MX2014015768A - Microorganismo recombinante para la produccion fermentativa de metionina. - Google Patents

Microorganismo recombinante para la produccion fermentativa de metionina.

Info

Publication number
MX2014015768A
MX2014015768A MX2014015768A MX2014015768A MX2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A
Authority
MX
Mexico
Prior art keywords
methionine
recombinant microorganism
fermentative production
microorganism
cobalamin
Prior art date
Application number
MX2014015768A
Other languages
English (en)
Other versions
MX355790B (es
Inventor
Rainer Figge
Wanda Dischert
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of MX2014015768A publication Critical patent/MX2014015768A/es
Publication of MX355790B publication Critical patent/MX355790B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01014—5-Methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (2.1.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

La presente invención se refiere a un microorganismo recombinante optimizado para la producción fermentativa de metionina, en donde se atenúa la actividad de la metionina sintetasa independiente de cobalamina MetE en dicho microorganismo; la invención se refiere también a un método para producir metionina por medio de fermentación.
MX2014015768A 2012-06-18 2012-06-18 Microorganismo recombinante para la produccion fermentativa de metionina. MX355790B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/001336 WO2013190343A1 (en) 2012-06-18 2012-06-18 Recombinant microorganism for the fermentative production of methionine

Publications (2)

Publication Number Publication Date
MX2014015768A true MX2014015768A (es) 2015-04-10
MX355790B MX355790B (es) 2018-04-27

Family

ID=46579255

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015768A MX355790B (es) 2012-06-18 2012-06-18 Microorganismo recombinante para la produccion fermentativa de metionina.

Country Status (14)

Country Link
US (1) US9506093B2 (es)
EP (1) EP2861726B1 (es)
JP (1) JP6100370B2 (es)
KR (1) KR101944150B1 (es)
CN (1) CN104411821B (es)
AU (1) AU2012383221A1 (es)
BR (1) BR112014031425B1 (es)
CA (1) CA2875139A1 (es)
ES (1) ES2632170T3 (es)
MX (1) MX355790B (es)
MY (1) MY168199A (es)
PL (1) PL2861726T3 (es)
RU (1) RU2629760C2 (es)
WO (1) WO2013190343A1 (es)

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BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
RU2678757C2 (ru) * 2013-08-30 2019-01-31 Эвоник Дегусса Гмбх Микроорганизмы для производства метионина с улучшенным выходом метионина
CN103981206B (zh) * 2014-06-06 2016-03-02 中国科学院天津工业生物技术研究所 一种筛选高产苏氨酸菌株的方法
MY194223A (en) 2014-09-01 2022-11-22 Evonik Operations Gmbh Method and microorganism for methionine production by fermentation with improved methionine efflux
CN108026516A (zh) * 2015-08-07 2018-05-11 赢创德固赛有限公司 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产
ES2748226T3 (es) 2015-11-27 2020-03-16 Evonik Operations Gmbh Procedimiento de producción de L-metionina
RU2018128142A (ru) 2016-01-08 2020-02-10 Эвоник Дегусса Гмбх Способ получения l-метионина по ферментативной технологии
CN105886449B (zh) * 2016-04-14 2019-07-26 浙江工业大学 一种重组大肠杆菌及其生产l-甲硫氨酸的应用
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
JP7188385B2 (ja) * 2016-10-26 2022-12-13 味の素株式会社 Ｌ－メチオニンまたは合成にｓ－アデノシルメチオニンを要求する代謝物の製造方法
KR102605543B1 (ko) * 2017-07-11 2023-11-22 아디쎄오 프랑스 에스에이에스 메티오닌-생산 효모
KR102016050B1 (ko) * 2018-03-20 2019-08-29 씨제이제일제당 주식회사 신규한 프로모터 및 이의 용도
WO2019212052A1 (en) 2018-05-04 2019-11-07 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-METHIONINE USING A BACTERIUM OF THE GENUS Pantoea
BR112021005543A2 (pt) 2018-09-28 2021-06-29 Ajinomoto Co., Inc. método para produzir l-metionina
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP2022521544A (ja) 2019-02-22 2022-04-08 味の素株式会社 ｙｄｉＪ遺伝子を過剰発現する腸内細菌科に属する細菌を用いたＬ－アミノ酸の製造方法
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido
KR102147776B1 (ko) * 2019-09-20 2020-08-26 대상 주식회사 L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법
JP2022550084A (ja) 2019-09-25 2022-11-30 味の素株式会社 細菌の発酵によるｌ－アミノ酸の製造方法
CN110819605B (zh) * 2020-01-07 2020-04-07 中国科学院天津工业生物技术研究所 甲硫氨酸合成酶突变体、突变基因及其在制备维生素b12中的应用
CN114381417B (zh) * 2022-03-24 2022-06-24 中国科学院天津工业生物技术研究所 一种提高谷氨酸棒杆菌对抑制物耐受性的方法

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Also Published As

Publication number Publication date
EP2861726A1 (en) 2015-04-22
MX355790B (es) 2018-04-27
EP2861726B1 (en) 2017-05-31
BR112014031425A2 (pt) 2017-08-01
CN104411821B (zh) 2017-08-08
JP6100370B2 (ja) 2017-03-22
BR112014031425B1 (pt) 2022-01-18
KR20150033649A (ko) 2015-04-01
RU2014151747A (ru) 2016-08-10
KR101944150B1 (ko) 2019-01-30
AU2012383221A1 (en) 2015-01-15
CN104411821A (zh) 2015-03-11
US20150247175A1 (en) 2015-09-03
US9506093B2 (en) 2016-11-29
RU2629760C2 (ru) 2017-09-06
PL2861726T3 (pl) 2017-11-30
WO2013190343A1 (en) 2013-12-27
JP2015519917A (ja) 2015-07-16
CA2875139A1 (en) 2013-12-27
ES2632170T3 (es) 2017-09-11
MY168199A (en) 2018-10-15

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