PH26017A - Aqueous antimicrobial ophthalmic solutions - Google Patents
Aqueous antimicrobial ophthalmic solutions Download PDFInfo
- Publication number
- PH26017A PH26017A PH39240A PH39240A PH26017A PH 26017 A PH26017 A PH 26017A PH 39240 A PH39240 A PH 39240A PH 39240 A PH39240 A PH 39240A PH 26017 A PH26017 A PH 26017A
- Authority
- PH
- Philippines
- Prior art keywords
- composition
- quaternary ammonium
- lenses
- compound
- agent
- Prior art date
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims description 11
- 239000002997 ophthalmic solution Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims description 47
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 15
- 125000000129 anionic group Chemical group 0.000 claims description 12
- 239000008139 complexing agent Substances 0.000 claims description 12
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 12
- -1 citrate ions Chemical class 0.000 claims description 10
- 235000002639 sodium chloride Nutrition 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 230000000249 desinfective effect Effects 0.000 claims description 9
- 239000004599 antimicrobial Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 7
- 150000001450 anions Chemical class 0.000 claims description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 6
- 229960000999 sodium citrate dihydrate Drugs 0.000 claims description 3
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229960002303 citric acid monohydrate Drugs 0.000 claims description 2
- 229940009662 edetate Drugs 0.000 claims description 2
- 229940124274 edetate disodium Drugs 0.000 claims description 2
- 230000006872 improvement Effects 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 2
- 229960002796 polystyrene sulfonate Drugs 0.000 claims description 2
- 239000011970 polystyrene sulfonate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 150000003868 ammonium compounds Chemical class 0.000 claims 2
- 239000000243 solution Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000003755 preservative agent Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229940075554 sorbate Drugs 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 150000001805 chlorine compounds Chemical group 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3723—Polyamines or polyalkyleneimines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/244,974 US5037647A (en) | 1988-09-15 | 1988-09-15 | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26017A true PH26017A (en) | 1992-01-29 |
Family
ID=22924837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39240A PH26017A (en) | 1988-09-15 | 1989-09-15 | Aqueous antimicrobial ophthalmic solutions |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5037647A (ja) |
| EP (1) | EP0359574B1 (ja) |
| JP (1) | JPH0649060B2 (ja) |
| AR (1) | AR247326A1 (ja) |
| AT (1) | ATE182081T1 (ja) |
| AU (1) | AU625099B2 (ja) |
| CA (1) | CA1334573C (ja) |
| DE (1) | DE68929031T2 (ja) |
| DK (1) | DK175224B1 (ja) |
| ES (1) | ES2136055T3 (ja) |
| FI (1) | FI105321B (ja) |
| GR (1) | GR3031328T3 (ja) |
| HK (1) | HK1011941A1 (ja) |
| MX (1) | MX168660B (ja) |
| NZ (1) | NZ230663A (ja) |
| PH (1) | PH26017A (ja) |
| WO (1) | WO1990002555A1 (ja) |
| ZA (1) | ZA897060B (ja) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL90680A (en) * | 1988-06-28 | 1994-04-12 | Ciba Geigy Ag | Poor solutions containing dodecyl (dimethyl) 2-phenoxyethyl (ammonium brocide and ATDE and methods of use) |
| US5547663A (en) * | 1991-11-08 | 1996-08-20 | Alcon Laboratories, Inc. | Absolute molecular weight polymers and methods for their use |
| US6051611A (en) * | 1991-11-08 | 2000-04-18 | Alcon Laboratories, Inc. | Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias |
| US5512597A (en) * | 1991-11-08 | 1996-04-30 | Alcon Laboratories, Inc. | Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials |
| EP0542686A1 (en) * | 1991-11-13 | 1993-05-19 | Ciba-Geigy Ag | Method and container for sterilizing or disinfecting |
| US5256420A (en) * | 1991-12-23 | 1993-10-26 | Ciba-Geigy Corporation | Method of imparting antimicrobial acitivity to an ophthalmic composition |
| US5356555A (en) * | 1992-09-14 | 1994-10-18 | Allergan, Inc. | Non-oxidative method and composition for simultaneously cleaning and disinfecting contact lenses using a protease with a disinfectant |
| US5370744B1 (en) * | 1993-08-27 | 1999-11-09 | Alcon Lab Inc | Process for cleaning and disinfecting contact lenses |
| AU733386B2 (en) * | 1993-08-27 | 2001-05-10 | Alcon Laboratories, Inc. | Process for cleaning and disinfecting contact lenses |
| AU5417501A (en) * | 1993-08-27 | 2001-09-20 | Alcon Laboratories, Inc. | Process for cleaning and disinfecting contact lenses |
| US5382599A (en) * | 1993-10-13 | 1995-01-17 | Allergan, Inc. | Method of inhibiting protozoan growth in eye care products using a polyvalent cation chelating agent |
| US5536494A (en) * | 1994-10-04 | 1996-07-16 | Alcon Laboratories, Inc. | Polyethylene oxide-containing quaternary ammunium polymers and pharmaceutical compositions containing an antimicrobial amount of same |
| US5603929A (en) * | 1994-11-16 | 1997-02-18 | Alcon Laboratories, Inc. | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds |
| WO2000028998A1 (fr) * | 1998-11-16 | 2000-05-25 | Rohto Pharmaceutical Co., Ltd. | Preparations ophtalmiques liquides |
| US6790816B2 (en) | 1999-09-24 | 2004-09-14 | Bausch & Lomb Incorporated | High osmolyte cleaning and disinfection method and solution for contact lenses |
| EP1250133B1 (en) * | 2000-01-25 | 2005-03-30 | Alcon Inc. | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
| US20020183233A1 (en) * | 2000-12-14 | 2002-12-05 | The Clorox Company, Delaware Corporation | Bactericidal cleaning wipe |
| US20030100465A1 (en) * | 2000-12-14 | 2003-05-29 | The Clorox Company, A Delaware Corporation | Cleaning composition |
| US7799751B2 (en) * | 2000-12-14 | 2010-09-21 | The Clorox Company | Cleaning composition |
| DE10137978A1 (de) * | 2001-08-02 | 2003-02-13 | Creavis Tech & Innovation Gmbh | Antimikrobielle Reinigungsmittel |
| JP4255656B2 (ja) | 2001-09-17 | 2009-04-15 | 株式会社メニコン | 眼科用液剤及びコンタクトレンズ用液剤 |
| US20040028645A1 (en) * | 2001-12-13 | 2004-02-12 | Masood Chowhan | Artificial tear composition adapted to be used with contact lenses |
| WO2003059193A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Use of nanoparticles as carriers for biocides in ophthalmic compositions |
| PL211494B1 (pl) * | 2001-12-21 | 2012-05-31 | Alcon | Zastosowanie syntetycznych, nieorganicznych nanocząstek jako nośników dla leków i kompozycja farmaceutyczna do oczu lub uszu |
| WO2003059263A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Inorganic nanoparticles to modify the viscosity and physical properties of ophthalmic and otic compositions. |
| US7282178B2 (en) * | 2005-06-03 | 2007-10-16 | Bausch & Lomb Incorporated | Composition and method for cleaning lipid deposits on contact lenses |
| US20060275173A1 (en) * | 2005-06-03 | 2006-12-07 | Bausch & Lomb Incorporated | Method for cleaning lipid deposits on silicone hydrogel contact lenses |
| US20060276359A1 (en) * | 2005-06-03 | 2006-12-07 | Bausch & Lomb Incorporated | Composition and method for cleaning lipid deposits on contact lenses |
| JP5135526B2 (ja) * | 2005-06-27 | 2013-02-06 | 株式会社メニコンネクト | コンタクトレンズ用液剤 |
| US20070053948A1 (en) * | 2005-09-08 | 2007-03-08 | Bausch & Lomb Incorporated | Lens care solution demonstration kit |
| TWI434926B (zh) * | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用 |
| US8227017B2 (en) * | 2007-11-13 | 2012-07-24 | Quick-Med Technologies, Inc. | System and method for enhancing the efficacy of antimicrobial contact lenses and other surfaces |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| CA2717679C (en) | 2008-03-17 | 2013-07-23 | Alcon Research, Ltd. | Aqueous pharmaceutical compositions containing borate-polyol complexes |
| RU2010151994A (ru) * | 2008-05-19 | 2012-06-27 | Алькон Рисерч, Лтд. (Us) | Фармацевтические композиции, включающие карбоксивинильный полимер и повидоновый полимер |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| US8431751B1 (en) | 2008-12-24 | 2013-04-30 | Alcon Research, Ltd. | Polymeric quaternary ammonium compounds with vicinal hydroxy groups |
| WO2010101971A1 (en) * | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
| WO2010101989A1 (en) * | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| TW201038295A (en) * | 2009-04-17 | 2010-11-01 | Alcon Res Ltd | Aqueous ophthalmic compositions containing anionic therapeutic agents |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| TWI547522B (zh) * | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
| TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
| US8999312B2 (en) | 2010-06-02 | 2015-04-07 | Alcon Research, Ltd. | Use of PBO-PEO-PBO block copolymers in ophthalmic compositions |
| BR112013026534A2 (pt) | 2011-04-22 | 2016-12-27 | Alcon Res Ltd | composição oftálmica com um sistema de realce da viscosidade tendo dois diferentes agentes de realce da viscosidade |
| KR20140022900A (ko) | 2011-04-22 | 2014-02-25 | 알콘 리서치, 리미티드 | 2종의 상이한 점도 증강제를 포함하는 점도 증강 시스템을 갖는 안과 조성물 |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
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| WO2014058402A2 (en) * | 2012-10-12 | 2014-04-17 | Alke Saglik Urunleri Sanayi Ve Ticaret Anonim Sirketi | Liquid cip (clean-in-place) detergent combinations |
| US10174006B2 (en) | 2013-06-06 | 2019-01-08 | Novartis Ag | Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease |
| SG11201603699SA (en) | 2013-12-17 | 2016-07-28 | Novartis Ag | A silicone hydrogel lens with a crosslinked hydrophilic coating |
| WO2017022781A1 (ja) * | 2015-08-03 | 2017-02-09 | 花王株式会社 | 抗菌型衣料用液体洗浄剤組成物 |
| TW201938141A (zh) | 2018-02-21 | 2019-10-01 | 瑞士商諾華公司 | 基於脂質的眼用乳劑 |
| CA3103503A1 (en) | 2018-07-02 | 2020-01-09 | Ayuvis Research, Inc. | Novel immunodulating small molecules |
| CN113423696A (zh) | 2019-02-15 | 2021-09-21 | 诺华股份有限公司 | 4-(7-羟基-2-异丙基-4-氧代-4h-喹唑啉-3-基)-苄腈的结晶形式及其配制品 |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
| CN116419918A (zh) | 2020-08-06 | 2023-07-11 | 诺华股份有限公司 | 4-(7-羟基-2-异丙基-4-氧代-4h-喹唑啉-3-基)-苄腈的结晶形式及其配制品 |
| CN113088411A (zh) * | 2021-04-08 | 2021-07-09 | 山西利普达医药科技有限公司 | 一种含聚季铵盐-1的眼用清洗灭活病毒组合物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US440771A (en) * | 1890-11-18 | Oil-cup | ||
| DE2930865A1 (de) * | 1979-07-30 | 1981-02-12 | Schuelke & Mayr Gmbh | Desinfektions- und konservierungsmittel |
| US4499077A (en) * | 1981-02-03 | 1985-02-12 | Stockel Richard F | Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects |
| US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| EP0145710A1 (en) * | 1983-05-25 | 1985-06-26 | Alcon Laboratories, Inc. | Ophthalmic solution |
| US4579960A (en) * | 1984-05-07 | 1986-04-01 | Schering Corporation | Stable solutions containing thimerosal |
| CA1259542A (en) * | 1984-09-28 | 1989-09-19 | Francis X. Smith | Disinfecting and preserving solutions for contact lenses and methods of use |
| US4599195A (en) * | 1984-12-28 | 1986-07-08 | Alcon Laboratories, Inc. | Solution and method for removing protein, lipid, and calcium deposits from contact lenses |
| EP0232250B1 (en) * | 1985-07-22 | 1990-01-31 | BAUSCH & LOMB INCORPORATED | Methods and solution for desinfecting and preserving contact lenses |
| DE3782981T2 (de) * | 1986-01-06 | 1993-04-08 | Allergan Inc | Erhoehung von enzymatischer wirksamkeit bei der reinigung von kontaktlinsen durch verwendung von hypotonischen loesungen. |
| US4734222A (en) * | 1986-04-03 | 1988-03-29 | Ciba-Geigy Corporation | Composition and method for cleaning soft and hard contact lenses |
| GB8625103D0 (en) * | 1986-10-20 | 1986-11-26 | Unilever Plc | Disinfectant compositions |
| BR8707615A (pt) * | 1986-12-24 | 1989-10-03 | Alcon Lab Inc | Composicao para limpeza de lentes de contato e processo para sua utilizacao |
| DE59005084D1 (de) * | 1989-09-21 | 1994-04-28 | Ciba Vision Ag | Antimikrobielle Zusammensetzungen. |
-
1988
- 1988-09-15 US US07/244,974 patent/US5037647A/en not_active Expired - Lifetime
-
1989
- 1989-09-13 CA CA000611333A patent/CA1334573C/en not_active Expired - Lifetime
- 1989-09-14 NZ NZ230663A patent/NZ230663A/en unknown
- 1989-09-15 AU AU43113/89A patent/AU625099B2/en not_active Expired
- 1989-09-15 ES ES89309381T patent/ES2136055T3/es not_active Expired - Lifetime
- 1989-09-15 PH PH39240A patent/PH26017A/en unknown
- 1989-09-15 AT AT89309381T patent/ATE182081T1/de not_active IP Right Cessation
- 1989-09-15 MX MX017572A patent/MX168660B/es unknown
- 1989-09-15 AR AR89314940A patent/AR247326A1/es active
- 1989-09-15 WO PCT/US1989/004002 patent/WO1990002555A1/en active IP Right Grant
- 1989-09-15 ZA ZA897060A patent/ZA897060B/xx unknown
- 1989-09-15 EP EP89309381A patent/EP0359574B1/en not_active Expired - Lifetime
- 1989-09-15 JP JP1509897A patent/JPH0649060B2/ja not_active Expired - Lifetime
- 1989-09-15 DE DE68929031T patent/DE68929031T2/de not_active Expired - Lifetime
-
1990
- 1990-05-02 FI FI902194A patent/FI105321B/fi active IP Right Grant
- 1990-05-09 DK DK199001156A patent/DK175224B1/da not_active IP Right Cessation
-
1998
- 1998-12-11 HK HK98113204A patent/HK1011941A1/xx not_active IP Right Cessation
-
1999
- 1999-09-24 GR GR990402430T patent/GR3031328T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE182081T1 (de) | 1999-07-15 |
| DK175224B1 (da) | 2004-07-12 |
| FI902194A0 (fi) | 1990-05-02 |
| WO1990002555A1 (en) | 1990-03-22 |
| DK115690A (da) | 1990-05-09 |
| AR247326A1 (es) | 1994-12-29 |
| FI105321B (fi) | 2000-07-31 |
| JPH0649060B2 (ja) | 1994-06-29 |
| EP0359574A3 (en) | 1990-08-29 |
| CA1334573C (en) | 1995-02-28 |
| JPH02502733A (ja) | 1990-08-30 |
| DE68929031D1 (de) | 1999-08-19 |
| ES2136055T3 (es) | 1999-11-16 |
| US5037647A (en) | 1991-08-06 |
| DK115690D0 (da) | 1990-05-09 |
| AU4311389A (en) | 1990-04-02 |
| ZA897060B (en) | 1991-05-29 |
| HK1011941A1 (en) | 1999-07-23 |
| GR3031328T3 (en) | 1999-12-31 |
| EP0359574A2 (en) | 1990-03-21 |
| EP0359574B1 (en) | 1999-07-14 |
| NZ230663A (en) | 1991-05-28 |
| AU625099B2 (en) | 1992-07-02 |
| DE68929031T2 (de) | 1999-11-11 |
| MX168660B (es) | 1993-06-02 |
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