AU2017357503B2 - New anthelmintic quinoline-3-carboxamide derivatives - Google Patents

New anthelmintic quinoline-3-carboxamide derivatives Download PDF

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Publication number
AU2017357503B2
AU2017357503B2 AU2017357503A AU2017357503A AU2017357503B2 AU 2017357503 B2 AU2017357503 B2 AU 2017357503B2 AU 2017357503 A AU2017357503 A AU 2017357503A AU 2017357503 A AU2017357503 A AU 2017357503A AU 2017357503 B2 AU2017357503 B2 AU 2017357503B2
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AU
Australia
Prior art keywords
alkyl
halogen atoms
group
halogenoalkyl
alkoxy
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AU2017357503A
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AU2017357503A1 (en
Inventor
Claudia BÖHM
Kirsten BÖRNGEN
Nils Griebenow
Ulrich Görgens
Maike HINK
Walter Hübsch
Thomas Ilg
Daniel Kulke
Johannes KÖBBERLING
Adeline KÖHLER
Niels Lindner
Hans-Georg Schwarz
Claudia WELZ
Wei Zhuang
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Elanco Animal Health GmbH
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Elanco Animal Health GmbH
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Assigned to ELANCO ANIMAL HEALTH GMBH reassignment ELANCO ANIMAL HEALTH GMBH Request to Amend Deed and Register Assignors: BAYER ANIMAL HEALTH GMBH
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2017357503A 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives Active AU2017357503B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198550.2 2016-11-11
EP16198550 2016-11-11
PCT/EP2017/078319 WO2018087036A1 (en) 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives

Publications (2)

Publication Number Publication Date
AU2017357503A1 AU2017357503A1 (en) 2019-05-02
AU2017357503B2 true AU2017357503B2 (en) 2022-02-17

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AU2017357503A Active AU2017357503B2 (en) 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives

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US (2) US10889573B2 (enExample)
EP (1) EP3538512B1 (enExample)
JP (1) JP7165129B2 (enExample)
KR (1) KR102595730B1 (enExample)
CN (1) CN109890793B (enExample)
AU (1) AU2017357503B2 (enExample)
CA (1) CA3043298A1 (enExample)
CL (1) CL2019001292A1 (enExample)
CO (1) CO2019004776A2 (enExample)
DK (1) DK3538512T3 (enExample)
DO (1) DOP2019000117A (enExample)
ES (1) ES2884073T3 (enExample)
IL (1) IL266407B (enExample)
MX (1) MX2019005569A (enExample)
MY (1) MY196327A (enExample)
NZ (1) NZ752550A (enExample)
PH (1) PH12019501034A1 (enExample)
PL (1) PL3538512T3 (enExample)
PT (1) PT3538512T (enExample)
SG (1) SG11201903059SA (enExample)
SI (1) SI3538512T1 (enExample)
TW (1) TWI821165B (enExample)
UA (1) UA126119C2 (enExample)
UY (1) UY37480A (enExample)
WO (1) WO2018087036A1 (enExample)
ZA (1) ZA201903708B (enExample)

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JP7403472B2 (ja) 2018-05-09 2023-12-22 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規キノリン誘導体
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3643711A1 (en) * 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
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AR116909A1 (es) * 2018-12-18 2021-06-23 Elanco Tiergesundheit Ag Derivados bicíclicos
JP7637630B2 (ja) 2019-03-19 2025-02-28 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
BR112021024726A2 (pt) 2019-06-07 2022-01-18 Elanco Tiergesundheit Ag Novos derivados bicíclicos
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
EP4077322A1 (en) 2019-12-18 2022-10-26 Intervet International B.V. Anthelmintic compounds comprising azaindoles structure
EP4077281A1 (en) * 2019-12-18 2022-10-26 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
JP2023521342A (ja) * 2020-04-09 2023-05-24 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 駆虫性化合物としての置換縮合アジン類
PH12022553222A1 (en) 2020-05-29 2024-02-12 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic heterocyclic compounds
CA3202092A1 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag Bicyclic derivatives
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CN116600807A (zh) 2020-12-11 2023-08-15 英特维特国际股份有限公司 包含噻吩并吡啶结构的驱虫化合物
EP4259606A1 (en) 2020-12-11 2023-10-18 Intervet International B.V. Anthelmintic compounds comprising a pyridine structure
EP4148052A1 (en) 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos
EP4694887A1 (en) 2023-04-14 2026-02-18 Elanco Animal Health GmbH Long-term prevention and/or treatment of a disease by slo-1 inhibitors
IL326231A (en) 2023-08-02 2026-03-01 Intervet Int Bv Carboxamide-4-quinoline compounds with anthelmintic activity
WO2026078157A2 (en) 2024-10-10 2026-04-16 Elanco Animal Health Gmbh Slo-1 modulators for prevention and/or treatment of a disease

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PL3538512T3 (pl) 2021-11-22
JP7165129B2 (ja) 2022-11-02
CL2019001292A1 (es) 2019-09-27
KR20190076980A (ko) 2019-07-02
CN109890793A (zh) 2019-06-14
RU2019117917A (ru) 2020-12-11
TW201829384A (zh) 2018-08-16
NZ752550A (en) 2023-03-31
EP3538512B1 (en) 2021-06-16
KR102595730B1 (ko) 2023-10-27
MY196327A (en) 2023-03-24
IL266407A (en) 2019-06-30
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