UY37250A - INDOL MACROCYCLIC DERIVATIVES - Google Patents

INDOL MACROCYCLIC DERIVATIVES

Info

Publication number
UY37250A
UY37250A UY0001037250A UY37250A UY37250A UY 37250 A UY37250 A UY 37250A UY 0001037250 A UY0001037250 A UY 0001037250A UY 37250 A UY37250 A UY 37250A UY 37250 A UY37250 A UY 37250A
Authority
UY
Uruguay
Prior art keywords
compounds
indol
preparing
pharmaceutical compositions
macrocyclic derivatives
Prior art date
Application number
UY0001037250A
Other languages
Spanish (es)
Inventor
Sarah Wagner Dra
Philipp Buchgraber Dr
Ulrich Klar Dr
Clara Christ Dra
Amaury Ernesto Fernandez-Montalvan Dr
Möwes Manfred
Philip Lienau Dr
Knut Eis Dr
Ulrike Sack Dra
Ursula Mönning Dra
Arne Scholz Dr
Joachim Kuhnke Dr
Kai Thede Dr
Nicolas Werbeck Dr
H Serrano-Wu Michael
Chris Lemke
David Mckinney
Mark Fitzgerald
Christopher Nasveschuk
Kiel Lazarski
James Ferrara Steven
Laura Furst
Guo Wei
Ryan Mccarren Patrick
Original Assignee
Bayer Ag
Broad Inst Inc
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Broad Inst Inc, Bayer Pharma AG filed Critical Bayer Ag
Publication of UY37250A publication Critical patent/UY37250A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a derivados de indol macrocíclicos de la fórmula general (I): en donde R1, R2, R3, R4, R5, R6, A y L son como se definen en la presente, métodos de preparación de dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para producir composiciones farmacéuticas para el tratamiento o prevención de enfermedades, en particular de enfermedades hiperproliferativas, como un único agente o en combinación con otros ingredientes activos.The present invention relates to macrocyclic indole derivatives of the general formula (I): wherein R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds to produce pharmaceutical compositions for the treatment or prevention of diseases, in particular hyperproliferative diseases, as a single agent or in combination with other ingredients assets.

UY0001037250A 2016-05-19 2017-05-19 INDOL MACROCYCLIC DERIVATIVES UY37250A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338942P 2016-05-19 2016-05-19
EP16172726 2016-06-02

Publications (1)

Publication Number Publication Date
UY37250A true UY37250A (en) 2018-01-02

Family

ID=56098125

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037250A UY37250A (en) 2016-05-19 2017-05-19 INDOL MACROCYCLIC DERIVATIVES

Country Status (4)

Country Link
CA (1) CA3024482A1 (en)
TW (1) TW201808957A (en)
UY (1) UY37250A (en)
WO (1) WO2017198341A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981932B2 (en) 2016-05-19 2021-04-20 Bayer Aktiengesellschaft Macrocyclic indole derivatives
EP3710456B1 (en) * 2017-11-17 2022-09-21 The Broad Institute, Inc. Macrocyclic indole derivatives
WO2019096907A1 (en) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Aryl annulated macrocyclic indole derivatives
EP3710451A1 (en) * 2017-11-17 2020-09-23 Bayer Aktiengesellschaft Substituted macrocyclic indole derivatives
US11286263B2 (en) 2017-11-17 2022-03-29 The Broad Institute, Inc. Macrocyclic fluorine substituted indole derivatives
EP3710450A1 (en) 2017-11-17 2020-09-23 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
WO2019096905A1 (en) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
WO2020236556A1 (en) * 2019-05-17 2020-11-26 The Broad Institute, Inc. Methods of preparing macrocyclic indoles
US11964978B2 (en) 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335564A (en) 2000-05-26 2001-12-04 Ube Ind Ltd Method for producing ester of 1-alkyl-5-substituted pyrazole-3-carboxylic acid
JP5496876B2 (en) 2007-04-16 2014-05-21 アッヴィ・インコーポレイテッド 7-Unsubstituted indole Mcl-1 inhibitors
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015031608A1 (en) * 2013-08-28 2015-03-05 Vanderbilt University Substituted indole mcl-1 inhibitors
US10533010B2 (en) 2014-03-27 2020-01-14 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof

Also Published As

Publication number Publication date
TW201808957A (en) 2018-03-16
WO2017198341A1 (en) 2017-11-23
WO2017198341A8 (en) 2019-01-03
CA3024482A1 (en) 2017-11-23

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20230612