PH12019501034A1 - New anthelmintic quinoline-3-carboxamide derivatives - Google Patents
New anthelmintic quinoline-3-carboxamide derivativesInfo
- Publication number
- PH12019501034A1 PH12019501034A1 PH12019501034A PH12019501034A PH12019501034A1 PH 12019501034 A1 PH12019501034 A1 PH 12019501034A1 PH 12019501034 A PH12019501034 A PH 12019501034A PH 12019501034 A PH12019501034 A PH 12019501034A PH 12019501034 A1 PH12019501034 A1 PH 12019501034A1
- Authority
- PH
- Philippines
- Prior art keywords
- compounds
- quinoline
- carboxamide derivatives
- new anthelmintic
- preparing
- Prior art date
Links
- 230000000507 anthelmentic effect Effects 0.000 title 1
- BLTDCIWCFCUQCB-UHFFFAOYSA-N quinoline-3-carboxamide Chemical class C1=CC=CC2=CC(C(=O)N)=CN=C21 BLTDCIWCFCUQCB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000006968 Helminthiasis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12019501034A1 true PH12019501034A1 (en) | 2019-12-02 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12019501034A PH12019501034A1 (en) | 2016-11-11 | 2019-05-09 | New anthelmintic quinoline-3-carboxamide derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (enExample) |
| EP (1) | EP3538512B1 (enExample) |
| JP (1) | JP7165129B2 (enExample) |
| KR (1) | KR102595730B1 (enExample) |
| CN (1) | CN109890793B (enExample) |
| AU (1) | AU2017357503B2 (enExample) |
| CA (1) | CA3043298A1 (enExample) |
| CL (1) | CL2019001292A1 (enExample) |
| CO (1) | CO2019004776A2 (enExample) |
| DK (1) | DK3538512T3 (enExample) |
| DO (1) | DOP2019000117A (enExample) |
| ES (1) | ES2884073T3 (enExample) |
| IL (1) | IL266407B (enExample) |
| MX (1) | MX2019005569A (enExample) |
| MY (1) | MY196327A (enExample) |
| NZ (1) | NZ752550A (enExample) |
| PH (1) | PH12019501034A1 (enExample) |
| PL (1) | PL3538512T3 (enExample) |
| PT (1) | PT3538512T (enExample) |
| SG (1) | SG11201903059SA (enExample) |
| SI (1) | SI3538512T1 (enExample) |
| TW (1) | TWI821165B (enExample) |
| UA (1) | UA126119C2 (enExample) |
| UY (1) | UY37480A (enExample) |
| WO (1) | WO2018087036A1 (enExample) |
| ZA (1) | ZA201903708B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3615527T3 (pl) | 2017-06-30 | 2024-07-01 | Elanco Animal Health Gmbh | Nowe pochodne azachinoliny |
| ES3024942T3 (en) | 2017-08-04 | 2025-06-05 | Elanco Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| MX2020006185A (es) * | 2017-12-15 | 2020-09-03 | Bayer Animal Health Gmbh | Proceso para la preparacion de derivados de quinolina. |
| CA3099610A1 (en) * | 2018-05-09 | 2019-11-14 | Bayer Animal Health Gmbh | New quinoline derivatives |
| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| CA3122106C (en) * | 2018-12-18 | 2024-05-28 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CA3122105A1 (en) * | 2018-12-18 | 2020-06-25 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| JP7693558B2 (ja) * | 2019-06-07 | 2025-06-17 | エランコ・ティアゲゾンタイト・アーゲー | 内部寄生虫を治療するための二環式誘導体 |
| TWI865563B (zh) * | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| JP7644121B2 (ja) | 2019-12-18 | 2025-03-11 | インターベット インターナショナル ベー． フェー． | アザインドール構造を含む駆虫剤化合物 |
| CA3164098A1 (en) * | 2019-12-18 | 2021-06-24 | Intervet International B.V. | Anthelmintic compounds comprising a quinoline structure |
| EP4132911A1 (en) * | 2020-04-09 | 2023-02-15 | Bayer Animal Health GmbH | Substituted condensed azines as anthelmintic compounds |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| EP4247809A2 (en) | 2020-11-18 | 2023-09-27 | Elanco Tiergesundheit AG | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| CN116685584A (zh) * | 2020-11-18 | 2023-09-01 | 礼蓝动物保健有限公司 | 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物 |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
| EP4259636A1 (en) | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4259606A1 (en) | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| KR20240112282A (ko) | 2021-11-01 | 2024-07-18 | 베링거잉겔하임베트메디카게엠베하 | 구충제 피롤로피리다진 화합물 |
| WO2024213752A1 (en) | 2023-04-14 | 2024-10-17 | Elanco Animal Health Gmbh | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| WO2025027117A1 (en) | 2023-08-02 | 2025-02-06 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
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2017
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/es unknown
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en not_active Ceased
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/zh active Active
- 2017-11-06 ES ES17791438T patent/ES2884073T3/es active Active
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/ja active Active
- 2017-11-06 UA UAA201906455A patent/UA126119C2/uk unknown
- 2017-11-06 PL PL17791438T patent/PL3538512T3/pl unknown
- 2017-11-06 SI SI201730854T patent/SI3538512T1/sl unknown
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-06 PT PT177914389T patent/PT3538512T/pt unknown
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/ko active Active
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/da active
- 2017-11-10 UY UY0001037480A patent/UY37480A/es not_active Application Discontinuation
- 2017-11-10 TW TW106138957A patent/TWI821165B/zh active
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2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/es unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/es unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/es unknown
- 2019-06-10 ZA ZA2019/03708A patent/ZA201903708B/en unknown
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2020
- 2020-10-30 US US17/085,880 patent/US11505545B2/en active Active
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