WO2017198341A8 - Macrocyclic indole derivatives - Google Patents

Macrocyclic indole derivatives Download PDF

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Publication number
WO2017198341A8
WO2017198341A8 PCT/EP2017/000629 EP2017000629W WO2017198341A8 WO 2017198341 A8 WO2017198341 A8 WO 2017198341A8 EP 2017000629 W EP2017000629 W EP 2017000629W WO 2017198341 A8 WO2017198341 A8 WO 2017198341A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
indole derivatives
macrocyclic indole
preparing
pharmaceutical compositions
Prior art date
Application number
PCT/EP2017/000629
Other languages
French (fr)
Other versions
WO2017198341A1 (en
Inventor
Sarah Anna Liesa Johannes WAGNER
Philipp BUCHGRABER
Ulrich Klar
Clara CHRIST
Amaury Ernesto FERNANDEZ-MONTALVAN
Manfred MÖWES
Philipp Lienau
Knut Eis
Ulrike SACK
Ursula MÖNNING
Arne Scholz
Joachim Kuhnke
Kai Thede
Nicolas WERBECK
Michael H. Serrano-Wu
Chris LEMKE
David Mckinney
Mark Fitzgerald
Christopher NASVESCHUK
Kiel LAZARSKI
Steven James FERRARA
Laura FURST
Guo Wei
Patrick Ryan MCCARREN
Original Assignee
Bayer Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
The Broad Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc. filed Critical Bayer Aktiengesellschaft
Priority to JP2018560883A priority Critical patent/JP7013389B2/en
Priority to CN201780030956.8A priority patent/CN109715632B/en
Priority to US16/301,871 priority patent/US10981932B2/en
Priority to CA3024482A priority patent/CA3024482A1/en
Priority to EP17734982.6A priority patent/EP3458459B1/en
Publication of WO2017198341A1 publication Critical patent/WO2017198341A1/en
Publication of WO2017198341A8 publication Critical patent/WO2017198341A8/en
Priority to US17/186,820 priority patent/US11492358B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Abstract

The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
PCT/EP2017/000629 2016-05-19 2017-05-17 Macrocyclic indole derivatives WO2017198341A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2018560883A JP7013389B2 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivative
CN201780030956.8A CN109715632B (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives
US16/301,871 US10981932B2 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives
CA3024482A CA3024482A1 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives
EP17734982.6A EP3458459B1 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives
US17/186,820 US11492358B1 (en) 2016-05-19 2021-02-26 Macrocyclic indole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662338942P 2016-05-19 2016-05-19
US62/338,942 2016-05-19
EP16172726.8 2016-06-02
EP16172726 2016-06-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/301,871 A-371-Of-International US10981932B2 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives
US17/186,820 Continuation US11492358B1 (en) 2016-05-19 2021-02-26 Macrocyclic indole derivatives

Publications (2)

Publication Number Publication Date
WO2017198341A1 WO2017198341A1 (en) 2017-11-23
WO2017198341A8 true WO2017198341A8 (en) 2019-01-03

Family

ID=56098125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/000629 WO2017198341A1 (en) 2016-05-19 2017-05-17 Macrocyclic indole derivatives

Country Status (4)

Country Link
CA (1) CA3024482A1 (en)
TW (1) TW201808957A (en)
UY (1) UY37250A (en)
WO (1) WO2017198341A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981932B2 (en) 2016-05-19 2021-04-20 Bayer Aktiengesellschaft Macrocyclic indole derivatives
WO2019096907A1 (en) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Aryl annulated macrocyclic indole derivatives
US11478451B1 (en) 2017-11-17 2022-10-25 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
WO2019096914A1 (en) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
UY37973A (en) * 2017-11-17 2019-06-28 Bayer Ag MACROCYCLIC INDOL DERIVATIVES
UY37971A (en) * 2017-11-17 2019-06-28 Bayer Ag SUBSTITUTED MACROCYCLIC INDOL DERITATES
US11286263B2 (en) 2017-11-17 2022-03-29 The Broad Institute, Inc. Macrocyclic fluorine substituted indole derivatives
US20220289762A1 (en) * 2019-05-17 2022-09-15 The Broad Institute, Inc. Methods of preparing macrocyclic indoles
US11964978B2 (en) 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335564A (en) 2000-05-26 2001-12-04 Ube Ind Ltd Method for producing ester of 1-alkyl-5-substituted pyrazole-3-carboxylic acid
ES2550753T3 (en) 2007-04-16 2015-11-12 Abbvie Inc. Indole derivatives unsubstituted at position 7 as Mcl-1 inhibitors
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CA2922341C (en) * 2013-08-28 2022-06-07 Vanderbilt University Substituted indole mcl-1 inhibitors
JP6757312B2 (en) 2014-03-27 2020-09-16 ヴァンダービルト ユニバーシティー Substituted indole MCL-1 inhibitor
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof

Also Published As

Publication number Publication date
TW201808957A (en) 2018-03-16
UY37250A (en) 2018-01-02
WO2017198341A1 (en) 2017-11-23
CA3024482A1 (en) 2017-11-23

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