PH12012500999A1 - Methods for improving the efficiency of simultaneous saccharification and fermentation reactions - Google Patents
Methods for improving the efficiency of simultaneous saccharification and fermentation reactionsInfo
- Publication number
- PH12012500999A1 PH12012500999A1 PH1/2012/500999A PH12012500999A PH12012500999A1 PH 12012500999 A1 PH12012500999 A1 PH 12012500999A1 PH 12012500999 A PH12012500999 A PH 12012500999A PH 12012500999 A1 PH12012500999 A1 PH 12012500999A1
- Authority
- PH
- Philippines
- Prior art keywords
- simultaneous saccharification
- improving
- efficiency
- methods
- fermentation reactions
- Prior art date
Links
- 238000000855 fermentation Methods 0.000 title abstract 3
- 230000004151 fermentation Effects 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 108010038658 exo-1,4-beta-D-xylosidase Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/22—Processes using, or culture media containing, cellulose or hydrolysates thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01037—Xylan 1,4-beta-xylosidase (3.2.1.37)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28991709P | 2009-12-23 | 2009-12-23 | |
| PCT/US2010/061082 WO2011079048A2 (en) | 2009-12-23 | 2010-12-17 | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12012500999A1 true PH12012500999A1 (en) | 2013-02-11 |
Family
ID=44196386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2012/500999A PH12012500999A1 (en) | 2009-12-23 | 2010-12-17 | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10138499B2 (enExample) |
| EP (1) | EP2516663B1 (enExample) |
| JP (2) | JP2013515482A (enExample) |
| KR (1) | KR20120106774A (enExample) |
| CN (2) | CN102686736B (enExample) |
| AU (1) | AU2010333801B2 (enExample) |
| CA (1) | CA2784355A1 (enExample) |
| CO (1) | CO6551739A2 (enExample) |
| MX (1) | MX2012007224A (enExample) |
| PH (1) | PH12012500999A1 (enExample) |
| RU (1) | RU2012131405A (enExample) |
| UA (1) | UA114276C2 (enExample) |
| WO (1) | WO2011079048A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011038019A2 (en) * | 2009-09-23 | 2011-03-31 | Danisco Us Inc. | Novel glycosyl hydrolase enzymes and uses thereof |
| JP2013515482A (ja) | 2009-12-23 | 2013-05-09 | ダニスコ・ユーエス・インク | 同時糖化発酵反応の効率を改善するための方法 |
| JP2011160753A (ja) * | 2010-02-12 | 2011-08-25 | Univ Of Tokyo | 糖の製造方法、エタノールの製造方法、及び乳酸の製造方法 |
| AR085379A1 (es) * | 2011-02-23 | 2013-09-25 | Syngenta Participations Ag | Potenciacion de sacarificacion enzimatica |
| KR20140017612A (ko) | 2011-03-17 | 2014-02-11 | 다니스코 유에스 인크. | 당화 공정에서 점도를 감소시키는 방법 |
| WO2013067964A1 (en) * | 2011-11-11 | 2013-05-16 | Novozymes, Inc. | Polypeptides having xylanase activity and polynucleotides encoding same |
| US20140289905A1 (en) * | 2011-11-11 | 2014-09-25 | Novozymes Inc. | Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same |
| EP2785732B1 (en) * | 2011-12-01 | 2017-04-12 | Novozymes, Inc. | Polypeptides having beta-xylosidase activity and polynucleotides encoding same |
| CN103060418A (zh) * | 2012-12-06 | 2013-04-24 | 南昌大学 | 一种构建混合菌体系发酵稻草秸秆生产乙醇的方法 |
| CA2892054A1 (en) | 2012-12-07 | 2014-06-12 | Ling Hua | Compositions and methods of use |
| EP3027741B1 (en) | 2013-07-29 | 2019-10-23 | Danisco US Inc. | Gh61 enzyme variants |
| WO2015048087A1 (en) * | 2013-09-25 | 2015-04-02 | Novozymes A/S | Processes of producing fermentation products |
| WO2015057520A1 (en) * | 2013-10-16 | 2015-04-23 | Novozymes A/S | Processes of producing fermentation products |
| WO2015086803A1 (en) * | 2013-12-13 | 2015-06-18 | Lantmännen Energi | Integration of first and second generation bioethanol processes |
| KR101806223B1 (ko) * | 2014-11-07 | 2017-12-07 | 한국과학기술연구원 | 리그닌-셀룰로오스 동시 분해 생촉매 및 이를 이용한 당화액과 바이오 연료의 제조방법 |
| US10612058B2 (en) * | 2014-12-19 | 2020-04-07 | Danisco Us Inc | Methods for saccharifying a starch substrate |
| BR112017028065A2 (pt) * | 2015-06-26 | 2018-09-11 | Novozymes As | sistema de bioacabamento |
| DK3416740T3 (da) | 2016-02-19 | 2021-02-08 | Intercontinental Great Brands Llc | Fremgangsmåder til dannelse af multiple værdistrømme ud fra biomassekilder |
| BR112018069721A2 (pt) | 2016-03-31 | 2019-02-05 | Toray Industries | fungo, métodos para produzir uma composição de celulase e para produzir glicose e xilo-oligossacarídeos |
| CN108779456B (zh) * | 2016-03-31 | 2022-04-05 | 东丽株式会社 | 蛋白质的制造方法 |
| WO2017220548A1 (en) * | 2016-06-20 | 2017-12-28 | Metgen Oy | Method for producing fructose from glucose obtained from lignocellulosic biomass |
| DK3472336T3 (da) * | 2016-06-20 | 2020-08-10 | Metgen Oy | Fremgangsmåde til fremstilling af xylulose fra xylose opnået fra lignocellulosebiomasse |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| CN109694890B (zh) * | 2017-10-24 | 2021-02-23 | 朱一民 | 混菌系统、利用其分解半纤维素的方法及生产酒精的方法 |
| RU2705262C2 (ru) * | 2018-03-29 | 2019-11-06 | Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Пущинский научный центр биологических исследований Российской академии наук" (ФИЦ ПНЦБИ РАН) | Ферментный препарат для гидролиза растительного сырья и способ его получения с помощью рекомбинантных продуцентов на основе pichia pastoris |
| CN108265018A (zh) * | 2018-04-04 | 2018-07-10 | 北京航天恒丰科技股份有限公司 | 一种使用秸秆发酵制备肥料的复合菌剂及其制备方法 |
| JP2020025468A (ja) * | 2018-08-09 | 2020-02-20 | 国立研究開発法人産業技術総合研究所 | キシラナーゼ及びその利用 |
| JP7339751B2 (ja) * | 2019-03-18 | 2023-09-06 | 積水化学工業株式会社 | エタノール |
| JP7323306B2 (ja) * | 2019-03-18 | 2023-08-08 | 積水化学工業株式会社 | エタノール |
| JP7339749B2 (ja) * | 2019-03-18 | 2023-09-06 | 積水化学工業株式会社 | エタノール |
| WO2020159964A1 (en) * | 2019-01-28 | 2020-08-06 | University Of Florida Research Foundation | Method for fermentation under reduced pressure |
| JP7339750B2 (ja) * | 2019-03-18 | 2023-09-06 | 積水化学工業株式会社 | エタノール |
| JP7323307B2 (ja) * | 2019-03-18 | 2023-08-08 | 積水化学工業株式会社 | エタノール |
| JP7323305B2 (ja) * | 2019-03-18 | 2023-08-08 | 積水化学工業株式会社 | エタノール |
| CN113365966A (zh) | 2019-01-28 | 2021-09-07 | 积水化学工业株式会社 | 乙醇 |
| AU2020299165B2 (en) * | 2019-07-01 | 2025-10-23 | Cotton Incorporated | Cotton textile waste fabric used as a biomass for the production of sugar |
| CN111004789B (zh) * | 2019-12-11 | 2021-10-15 | 云南师范大学 | 一种耐硫酸铵的木糖苷酶突变体v322dh328dt329e |
| CN111334538B (zh) * | 2020-03-20 | 2023-04-11 | 鄂州职业大学 | 一种强化绳状青霉发酵葡萄糖生产葡萄糖酸的方法 |
| CN111500338B (zh) * | 2020-05-28 | 2021-09-07 | 广东洁冠科技有限公司 | 一种燃速快的生物质燃料制造设备 |
| CN115232840B (zh) * | 2021-12-15 | 2025-03-21 | 中粮营养健康研究院有限公司 | 乙醇的连续发酵方法 |
| FR3143030A1 (fr) | 2022-12-08 | 2024-06-14 | IFP Energies Nouvelles | Procédé de séparation de l’enzyme bêta-xylosidase à partir d’un mélange d’enzymes |
| WO2024258820A2 (en) * | 2023-06-13 | 2024-12-19 | Novozymes A/S | Processes for producing fermentation products using engineered yeast expressing a beta-xylosidase |
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-
2010
- 2010-12-17 JP JP2012546088A patent/JP2013515482A/ja active Pending
- 2010-12-17 US US13/516,610 patent/US10138499B2/en active Active
- 2010-12-17 CN CN201080058488.3A patent/CN102686736B/zh active Active
- 2010-12-17 CN CN201710333406.5A patent/CN107287250A/zh active Pending
- 2010-12-17 UA UAA201208931A patent/UA114276C2/uk unknown
- 2010-12-17 WO PCT/US2010/061082 patent/WO2011079048A2/en not_active Ceased
- 2010-12-17 CA CA2784355A patent/CA2784355A1/en not_active Abandoned
- 2010-12-17 AU AU2010333801A patent/AU2010333801B2/en not_active Ceased
- 2010-12-17 PH PH1/2012/500999A patent/PH12012500999A1/en unknown
- 2010-12-17 RU RU2012131405/10A patent/RU2012131405A/ru not_active Application Discontinuation
- 2010-12-17 EP EP10813055.0A patent/EP2516663B1/en active Active
- 2010-12-17 KR KR1020127016149A patent/KR20120106774A/ko not_active Withdrawn
- 2010-12-17 MX MX2012007224A patent/MX2012007224A/es unknown
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2012
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2016
- 2016-03-16 JP JP2016052143A patent/JP2016154548A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2016154548A (ja) | 2016-09-01 |
| WO2011079048A9 (en) | 2011-08-25 |
| BR112012018407A2 (pt) | 2015-10-06 |
| WO2011079048A2 (en) | 2011-06-30 |
| CO6551739A2 (es) | 2012-10-31 |
| MX2012007224A (es) | 2012-07-30 |
| UA114276C2 (uk) | 2017-05-25 |
| EP2516663A2 (en) | 2012-10-31 |
| JP2013515482A (ja) | 2013-05-09 |
| EP2516663B1 (en) | 2020-02-12 |
| AU2010333801B2 (en) | 2015-12-17 |
| CN102686736A (zh) | 2012-09-19 |
| CA2784355A1 (en) | 2011-06-30 |
| WO2011079048A3 (en) | 2012-06-14 |
| CN102686736B (zh) | 2017-05-31 |
| CN107287250A (zh) | 2017-10-24 |
| AU2010333801A1 (en) | 2012-06-07 |
| US10138499B2 (en) | 2018-11-27 |
| US20130143277A1 (en) | 2013-06-06 |
| BR112012018407A8 (pt) | 2018-11-27 |
| KR20120106774A (ko) | 2012-09-26 |
| RU2012131405A (ru) | 2014-01-27 |
| US20190161772A1 (en) | 2019-05-30 |
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