UA118673C2 - Похідні 11-гідроксилу жовчних кислот та їх амінокислотні кон'югати як модулятори фарнезоїдного x-рецептора - Google Patents

Похідні 11-гідроксилу жовчних кислот та їх амінокислотні кон'югати як модулятори фарнезоїдного x-рецептора

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Publication number
UA118673C2
UA118673C2 UAA201511098A UAA201511098A UA118673C2 UA 118673 C2 UA118673 C2 UA 118673C2 UA A201511098 A UAA201511098 A UA A201511098A UA A201511098 A UAA201511098 A UA A201511098A UA 118673 C2 UA118673 C2 UA 118673C2
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Ukraine
Prior art keywords
amino acid
farnesoid
hydroxyl
derivatives
receptor modulators
Prior art date
Application number
UAA201511098A
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English (en)
Inventor
Роберто Пелліччарі
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Інтерсепт Фармасутікалз, Інк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50721801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA118673(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Інтерсепт Фармасутікалз, Інк. filed Critical Інтерсепт Фармасутікалз, Інк.
Publication of UA118673C2 publication Critical patent/UA118673C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Згідно з винаходом запропоновано сполуку формули (І) EMBED ISISServer (I) або її фармацевтично прийнятну сіль, сольват або амінокислотний кон'югат, в якій R1, R2, R3, R4, R5 та R6 описано. Винахід загалом стосується агоністів FXR та способів їх виготовлення та застосування.
UAA201511098A 2013-05-14 2014-05-14 Похідні 11-гідроксилу жовчних кислот та їх амінокислотні кон'югати як модулятори фарнезоїдного x-рецептора UA118673C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361823169P 2013-05-14 2013-05-14
PCT/EP2014/059896 WO2014184271A1 (en) 2013-05-14 2014-05-14 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

Publications (1)

Publication Number Publication Date
UA118673C2 true UA118673C2 (uk) 2019-02-25

Family

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Family Applications (1)

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UAA201511098A UA118673C2 (uk) 2013-05-14 2014-05-14 Похідні 11-гідроксилу жовчних кислот та їх амінокислотні кон'югати як модулятори фарнезоїдного x-рецептора

Country Status (37)

Country Link
US (6) US9611289B2 (uk)
EP (4) EP2997035B8 (uk)
JP (2) JP6326131B2 (uk)
KR (1) KR102229952B1 (uk)
CN (2) CN108245523B (uk)
AU (1) AU2014267324B2 (uk)
BR (1) BR112015028399B1 (uk)
CA (1) CA2912139C (uk)
CL (2) CL2015003344A1 (uk)
CR (1) CR20150643A (uk)
CY (1) CY1122614T1 (uk)
DK (4) DK3848038T3 (uk)
EA (1) EA030152B1 (uk)
ES (4) ES2843737T3 (uk)
GT (1) GT201500324A (uk)
HK (2) HK1253326A1 (uk)
HR (1) HRP20180931T1 (uk)
HU (1) HUE037996T2 (uk)
IL (2) IL242555B (uk)
LT (1) LT2997035T (uk)
MA (1) MA38647B1 (uk)
ME (1) ME03082B (uk)
MX (1) MX352065B (uk)
MY (1) MY187886A (uk)
NI (1) NI201500160A (uk)
PE (1) PE20160665A1 (uk)
PH (1) PH12015502576B1 (uk)
PL (3) PL3360882T3 (uk)
PT (3) PT3360881T (uk)
RS (1) RS57372B1 (uk)
SA (1) SA515370140B1 (uk)
SG (1) SG11201509352XA (uk)
SI (3) SI3360882T1 (uk)
TN (1) TN2015000497A1 (uk)
TR (1) TR201809041T4 (uk)
UA (1) UA118673C2 (uk)
WO (1) WO2014184271A1 (uk)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2248581T3 (es) 2001-03-12 2006-03-16 Intercept Pharmaceuticals, Inc. Esteroides como agonistas de fxr.
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
CA2912139C (en) 2013-05-14 2021-04-20 Roberto Pellicciari 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
US10077268B2 (en) 2014-03-13 2018-09-18 Salk Institute For Biological Studies FXR agonists and methods for making and using
US10301268B2 (en) 2014-03-13 2019-05-28 The Salk Institute For Biological Studies Analogs of fexaramine and methods of making and using
HUE048351T2 (hu) * 2014-05-29 2020-07-28 Bar Pharmaceuticals S R L Kolán-származékok alkalmazása FXR és TGR5/GPBAR1 mediált betegségek kezelésére és/vagy prevenciójára
AU2015343025A1 (en) 2014-11-06 2017-06-08 Enanta Pharmaceuticals, Inc. Bile acid analogs an FXR/TGR5 agonists and methods of use thereof
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
WO2016079520A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
DK3221331T3 (da) 2014-11-19 2019-12-02 Nzp Uk Ltd 6-alkyl-7-hydroxy-4-en-3-on-steroider som mellemprodukter til fremstilling af steroide fxr-modulatorer
CA2968305A1 (en) 2014-11-19 2016-05-26 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
KR20170099909A (ko) 2014-11-26 2017-09-01 이난타 파마슈티칼스, 인코포레이티드 Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법
MA41094A (fr) * 2014-12-02 2017-10-10 Lilly Co Eli Procédés de traitement de troubles rénaux
CN105348365A (zh) * 2014-12-03 2016-02-24 四川百利药业有限责任公司 一种胆酸衍生物及其制备方法、药物组合物和用途
CN104523703A (zh) * 2014-12-24 2015-04-22 聂飚 一种游离脂肪酸转运蛋白小分子抑制物的应用
TW201628625A (zh) * 2015-02-06 2016-08-16 英特賽普醫藥品公司 組合療法醫藥組成物
AU2016219266A1 (en) 2015-02-11 2017-08-10 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
MX2017011399A (es) * 2015-03-09 2018-03-16 Intercept Pharmaceuticals Inc Métodos para modular la densidad ósea.
CN107531741A (zh) 2015-03-10 2018-01-02 美莱斯股份有限公司 氟化和烷基化胆酸
WO2016149111A1 (en) * 2015-03-13 2016-09-22 Salk Institute For Biological Studies Treating latent autoimmune diabetes of adults with farnesoid x receptor agonists to activate intestinal receptors
DK3277286T3 (da) * 2015-03-31 2021-07-05 Enanta Pharm Inc Galdesydererivater som fxr/tgr5-agonister og anvendelsesmetoder deraf
CR20170456A (es) * 2015-04-07 2018-06-13 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapias combinadas
WO2016168553A1 (en) * 2015-04-17 2016-10-20 Concert Pharmaceuticals, Inc. Deuterated obeticholic acid
PE20180690A1 (es) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
CN106478759A (zh) * 2015-08-31 2017-03-08 陕西合成药业股份有限公司 奥贝胆酸衍生物及其制备方法和用途
US10548906B2 (en) * 2015-09-21 2020-02-04 Intercept Pharmaceuticals, Inc. Methods of promoting hepatic regeneration
MA45761A (fr) * 2015-10-07 2021-04-21 Intercept Pharmaceuticals Inc Modulateurs du récepteur farnésoïde x
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2017147174A1 (en) * 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
US10323060B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
JP6892457B2 (ja) * 2016-03-11 2021-06-23 インターセプト ファーマシューティカルズ， インコーポレイテッド ３−デスオキシ誘導体およびその医薬組成物
IL262342B (en) * 2016-04-13 2022-08-01 Intercept Pharmaceuticals Inc fxr agonist for use as a drug for the treatment or prevention of hepatocellular carcinoma
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
CA2968836A1 (en) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
EP3730487B1 (en) 2016-06-13 2022-04-27 Gilead Sciences, Inc. Azetidine derivatives as fxr (nr1h4) modulators
JP7057783B2 (ja) 2016-11-29 2022-04-20 エナンタ ファーマシューティカルズ インコーポレイテッド スルホニル尿素胆汁酸誘導体の調製方法
WO2018152171A1 (en) 2017-02-14 2018-08-23 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr agonists and methods of use thereof
JP2020508316A (ja) 2017-02-21 2020-03-19 ジェンフィＧｅｎｆｉｔ Ｐｐａｒアゴニストとｆｘｒアゴニストとの組合せ
EP3585405A4 (en) * 2017-02-23 2020-12-09 Intercept Pharmaceuticals, Inc. PHARMACEUTICAL COMPOSITIONS CONSISTING OF A BILIARY ACID DERIVATIVE AND A MICROBIOME AS WELL AS THEIR USES
EP4122464B1 (en) 2017-03-28 2024-05-15 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
MX2019011844A (es) 2017-04-07 2021-11-30 Enanta Pharm Inc Proceso para la preparación de derivados de ácidos biliares de sulfonil carbamato.
WO2018226724A1 (en) * 2017-06-05 2018-12-13 Intercept Pharmaceuticals, Inc. Treatment and prevention of diabetic eye diseases with a bile acid derivatives
WO2018237350A1 (en) * 2017-06-23 2018-12-27 Intercept Pharmaceuticals, Inc. METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES
MX2020000873A (es) 2017-07-24 2020-07-22 Intercept Pharmaceuticals Inc Derivados de ácidos biliares marcados isotópicamente.
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN109182451B (zh) * 2018-08-21 2021-06-11 四川大学 细胞色素cyp3a7酶的新型特异性探针反应及其应用
EP4360632A2 (en) 2019-01-15 2024-05-01 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
AU2020225225B2 (en) 2019-02-19 2022-12-22 Gilead Sciences, Inc. Solid forms of FXR agonists
CN114144185A (zh) 2019-05-30 2022-03-04 英特塞普特医药品公司 用于治疗胆汁淤积性肝病的包含fxr激动剂和贝特类的药物组合物
KR20220035365A (ko) 2019-07-18 2022-03-22 엔요 파마 인터페론의 부작용을 감소시키는 방법
CN110540955B (zh) * 2019-08-28 2021-09-17 北京协同创新研究院 一种提高分化细胞中nrob2基因表达量的方法
WO2021144330A1 (en) 2020-01-15 2021-07-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fxr agonists for treating an infection by hepatitis d virus
EP4277622A1 (en) 2021-01-14 2023-11-22 ENYO Pharma Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
TW202308629A (zh) 2021-04-28 2023-03-01 法商Ｅｎｙｏ製藥公司 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效
WO2022233398A1 (en) * 2021-05-04 2022-11-10 Kostner Pharma Gmbh COMPOUNDS FOR REDUCING LIPOPROTEIN(a)
WO2023288123A1 (en) 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2080775A (en) * 1934-08-22 1937-05-18 Celanese Corp Shedding mechanism for circular looms
US2802775A (en) 1953-05-29 1957-08-13 Merck & Co Inc 11 alpha-hydroxylation of steroids by aspergillus ochraceus
JPS59205396A (ja) * 1983-05-09 1984-11-20 Kuraray Co Ltd １１β−ヒドロキシプレグナ−４−エン−３−オン−２０−カルブアルデヒド及びその製造法
EP1140079B1 (en) 1998-12-23 2009-06-03 Glaxo Group Limited Assays for ligands for nuclear receptors
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
PT1734970E (pt) * 2004-03-12 2015-03-11 Intercept Pharmaceuticals Inc Tratamento de fibrose utilizando ligandos de rfx
AU2007265457C1 (en) * 2006-06-27 2012-11-29 Intercept Pharmaceuticals, Inc. Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
CA2912139C (en) 2013-05-14 2021-04-20 Roberto Pellicciari 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

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US20140371190A1 (en) 2014-12-18
AU2014267324B2 (en) 2017-11-02
HK1253326A1 (zh) 2019-06-14
EA030152B1 (ru) 2018-06-29
CY1122614T1 (el) 2020-07-31
EP3848038B1 (en) 2022-11-09
HK1221471A1 (zh) 2017-06-02
BR112015028399A2 (pt) 2017-07-25
DK3360881T3 (da) 2021-03-15
US10532061B2 (en) 2020-01-14
US9611289B2 (en) 2017-04-04
SI3360881T1 (sl) 2021-06-30
CN105377870A (zh) 2016-03-02
US20210228599A1 (en) 2021-07-29
BR112015028399B1 (pt) 2021-11-16
US11000532B2 (en) 2021-05-11
CR20150643A (es) 2016-06-01
JP2018127481A (ja) 2018-08-16
EP3360882B1 (en) 2020-12-09
IL242555B (en) 2020-04-30
ES2936638T3 (es) 2023-03-21
EP2997035A1 (en) 2016-03-23
LT2997035T (lt) 2018-08-10
PL3360882T3 (pl) 2021-10-25
EP2997035B1 (en) 2018-03-28
JP2016518429A (ja) 2016-06-23
JP6326131B2 (ja) 2018-05-16
EP3360881A1 (en) 2018-08-15
PE20160665A1 (es) 2016-08-07
SA515370140B1 (ar) 2017-04-11
ES2847002T3 (es) 2021-07-30
PT3360881T (pt) 2021-02-19
KR20160007586A (ko) 2016-01-20
KR102229952B1 (ko) 2021-03-22
MY187886A (en) 2021-10-26
RS57372B1 (sr) 2018-08-31
US20200297739A1 (en) 2020-09-24
CL2016001809A1 (es) 2017-01-27
DK2997035T3 (en) 2018-07-02
HRP20180931T1 (hr) 2018-10-05
ES2671427T3 (es) 2018-06-06
CN108245523A (zh) 2018-07-06
CN105377870B (zh) 2018-04-03
ME03082B (me) 2019-01-20
PT2997035T (pt) 2018-07-18
MA38647B1 (fr) 2019-05-31
CA2912139C (en) 2021-04-20
SI2997035T1 (sl) 2018-10-30
TR201809041T4 (tr) 2018-07-23
DK3848038T3 (da) 2023-02-06
ES2843737T3 (es) 2021-07-20
PL3360881T3 (pl) 2021-11-15
IL242555A0 (en) 2016-02-01
PH12015502576A1 (en) 2016-02-29
EP3360881B1 (en) 2020-12-09
IL272718A (en) 2020-04-30
GT201500324A (es) 2017-09-28
PT3360882T (pt) 2021-02-12
MX352065B (es) 2017-11-08
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TN2015000497A1 (en) 2017-04-06
PL2997035T3 (pl) 2018-10-31
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SI3360882T1 (sl) 2021-06-30
DK3360882T3 (da) 2021-03-08
IL272718B (en) 2020-11-30
HUE037996T2 (hu) 2018-09-28
AU2014267324A1 (en) 2015-11-26
CA2912139A1 (en) 2014-11-20
CN108245523B (zh) 2021-03-26
US20230233581A1 (en) 2023-07-27
WO2014184271A1 (en) 2014-11-20
US20190209586A1 (en) 2019-07-11
CL2015003344A1 (es) 2016-07-15
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NZ714082A (en) 2021-02-26
SG11201509352XA (en) 2015-12-30
EA201592055A1 (ru) 2016-11-30
US20170216316A1 (en) 2017-08-03
EP3848038A1 (en) 2021-07-14
EP2997035B8 (en) 2018-05-23

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