PH16751A - Process for preparing 1-(3-bromo-2-alkylpropanoyl-l-proline derivatives - Google Patents

Process for preparing 1-(3-bromo-2-alkylpropanoyl-l-proline derivatives

Info

Publication number
PH16751A
PH16751A PH25215A PH25215A PH16751A PH 16751 A PH16751 A PH 16751A PH 25215 A PH25215 A PH 25215A PH 25215 A PH25215 A PH 25215A PH 16751 A PH16751 A PH 16751A
Authority
PH
Philippines
Prior art keywords
alkylpropanoyl
bromo
preparing
proline derivatives
proline
Prior art date
Application number
PH25215A
Inventor
Roger Crossley
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of PH16751A publication Critical patent/PH16751A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PH25215A 1980-02-26 1981-02-12 Process for preparing 1-(3-bromo-2-alkylpropanoyl-l-proline derivatives PH16751A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8006414 1980-02-26

Publications (1)

Publication Number Publication Date
PH16751A true PH16751A (en) 1984-02-10

Family

ID=10511671

Family Applications (3)

Application Number Title Priority Date Filing Date
PH25215A PH16751A (en) 1980-02-26 1981-02-12 Process for preparing 1-(3-bromo-2-alkylpropanoyl-l-proline derivatives
PH26893A PH17373A (en) 1980-02-26 1982-02-19 Novel processes for preparing proline derivatives and analogous compounds
PH26894A PH17181A (en) 1980-02-26 1982-02-19 Novel processes for preparing proline derivatives and analogous compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
PH26893A PH17373A (en) 1980-02-26 1982-02-19 Novel processes for preparing proline derivatives and analogous compounds
PH26894A PH17181A (en) 1980-02-26 1982-02-19 Novel processes for preparing proline derivatives and analogous compounds

Country Status (11)

Country Link
US (4) US4349480A (en)
EP (1) EP0035336B1 (en)
JP (2) JPS56128755A (en)
AR (2) AR227663A1 (en)
AU (2) AU544337B2 (en)
CA (1) CA1154782A (en)
DE (1) DE3174292D1 (en)
GB (1) GB2070005B (en)
IE (1) IE50839B1 (en)
PH (3) PH16751A (en)
ZA (1) ZA81743B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
NL180746C (en) * 1983-11-18 1987-04-16 Matthijs Cornelis Evers PROCESS FOR PREPARING CAPTOPRIL.
JPH0662671B2 (en) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 Proline derivative
HU196368B (en) * 1986-07-04 1988-11-28 Egyt Gyogyszervegyeszeti Gyar Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
US5237073A (en) * 1988-08-26 1993-08-17 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DE69220744T2 (en) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituted indan-2-mercaptoacetylamide compounds with enkephalinase and ACE inhibitory activity
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
ATE164593T1 (en) * 1992-02-14 1998-04-15 Merrell Pharma Inc AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES WITH ENKEPHALINASE AND ACE INHIBITORY EFFECTS
AU669364B2 (en) * 1992-05-15 1996-06-06 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido pyridazo(1,2)pyridazine, pyrazolo(1,2)pyridazine, pyridazo(1,2-a)(1,2)diazepine and pyrazolo(1,2-a)(1,2)diazepine derivatives useful as inhibitors of enkephalinase and ace
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ES2155852T3 (en) * 1992-10-30 2001-06-01 Merrell Pharma Inc DERIVATIVES OF BICYCLE LACTAMA OF MERCAPTOACETILAMIDE USEFUL AS INHIBITORS OF ENCEFALINASA AND ECA.
ATE191485T1 (en) * 1994-02-14 2000-04-15 Merrell Pharma Inc MERCAPTOACETYLAMIDE-1,3,4,5- TETRAHYDROBENZO(C)AZEPINE-3-A DISULFIDE DERIVATIVE AS ENKEPHALINASE AND ACE INHIBITORS
CN1142831A (en) * 1994-02-14 1997-02-12 默里尔药物公司 Novel 2-substituted indane-2-mercaploacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
JP3596778B2 (en) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DE69514912T2 (en) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC USE OF AMINOACETYLMERCAPTO DERIVATIVES
NZ282565A (en) * 1994-03-24 1999-11-29 Merrell Pharma Inc Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US7531217B2 (en) * 2004-12-15 2009-05-12 Iowa State University Research Foundation, Inc. Methods for making high-temperature coatings having Pt metal modified γ-Ni +γ′-Ni3Al alloy compositions and a reactive element

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT986630B (en) * 1972-04-20 1975-01-30 Pierres Holding Sa PROCEDURE FOR PRECISION MACHINING OF PIECES BY LASER RADIATION AND DEVICE FOR EXECUTION OF THE PROCEDURE
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4129566A (en) * 1978-02-15 1978-12-12 E. R. Squibb & Sons, Inc. Derivatives of dehydrocyclicimino acids
US4127535A (en) * 1977-06-16 1978-11-28 Coy David Howard Novel dipeptides, intermediates therefor, and compositions and methods employing said dipeptides
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
CA1109475A (en) * 1978-07-27 1981-09-22 Miguel A. Ondetti Thiopropanoylamino acid derivatives
US4192945A (en) * 1978-12-07 1980-03-11 E. R. Squibb & Sons, Inc. Process for preparing proline and homoproline derivatives
EP0017390A3 (en) * 1979-03-23 1981-06-24 American Home Products Corporation Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
US4454291A (en) * 1981-07-20 1984-06-12 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
AU566441B2 (en) 1987-10-22
JPS62199283U (en) 1987-12-18
GB2070005B (en) 1984-12-19
AU3912685A (en) 1985-07-11
PH17181A (en) 1984-06-13
GB2070005A (en) 1981-09-03
IE810210L (en) 1981-08-26
AU544337B2 (en) 1985-05-23
AU6694181A (en) 1981-09-03
IE50839B1 (en) 1986-07-23
CA1154782A (en) 1983-10-04
ZA81743B (en) 1982-09-29
EP0035336A2 (en) 1981-09-09
PH17373A (en) 1984-08-06
JPS56128755A (en) 1981-10-08
AR227663A1 (en) 1982-11-30
AR231987A1 (en) 1985-04-30
DE3174292D1 (en) 1986-05-15
EP0035336A3 (en) 1981-11-25
EP0035336B1 (en) 1986-04-09
US4578480A (en) 1986-03-25
US4506082A (en) 1985-03-19
US4391752A (en) 1983-07-05
US4349480A (en) 1982-09-14

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