AT362792B - Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen - Google Patents

Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen

Info

Publication number
AT362792B
AT362792B AT0400878A AT400878A AT362792B AT 362792 B AT362792 B AT 362792B AT 0400878 A AT0400878 A AT 0400878A AT 400878 A AT400878 A AT 400878A AT 362792 B AT362792 B AT 362792B
Authority
AT
Austria
Prior art keywords
salts
producing new
phthalazine derivatives
new phthalazine
derivatives
Prior art date
Application number
AT0400878A
Other languages
English (en)
Other versions
ATA400878A (de
Inventor
Simon Fraser Campbell
John Christopher Danilewicz
Anthony Garth Evans
Allen Leslie Ham
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to AT0305080A priority Critical patent/AT363096B/de
Publication of ATA400878A publication Critical patent/ATA400878A/de
Application granted granted Critical
Publication of AT362792B publication Critical patent/AT362792B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT0400878A 1977-06-03 1978-06-02 Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen AT362792B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0305080A AT363096B (de) 1977-06-03 1980-06-10 Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2358277 1977-06-03

Publications (2)

Publication Number Publication Date
ATA400878A ATA400878A (de) 1980-11-15
AT362792B true AT362792B (de) 1981-06-10

Family

ID=10198020

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0400878A AT362792B (de) 1977-06-03 1978-06-02 Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen
AT0305080A AT363096B (de) 1977-06-03 1980-06-10 Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0305080A AT363096B (de) 1977-06-03 1980-06-10 Verfahren zur herstellung von neuen phthalazinderivaten und deren salzen

Country Status (29)

Country Link
US (1) US4289772A (de)
JP (1) JPS5416488A (de)
AR (2) AR222013A1 (de)
AT (2) AT362792B (de)
AU (1) AU505373B1 (de)
BE (1) BE867727A (de)
CA (1) CA1111850A (de)
DD (1) DD137355A5 (de)
DE (1) DE2824064A1 (de)
DK (1) DK248078A (de)
EG (1) EG13527A (de)
ES (4) ES470470A1 (de)
FI (1) FI781753A (de)
FR (1) FR2392986A1 (de)
GB (1) GB2000136B (de)
GR (1) GR74402B (de)
HU (1) HU179745B (de)
IL (1) IL54842A (de)
IN (3) IN148482B (de)
IT (1) IT1094944B (de)
LU (1) LU79761A1 (de)
NL (1) NL7806016A (de)
NO (1) NO781935L (de)
NZ (1) NZ187453A (de)
PL (3) PL116437B1 (de)
PT (1) PT68126A (de)
SE (1) SE7806519L (de)
SU (2) SU856383A3 (de)
ZA (1) ZA783183B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
IL59619A0 (en) * 1979-03-28 1980-06-30 Pfizer Phthalazine derivatives,their preparation and pharmaceutical compositions containing them
CA1173037A (en) * 1980-03-01 1984-08-21 John L. Archibald Piperidino ureas as antidepressants
GB8320958D0 (en) * 1983-08-03 1983-09-07 Pfizer Ltd Quinazoline cardiac stimulants
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
EP0621267A1 (de) * 1993-04-07 1994-10-26 Shell Internationale Researchmaatschappij B.V. Spiropiperidinderivate und ihre Verwendung als Fungizide
AU5772196A (en) * 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
CN1121220C (zh) * 1996-08-20 2003-09-17 卫材株式会社 稠合哒嗪系化合物的勃起机能不全症治疗剂
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
RU2333210C2 (ru) * 2002-08-16 2008-09-10 Янссен Фармацевтика Н.В. Соединения пиперидинила, селективно связывающие интегрины
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
US20060019975A1 (en) * 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
JP2009524637A (ja) * 2006-01-27 2009-07-02 ファイザー・プロダクツ・インク アミノフタラジン誘導体化合物
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
EP1900731A1 (de) * 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
EP2068872A1 (de) 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
RU2010106974A (ru) 2007-08-07 2011-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) Ариловые эфиры пирролидина в качестве антагонистов рецепторов nk3
ATE519738T1 (de) 2007-08-22 2011-08-15 Hoffmann La Roche Pyrrolidinarylether als nk3-rezeptorantagonisten
CA2699464A1 (en) * 2007-09-14 2009-03-19 F. Hoffmann-La Roche Ag Piperidine derivatives as nk3 receptor antagonists
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
EP2804603A1 (de) 2012-01-10 2014-11-26 President and Fellows of Harvard College Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür
CN113087654B (zh) * 2021-04-15 2022-12-23 苏州昊帆生物股份有限公司 哌啶-4-丁胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094044A (en) * 1965-07-12 1967-12-06 Vantorex Ltd Phthalazine derivatives
GB1199768A (en) 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
GB1460389A (en) 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Also Published As

Publication number Publication date
IN148482B (de) 1981-03-07
US4289772A (en) 1981-09-15
SU856383A3 (ru) 1981-08-15
FI781753A (fi) 1978-12-04
IT7824106A0 (it) 1978-06-01
CA1111850A (en) 1981-11-03
JPS5538351B2 (de) 1980-10-03
IT1094944B (it) 1985-08-10
PL207337A1 (pl) 1979-06-04
GB2000136B (en) 1982-01-06
LU79761A1 (fr) 1980-01-22
PL116437B1 (en) 1981-06-30
FR2392986A1 (fr) 1978-12-29
PL116420B1 (en) 1981-06-30
DK248078A (da) 1978-12-04
GR74402B (de) 1984-06-28
ATA400878A (de) 1980-11-15
BE867727A (fr) 1978-12-01
IL54842A (en) 1982-01-31
HU179745B (en) 1982-12-28
AR223999A1 (es) 1981-10-15
JPS5416488A (en) 1979-02-07
ES478199A1 (es) 1980-01-16
NL7806016A (nl) 1978-12-05
FR2392986B1 (de) 1982-07-16
EG13527A (en) 1981-12-31
SE7806519L (sv) 1978-12-04
PL113208B1 (en) 1980-11-29
ES478200A1 (es) 1980-01-01
ES470470A1 (es) 1979-09-01
IN149973B (de) 1982-06-19
ES478201A1 (es) 1980-02-01
ZA783183B (en) 1979-06-27
GB2000136A (en) 1979-01-04
NO781935L (no) 1978-12-05
ATA305080A (de) 1980-12-15
IL54842A0 (en) 1978-08-31
IN149550B (de) 1982-01-16
SU862826A3 (ru) 1981-09-07
PT68126A (en) 1978-07-01
DE2824064A1 (de) 1978-12-14
DD137355A5 (de) 1979-08-29
AU505373B1 (en) 1979-11-15
AT363096B (de) 1981-07-10
NZ187453A (en) 1980-12-19
AR222013A1 (es) 1981-04-15

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee