PL116437B1 - Process for preparing novel phthalazine derivatives - Google Patents

Process for preparing novel phthalazine derivatives Download PDF

Info

Publication number
PL116437B1
PL116437B1 PL1978217897A PL21789778A PL116437B1 PL 116437 B1 PL116437 B1 PL 116437B1 PL 1978217897 A PL1978217897 A PL 1978217897A PL 21789778 A PL21789778 A PL 21789778A PL 116437 B1 PL116437 B1 PL 116437B1
Authority
PL
Poland
Prior art keywords
formula
radical
group
phthalazine
hydrogen atom
Prior art date
Application number
PL1978217897A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL116437B1 publication Critical patent/PL116437B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL1978217897A 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives PL116437B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2358277 1977-06-03

Publications (1)

Publication Number Publication Date
PL116437B1 true PL116437B1 (en) 1981-06-30

Family

ID=10198020

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1978207337A PL113208B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978217896A PL116420B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978217897A PL116437B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL1978207337A PL113208B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978217896A PL116420B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives

Country Status (29)

Country Link
US (1) US4289772A (OSRAM)
JP (1) JPS5416488A (OSRAM)
AR (2) AR222013A1 (OSRAM)
AT (2) AT362792B (OSRAM)
AU (1) AU505373B1 (OSRAM)
BE (1) BE867727A (OSRAM)
CA (1) CA1111850A (OSRAM)
DD (1) DD137355A5 (OSRAM)
DE (1) DE2824064A1 (OSRAM)
DK (1) DK248078A (OSRAM)
EG (1) EG13527A (OSRAM)
ES (4) ES470470A1 (OSRAM)
FI (1) FI781753A7 (OSRAM)
FR (1) FR2392986A1 (OSRAM)
GB (1) GB2000136B (OSRAM)
GR (1) GR74402B (OSRAM)
HU (1) HU179745B (OSRAM)
IL (1) IL54842A (OSRAM)
IN (3) IN148482B (OSRAM)
IT (1) IT1094944B (OSRAM)
LU (1) LU79761A1 (OSRAM)
NL (1) NL7806016A (OSRAM)
NO (1) NO781935L (OSRAM)
NZ (1) NZ187453A (OSRAM)
PL (3) PL113208B1 (OSRAM)
PT (1) PT68126A (OSRAM)
SE (1) SE7806519L (OSRAM)
SU (2) SU856383A3 (OSRAM)
ZA (1) ZA783183B (OSRAM)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
IL59619A0 (en) * 1979-03-28 1980-06-30 Pfizer Phthalazine derivatives,their preparation and pharmaceutical compositions containing them
IL62200A (en) * 1980-03-01 1984-09-30 Wyeth John & Brother Ltd Piperidine derivatives,their preparation and pharmaceutical compositions containing them
GB8320958D0 (en) * 1983-08-03 1983-09-07 Pfizer Ltd Quinazoline cardiac stimulants
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
EP0621267A1 (en) * 1993-04-07 1994-10-26 Shell Internationale Researchmaatschappij B.V. Spiropiperidine derivatives and their use as fungicides
US5728712A (en) * 1995-05-19 1998-03-17 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
WO1998007430A1 (en) * 1996-08-20 1998-02-26 Eisai Co., Ltd. Remedy for erection failure comprising fused pyridazine compound
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
WO2004020435A1 (en) * 2002-08-16 2004-03-11 Janssen Pharmaceutica N.V. Piperidinyl compounds that selectively bind integrins
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
US20060019975A1 (en) * 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
BRPI0707223A2 (pt) * 2006-01-27 2011-04-26 Pfizer Prod Inc compostos de derivados de aminoftalazina
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
EP1900731A1 (de) * 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
MX2010001080A (es) 2007-08-07 2010-03-01 Hoffmann La Roche Pirrolidin-aril-eteres como antagonistas de receptor de nk3.
ATE519738T1 (de) 2007-08-22 2011-08-15 Hoffmann La Roche Pyrrolidinarylether als nk3-rezeptorantagonisten
CA2699464A1 (en) * 2007-09-14 2009-03-19 F. Hoffmann-La Roche Ag Piperidine derivatives as nk3 receptor antagonists
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
CA3198661A1 (en) 2020-10-13 2022-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
CN113087654B (zh) * 2021-04-15 2022-12-23 苏州昊帆生物股份有限公司 哌啶-4-丁胺的制备方法
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094044A (en) * 1965-07-12 1967-12-06 Vantorex Ltd Phthalazine derivatives
GB1199768A (en) 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
GB1460389A (en) 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Also Published As

Publication number Publication date
NZ187453A (en) 1980-12-19
DD137355A5 (de) 1979-08-29
IN148482B (OSRAM) 1981-03-07
AU505373B1 (en) 1979-11-15
LU79761A1 (fr) 1980-01-22
PL207337A1 (pl) 1979-06-04
FI781753A7 (fi) 1978-12-04
DE2824064A1 (de) 1978-12-14
NO781935L (no) 1978-12-05
ES478199A1 (es) 1980-01-16
ES470470A1 (es) 1979-09-01
SE7806519L (sv) 1978-12-04
ZA783183B (en) 1979-06-27
AR222013A1 (es) 1981-04-15
EG13527A (en) 1981-12-31
AT363096B (de) 1981-07-10
PT68126A (en) 1978-07-01
DK248078A (da) 1978-12-04
SU856383A3 (ru) 1981-08-15
ES478201A1 (es) 1980-02-01
GB2000136B (en) 1982-01-06
IL54842A0 (en) 1978-08-31
GB2000136A (en) 1979-01-04
JPS5538351B2 (OSRAM) 1980-10-03
IN149550B (OSRAM) 1982-01-16
US4289772A (en) 1981-09-15
IL54842A (en) 1982-01-31
GR74402B (OSRAM) 1984-06-28
ES478200A1 (es) 1980-01-01
IT1094944B (it) 1985-08-10
BE867727A (fr) 1978-12-01
JPS5416488A (en) 1979-02-07
ATA400878A (de) 1980-11-15
IT7824106A0 (it) 1978-06-01
PL116420B1 (en) 1981-06-30
FR2392986B1 (OSRAM) 1982-07-16
IN149973B (OSRAM) 1982-06-19
HU179745B (en) 1982-12-28
ATA305080A (de) 1980-12-15
FR2392986A1 (fr) 1978-12-29
SU862826A3 (ru) 1981-09-07
NL7806016A (nl) 1978-12-05
AT362792B (de) 1981-06-10
CA1111850A (en) 1981-11-03
AR223999A1 (es) 1981-10-15
PL113208B1 (en) 1980-11-29

Similar Documents

Publication Publication Date Title
PL116437B1 (en) Process for preparing novel phthalazine derivatives
RU2024521C1 (ru) Производные дифенилметилимидазола или их фармацевтически приемлемые соли
SU1340589A3 (ru) Способ получени 2-(4-замещенных пиперазино-4-амино-6,7-диметокси)хинолинов или их гидрохлоридов
US4690924A (en) 1,7-Naphthyridine derivatives and medicinal preparations containing same
IE51179B1 (en) Pyridoxine derivatives,process for preparing them and use in therapeutics
EP0390654A1 (en) Aminobenzenesulfonic acid derivative
EP0237573A1 (en) Novel benzothiazine derivatives
US4381398A (en) Amino-alcohol derivatives
US4575508A (en) 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents
EP0784055A1 (en) Pyrimidinylpyrazole derivative
US5965600A (en) 3-(bis-substituted phenylmethylene) oxindole derivatives
US4243666A (en) 4-Amino-2-piperidino-quinazolines
FR2512820A1 (fr) Nouveaux derives de benzothiazoline utiles comme medicaments et procede pour leur preparation
PL135878B1 (en) Process for preparing novel bicyclic compounds
US5053409A (en) Aminobenzenesulfonic acid derivatives
US4616023A (en) Pharmaceutical compositions of 4-(dibenzo-[a,d]cycloalkenyl)piperazine compounds and methods
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
EP0503079A1 (en) Pyridazinone-substituted ethynylphenyl derivative and remedy for circulatory organ disease containing the same as active ingredient
EP0160451B1 (en) Dihydropyridine-3,5-dicarboxylic acid ester derivative isomers, their preparation, and pharmaceutical compositions containing them
US4199582A (en) Piperazine containing dihydronaphthalene derivatives and compositions
CA1083151A (en) Naphthalenone phthalazinylhydrazones
US4481207A (en) 1-Phenethyl-alpha-phenyl-piperidine-3-propanenitriles and their pharmaceutical uses
JP3269658B2 (ja) フェノール誘導体
US4843085A (en) Pyridine derivatives, process for production thereof and pharmaceutical compositions useful as anti-arhytmics
US4792553A (en) Diene derivatives and vasodilators containing the same