ZA201903708B - New anthelmintic quinoline-3-carboxamide derivatives - Google Patents
New anthelmintic quinoline-3-carboxamide derivativesInfo
- Publication number
- ZA201903708B ZA201903708B ZA2019/03708A ZA201903708A ZA201903708B ZA 201903708 B ZA201903708 B ZA 201903708B ZA 2019/03708 A ZA2019/03708 A ZA 2019/03708A ZA 201903708 A ZA201903708 A ZA 201903708A ZA 201903708 B ZA201903708 B ZA 201903708B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinoline
- carboxamide derivatives
- new anthelmintic
- anthelmintic
- new
- Prior art date
Links
- 230000000507 anthelmentic effect Effects 0.000 title 1
- BLTDCIWCFCUQCB-UHFFFAOYSA-N quinoline-3-carboxamide Chemical class C1=CC=CC2=CC(C(=O)N)=CN=C21 BLTDCIWCFCUQCB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201903708B true ZA201903708B (en) | 2022-11-30 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2019/03708A ZA201903708B (en) | 2016-11-11 | 2019-06-10 | New anthelmintic quinoline-3-carboxamide derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (enExample) |
| EP (1) | EP3538512B1 (enExample) |
| JP (1) | JP7165129B2 (enExample) |
| KR (1) | KR102595730B1 (enExample) |
| CN (1) | CN109890793B (enExample) |
| AU (1) | AU2017357503B2 (enExample) |
| CA (1) | CA3043298A1 (enExample) |
| CL (1) | CL2019001292A1 (enExample) |
| CO (1) | CO2019004776A2 (enExample) |
| DK (1) | DK3538512T3 (enExample) |
| DO (1) | DOP2019000117A (enExample) |
| ES (1) | ES2884073T3 (enExample) |
| IL (1) | IL266407B (enExample) |
| MX (1) | MX2019005569A (enExample) |
| MY (1) | MY196327A (enExample) |
| NZ (1) | NZ752550A (enExample) |
| PH (1) | PH12019501034A1 (enExample) |
| PL (1) | PL3538512T3 (enExample) |
| PT (1) | PT3538512T (enExample) |
| SG (1) | SG11201903059SA (enExample) |
| SI (1) | SI3538512T1 (enExample) |
| TW (1) | TWI821165B (enExample) |
| UA (1) | UA126119C2 (enExample) |
| UY (1) | UY37480A (enExample) |
| WO (1) | WO2018087036A1 (enExample) |
| ZA (1) | ZA201903708B (enExample) |
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| JP7210483B2 (ja) | 2017-06-30 | 2023-01-23 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規アザキノリン誘導体 |
| US11254661B2 (en) * | 2017-08-04 | 2022-02-22 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| MX2020006185A (es) * | 2017-12-15 | 2020-09-03 | Bayer Animal Health Gmbh | Proceso para la preparacion de derivados de quinolina. |
| CN112074514B (zh) | 2018-05-09 | 2024-10-29 | 礼蓝动物保健有限公司 | 新的喹啉衍生物 |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| US20220064159A1 (en) | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| NZ777370A (en) * | 2018-12-18 | 2024-11-29 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| KR20220002890A (ko) | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
| US20200385398A1 (en) | 2019-06-07 | 2020-12-10 | Elanco Tiergesundheit Ag | New bicyclic derivatives |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| JP2023507173A (ja) * | 2019-12-18 | 2023-02-21 | インターベット インターナショナル ベー． フェー． | キノリン構造を含む駆虫剤化合物 |
| MX2022007671A (es) | 2019-12-18 | 2022-07-19 | Intervet Int Bv | Compuestos antihelminticos que comprenden una estructura de azaindoles. |
| WO2021204930A1 (en) | 2020-04-09 | 2021-10-14 | Bayer Animal Health Gmbh | Substituted condensed azines as anthelmintic compounds |
| BR112022024156A2 (pt) | 2020-05-29 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Compostos heterocílicos antelmínticos |
| CN116685584A (zh) * | 2020-11-18 | 2023-09-01 | 礼蓝动物保健有限公司 | 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物 |
| US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| AU2021398540A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| WO2022122988A1 (en) | 2020-12-11 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| WO2023073641A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
| EP4694887A1 (en) | 2023-04-14 | 2026-02-18 | Elanco Animal Health GmbH | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| CN121620507A (zh) | 2023-08-02 | 2026-03-06 | 英特维特国际股份有限公司 | 具有驱虫活性的甲酰胺-4-喹啉化合物 |
| WO2026078157A2 (en) | 2024-10-10 | 2026-04-16 | Elanco Animal Health Gmbh | Slo-1 modulators for prevention and/or treatment of a disease |
| WO2026115027A1 (en) | 2024-11-28 | 2026-06-04 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
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2017
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 PT PT177914389T patent/PT3538512T/pt unknown
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/zh active Active
- 2017-11-06 PL PL17791438T patent/PL3538512T3/pl unknown
- 2017-11-06 ES ES17791438T patent/ES2884073T3/es active Active
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/ko active Active
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/ja active Active
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/es unknown
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/da active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en not_active Ceased
- 2017-11-06 SI SI201730854T patent/SI3538512T1/sl unknown
- 2017-11-06 UA UAA201906455A patent/UA126119C2/uk unknown
- 2017-11-10 TW TW106138957A patent/TWI821165B/zh active
- 2017-11-10 UY UY0001037480A patent/UY37480A/es not_active Application Discontinuation
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2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/es unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/es unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/es unknown
- 2019-06-10 ZA ZA2019/03708A patent/ZA201903708B/en unknown
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2020
- 2020-10-30 US US17/085,880 patent/US11505545B2/en active Active
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