PH26981A - Intravaginal devices - Google Patents
Intravaginal devices Download PDFInfo
- Publication number
- PH26981A PH26981A PH35384A PH35384A PH26981A PH 26981 A PH26981 A PH 26981A PH 35384 A PH35384 A PH 35384A PH 35384 A PH35384 A PH 35384A PH 26981 A PH26981 A PH 26981A
- Authority
- PH
- Philippines
- Prior art keywords
- estradiol
- core
- elastomer
- ring
- release rate
- Prior art date
Links
- 229960005309 estradiol Drugs 0.000 claims abstract description 30
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 12
- 229920001971 elastomer Polymers 0.000 claims description 29
- 239000000806 elastomer Substances 0.000 claims description 29
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 abstract description 4
- 229930182833 estradiol Natural products 0.000 description 11
- 238000000338 in vitro Methods 0.000 description 7
- 150000003431 steroids Chemical class 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 5
- 229940011871 estrogen Drugs 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 206010030247 Oestrogen deficiency Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 description 1
- BOZRCGLDOHDZBP-UHFFFAOYSA-N 2-ethylhexanoic acid;tin Chemical compound [Sn].CCCCC(CC)C(O)=O BOZRCGLDOHDZBP-UHFFFAOYSA-N 0.000 description 1
- 208000004483 Dyspareunia Diseases 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 101000687911 Homo sapiens Transcription factor SOX-3 Proteins 0.000 description 1
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010027566 Micturition urgency Diseases 0.000 description 1
- 206010033165 Ovarian failure Diseases 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100024276 Transcription factor SOX-3 Human genes 0.000 description 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
- 206010047998 Withdrawal bleed Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 125000005474 octanoate group Chemical group 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 201000004535 ovarian dysfunction Diseases 0.000 description 1
- 231100000539 ovarian failure Toxicity 0.000 description 1
- 230000011599 ovarian follicle development Effects 0.000 description 1
- 201000009958 panhypopituitarism Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 208000022934 urinary frequency Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Paper (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
- Seal Device For Vehicle (AREA)
- Window Of Vehicle (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Steroid Compounds (AREA)
- Nonmetallic Welding Materials (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8602666A SE8602666D0 (sv) | 1986-06-16 | 1986-06-16 | Intravaginal devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26981A true PH26981A (en) | 1992-12-28 |
Family
ID=20364821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH35384A PH26981A (en) | 1986-06-16 | 1987-06-10 | Intravaginal devices |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4871543A (sv) |
| EP (1) | EP0253109B1 (sv) |
| JP (1) | JP2671953B2 (sv) |
| KR (1) | KR920005824B1 (sv) |
| CN (1) | CN1034391C (sv) |
| AT (1) | ATE68097T1 (sv) |
| AU (1) | AU599988B2 (sv) |
| CA (1) | CA1314482C (sv) |
| DE (1) | DE3773557D1 (sv) |
| DK (1) | DK175529B1 (sv) |
| ES (1) | ES2026481T3 (sv) |
| FI (1) | FI91709C (sv) |
| GR (1) | GR3003551T3 (sv) |
| HU (1) | HU205014B (sv) |
| IE (1) | IE60654B1 (sv) |
| IL (1) | IL82769A (sv) |
| NO (2) | NO172784C (sv) |
| NZ (1) | NZ220616A (sv) |
| PH (1) | PH26981A (sv) |
| PT (1) | PT85082B (sv) |
| SE (1) | SE8602666D0 (sv) |
| ZA (1) | ZA874174B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5188835A (en) * | 1986-06-16 | 1993-02-23 | Kabi Pharmacia Ab | Intravaginal devices |
| US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
| FI95768C (sv) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Intravaginalt doseringssystem |
| FI93922C (sv) * | 1993-06-17 | 1995-06-26 | Leiras Oy | Anordning för avgivande av verksamt ämne |
| IL116433A (en) * | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
| US5861431A (en) * | 1995-06-07 | 1999-01-19 | Iotek, Inc. | Incontinence treatment |
| US5988169A (en) * | 1996-03-29 | 1999-11-23 | Iotek, Inc. | Vaginal insert and method for treating urogenital disorders |
| US6030375A (en) * | 1996-03-29 | 2000-02-29 | Iotek, Inc. | Compressible vaginal insert and method for treating urogenital disorders |
| US5816248A (en) * | 1996-03-29 | 1998-10-06 | Iotek, Inc. | Channeled vaginal insert and method for treating urogenital disorders |
| US5891868A (en) * | 1997-11-21 | 1999-04-06 | Kaiser Foundation Health Plan, Inc. | Methods for treating postmenopausal women using ultra-low doses of estrogen |
| JP2005519964A (ja) * | 2002-03-11 | 2005-07-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | スルファターゼ阻害プロゲストゲンのみの避妊レジメン |
| PT1482948E (pt) * | 2002-03-11 | 2006-11-30 | Janssen Pharmaceutica Nv | Terapia de substituição hormonal contínua com progestogénio inibidor de sulfatase |
| US20030219471A1 (en) * | 2002-03-11 | 2003-11-27 | Caubel Patrick Michel | Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens |
| AU2004233997C1 (en) * | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
| US7816546B2 (en) * | 2003-06-30 | 2010-10-19 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
| SI2359807T1 (sl) * | 2008-02-04 | 2017-10-30 | Ferring B.V. | Monolitni intravaginalni obroč, ki vsebuje progesteron ter postopki za njegovo izdelavo in uporabo |
| AU2020397648B2 (en) | 2019-12-06 | 2022-03-24 | Prathima Chowdary | Sustained release estrogen vaginal ring pessary for treatment of atrophy, cystitis and uterovaginal prolapse |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| IN142428B (sv) * | 1974-07-05 | 1977-07-09 | Schering Ag | |
| DE2450107A1 (de) * | 1974-10-18 | 1976-04-29 | Schering Ag | Vaginalring |
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| DE2611535A1 (de) * | 1976-03-16 | 1977-09-29 | Schering Ag | 6alpha-hydroxy-8alpha-oestradiole |
| JPS5845440B2 (ja) * | 1978-08-29 | 1983-10-08 | 呉羽化学工業株式会社 | プロスタグランジン誘導体とその製造方法及び薬剤 |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| US4250611A (en) * | 1979-04-19 | 1981-02-17 | Alza Corporation | Process for making drug delivery device with reservoir |
| US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
| US4425339A (en) * | 1981-04-09 | 1984-01-10 | Syntex (U.S.A.) Inc. | Treatment of menopausal symptoms |
| EP0117117A1 (en) * | 1983-02-22 | 1984-08-29 | Joachim Georg Liehr | Improvements in or relating to the treatment of estrogen deficiency conditions |
| AU582540B2 (en) * | 1983-08-05 | 1989-04-06 | Pre Jay Holdings Ltd. | A method of hormonal treatment of perimenopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor |
| EP0180264A1 (en) * | 1984-10-12 | 1986-05-07 | Akzo N.V. | Release system for two or more active substances |
-
1986
- 1986-06-16 SE SE8602666A patent/SE8602666D0/sv unknown
-
1987
- 1987-05-26 IE IE137787A patent/IE60654B1/en not_active IP Right Cessation
- 1987-05-27 EP EP87107710A patent/EP0253109B1/en not_active Expired - Lifetime
- 1987-05-27 ES ES198787107710T patent/ES2026481T3/es not_active Expired - Lifetime
- 1987-05-27 DE DE8787107710T patent/DE3773557D1/de not_active Expired - Lifetime
- 1987-05-27 AT AT87107710T patent/ATE68097T1/de not_active IP Right Cessation
- 1987-06-03 CA CA000538695A patent/CA1314482C/en not_active Expired - Lifetime
- 1987-06-04 IL IL82769A patent/IL82769A/xx not_active IP Right Cessation
- 1987-06-09 NZ NZ220616A patent/NZ220616A/xx unknown
- 1987-06-10 PH PH35384A patent/PH26981A/en unknown
- 1987-06-10 ZA ZA874174A patent/ZA874174B/xx unknown
- 1987-06-12 CN CN87104229A patent/CN1034391C/zh not_active Expired - Lifetime
- 1987-06-12 US US07/060,833 patent/US4871543A/en not_active Expired - Lifetime
- 1987-06-12 FI FI872629A patent/FI91709C/sv not_active IP Right Cessation
- 1987-06-15 JP JP62148881A patent/JP2671953B2/ja not_active Expired - Lifetime
- 1987-06-15 HU HU872705A patent/HU205014B/hu unknown
- 1987-06-15 AU AU74222/87A patent/AU599988B2/en not_active Expired
- 1987-06-15 NO NO872489A patent/NO172784C/no unknown
- 1987-06-15 DK DK198703034A patent/DK175529B1/da not_active IP Right Cessation
- 1987-06-15 PT PT85082A patent/PT85082B/pt unknown
- 1987-06-16 KR KR1019870006101A patent/KR920005824B1/ko not_active IP Right Cessation
-
1992
- 1992-01-09 GR GR920400009T patent/GR3003551T3/el unknown
-
1997
- 1997-01-13 NO NO1997001C patent/NO1997001I1/no unknown
Also Published As
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