MA38647B1 - Dérivés 11-hydroxyle d'acides biliaires et leurs conjugués d'acides aminés en tant que modulateurs du récepteur de farnésoïde x - Google Patents
Dérivés 11-hydroxyle d'acides biliaires et leurs conjugués d'acides aminés en tant que modulateurs du récepteur de farnésoïde xInfo
- Publication number
- MA38647B1 MA38647B1 MA38647A MA38647A MA38647B1 MA 38647 B1 MA38647 B1 MA 38647B1 MA 38647 A MA38647 A MA 38647A MA 38647 A MA38647 A MA 38647A MA 38647 B1 MA38647 B1 MA 38647B1
- Authority
- MA
- Morocco
- Prior art keywords
- amino acid
- receptor modulators
- acid derivatives
- conjugates
- bile acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne un composé de formule (i) ou un sel, solvate ou conjugué d'acide aminé pharmaceutiquement acceptable de celui-ci, r
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361823169P | 2013-05-14 | 2013-05-14 | |
PCT/EP2014/059896 WO2014184271A1 (fr) | 2013-05-14 | 2014-05-14 | Dérivés 11-hydroxyle d'acides biliaires et leurs conjugués d'acides aminés en tant que modulateurs du récepteur de farnésoïde x |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38647B1 true MA38647B1 (fr) | 2019-05-31 |
Family
ID=50721801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38647A MA38647B1 (fr) | 2013-05-14 | 2014-05-14 | Dérivés 11-hydroxyle d'acides biliaires et leurs conjugués d'acides aminés en tant que modulateurs du récepteur de farnésoïde x |
Country Status (37)
Country | Link |
---|---|
US (6) | US9611289B2 (fr) |
EP (4) | EP3848038B1 (fr) |
JP (2) | JP6326131B2 (fr) |
KR (1) | KR102229952B1 (fr) |
CN (2) | CN108245523B (fr) |
AU (1) | AU2014267324B2 (fr) |
BR (1) | BR112015028399B1 (fr) |
CA (1) | CA2912139C (fr) |
CL (2) | CL2015003344A1 (fr) |
CR (1) | CR20150643A (fr) |
CY (1) | CY1122614T1 (fr) |
DK (4) | DK3360881T3 (fr) |
EA (1) | EA030152B1 (fr) |
ES (4) | ES2847002T3 (fr) |
GT (1) | GT201500324A (fr) |
HK (2) | HK1221471A1 (fr) |
HR (1) | HRP20180931T1 (fr) |
HU (1) | HUE037996T2 (fr) |
IL (2) | IL242555B (fr) |
LT (1) | LT2997035T (fr) |
MA (1) | MA38647B1 (fr) |
ME (1) | ME03082B (fr) |
MX (1) | MX352065B (fr) |
MY (1) | MY187886A (fr) |
NI (1) | NI201500160A (fr) |
PE (1) | PE20160665A1 (fr) |
PH (1) | PH12015502576A1 (fr) |
PL (3) | PL3360882T3 (fr) |
PT (3) | PT3360881T (fr) |
RS (1) | RS57372B1 (fr) |
SA (1) | SA515370140B1 (fr) |
SG (1) | SG11201509352XA (fr) |
SI (3) | SI3360881T1 (fr) |
TN (1) | TN2015000497A1 (fr) |
TR (1) | TR201809041T4 (fr) |
UA (1) | UA118673C2 (fr) |
WO (1) | WO2014184271A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL157816A0 (en) | 2001-03-12 | 2004-03-28 | Roberto Pellicciari | Steroids as agonists for fxr |
EP2545964A1 (fr) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité |
ES2847002T3 (es) | 2013-05-14 | 2021-07-30 | Intercept Pharmaceuticals Inc | Derivados 11-hidroxil-6-sustituidos de ácidos biliares y conjugados de aminoácido de los mismos como moduladores del receptor X farnesoide |
US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
JP6820253B2 (ja) * | 2014-05-29 | 2021-01-27 | バール ファーマシューティカルズ ソチエタ レスポンサビリタ リミタータ | Fxb及びtgr5/gpbar1介在性疾患の治療及び/又は予防に使用するためのコラン誘導体 |
MX2017005935A (es) | 2014-11-06 | 2018-01-11 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas fxr/tgr5 y métodos de uso de los mismos. |
KR102527821B1 (ko) | 2014-11-19 | 2023-05-02 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드 |
PL3221333T3 (pl) | 2014-11-19 | 2020-01-31 | NZP UK Limited | Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
EA033427B1 (ru) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
CN107108687B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 |
US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
MX2017006833A (es) | 2014-11-26 | 2018-02-13 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos. |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
MA41094A (fr) * | 2014-12-02 | 2017-10-10 | Lilly Co Eli | Procédés de traitement de troubles rénaux |
CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
ES2905872T3 (es) * | 2015-02-06 | 2022-04-12 | Intercept Pharmaceuticals Inc | Composiciones farmacéuticas para terapia combinada |
EP3256134A4 (fr) | 2015-02-11 | 2018-10-03 | Enanta Pharmaceuticals, Inc. | Analogues de l'acide biliaire utilisés comme agonistes de fxr/tgr5 et leurs procédés d'utilisation |
CN107530361A (zh) * | 2015-03-09 | 2018-01-02 | 英特塞普特医药品公司 | 用于调节骨密度的方法 |
WO2016145216A1 (fr) * | 2015-03-10 | 2016-09-15 | Metselex, Inc. | Acides biliaires fluorés et alkylés |
JP2018510866A (ja) * | 2015-03-13 | 2018-04-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腸受容体を活性化させるための、ファルネソイドx受容体アゴニストでの、成体の潜在性自己免疫性糖尿病の治療 |
SI3277286T1 (sl) | 2015-03-31 | 2021-09-30 | Enanta Pharmaceuticals, Inc. | Derivati žolčne kisline kot antagonisti FXR/TGR5 in metode za njihovo uporabo |
US10894054B2 (en) * | 2015-04-07 | 2021-01-19 | Intercept Pharmaceuticals, Inc. | FXR agonist compositions for combination therapy |
WO2016168553A1 (fr) * | 2015-04-17 | 2016-10-20 | Concert Pharmaceuticals, Inc. | Acide obéticholique deutéré |
PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
CN106478759A (zh) * | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
WO2017053428A1 (fr) | 2015-09-21 | 2017-03-30 | Intercept Pharmaceuticals, Inc. | Procédés pour favoriser la régénération hépatique |
EP3981779A1 (fr) * | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Modulateurs du récepteur farnésoïde x |
WO2017147137A1 (fr) * | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Dérivés d'acide benzoïque d'acide biliaire utilisés en tant qu'agonistes de fxr/tgr5 et leurs méthodes d'utilisation |
WO2017147174A1 (fr) * | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Analogues de l'acide biliaire contenant de l'hétéroaryle utilisés comme agonistes de fxr/tgr5 et leurs méthodes d'utilisation |
WO2017147159A1 (fr) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Dérivés d'acide biliaire utilisés deutérés utilisés comme agonistes de fxr/tgr5 et leurs méthodes d'utilisation |
EA038632B1 (ru) * | 2016-03-11 | 2021-09-27 | Интерсепт Фармасьютикалз, Инк. | 7,11-дигидрокси-6-этил-5-холан-24-овая кислота и фармацевтические композиции на ее основе для лечения или предупреждения заболевания или состояния, опосредованных фарнезоидным х-рецептором (fxr) |
IL262342B (en) * | 2016-04-13 | 2022-08-01 | Intercept Pharmaceuticals Inc | fxr agonist for use as a drug for the treatment or prevention of hepatocellular carcinoma |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
CA2968836A1 (fr) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Composes modulant fxr (nr1h4) |
ES2921432T3 (es) | 2016-06-13 | 2022-08-25 | Gilead Sciences Inc | Derivados de azetidina como moduladores de FXR (NR1H4) |
US10584145B2 (en) | 2016-11-29 | 2020-03-10 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
WO2018152171A1 (fr) | 2017-02-14 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Dérivés d'acide biliaire utilisés comme agonistes de fxr et leurs procédés d'utilisation |
BR112019017312A2 (pt) | 2017-02-21 | 2020-04-14 | Genfit | combinação de um agonista de ppar com um agonista de fxr |
CN110461337A (zh) * | 2017-02-23 | 2019-11-15 | 英特塞普特医药品公司 | 具有胆汁酸衍生物和微生物组的药物组合物及其用途 |
EP4424364A2 (fr) | 2017-03-28 | 2024-09-04 | Gilead Sciences, Inc. | Méthodes de traitement d'une maladie hépatique |
KR102624997B1 (ko) | 2017-04-07 | 2024-01-12 | 이난타 파마슈티칼스, 인코포레이티드 | 술포닐 카바메이트 담즙산 유도체의 제조 방법 |
WO2018226724A1 (fr) * | 2017-06-05 | 2018-12-13 | Intercept Pharmaceuticals, Inc. | Traitement et prévention de maladies oculaires diabétiques avec un dérivé d'acide biliaire |
JP7224307B2 (ja) * | 2017-06-23 | 2023-02-17 | インターセプト ファーマシューティカルズ, インコーポレイテッド | 胆汁酸誘導体の調製のための方法及び中間体 |
MX2020000873A (es) | 2017-07-24 | 2020-07-22 | Intercept Pharmaceuticals Inc | Derivados de ácidos biliares marcados isotópicamente. |
GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
CN109182451B (zh) * | 2018-08-21 | 2021-06-11 | 四川大学 | 细胞色素cyp3a7酶的新型特异性探针反应及其应用 |
HUE065889T2 (hu) | 2019-01-15 | 2024-06-28 | Gilead Sciences Inc | Izoxazol vegyület mint FXR agonista és az azt tartalmazó gyógyszerészeti készítmények |
EP3927683A1 (fr) | 2019-02-19 | 2021-12-29 | Gilead Sciences, Inc. | Formes solides d'agonistes de fxr |
EP3976049A1 (fr) | 2019-05-30 | 2022-04-06 | Intercept Pharmaceuticals, Inc. | Compositions pharmaceutiques comprenant un agoniste de fxr et un fibrate pour une utilisation dans le traitement d'une maladie hépatique cholestatique |
WO2021009332A1 (fr) | 2019-07-18 | 2021-01-21 | Enyo Pharma | Procédé pour diminuer les effets secondaires de l'interféron |
CN110540955B (zh) * | 2019-08-28 | 2021-09-17 | 北京协同创新研究院 | 一种提高分化细胞中nrob2基因表达量的方法 |
AU2021207253A1 (en) | 2020-01-15 | 2022-06-09 | Centre National De La Recherche Scientifique | Use of FXR agonists for treating an infection by hepatitis D virus |
AU2022209084A1 (en) | 2021-01-14 | 2023-08-10 | Centre Leon Bérard | Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection |
EP4329761A1 (fr) | 2021-04-28 | 2024-03-06 | ENYO Pharma | Potentialisation forte d'effets d'agonistes de tlr3 à l'aide d'agonistes de fxr en tant que traitement combiné |
WO2022233398A1 (fr) * | 2021-05-04 | 2022-11-10 | Kostner Pharma Gmbh | Composés pour réduire la lipoprotéine (a) |
WO2023288123A1 (fr) | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Procédés et intermédiaires pour la préparation d'acide 3.alpha.,7.alpha.,11.bêta.-trihydroxy-6.alpha.-éthyl-5.bêta.-cholan-24-oïque |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2080775A (en) * | 1934-08-22 | 1937-05-18 | Celanese Corp | Shedding mechanism for circular looms |
US2802775A (en) * | 1953-05-29 | 1957-08-13 | Merck & Co Inc | 11 alpha-hydroxylation of steroids by aspergillus ochraceus |
JPS59205396A (ja) * | 1983-05-09 | 1984-11-20 | Kuraray Co Ltd | 11β−ヒドロキシプレグナ−4−エン−3−オン−20−カルブアルデヒド及びその製造法 |
US6639078B1 (en) | 1998-12-23 | 2003-10-28 | Smithkline Beecham Corporation | Assays for ligands for nuclear receptors |
ITMI20021532A1 (it) * | 2002-07-12 | 2004-01-12 | Roberto Pellicciari | Composti chimici |
EP1568706A1 (fr) * | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Nouveau agonist steroidal pour FXR |
DK1734970T3 (en) * | 2004-03-12 | 2015-02-16 | Intercept Pharmaceuticals Inc | Treatment of fibrosis using FXR ligands |
EP2040713B1 (fr) * | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Dérivés de l'acide biliaire en tant que des ligands de fxr pour la prévention ou le traitement de maladies ou conditions médiées par le fxr |
ES2847002T3 (es) | 2013-05-14 | 2021-07-30 | Intercept Pharmaceuticals Inc | Derivados 11-hidroxil-6-sustituidos de ácidos biliares y conjugados de aminoácido de los mismos como moduladores del receptor X farnesoide |
-
2014
- 2014-05-14 ES ES18163622T patent/ES2847002T3/es active Active
- 2014-05-14 SI SI201431742T patent/SI3360881T1/sl unknown
- 2014-05-14 JP JP2016513357A patent/JP6326131B2/ja active Active
- 2014-05-14 TR TR2018/09041T patent/TR201809041T4/tr unknown
- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 MY MYPI2015002734A patent/MY187886A/en unknown
- 2014-05-14 EP EP20211780.0A patent/EP3848038B1/fr active Active
- 2014-05-14 EA EA201592055A patent/EA030152B1/ru unknown
- 2014-05-14 PT PT181636226T patent/PT3360881T/pt unknown
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 PL PL18163623T patent/PL3360882T3/pl unknown
- 2014-05-14 SG SG11201509352XA patent/SG11201509352XA/en unknown
- 2014-05-14 SI SI201431741T patent/SI3360882T1/sl unknown
- 2014-05-14 AU AU2014267324A patent/AU2014267324B2/en active Active
- 2014-05-14 US US14/120,366 patent/US9611289B2/en active Active
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
- 2014-05-14 ES ES14723820.8T patent/ES2671427T3/es active Active
- 2014-05-14 BR BR112015028399-3A patent/BR112015028399B1/pt active IP Right Grant
- 2014-05-14 EP EP18163622.6A patent/EP3360881B1/fr active Active
- 2014-05-14 SI SI201430701T patent/SI2997035T1/sl unknown
- 2014-05-14 WO PCT/EP2014/059896 patent/WO2014184271A1/fr active Application Filing
- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 DK DK14723820.8T patent/DK2997035T3/en active
- 2014-05-14 PT PT181636234T patent/PT3360882T/pt unknown
- 2014-05-14 RS RS20180690A patent/RS57372B1/sr unknown
- 2014-05-14 PL PL14723820T patent/PL2997035T3/pl unknown
- 2014-05-14 CA CA2912139A patent/CA2912139C/fr active Active
- 2014-05-14 PE PE2015002397A patent/PE20160665A1/es unknown
- 2014-05-14 EP EP18163623.4A patent/EP3360882B1/fr active Active
- 2014-05-14 KR KR1020157034951A patent/KR102229952B1/ko active IP Right Grant
- 2014-05-14 ME MEP-2018-159A patent/ME03082B/fr unknown
- 2014-05-14 LT LTEP14723820.8T patent/LT2997035T/lt unknown
- 2014-05-14 ES ES18163623T patent/ES2843737T3/es active Active
- 2014-05-14 PT PT147238208T patent/PT2997035T/pt unknown
- 2014-05-14 HU HUE14723820A patent/HUE037996T2/hu unknown
- 2014-05-14 CN CN201810162562.4A patent/CN108245523B/zh not_active Expired - Fee Related
- 2014-05-14 EP EP14723820.8A patent/EP2997035B8/fr active Active
- 2014-05-14 ES ES20211780T patent/ES2936638T3/es active Active
- 2014-05-14 CN CN201480036949.5A patent/CN105377870B/zh active Active
- 2014-05-14 PL PL18163622T patent/PL3360881T3/pl unknown
- 2014-05-14 DK DK20211780.0T patent/DK3848038T3/da active
- 2014-05-14 DK DK18163623.4T patent/DK3360882T3/da active
-
2015
- 2015-11-12 SA SA515370140A patent/SA515370140B1/ar unknown
- 2015-11-12 IL IL242555A patent/IL242555B/en active IP Right Grant
- 2015-11-13 GT GT201500324A patent/GT201500324A/es unknown
- 2015-11-13 CL CL2015003344A patent/CL2015003344A1/es unknown
- 2015-11-13 NI NI201500160A patent/NI201500160A/es unknown
- 2015-11-13 PH PH12015502576A patent/PH12015502576A1/en unknown
- 2015-12-07 CR CR20150643A patent/CR20150643A/es unknown
-
2016
- 2016-07-15 CL CL2016001809A patent/CL2016001809A1/es unknown
- 2016-08-15 HK HK16109719.3A patent/HK1221471A1/zh unknown
- 2016-08-15 HK HK18112619.6A patent/HK1253326A1/zh unknown
-
2017
- 2017-02-16 US US15/434,685 patent/US20170216316A1/en not_active Abandoned
-
2018
- 2018-04-13 JP JP2018077654A patent/JP2018127481A/ja not_active Withdrawn
- 2018-06-01 CY CY20181100583T patent/CY1122614T1/el unknown
- 2018-06-15 HR HRP20180931TT patent/HRP20180931T1/hr unknown
- 2018-09-06 US US16/124,139 patent/US10532061B2/en active Active
-
2019
- 2019-11-26 US US16/695,528 patent/US11000532B2/en active Active
-
2020
- 2020-02-17 IL IL272718A patent/IL272718B/en active IP Right Grant
-
2021
- 2021-04-13 US US17/228,819 patent/US20210228599A1/en not_active Abandoned
-
2023
- 2023-04-03 US US18/295,091 patent/US20230233581A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA38647B1 (fr) | Dérivés 11-hydroxyle d'acides biliaires et leurs conjugués d'acides aminés en tant que modulateurs du récepteur de farnésoïde x | |
CY1124404T1 (el) | Παραγωγα χολικου οξεος ως αγωνιστες fxr/tgr5 και μεθοδοι χρησης αυτων | |
CY1124882T1 (el) | Αναλογα 1,4-διϋποκατεστημενης πυριδαζινης και μεθοδοι για την θεραπευτικη αγωγη καταστασεων συναφων με ανεπαρκεια smn | |
MA34644B1 (fr) | Dérivés de pyrazole aminopyrimidine en tant que modulateurs du lrrk2 | |
MA38922A3 (fr) | Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'integrase du vih | |
CY1120480T1 (el) | Ενωσεις πυραζολοπυριμιδινης | |
BR112015009395A2 (pt) | processo para preparação de derivados do ácido biliar | |
MA37142A3 (fr) | Dérivés de dihydro-benzo-oxazine et de dihydro-pyrido-oxazine | |
PH12018500777A1 (en) | Farnesoid x receptor modulators | |
EA201390908A1 (ru) | Производные бицикло[3.2.1]октиламида и их применение | |
ECSP12012290A (es) | Formulaciones farmacéuticas | |
EA201590118A1 (ru) | Производные пирролидина и их применение в качестве модуляторов пути активации комплемента | |
EA200870423A1 (ru) | Производные триазолпиразинов, применимые в качестве противораковых агентов | |
EA201101026A1 (ru) | Ингибиторы бета-секретазы | |
MA38403A1 (fr) | Nouveaux dérivés de pyrazole modulateurs specifiques de cb2 | |
BR112016011755A2 (pt) | derivado de ureia ou sal farmacologicamente aceitável do mesmo | |
EA201492023A1 (ru) | Регуляторы пути комплемента и их применение | |
EA201690247A1 (ru) | Аминометилбиарильные производные-ингибиторы фактора d комплемента и их применения | |
EA201071329A1 (ru) | Диамидные производные адамантана и их применение | |
MA38583B1 (fr) | Dérivés de dolastatine 10 et d'auristatines | |
BR112014026266A2 (pt) | derivado de quinazolidinadiona | |
BRPI1014802B8 (pt) | profármacos de triptolida. | |
MA41337A (fr) | Dérivés de l'hydroxyalkyl pipérazine utilisés comme modulateurs du récepteur cxcr3 | |
UY32055A (es) | Derivados sustituidos de la 5-Halo-N2-[sustituido](1-metil-1H-imidazol-4-il)pirimidin-2,-diamina y sus sales farmacéuticamente aceptables, procesos de preparación, composiciones y aplicaciones. | |
CY1125355T1 (el) | Πεντακυκλικη ενωση |