PH18135A - N-thiazolylmethylthioalkyl-n'-alkylamidines,compositions and method of inhibiting gastric acid secretion - Google Patents

N-thiazolylmethylthioalkyl-n'-alkylamidines,compositions and method of inhibiting gastric acid secretion

Info

Publication number
PH18135A
PH18135A PH26296A PH26296A PH18135A PH 18135 A PH18135 A PH 18135A PH 26296 A PH26296 A PH 26296A PH 26296 A PH26296 A PH 26296A PH 18135 A PH18135 A PH 18135A
Authority
PH
Philippines
Prior art keywords
thiazolylmethylthioalkyl
alkylamidines
compositions
gastric acid
acid secretion
Prior art date
Application number
PH26296A
Other languages
English (en)
Inventor
Richard Paul Pioch
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH18135(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PH18135A publication Critical patent/PH18135A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH26296A 1980-10-02 1981-10-01 N-thiazolylmethylthioalkyl-n'-alkylamidines,compositions and method of inhibiting gastric acid secretion PH18135A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/193,192 US4375547A (en) 1980-10-02 1980-10-02 N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Publications (1)

Publication Number Publication Date
PH18135A true PH18135A (en) 1985-04-03

Family

ID=22712591

Family Applications (1)

Application Number Title Priority Date Filing Date
PH26296A PH18135A (en) 1980-10-02 1981-10-01 N-thiazolylmethylthioalkyl-n'-alkylamidines,compositions and method of inhibiting gastric acid secretion

Country Status (36)

Country Link
US (1) US4375547A (de)
EP (1) EP0049618B1 (de)
JP (1) JPS5791980A (de)
KR (1) KR850001795B1 (de)
AR (1) AR241439A1 (de)
AU (1) AU542553B2 (de)
BG (1) BG60249B2 (de)
CA (1) CA1166248A (de)
CS (1) CS227015B2 (de)
CY (1) CY1351A (de)
DD (1) DD200371A5 (de)
DE (1) DE3171819D1 (de)
DK (2) DK164056C (de)
EG (1) EG15678A (de)
ES (2) ES8301950A1 (de)
FI (2) FI813058L (de)
GB (1) GB2084581B (de)
GR (1) GR75023B (de)
HK (1) HK15987A (de)
HU (1) HU188697B (de)
IE (1) IE51603B1 (de)
IL (1) IL63980A (de)
LU (1) LU88293I2 (de)
MX (1) MX5723A (de)
MY (1) MY8700247A (de)
NL (1) NL930107I2 (de)
NO (1) NO155885C (de)
NZ (1) NZ198523A (de)
PH (1) PH18135A (de)
PL (2) PL130526B1 (de)
PT (1) PT73757B (de)
RO (2) RO85815B (de)
SU (1) SU1184443A3 (de)
UA (1) UA6081A1 (de)
YU (1) YU42728B (de)
ZA (1) ZA816817B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
FR2531703A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4587344A (en) * 1983-02-07 1986-05-06 Eli Lilly And Company Isothiourea synthesis process
RO87706A (ro) * 1983-02-07 1985-10-31 Eli Lilly And Co,Us Procedeu pentru prepararea nizatidinei
US4468517A (en) * 1983-05-12 1984-08-28 Eli Lilly And Company Synthesis of thiazoles
DE3417127A1 (de) * 1984-05-09 1985-11-14 Papst-Motoren GmbH & Co KG, 7742 St Georgen Kleinstventilator
DE3531504A1 (de) * 1985-09-04 1987-03-12 Basf Ag 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel
ZA869438B (en) * 1985-12-18 1988-07-27 Lilly Co Eli Synthesis of nizatidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate
DE3784698D1 (de) * 1987-04-06 1993-04-15 Heumann Pharma Gmbh & Co Verfahren zur herstellung von nitroethenderivaten.
ES2007959A6 (es) * 1988-07-11 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados tiazolicos.
PT515121E (pt) * 1991-05-21 2001-04-30 Lilly Co Eli Processo para preparar intermediarios da nizatidina e compostos relacionados
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
WO1993023360A1 (fr) * 1992-05-12 1993-11-25 Zeria Pharmaceutical Co., Ltd. Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament
US5541335A (en) * 1994-07-11 1996-07-30 Torcan Chemical Ltd. Process for preparing nizatidine
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
WO1998011081A1 (en) * 1996-09-11 1998-03-19 Knoll Aktiengesellschaft Process for the preparation of nizatidine
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
CA2349575A1 (en) 1998-11-17 2000-05-25 Nitromed, Inc. Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use
EP1579862A1 (de) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
US20080044481A1 (en) * 2004-05-27 2008-02-21 Mordechai Harel Microparticles for Oral Delivery
US20080045575A1 (en) * 2004-12-29 2008-02-21 Van Dyke Thomas E Delivery of H2 Antagonists
EP1920785A1 (de) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Pimobendan-Cyclodextrin Komplex enthaltendes flüssiges Präparat
US20090275622A1 (en) * 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
CN113181110A (zh) 2013-07-19 2021-07-30 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
WO2015082389A1 (en) 2013-12-04 2015-06-11 Boehringer Ingelheim Vetmedica Gmbh Improved pharmaceutical compositions of pimobendan
WO2015155297A1 (en) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (de) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmazeutische Kombinationen aus Rivaroxaban und Histamin-H2-Rezeptorantagonisten
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (16)

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GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917593A (en) * 1972-05-22 1975-11-04 Smithkline Corp N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides
US3853865A (en) * 1972-06-26 1974-12-10 Smithkline Corp N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
US4061637A (en) * 1974-05-14 1977-12-06 Istituto Luso Farmaco D'italia S.R.L. Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
US4173644A (en) * 1975-02-03 1979-11-06 Smith Kline & French Laboratories Limited Thiourea compounds, compositions and methods and use
US4166856A (en) * 1975-05-21 1979-09-04 Smith Kline & French Laboratories Limited Thiazole and isothiazole derivative as blockers of histamine H2 -receptors
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
DE2905134A1 (de) * 1978-02-17 1979-08-23 Degussa Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives

Also Published As

Publication number Publication date
JPH021141B2 (de) 1990-01-10
NO813334L (no) 1982-04-05
RO85815A (ro) 1984-11-25
NZ198523A (en) 1985-12-13
YU236481A (en) 1983-10-31
IL63980A (en) 1986-04-29
AU542553B2 (en) 1985-02-28
EG15678A (en) 1986-12-30
AR241439A1 (es) 1992-07-31
MY8700247A (en) 1987-12-31
EP0049618A1 (de) 1982-04-14
YU42728B (en) 1988-12-31
ES505950A0 (es) 1983-01-01
SU1184443A3 (ru) 1985-10-07
BG60249B1 (bg) 1994-03-24
HU188697B (en) 1986-05-28
BG60249B2 (en) 1994-03-24
GB2084581B (en) 1985-02-27
GR75023B (de) 1984-07-12
PL238035A1 (en) 1983-02-28
AU7594581A (en) 1982-04-08
RO82215A (ro) 1983-07-07
DK12391A (da) 1991-01-24
ES514868A0 (es) 1983-05-01
ES8301950A1 (es) 1983-01-01
NL930107I2 (nl) 1997-02-03
DK12391D0 (da) 1991-01-24
DD200371A5 (de) 1983-04-20
FI813058L (fi) 1982-04-03
EP0049618B1 (de) 1985-08-14
KR850001795B1 (ko) 1985-12-21
DK435181A (da) 1982-05-12
NL930107I1 (nl) 1993-10-18
RO85815B (ro) 1984-11-30
MX5723A (es) 1993-12-01
CA1166248A (en) 1984-04-24
IE51603B1 (en) 1987-01-21
DK167759B1 (da) 1993-12-13
US4375547A (en) 1983-03-01
JPS5791980A (en) 1982-06-08
LU88293I2 (fr) 1994-05-04
UA6081A1 (uk) 1994-12-29
GB2084581A (en) 1982-04-15
HK15987A (en) 1987-02-27
PL130626B1 (en) 1984-08-31
DK164056B (da) 1992-05-04
ZA816817B (en) 1983-05-25
CS227015B2 (en) 1984-04-16
CY1351A (en) 1987-04-24
NO155885B (no) 1987-03-09
IL63980A0 (en) 1982-01-31
PT73757B (en) 1983-01-13
PL233295A1 (de) 1982-12-20
ES8306135A1 (es) 1983-05-01
DK164056C (da) 1992-09-28
NO155885C (no) 1987-06-17
DE3171819D1 (en) 1985-09-19
KR830007602A (ko) 1983-11-04
IE812285L (en) 1982-04-02
FI76570B (fi) 1988-07-29
FI76570C (fi) 1988-11-10
PL130526B1 (en) 1984-08-31
PT73757A (en) 1981-11-01
RO82215B (ro) 1983-06-30

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