BG35465A3 - Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid - Google Patents

Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid

Info

Publication number
BG35465A3
BG35465A3 BG8150518A BG5051881A BG35465A3 BG 35465 A3 BG35465 A3 BG 35465A3 BG 8150518 A BG8150518 A BG 8150518A BG 5051881 A BG5051881 A BG 5051881A BG 35465 A3 BG35465 A3 BG 35465A3
Authority
BG
Bulgaria
Prior art keywords
piperidine
cyclohexyl
aryl
carbonic acid
preparing derivatives
Prior art date
Application number
BG8150518A
Other languages
English (en)
Inventor
Staokbroekx
Luyckx
Willems
Original Assignee
Janssen Pharmaceutica Nv,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv,Us filed Critical Janssen Pharmaceutica Nv,Us
Publication of BG35465A3 publication Critical patent/BG35465A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG8150518A 1980-01-24 1981-01-23 Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid BG35465A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
BG35465A3 true BG35465A3 (en) 1984-04-15

Family

ID=26812674

Family Applications (2)

Application Number Title Priority Date Filing Date
BG8150518A BG35465A3 (en) 1980-01-24 1981-01-23 Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid
BG97872A BG60472B2 (bg) 1980-01-24 1993-06-16 Производни на 1-(циклохексил или циклохексенил)-4-арил-4- пиперидинкарбоксилова киселина

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG97872A BG60472B2 (bg) 1980-01-24 1993-06-16 Производни на 1-(циклохексил или циклохексенил)-4-арил-4- пиперидинкарбоксилова киселина

Country Status (25)

Country Link
US (1) US4369184A (fr)
EP (1) EP0034415B1 (fr)
AU (1) AU538130B2 (fr)
BG (2) BG35465A3 (fr)
CA (1) CA1187080A (fr)
CS (1) CS221818B2 (fr)
DE (1) DE3163787D1 (fr)
DK (1) DK152670C (fr)
ES (2) ES498793A0 (fr)
FI (1) FI76562C (fr)
GR (1) GR71898B (fr)
HK (1) HK81088A (fr)
HU (1) HU183293B (fr)
IE (1) IE50706B1 (fr)
IL (1) IL61968A (fr)
LU (1) LU88220I2 (fr)
MA (1) MA19046A1 (fr)
MY (1) MY8700593A (fr)
NL (1) NL930017I2 (fr)
NO (1) NO1994012I1 (fr)
NZ (1) NZ196117A (fr)
PH (1) PH16611A (fr)
PL (2) PL127483B1 (fr)
SU (1) SU1230467A3 (fr)
YU (1) YU48446B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
WO1995025518A1 (fr) * 1994-03-18 1995-09-28 Ciba-Geigy Ag Solution aqueuse de levocabastine a usage ophtalmique
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
EP0954326B2 (fr) 1996-04-19 2009-07-22 Grifols Inc. Procede d'inactivation de virus dans des proteines sanguines lyophilisees
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
KR101067795B1 (ko) * 2002-08-30 2011-09-27 니코메드 게엠베하 알레르기성 비염을 치료하기 위한 사이클레소나이드 및 항히스타민제의 조합물의 용도
US20070203111A1 (en) * 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
EP2034970B1 (fr) 2006-06-01 2012-08-01 MSD Consumer Care, Inc. Formulations pharmaceutiques de phényléphrine et compositions pour absorption par le côlon
US20090281156A1 (en) * 2007-12-21 2009-11-12 Schering-Plough Healthcare Products, Inc, Enhancing photostabilization of oxymetazoline
CA2856076C (fr) 2011-11-18 2020-02-25 Heptares Therapeutics Limited Agonistes du recepteur muscarinique m1
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (fr) * 1965-06-29

Also Published As

Publication number Publication date
PL127483B1 (en) 1983-10-31
EP0034415A1 (fr) 1981-08-26
NL930017I1 (nl) 1993-05-03
DK29381A (da) 1981-07-25
YU18381A (en) 1983-10-31
ES8307219A1 (es) 1983-07-01
MY8700593A (en) 1987-12-31
GR71898B (fr) 1983-08-11
NO1994012I1 (no) 1994-08-30
PL229365A1 (fr) 1982-03-29
IE810125L (en) 1981-07-24
CS221818B2 (en) 1983-04-29
ES508441A0 (es) 1983-07-01
PH16611A (en) 1983-11-24
DK152670B (da) 1988-04-11
YU48446B (sh) 1998-07-10
MA19046A1 (fr) 1981-10-01
SU1230467A3 (ru) 1986-05-07
FI810193L (fi) 1981-07-25
HK81088A (en) 1988-10-14
LU88220I2 (fr) 1994-02-03
FI76562B (fi) 1988-07-29
CA1187080A (fr) 1985-05-14
FI76562C (fi) 1988-11-10
AU538130B2 (en) 1984-08-02
IL61968A0 (en) 1981-02-27
HU183293B (en) 1984-04-28
ES8204421A1 (es) 1982-05-01
BG60472B2 (bg) 1995-04-28
ES498793A0 (es) 1982-05-01
PL127679B1 (en) 1983-11-30
DK152670C (da) 1988-08-22
IL61968A (en) 1984-09-30
EP0034415B1 (fr) 1984-05-30
AU6625581A (en) 1981-07-30
US4369184A (en) 1983-01-18
PL233921A1 (fr) 1982-06-21
NL930017I2 (nl) 1993-07-16
NZ196117A (en) 1984-05-31
DE3163787D1 (en) 1984-07-05
IE50706B1 (en) 1986-06-25

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