PH12018500409A1 - New bicyclic compounds as dual atx/ca inhibitors - Google Patents

New bicyclic compounds as dual atx/ca inhibitors

Info

Publication number
PH12018500409A1
PH12018500409A1 PH12018500409A PH12018500409A PH12018500409A1 PH 12018500409 A1 PH12018500409 A1 PH 12018500409A1 PH 12018500409 A PH12018500409 A PH 12018500409A PH 12018500409 A PH12018500409 A PH 12018500409A PH 12018500409 A1 PH12018500409 A1 PH 12018500409A1
Authority
PH
Philippines
Prior art keywords
inhibitors
bicyclic compounds
new bicyclic
atx
dual
Prior art date
Application number
PH12018500409A
Other languages
English (en)
Inventor
Jerome Hert
Daniel Hunziker
Patrizio Mattei
Markus Rudolph
Petra Schmitz
Christoph Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PH12018500409A1 publication Critical patent/PH12018500409A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
PH12018500409A 2015-09-24 2018-02-23 New bicyclic compounds as dual atx/ca inhibitors PH12018500409A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
PH12018500409A1 true PH12018500409A1 (en) 2018-08-29

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12018500409A PH12018500409A1 (en) 2015-09-24 2018-02-23 New bicyclic compounds as dual atx/ca inhibitors

Country Status (19)

Country Link
US (2) US10738053B2 (OSRAM)
EP (1) EP3353181B1 (OSRAM)
JP (1) JP6845230B2 (OSRAM)
KR (1) KR20180053408A (OSRAM)
CN (1) CN107614505B (OSRAM)
AR (1) AR106100A1 (OSRAM)
AU (1) AU2016328365B2 (OSRAM)
BR (1) BR112017026682A2 (OSRAM)
CA (1) CA2984585A1 (OSRAM)
CL (1) CL2018000649A1 (OSRAM)
CO (1) CO2017011152A2 (OSRAM)
CR (1) CR20180143A (OSRAM)
IL (1) IL255511B (OSRAM)
MX (1) MX2017015034A (OSRAM)
PE (1) PE20180233A1 (OSRAM)
PH (1) PH12018500409A1 (OSRAM)
RU (1) RU2725138C2 (OSRAM)
TW (1) TW201725206A (OSRAM)
WO (1) WO2017050747A1 (OSRAM)

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EA037928B1 (ru) 2014-03-26 2021-06-08 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
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KR20180054830A (ko) * 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서의 이환형 화합물
EP3353178B1 (en) 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
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CN107922412B (zh) 2015-09-24 2021-02-23 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
RU2019132254A (ru) * 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
EP4003978B1 (en) 2019-07-22 2024-05-01 Boehringer Ingelheim International GmbH N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway or fibrotic diseases
CN116806150A (zh) 2021-01-05 2023-09-26 载度思生命科学有限公司 新的自分泌运动因子抑制剂

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