US5370744B1 - Process for cleaning and disinfecting contact lenses - Google Patents

Process for cleaning and disinfecting contact lenses Download PDF

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Publication number
US5370744B1
US5370744B1 US11314293A US5370744B1 US 5370744 B1 US5370744 B1 US 5370744B1 US 11314293 A US11314293 A US 11314293A US 5370744 B1 US5370744 B1 US 5370744B1
Authority
US
United States
Prior art keywords
cleaning
contact lenses
disinfecting contact
cleaning agent
lenses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Masood Chowhan
Thierry Bilbault
Ronald P Quintana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22347782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US5370744(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Priority to US08113142 priority Critical patent/US5370744B1/en
Assigned to ALCON LABORATORIES, INC. reassignment ALCON LABORATORIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BILBAULT, THIERRY, CHOWHAN, MASOOD, QUINTANA, RONALD P.
Priority to PT98123311T priority patent/PT909808E/en
Priority to DE69430763T priority patent/DE69430763T2/en
Priority to EP98123311A priority patent/EP0909808B1/en
Priority to EP94927215A priority patent/EP0666899B1/en
Priority to CA002257648A priority patent/CA2257648C/en
Priority to PCT/US1994/009521 priority patent/WO1995006099A1/en
Priority to AU76730/94A priority patent/AU7673094A/en
Priority to AT94927215T priority patent/ATE180507T1/en
Priority to AT98123311T priority patent/ATE218610T1/en
Priority to CA002146860A priority patent/CA2146860C/en
Priority to ES94927215T priority patent/ES2131704T3/en
Priority to ES98123311T priority patent/ES2174383T3/en
Priority to DK98123311T priority patent/DK0909808T3/en
Priority to DE69418694T priority patent/DE69418694T2/en
Priority to DK94927215T priority patent/DK0666899T3/en
Priority to JP7507732A priority patent/JP2939339B2/en
Publication of US5370744A publication Critical patent/US5370744A/en
Priority to HK98112880A priority patent/HK1011706A1/en
Priority to GR990401234T priority patent/GR3030275T3/en
Priority to HK99102739A priority patent/HK1018076A1/en
Publication of US5370744B1 publication Critical patent/US5370744B1/en
Application granted granted Critical
Assigned to ALCON MANUFACTURING, LTD. reassignment ALCON MANUFACTURING, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ALCON LABORATORIES, INC.
Assigned to ALCON RESEARCH, LTD. reassignment ALCON RESEARCH, LTD. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: ALCON MANUFACTURING, LTD.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/34—Organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A61L12/145—Polymeric quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2082—Polycarboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2086—Hydroxy carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/378—(Co)polymerised monomers containing sulfur, e.g. sulfonate
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/02—Inorganic compounds
    • C11D7/04—Water-soluble compounds
    • C11D7/10—Salts
    • C11D7/16—Phosphates including polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/265—Carboxylic acids or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/32—Organic compounds containing nitrogen
    • C11D7/3245—Aminoacids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/32—Organic compounds containing nitrogen
    • C11D7/3272—Urea, guanidine or derivatives thereof

Abstract

An improved process for cleaning and disinfecting contact lenses with a single solution is described. The process utilizes the cleaning effect of a cleaning agent in combination with the solvent action of water and physical agitation of the lens (i.e. by means of rubbing) to achieve a degree of cleaning which is comparable to or better than prior processes which utilize surfactant-cleaners. The cleaning agent is selected from polycarboxylates. The preferred cleaning agent is citrate. The process also offers greater convenience, relative to many prior systems for cleaning and disinfecting contact lenses, since the need to utilize additional products to clean the lenses is eliminated.
US08113142 1993-08-27 1993-08-27 Process for cleaning and disinfecting contact lenses Expired - Lifetime US5370744B1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
US08113142 US5370744B1 (en) 1993-08-27 1993-08-27 Process for cleaning and disinfecting contact lenses
JP7507732A JP2939339B2 (en) 1993-08-27 1994-08-24 How to clean and sterilize contact lenses
ES94927215T ES2131704T3 (en) 1993-08-27 1994-08-24 CLEANING AND DISINFECTION OF CONTACT LENSES.
DE69418694T DE69418694T2 (en) 1993-08-27 1994-08-24 CLEANING AND DISINFECTING CONTACT LENSES
EP98123311A EP0909808B1 (en) 1993-08-27 1994-08-24 Process for cleaning and disinfecting contact lenses
EP94927215A EP0666899B1 (en) 1993-08-27 1994-08-24 Cleaning and disinfecting contact lenses
CA002257648A CA2257648C (en) 1993-08-27 1994-08-24 Process for cleaning and disinfecting contact lenses
PCT/US1994/009521 WO1995006099A1 (en) 1993-08-27 1994-08-24 Process for cleaning and disinfecting contact lenses
AU76730/94A AU7673094A (en) 1993-08-27 1994-08-24 Process for cleaning and disinfecting contact lenses
AT94927215T ATE180507T1 (en) 1993-08-27 1994-08-24 CLEANING AND DISINFECTING CONTACT LENSES
AT98123311T ATE218610T1 (en) 1993-08-27 1994-08-24 METHOD FOR CLEANING AND DISINFECTING CONTACT LENSES
CA002146860A CA2146860C (en) 1993-08-27 1994-08-24 Process for cleaning and disinfecting contact lenses
PT98123311T PT909808E (en) 1993-08-27 1994-08-24 PROCESS FOR CLEANING AND DISINFECTING CONTACT LENSES
ES98123311T ES2174383T3 (en) 1993-08-27 1994-08-24 PROCEDURE FOR CLEANING AND DISINFECTING CONTACT LENSES.
DK98123311T DK0909808T3 (en) 1993-08-27 1994-08-24 Method of cleaning and disinfecting contact lenses
DE69430763T DE69430763T2 (en) 1993-08-27 1994-08-24 Procedures for cleaning and disinfecting contact lenses
DK94927215T DK0666899T3 (en) 1993-08-27 1994-08-24 Contact lens cleaning and disinfection
HK98112880A HK1011706A1 (en) 1993-08-27 1998-12-07 Cleaning and disinfecting contact lenses
GR990401234T GR3030275T3 (en) 1993-08-27 1999-05-27 Process for cleaning and disinfecting contact lenses.
HK99102739A HK1018076A1 (en) 1993-08-27 1999-06-28 Process for cleaning and disinfecting contact lenses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08113142 US5370744B1 (en) 1993-08-27 1993-08-27 Process for cleaning and disinfecting contact lenses

Publications (2)

Publication Number Publication Date
US5370744A US5370744A (en) 1994-12-06
US5370744B1 true US5370744B1 (en) 1999-11-09

Family

ID=22347782

Family Applications (1)

Application Number Title Priority Date Filing Date
US08113142 Expired - Lifetime US5370744B1 (en) 1993-08-27 1993-08-27 Process for cleaning and disinfecting contact lenses

Country Status (13)

Country Link
US (1) US5370744B1 (en)
EP (2) EP0909808B1 (en)
JP (1) JP2939339B2 (en)
AT (2) ATE218610T1 (en)
AU (1) AU7673094A (en)
CA (1) CA2146860C (en)
DE (2) DE69430763T2 (en)
DK (2) DK0909808T3 (en)
ES (2) ES2131704T3 (en)
GR (1) GR3030275T3 (en)
HK (2) HK1011706A1 (en)
PT (1) PT909808E (en)
WO (1) WO1995006099A1 (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000931A1 (en) * 1995-06-23 1997-01-09 Bausch & Lomb Incorporated Method for cleaning contact lenses utilizing polysulfonates
US5604190A (en) * 1995-06-07 1997-02-18 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
US5723421A (en) * 1995-06-07 1998-03-03 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
US5925317A (en) * 1996-01-22 1999-07-20 Bausch & Lomb Incorporated Dual neutralization system for iodine treatment of contact lenses
US6172017B1 (en) 1993-12-29 2001-01-09 Bausch & Lomb Incorporated Carbohydrate composition and method for cleaning and disinfecting contact lenses
US20040121923A1 (en) * 2002-12-23 2004-06-24 Bor-Shyue Hong Contact lens care compositions containing chitin derivatives
EP1473584A1 (en) * 2002-02-07 2004-11-03 Ophtecs Corporation Contact lens solution
US20060008520A1 (en) * 2004-04-01 2006-01-12 Lerner E I Delayed release formulations of 6-mercaptopurine
US20060009473A1 (en) * 2004-04-01 2006-01-12 Lerner E I Formulations of 6-mercaptopurine
US20080138310A1 (en) * 2006-12-11 2008-06-12 Alcon Manufacturing, Ltd. Use of PEO-PBO block copolymers in ophthalmic compositions
US20090263482A1 (en) * 2008-04-18 2009-10-22 Vered Rosenberger Treatment of inflammatory bowel disease with 6-mercaptopurine
US20110008276A1 (en) * 2009-07-07 2011-01-13 Alcon Research, Ltd. Ethyleneoxide butyleneoxide block copolymer compositions
US8999312B2 (en) 2010-06-02 2015-04-07 Alcon Research, Ltd. Use of PBO-PEO-PBO block copolymers in ophthalmic compositions
FR3054458A1 (en) * 2016-08-01 2018-02-02 Altimat USE OF LOW-MINERALIZED WATER AS A CLEANER
US10828308B2 (en) 2015-10-16 2020-11-10 Hadasit Medical Research Services And Development Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2236180T3 (en) * 2000-01-25 2005-07-16 Alcon Inc. ANTIALERGIC OPHTHALMIC COMPOSITIONS SUITABLE FOR USE WITH CONTACT LENSES.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116319A (en) * 1981-01-13 1982-07-20 Toyo Contact Lens Co Ltd Contamination preventing liquid for contact lens
US4525346A (en) * 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
JPS5945399A (en) * 1982-09-07 1984-03-14 東洋コンタクトレンズ株式会社 Removal of foulant stuck to contact lens
FR2544880B1 (en) * 1983-04-20 1986-08-29 Pos Lab PROCESS FOR THE CLEANING AND DECONTAMINATION OF CONTACT LENSES AND COMPOSITION FOR ITS IMPLEMENTATION
WO1985001209A1 (en) * 1983-09-15 1985-03-28 University Of Bath Disinfection of contact lenses
US4614549A (en) * 1983-10-24 1986-09-30 Bausch & Lomb Incorporated Method for enzymatic cleaning and disinfecting contact lenses
US4609493A (en) * 1984-12-28 1986-09-02 Alcon Laboratories, Inc. Solution and method for removing inorganic and organic deposits from contact lenses
US4599195A (en) * 1984-12-28 1986-07-08 Alcon Laboratories, Inc. Solution and method for removing protein, lipid, and calcium deposits from contact lenses
JPS61219928A (en) * 1985-03-26 1986-09-30 Toray Ind Inc Cleaner for contact lens and its cleaning method
US4839082A (en) * 1986-12-24 1989-06-13 Alcon Laboratories, Inc. Contact lens cleaning compositions containing a carboxy vinyl polymer
US5037647A (en) * 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
CA2009118C (en) * 1989-02-21 1996-02-27 Mary F. Mowrey-Mckee Method and composition for cleaning and disinfecting contact lenses
CA2041871C (en) * 1990-05-09 2000-07-11 Ruth A. Rosenthal Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes
HU209538B (en) * 1990-05-09 1994-07-28 Vepex Contractor Ltd Set and cleaning composition for treating contactlenses

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6172017B1 (en) 1993-12-29 2001-01-09 Bausch & Lomb Incorporated Carbohydrate composition and method for cleaning and disinfecting contact lenses
US5604190A (en) * 1995-06-07 1997-02-18 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
US5723421A (en) * 1995-06-07 1998-03-03 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
US5939369A (en) * 1995-06-07 1999-08-17 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
US5948738A (en) * 1995-06-07 1999-09-07 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
WO1997000931A1 (en) * 1995-06-23 1997-01-09 Bausch & Lomb Incorporated Method for cleaning contact lenses utilizing polysulfonates
US5925317A (en) * 1996-01-22 1999-07-20 Bausch & Lomb Incorporated Dual neutralization system for iodine treatment of contact lenses
EP1473584A1 (en) * 2002-02-07 2004-11-03 Ophtecs Corporation Contact lens solution
US20050074467A1 (en) * 2002-02-07 2005-04-07 Masaaki Fujita Contact lens solution
EP1473584A4 (en) * 2002-02-07 2005-07-06 Ophtecs Corp Contact lens solution
US20040121923A1 (en) * 2002-12-23 2004-06-24 Bor-Shyue Hong Contact lens care compositions containing chitin derivatives
US20040121924A1 (en) * 2002-12-23 2004-06-24 Bor-Shyue Hong Contact lens care compositions containing chitosan derivatives
US8653060B2 (en) 2004-04-01 2014-02-18 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
US9375403B2 (en) 2004-04-01 2016-06-28 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
US10525009B2 (en) 2004-04-01 2020-01-07 Hadasit Medical Research Services And Development Ltd. Formulations of 6-mercaptopurine
US20090042914A1 (en) * 2004-04-01 2009-02-12 Teva Pharmaceuticals Usa, Inc. Delayed release formulations of 6-mercaptopurine
US20060009473A1 (en) * 2004-04-01 2006-01-12 Lerner E I Formulations of 6-mercaptopurine
US9180097B2 (en) 2004-04-01 2015-11-10 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
US20060008520A1 (en) * 2004-04-01 2006-01-12 Lerner E I Delayed release formulations of 6-mercaptopurine
US8188067B2 (en) * 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
US8318144B2 (en) 2006-12-11 2012-11-27 Alcon Research, Ltd. Use of PEO-PBO block copolymers in ophthalmic compositions
US20110059039A1 (en) * 2006-12-11 2011-03-10 Alcon Research, Ltd. Use of peo-pbo block copolymers in ophthalmic compositions
US9574160B2 (en) 2006-12-11 2017-02-21 Alcon Research, Ltd. Use of PEO-PBO block copolymers in ophthalmic compositions
US20080138310A1 (en) * 2006-12-11 2008-06-12 Alcon Manufacturing, Ltd. Use of PEO-PBO block copolymers in ophthalmic compositions
US20090263482A1 (en) * 2008-04-18 2009-10-22 Vered Rosenberger Treatment of inflammatory bowel disease with 6-mercaptopurine
US9175249B2 (en) 2009-07-07 2015-11-03 Alcon Research, Ltd. Ethyleneoxide butyleneoxide block copolymer compositions
US20110008276A1 (en) * 2009-07-07 2011-01-13 Alcon Research, Ltd. Ethyleneoxide butyleneoxide block copolymer compositions
US8999312B2 (en) 2010-06-02 2015-04-07 Alcon Research, Ltd. Use of PBO-PEO-PBO block copolymers in ophthalmic compositions
US9521842B2 (en) 2010-06-02 2016-12-20 Alcon Research, Ltd. Use of PBO-PEO-PBO block copolymers in ophthalmic compositions
US10828308B2 (en) 2015-10-16 2020-11-10 Hadasit Medical Research Services And Development Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine
FR3054458A1 (en) * 2016-08-01 2018-02-02 Altimat USE OF LOW-MINERALIZED WATER AS A CLEANER

Also Published As

Publication number Publication date
EP0909808B1 (en) 2002-06-05
AU7673094A (en) 1995-03-21
ES2131704T3 (en) 1999-08-01
DE69418694T2 (en) 1999-09-30
JPH08503084A (en) 1996-04-02
ES2174383T3 (en) 2002-11-01
HK1011706A1 (en) 1999-07-16
DK0666899T3 (en) 1999-11-08
CA2146860C (en) 1999-07-06
EP0909808A3 (en) 1999-07-28
ATE218610T1 (en) 2002-06-15
WO1995006099A1 (en) 1995-03-02
EP0666899B1 (en) 1999-05-26
CA2146860A1 (en) 1995-03-02
EP0666899A1 (en) 1995-08-16
DE69430763T2 (en) 2003-02-06
GR3030275T3 (en) 1999-08-31
DE69430763D1 (en) 2002-07-11
ATE180507T1 (en) 1999-06-15
DK0909808T3 (en) 2002-09-30
US5370744A (en) 1994-12-06
PT909808E (en) 2002-10-31
JP2939339B2 (en) 1999-08-25
HK1018076A1 (en) 1999-12-10
EP0909808A2 (en) 1999-04-21
DE69418694D1 (en) 1999-07-01

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