av terapeutiskt verkande, substituerade 6-(4-morfolino-fenyl)-4,5-dihydro- 3(2h)-pyridazinoner och deras syraadditionssalter.
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58140076A (ja) * 1982-02-09 1983-08-19 Mitsubishi Chem Ind Ltd ピリダジノン誘導体又はその塩類
DE3204375C2 (de) * 1982-02-09 1983-12-01 J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle Verfahren zur Herabsetzung der Saugfähigkeit von Holz
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
US4946842A (en) * 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants

Also Published As

Publication number Publication date
PT79819A (en) 1985-02-01
DK9185A (da) 1985-07-14
DK162519C (da) 1992-03-30
HU193591B (en) 1987-11-30
HUT37128A (en) 1985-11-28
KR920006781B1 (ko) 1992-08-17
EP0150937B1 (en) 1988-09-14
DD231350A5 (de) 1985-12-24
ATE37179T1 (de) 1988-09-15
AU572252B2 (en) 1988-05-05
IL74031A0 (en) 1985-04-30
GR850068B (forum.php) 1985-05-03
JPS63313775A (ja) 1988-12-21
JPS63313776A (ja) 1988-12-21
ES8607949A1 (es) 1986-06-01
RO92607A (ro) 1987-11-30
ES8706645A1 (es) 1987-07-01
FI850140L (fi) 1985-07-14
US4654342A (en) 1987-03-31
DK162519B (da) 1991-11-11
DE3564941D1 (en) 1988-10-20
WO1985003076A1 (en) 1985-07-18
MY100124A (en) 1989-12-18
PL251516A1 (en) 1985-12-17
ES8703846A1 (es) 1987-03-01
ZA85251B (en) 1986-08-27
FI850140A7 (fi) 1985-07-14
EP0150937A2 (en) 1985-08-07
AU3761185A (en) 1985-07-18
JO1351B1 (en) 1986-11-30
EP0150937A3 (en) 1985-08-21
DK9185D0 (da) 1985-01-08
KR850005417A (ko) 1985-08-26
NZ210816A (en) 1987-06-30
JPS60158181A (ja) 1985-08-19
GB8400863D0 (en) 1984-02-15
CA1251209A (en) 1989-03-14
CN85101722A (zh) 1987-01-31
SU1396963A3 (ru) 1988-05-15
IE850069L (en) 1985-07-13
IL74031A (en) 1988-07-31
ES549629A0 (es) 1987-03-01
PT79819B (en) 1987-01-07
CA1260471A (en) 1989-09-26
IE57969B1 (en) 1993-06-02
ES554965A0 (es) 1987-07-01
CA1260471C (forum.php) 1989-09-26
ZW385A1 (en) 1985-08-07
FI850140A0 (fi) 1985-01-11
NO850129L (no) 1985-07-15
ES539446A0 (es) 1986-06-01
PH22136A (en) 1988-06-01
CS248731B2 (en) 1987-02-12

Similar Documents

Publication Publication Date Title
PL147123B1 (en) Method of obtaining novel derivatives of dihydropyridazinone
CA1309718C (en) 5-(6-imidazo[1,2-a]pyridyl)pyridine derivative
FI79312C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 2-fenyl-1h-imidazo-/4,5-c/pyridiner och n-oxider och syra-additionssalter daerav.
SU1215621A3 (ru) Способ получени карбостирильных производных или их фармацевтически приемлемых солей
PL136217B1 (en) Method of obtaining novel derivatives of 4-amino-6,7-dimetoxy-2-piprazinoquinazoline
EP0611660A2 (de) Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0208518B1 (en) 6-phenyl-pyridazinyl compounds
DE68925270T2 (de) Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidinderivate und diese enthaltende Arzneimittel
NZ207914A (en) Indeno-pyridazinones and pharmaceutical compositions
DE2643753A1 (de) Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine
CS262690B2 (en) Process for preparing 1-/hydroxystyryl/-5h-2,3-benzodiazepines
DE69029303T2 (de) 5-Triazolo(3,4-i)purinderivate
EP0201988A2 (en) Dihydropyridazinone derivatives
US4766123A (en) Methylamidine compounds
EP0199465A2 (en) Cyanoalkanimidamido compounds
SU852173A3 (ru) Способ получени производных дигидРОиМидАзО изОХиНО-лиНА или иХ СОлЕй
US4416882A (en) Di(alkylamino) derivatives of chloronitropyrazines useful as adjuncts to radiation therapy
EP0029559A2 (en) 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
DE69318869T2 (de) Pyrazolo(3,4-a)acridinderivate als Analgetika
US4697021A (en) 1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents
US4716170A (en) 5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use
US4657915A (en) 1,6-naphthyridine-2(1H)-ones and their use as cardiotonic agents
US4634772A (en) 2-[2-(di-lower-alkylamino)-1-propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents
KR100267595B1 (ko) 신규한 이소퀴놀린계 항암 활성 화합물
JPS61212582A (ja) ジヒドロピリダジノン誘導体