PH12014502739B1 - Macrocyclic inhibitors of flaviviridae viruses - Google Patents

Macrocyclic inhibitors of flaviviridae viruses Download PDF

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Publication number
PH12014502739B1
PH12014502739B1 PH12014502739A PH12014502739A PH12014502739B1 PH 12014502739 B1 PH12014502739 B1 PH 12014502739B1 PH 12014502739 A PH12014502739 A PH 12014502739A PH 12014502739 A PH12014502739 A PH 12014502739A PH 12014502739 B1 PH12014502739 B1 PH 12014502739B1
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Philippines
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alkyl
compound
alkoxy
mmol
halo
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PH12014502739A
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PH12014502739A1 (en
Inventor
Steadman Victoria Alexandra
Karine G Poullennec
Lazarides Linos
Aciro Caroline
Dean David Kenneth
Keats Andrew John
Siegel Dustin Scott
Schrier Adam James
Mackman Richard
Jansa Petr
Watt Greg
Highton Adrian John
Chiva Jean Yves
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Gilead Sciences Inc
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Publication of PH12014502739A1 publication Critical patent/PH12014502739A1/en
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    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
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    • A61P31/12Antivirals
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    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • A61P37/02Immunomodulators
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • AHUMAN NECESSITIES
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    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15Depsipeptides; Derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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PH12014502739A 2012-06-08 2014-12-05 Macrocyclic inhibitors of flaviviridae viruses PH12014502739B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657562P 2012-06-08 2012-06-08
PCT/US2013/044812 WO2013185093A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (2)

Publication Number Publication Date
PH12014502739A1 PH12014502739A1 (en) 2015-02-02
PH12014502739B1 true PH12014502739B1 (en) 2015-02-02

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EP (2) EP2861601B1 (enExample)
JP (1) JP6273268B2 (enExample)
KR (1) KR102185152B1 (enExample)
CN (1) CN104781261B (enExample)
AP (1) AP2015008189A0 (enExample)
AR (1) AR091279A1 (enExample)
AU (1) AU2013270670B2 (enExample)
BR (1) BR112014030639A2 (enExample)
CA (1) CA2875690C (enExample)
CL (1) CL2014003337A1 (enExample)
CR (1) CR20150018A (enExample)
EA (1) EA027134B1 (enExample)
EC (1) ECSP15000435A (enExample)
ES (2) ES2672480T3 (enExample)
IL (1) IL236007B (enExample)
IN (1) IN2014MN02657A (enExample)
MA (1) MA37712B1 (enExample)
MD (1) MD20140135A2 (enExample)
MX (1) MX358372B (enExample)
NO (1) NO2885641T3 (enExample)
NZ (1) NZ703062A (enExample)
PE (1) PE20150862A1 (enExample)
PH (1) PH12014502739B1 (enExample)
PL (1) PL2861601T3 (enExample)
PT (1) PT2861601T (enExample)
SG (2) SG11201408064PA (enExample)
SI (1) SI2861601T1 (enExample)
TW (1) TWI616448B (enExample)
UA (1) UA115664C2 (enExample)
UY (1) UY34851A (enExample)
WO (1) WO2013185093A1 (enExample)
ZA (1) ZA201409215B (enExample)

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