PE20160665A1 - Derivados 11-hidroxilo de acidos biliares y conjugados de aminoacidos de los mismos como moduladores del receptor de farnesoid x - Google Patents
Derivados 11-hidroxilo de acidos biliares y conjugados de aminoacidos de los mismos como moduladores del receptor de farnesoid xInfo
- Publication number
- PE20160665A1 PE20160665A1 PE2015002397A PE2015002397A PE20160665A1 PE 20160665 A1 PE20160665 A1 PE 20160665A1 PE 2015002397 A PE2015002397 A PE 2015002397A PE 2015002397 A PE2015002397 A PE 2015002397A PE 20160665 A1 PE20160665 A1 PE 20160665A1
- Authority
- PE
- Peru
- Prior art keywords
- receptor
- farnesoid
- conjugates
- modulators
- amino acids
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS 11-HIDROXILO DE ACIDOS BILIARES DE FORMULA (I) O UN CONJUGADO DE AMINOACIDO FARMACEUTICAMENTE ACEPTABLE DEL MISMO DONDE R1 ES HIDROXILO; R2, R3, R4, R5 Y R6 SON TAL COMO SE DEFINEN EN LA DESCRIPCION. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS SELECTIVOS DEL RECEPTOR X FERNESOIDE (FXR) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, HEPATICA CRONICA, METABOLICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823169P | 2013-05-14 | 2013-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160665A1 true PE20160665A1 (es) | 2016-08-07 |
Family
ID=50721801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002397A PE20160665A1 (es) | 2013-05-14 | 2014-05-14 | Derivados 11-hidroxilo de acidos biliares y conjugados de aminoacidos de los mismos como moduladores del receptor de farnesoid x |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US9611289B2 (es) |
| EP (4) | EP2997035B8 (es) |
| JP (2) | JP6326131B2 (es) |
| KR (1) | KR102229952B1 (es) |
| CN (2) | CN108245523B (es) |
| AU (1) | AU2014267324B2 (es) |
| BR (1) | BR112015028399B1 (es) |
| CA (1) | CA2912139C (es) |
| CL (2) | CL2015003344A1 (es) |
| CR (1) | CR20150643A (es) |
| CY (1) | CY1122614T1 (es) |
| DK (4) | DK3848038T3 (es) |
| EA (1) | EA030152B1 (es) |
| ES (4) | ES2843737T3 (es) |
| GT (1) | GT201500324A (es) |
| HK (2) | HK1253326A1 (es) |
| HR (1) | HRP20180931T1 (es) |
| HU (1) | HUE037996T2 (es) |
| IL (2) | IL242555B (es) |
| LT (1) | LT2997035T (es) |
| MA (1) | MA38647B1 (es) |
| ME (1) | ME03082B (es) |
| MX (1) | MX352065B (es) |
| MY (1) | MY187886A (es) |
| NI (1) | NI201500160A (es) |
| PE (1) | PE20160665A1 (es) |
| PH (1) | PH12015502576B1 (es) |
| PL (3) | PL3360882T3 (es) |
| PT (3) | PT3360881T (es) |
| RS (1) | RS57372B1 (es) |
| SA (1) | SA515370140B1 (es) |
| SG (1) | SG11201509352XA (es) |
| SI (3) | SI3360882T1 (es) |
| TN (1) | TN2015000497A1 (es) |
| TR (1) | TR201809041T4 (es) |
| UA (1) | UA118673C2 (es) |
| WO (1) | WO2014184271A1 (es) |
Families Citing this family (58)
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| ES2248581T3 (es) | 2001-03-12 | 2006-03-16 | Intercept Pharmaceuticals, Inc. | Esteroides como agonistas de fxr. |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| CA2912139C (en) | 2013-05-14 | 2021-04-20 | Roberto Pellicciari | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
| US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
| US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| HUE048351T2 (hu) * | 2014-05-29 | 2020-07-28 | Bar Pharmaceuticals S R L | Kolán-származékok alkalmazása FXR és TGR5/GPBAR1 mediált betegségek kezelésére és/vagy prevenciójára |
| AU2015343025A1 (en) | 2014-11-06 | 2017-06-08 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an FXR/TGR5 agonists and methods of use thereof |
| EA033445B1 (ru) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
| WO2016079520A1 (en) | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| DK3221331T3 (da) | 2014-11-19 | 2019-12-02 | Nzp Uk Ltd | 6-alkyl-7-hydroxy-4-en-3-on-steroider som mellemprodukter til fremstilling af steroide fxr-modulatorer |
| CA2968305A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| KR20170099909A (ko) | 2014-11-26 | 2017-09-01 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| MA41094A (fr) * | 2014-12-02 | 2017-10-10 | Lilly Co Eli | Procédés de traitement de troubles rénaux |
| CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
| CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
| TW201628625A (zh) * | 2015-02-06 | 2016-08-16 | 英特賽普醫藥品公司 | 組合療法醫藥組成物 |
| AU2016219266A1 (en) | 2015-02-11 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
| MX2017011399A (es) * | 2015-03-09 | 2018-03-16 | Intercept Pharmaceuticals Inc | Métodos para modular la densidad ósea. |
| CN107531741A (zh) | 2015-03-10 | 2018-01-02 | 美莱斯股份有限公司 | 氟化和烷基化胆酸 |
| WO2016149111A1 (en) * | 2015-03-13 | 2016-09-22 | Salk Institute For Biological Studies | Treating latent autoimmune diabetes of adults with farnesoid x receptor agonists to activate intestinal receptors |
| DK3277286T3 (da) * | 2015-03-31 | 2021-07-05 | Enanta Pharm Inc | Galdesydererivater som fxr/tgr5-agonister og anvendelsesmetoder deraf |
| CR20170456A (es) * | 2015-04-07 | 2018-06-13 | Intercept Pharmaceuticals Inc | Composiciones farmacéuticas para terapias combinadas |
| WO2016168553A1 (en) * | 2015-04-17 | 2016-10-20 | Concert Pharmaceuticals, Inc. | Deuterated obeticholic acid |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| CN106478759A (zh) * | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
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| MA45761A (fr) * | 2015-10-07 | 2021-04-21 | Intercept Pharmaceuticals Inc | Modulateurs du récepteur farnésoïde x |
| US10364267B2 (en) | 2016-02-23 | 2019-07-30 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| WO2017147174A1 (en) * | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
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| JP6892457B2 (ja) * | 2016-03-11 | 2021-06-23 | インターセプト ファーマシューティカルズ， インコーポレイテッド | ３−デスオキシ誘導体およびその医薬組成物 |
| IL262342B (en) * | 2016-04-13 | 2022-08-01 | Intercept Pharmaceuticals Inc | fxr agonist for use as a drug for the treatment or prevention of hepatocellular carcinoma |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| EP3730487B1 (en) | 2016-06-13 | 2022-04-27 | Gilead Sciences, Inc. | Azetidine derivatives as fxr (nr1h4) modulators |
| JP7057783B2 (ja) | 2016-11-29 | 2022-04-20 | エナンタ ファーマシューティカルズ インコーポレイテッド | スルホニル尿素胆汁酸誘導体の調製方法 |
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| JP2020508316A (ja) | 2017-02-21 | 2020-03-19 | ジェンフィＧｅｎｆｉｔ | Ｐｐａｒアゴニストとｆｘｒアゴニストとの組合せ |
| EP3585405A4 (en) * | 2017-02-23 | 2020-12-09 | Intercept Pharmaceuticals, Inc. | PHARMACEUTICAL COMPOSITIONS CONSISTING OF A BILIARY ACID DERIVATIVE AND A MICROBIOME AS WELL AS THEIR USES |
| EP4122464B1 (en) | 2017-03-28 | 2024-05-15 | Gilead Sciences, Inc. | Therapeutic combinations for treating liver diseases |
| MX2019011844A (es) | 2017-04-07 | 2021-11-30 | Enanta Pharm Inc | Proceso para la preparación de derivados de ácidos biliares de sulfonil carbamato. |
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| WO2018237350A1 (en) * | 2017-06-23 | 2018-12-27 | Intercept Pharmaceuticals, Inc. | METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES |
| MX2020000873A (es) | 2017-07-24 | 2020-07-22 | Intercept Pharmaceuticals Inc | Derivados de ácidos biliares marcados isotópicamente. |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN109182451B (zh) * | 2018-08-21 | 2021-06-11 | 四川大学 | 细胞色素cyp3a7酶的新型特异性探针反应及其应用 |
| EP4360632A2 (en) | 2019-01-15 | 2024-05-01 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| AU2020225225B2 (en) | 2019-02-19 | 2022-12-22 | Gilead Sciences, Inc. | Solid forms of FXR agonists |
| CN114144185A (zh) | 2019-05-30 | 2022-03-04 | 英特塞普特医药品公司 | 用于治疗胆汁淤积性肝病的包含fxr激动剂和贝特类的药物组合物 |
| KR20220035365A (ko) | 2019-07-18 | 2022-03-22 | 엔요 파마 | 인터페론의 부작용을 감소시키는 방법 |
| CN110540955B (zh) * | 2019-08-28 | 2021-09-17 | 北京协同创新研究院 | 一种提高分化细胞中nrob2基因表达量的方法 |
| WO2021144330A1 (en) | 2020-01-15 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fxr agonists for treating an infection by hepatitis d virus |
| EP4277622A1 (en) | 2021-01-14 | 2023-11-22 | ENYO Pharma | Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection |
| TW202308629A (zh) | 2021-04-28 | 2023-03-01 | 法商Ｅｎｙｏ製藥公司 | 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效 |
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| US2080775A (en) * | 1934-08-22 | 1937-05-18 | Celanese Corp | Shedding mechanism for circular looms |
| US2802775A (en) | 1953-05-29 | 1957-08-13 | Merck & Co Inc | 11 alpha-hydroxylation of steroids by aspergillus ochraceus |
| JPS59205396A (ja) * | 1983-05-09 | 1984-11-20 | Kuraray Co Ltd | １１β−ヒドロキシプレグナ−４−エン−３−オン−２０−カルブアルデヒド及びその製造法 |
| EP1140079B1 (en) | 1998-12-23 | 2009-06-03 | Glaxo Group Limited | Assays for ligands for nuclear receptors |
| ITMI20021532A1 (it) * | 2002-07-12 | 2004-01-12 | Roberto Pellicciari | Composti chimici |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| PT1734970E (pt) * | 2004-03-12 | 2015-03-11 | Intercept Pharmaceuticals Inc | Tratamento de fibrose utilizando ligandos de rfx |
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| CA2912139C (en) | 2013-05-14 | 2021-04-20 | Roberto Pellicciari | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
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2014
- 2014-05-14 CA CA2912139A patent/CA2912139C/en active Active
- 2014-05-14 ES ES18163623T patent/ES2843737T3/es active Active
- 2014-05-14 DK DK20211780.0T patent/DK3848038T3/da active
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
- 2014-05-14 US US14/120,366 patent/US9611289B2/en active Active
- 2014-05-14 LT LTEP14723820.8T patent/LT2997035T/lt unknown
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 PE PE2015002397A patent/PE20160665A1/es unknown
- 2014-05-14 ES ES20211780T patent/ES2936638T3/es active Active
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- 2014-05-14 EA EA201592055A patent/EA030152B1/ru unknown
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- 2014-05-14 PL PL18163623T patent/PL3360882T3/pl unknown
- 2014-05-14 TR TR2018/09041T patent/TR201809041T4/tr unknown
- 2014-05-14 EP EP20211780.0A patent/EP3848038B1/en active Active
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- 2014-05-14 KR KR1020157034951A patent/KR102229952B1/ko active IP Right Grant
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- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 EP EP18163623.4A patent/EP3360882B1/en active Active
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- 2014-05-14 JP JP2016513357A patent/JP6326131B2/ja active Active
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- 2014-05-14 DK DK18163623.4T patent/DK3360882T3/da active
- 2014-05-14 PT PT181636226T patent/PT3360881T/pt unknown
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- 2014-05-14 SI SI201431741T patent/SI3360882T1/sl unknown
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- 2014-05-14 DK DK14723820.8T patent/DK2997035T3/en active
- 2014-05-14 ES ES14723820.8T patent/ES2671427T3/es active Active
- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 HU HUE14723820A patent/HUE037996T2/hu unknown
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- 2014-05-14 WO PCT/EP2014/059896 patent/WO2014184271A1/en active Application Filing
- 2014-05-14 SI SI201430701T patent/SI2997035T1/sl unknown
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2015
- 2015-11-12 IL IL242555A patent/IL242555B/en active IP Right Grant
- 2015-11-12 SA SA515370140A patent/SA515370140B1/ar unknown
- 2015-11-13 GT GT201500324A patent/GT201500324A/es unknown
- 2015-11-13 PH PH12015502576A patent/PH12015502576B1/en unknown
- 2015-11-13 NI NI201500160A patent/NI201500160A/es unknown
- 2015-11-13 CL CL2015003344A patent/CL2015003344A1/es unknown
- 2015-12-07 CR CR20150643A patent/CR20150643A/es unknown
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2016
- 2016-07-15 CL CL2016001809A patent/CL2016001809A1/es unknown
- 2016-08-15 HK HK18112619.6A patent/HK1253326A1/zh unknown
- 2016-08-15 HK HK16109719.3A patent/HK1221471A1/zh unknown
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2017
- 2017-02-16 US US15/434,685 patent/US20170216316A1/en not_active Abandoned
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2018
- 2018-04-13 JP JP2018077654A patent/JP2018127481A/ja not_active Withdrawn
- 2018-06-01 CY CY20181100583T patent/CY1122614T1/el unknown
- 2018-06-15 HR HRP20180931TT patent/HRP20180931T1/hr unknown
- 2018-09-06 US US16/124,139 patent/US10532061B2/en active Active
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2019
- 2019-11-26 US US16/695,528 patent/US11000532B2/en active Active
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2020
- 2020-02-17 IL IL272718A patent/IL272718B/en active IP Right Grant
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2021
- 2021-04-13 US US17/228,819 patent/US20210228599A1/en not_active Abandoned
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2023
- 2023-04-03 US US18/295,091 patent/US20230233581A1/en active Pending
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