PL121469B1 - Process for preparing novel derivatives of thioethianic acidsloty - Google Patents

Process for preparing novel derivatives of thioethianic acidsloty Download PDF

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Publication number
PL121469B1
PL121469B1 PL1979214676A PL21467679A PL121469B1 PL 121469 B1 PL121469 B1 PL 121469B1 PL 1979214676 A PL1979214676 A PL 1979214676A PL 21467679 A PL21467679 A PL 21467679A PL 121469 B1 PL121469 B1 PL 121469B1
Authority
PL
Poland
Prior art keywords
formula
group
methyl
carbon atoms
compound
Prior art date
Application number
PL1979214676A
Other languages
English (en)
Polish (pl)
Other versions
PL214676A1 (Direct
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of PL214676A1 publication Critical patent/PL214676A1/xx
Publication of PL121469B1 publication Critical patent/PL121469B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL1979214676A 1978-04-05 1979-04-04 Process for preparing novel derivatives of thioethianic acidsloty PL121469B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,388 US4188385A (en) 1978-04-05 1978-04-05 Thioetianic acid derivatives

Publications (2)

Publication Number Publication Date
PL214676A1 PL214676A1 (Direct) 1980-01-02
PL121469B1 true PL121469B1 (en) 1982-05-31

Family

ID=25401484

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1979214676A PL121469B1 (en) 1978-04-05 1979-04-04 Process for preparing novel derivatives of thioethianic acidsloty

Country Status (28)

Country Link
US (1) US4188385A (Direct)
EP (1) EP0004741B1 (Direct)
JP (2) JPS54141758A (Direct)
AR (1) AR226035A1 (Direct)
AT (1) AT368168B (Direct)
AU (1) AU526025B2 (Direct)
CA (1) CA1134345A (Direct)
CS (1) CS203956B2 (Direct)
DE (2) DE2912331A1 (Direct)
DK (1) DK147735C (Direct)
ES (1) ES479271A1 (Direct)
FI (1) FI66393C (Direct)
FR (1) FR2421912A1 (Direct)
GB (1) GB2018256B (Direct)
GR (1) GR67275B (Direct)
HK (1) HK41284A (Direct)
HU (1) HU179314B (Direct)
IL (1) IL56972A0 (Direct)
IT (1) IT1120954B (Direct)
MY (1) MY8500575A (Direct)
NO (1) NO152935C (Direct)
NZ (1) NZ190076A (Direct)
PL (1) PL121469B1 (Direct)
PT (1) PT69409A (Direct)
SG (1) SG6786G (Direct)
SU (1) SU1052161A3 (Direct)
YU (1) YU40929B (Direct)
ZA (1) ZA791635B (Direct)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
CA1201114A (en) * 1980-02-15 1986-02-25 Gordon H. Phillipps Androstane carbothioates
FI70904C (fi) * 1980-02-15 1986-10-27 Glaxo Group Ltd Foerfarande foer framstaellning av terapeutiskt anvaendbara 11eta,17alfa-dihydroxi-3-oxo- -androst-4-en-17beta-tiokarbo xyater
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) * 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
NZ259401A (en) * 1992-12-24 1996-10-28 Rhone Poulenc Rorer Ltd (20s)-16<alpha>,17<alpha>-methylenedioxy-11<beta>-hydroxy-17<beta>-( sulphur substituted)androst- -an-3-one or -en-3-one derivatives
AU721865B2 (en) * 1995-12-29 2000-07-13 Glaxo Group Limited Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
CZ2003353A3 (cs) * 2000-08-05 2003-05-14 Glaxo Group Limited Estery steroidních thiokyselin
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CN1302007C (zh) * 2001-04-30 2007-02-28 葛兰素集团有限公司 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物
JP2005500290A (ja) * 2001-06-12 2005-01-06 グラクソ　グループ　リミテッド 抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
MX2010007023A (es) * 2007-12-21 2010-09-30 Schering Corp Agonistas del receptor glucocorticoide sustituido de c20-c21.
WO2010147947A2 (en) 2009-06-16 2010-12-23 Schering Corporation NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509171A (en) * 1946-02-06 1950-05-23 Ciba Ltd Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Also Published As

Publication number Publication date
FI66393B (fi) 1984-06-29
AU526025B2 (en) 1982-12-16
IT7967652A0 (it) 1979-03-28
JPS6140648B2 (Direct) 1986-09-10
FR2421912A1 (fr) 1979-11-02
YU40929B (en) 1986-08-31
YU80379A (en) 1983-04-30
SU1052161A3 (ru) 1983-10-30
HU179314B (en) 1982-09-28
GB2018256B (en) 1983-02-02
ATA251979A (de) 1982-01-15
PT69409A (en) 1979-04-01
EP0004741A2 (en) 1979-10-17
HK41284A (en) 1984-05-18
FR2421912B1 (Direct) 1981-03-20
IT1120954B (it) 1986-03-26
JPS611038B2 (Direct) 1986-01-13
AT368168B (de) 1982-09-27
CS203956B2 (en) 1981-03-31
DE2960096D1 (en) 1981-03-19
FI66393C (fi) 1984-10-10
JPS54141758A (en) 1979-11-05
DE2912331A1 (de) 1979-10-18
DK147735B (da) 1984-11-26
PL214676A1 (Direct) 1980-01-02
GB2018256A (en) 1979-10-17
DK136579A (da) 1979-10-06
AR226035A1 (es) 1982-05-31
NO152935B (no) 1985-09-09
IL56972A0 (en) 1979-05-31
EP0004741A3 (en) 1979-11-14
NO791140L (no) 1979-10-08
CA1134345A (en) 1982-10-26
NZ190076A (en) 1984-07-31
DK147735C (da) 1985-08-19
ES479271A1 (es) 1980-01-16
SG6786G (en) 1986-08-01
US4188385A (en) 1980-02-12
GR67275B (Direct) 1981-06-26
MY8500575A (en) 1985-12-31
JPS6069019A (ja) 1985-04-19
AU4558379A (en) 1979-10-18
NO152935C (no) 1985-12-18
ZA791635B (en) 1980-11-26
EP0004741B1 (en) 1981-01-28
FI791081A7 (fi) 1979-10-06

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