PL127679B1 - Process for preparing novel derivatives of 1-/cyclohexyl/-4-aryl-4-piperidinecarboxylic acid - Google Patents

Process for preparing novel derivatives of 1-/cyclohexyl/-4-aryl-4-piperidinecarboxylic acid Download PDF

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Publication number
PL127679B1
PL127679B1 PL1981229365A PL22936581A PL127679B1 PL 127679 B1 PL127679 B1 PL 127679B1 PL 1981229365 A PL1981229365 A PL 1981229365A PL 22936581 A PL22936581 A PL 22936581A PL 127679 B1 PL127679 B1 PL 127679B1
Authority
PL
Poland
Prior art keywords
parts
group
formula
phenyl
lower alkoxy
Prior art date
Application number
PL1981229365A
Other languages
English (en)
Polish (pl)
Other versions
PL229365A1 (fr
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL229365A1 publication Critical patent/PL229365A1/xx
Publication of PL127679B1 publication Critical patent/PL127679B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL1981229365A 1980-01-24 1981-01-23 Process for preparing novel derivatives of 1-/cyclohexyl/-4-aryl-4-piperidinecarboxylic acid PL127679B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (2)

Publication Number Publication Date
PL229365A1 PL229365A1 (fr) 1982-03-29
PL127679B1 true PL127679B1 (en) 1983-11-30

Family

ID=26812674

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1981233921A PL127483B1 (en) 1980-01-24 1981-01-23 Method of obtaining new derivatives of 1-/cyclohexylo/-4-acrylo-4-piperidinylocarboxylic acid
PL1981229365A PL127679B1 (en) 1980-01-24 1981-01-23 Process for preparing novel derivatives of 1-/cyclohexyl/-4-aryl-4-piperidinecarboxylic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL1981233921A PL127483B1 (en) 1980-01-24 1981-01-23 Method of obtaining new derivatives of 1-/cyclohexylo/-4-acrylo-4-piperidinylocarboxylic acid

Country Status (25)

Country Link
US (1) US4369184A (fr)
EP (1) EP0034415B1 (fr)
AU (1) AU538130B2 (fr)
BG (2) BG35465A3 (fr)
CA (1) CA1187080A (fr)
CS (1) CS221818B2 (fr)
DE (1) DE3163787D1 (fr)
DK (1) DK152670C (fr)
ES (2) ES498793A0 (fr)
FI (1) FI76562C (fr)
GR (1) GR71898B (fr)
HK (1) HK81088A (fr)
HU (1) HU183293B (fr)
IE (1) IE50706B1 (fr)
IL (1) IL61968A (fr)
LU (1) LU88220I2 (fr)
MA (1) MA19046A1 (fr)
MY (1) MY8700593A (fr)
NL (1) NL930017I2 (fr)
NO (1) NO1994012I1 (fr)
NZ (1) NZ196117A (fr)
PH (1) PH16611A (fr)
PL (2) PL127483B1 (fr)
SU (1) SU1230467A3 (fr)
YU (1) YU48446B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
WO1995025518A1 (fr) * 1994-03-18 1995-09-28 Ciba-Geigy Ag Solution aqueuse de levocabastine a usage ophtalmique
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
WO1997039761A1 (fr) 1996-04-19 1997-10-30 Alpha Therapeutic Corporation Procede d'inactivation de virus dans des proteines sanguines lyophilisees
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
PT1545548E (pt) * 2002-08-30 2010-09-02 Nycomed Gmbh Utilização da combinação de ciclesonida e anti-histamínicos para o tratamento de rinite alérgica
CN101394847B (zh) * 2006-01-06 2017-05-24 塞普拉柯公司 作为单胺重摄取抑制剂的环烷基胺类
BRPI0712532A2 (pt) 2006-06-01 2013-04-02 Schering Plough Healthcare Prod Inc formulaÇÕes e composiÇÕes farmacÊuticas de fenilefrina para absorÇço colânica
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
CN101951886A (zh) * 2007-12-21 2011-01-19 先灵-普劳健康护理产品公司 增强羟甲唑啉的光稳定性
CN106831541B (zh) 2011-11-18 2019-09-06 赫普泰雅治疗有限公司 毒蕈碱性m1受体激动剂
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (fr) * 1965-06-29

Also Published As

Publication number Publication date
ES8204421A1 (es) 1982-05-01
CS221818B2 (en) 1983-04-29
EP0034415B1 (fr) 1984-05-30
BG60472B2 (bg) 1995-04-28
IE810125L (en) 1981-07-24
YU48446B (sh) 1998-07-10
NL930017I2 (nl) 1993-07-16
EP0034415A1 (fr) 1981-08-26
NO1994012I1 (no) 1994-08-30
ES498793A0 (es) 1982-05-01
AU538130B2 (en) 1984-08-02
US4369184A (en) 1983-01-18
DK152670B (da) 1988-04-11
PL229365A1 (fr) 1982-03-29
DE3163787D1 (en) 1984-07-05
CA1187080A (fr) 1985-05-14
YU18381A (en) 1983-10-31
PL233921A1 (fr) 1982-06-21
FI76562C (fi) 1988-11-10
PH16611A (en) 1983-11-24
IE50706B1 (en) 1986-06-25
NZ196117A (en) 1984-05-31
IL61968A (en) 1984-09-30
MA19046A1 (fr) 1981-10-01
HU183293B (en) 1984-04-28
GR71898B (fr) 1983-08-11
PL127483B1 (en) 1983-10-31
NL930017I1 (nl) 1993-05-03
BG35465A3 (en) 1984-04-15
AU6625581A (en) 1981-07-30
LU88220I2 (fr) 1994-02-03
DK29381A (da) 1981-07-25
ES8307219A1 (es) 1983-07-01
FI76562B (fi) 1988-07-29
IL61968A0 (en) 1981-02-27
DK152670C (da) 1988-08-22
HK81088A (en) 1988-10-14
ES508441A0 (es) 1983-07-01
MY8700593A (en) 1987-12-31
FI810193L (fi) 1981-07-25
SU1230467A3 (ru) 1986-05-07

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