CN109890793B - 新的抗蠕虫药喹啉-3-甲酰胺衍生物 - Google Patents

新的抗蠕虫药喹啉-3-甲酰胺衍生物 Download PDF

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Publication number
CN109890793B
CN109890793B CN201780069050.7A CN201780069050A CN109890793B CN 109890793 B CN109890793 B CN 109890793B CN 201780069050 A CN201780069050 A CN 201780069050A CN 109890793 B CN109890793 B CN 109890793B
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alkyl
halogen atoms
haloalkyl
alkoxy
halogen
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Chinese (zh)
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CN109890793A (zh
Inventor
W.霍伊布施
J.克伯林
A.克勒
H-G.施瓦茨
D.库尔克
C.韦尔茨
T.伊尔格
K.伯恩根
庄伟�
N.格里贝诺夫
C.伯姆
N.林德纳
M.欣克
U.格根斯
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Lilan Animal Health Care Co ltd
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Bayer Animal Health GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201780069050.7A 2016-11-11 2017-11-06 新的抗蠕虫药喹啉-3-甲酰胺衍生物 Active CN109890793B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198550 2016-11-11
EP16198550.2 2016-11-11
PCT/EP2017/078319 WO2018087036A1 (en) 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives

Publications (2)

Publication Number Publication Date
CN109890793A CN109890793A (zh) 2019-06-14
CN109890793B true CN109890793B (zh) 2022-11-18

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EP (1) EP3538512B1 (enExample)
JP (1) JP7165129B2 (enExample)
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CN (1) CN109890793B (enExample)
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CL (1) CL2019001292A1 (enExample)
CO (1) CO2019004776A2 (enExample)
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DO (1) DOP2019000117A (enExample)
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IL (1) IL266407B (enExample)
MX (1) MX2019005569A (enExample)
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UA (1) UA126119C2 (enExample)
UY (1) UY37480A (enExample)
WO (1) WO2018087036A1 (enExample)
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CN111448192B (zh) * 2017-12-15 2024-04-12 拜耳动物保健有限责任公司 用于制备驱蠕虫的4-氨基-喹啉-3-甲酰胺衍生物的方法
AU2019266511B2 (en) * 2018-05-09 2022-12-08 Elanco Animal Health Gmbh New quinoline derivatives
CA3106092A1 (en) 2018-07-09 2020-01-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
EP3643711A1 (en) * 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
US20220064159A1 (en) * 2018-12-18 2022-03-03 Elanco Tiergesundheit Ag Bicyclic derivatives
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CN119285648A (zh) 2019-03-19 2025-01-10 勃林格殷格翰动物保健有限公司 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
EP3980414A1 (en) * 2019-06-07 2022-04-13 Elanco Tiergesundheit AG Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CN114845994B (zh) * 2019-12-18 2025-07-18 英特维特国际股份有限公司 包含喹啉结构的驱虫化合物
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AU2021253168A1 (en) * 2020-04-09 2022-11-03 Elanco Animal Health Gmbh Substituted condensed azines as anthelmintic compounds
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CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
AU2021384833A1 (en) 2020-11-18 2023-06-15 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) * 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
CA3203279A1 (en) 2020-12-11 2022-06-16 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
AU2021398540A1 (en) 2020-12-11 2023-06-22 Intervet International B.V. Anthelmintic compounds comprising a pyridine structure
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PE20250675A1 (es) 2021-11-01 2025-03-04 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelminticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
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US10889573B2 (en) 2021-01-12
CO2019004776A2 (es) 2019-07-31
US20210115026A1 (en) 2021-04-22
KR20190076980A (ko) 2019-07-02
IL266407B (en) 2021-10-31
ES2884073T3 (es) 2021-12-10
DOP2019000117A (es) 2019-05-31
CL2019001292A1 (es) 2019-09-27
CA3043298A1 (en) 2018-05-17
US11505545B2 (en) 2022-11-22
SI3538512T1 (sl) 2021-09-30
AU2017357503A1 (en) 2019-05-02
EP3538512B1 (en) 2021-06-16
UA126119C2 (uk) 2022-08-17
US20200024264A1 (en) 2020-01-23
JP7165129B2 (ja) 2022-11-02
DK3538512T3 (da) 2021-07-05
PT3538512T (pt) 2021-08-16
CN109890793A (zh) 2019-06-14
TW201829384A (zh) 2018-08-16
KR102595730B1 (ko) 2023-10-27
PH12019501034A1 (en) 2019-12-02
ZA201903708B (en) 2022-11-30
TWI821165B (zh) 2023-11-11
IL266407A (en) 2019-06-30
RU2019117917A3 (enExample) 2021-03-05
MX2019005569A (es) 2019-09-05
RU2019117917A (ru) 2020-12-11
JP2019535706A (ja) 2019-12-12
SG11201903059SA (en) 2019-05-30
BR112019009529A2 (pt) 2019-07-30
AU2017357503B2 (en) 2022-02-17
PL3538512T3 (pl) 2021-11-22
UY37480A (es) 2018-06-29
WO2018087036A1 (en) 2018-05-17
MY196327A (en) 2023-03-24

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