PE20121494A1 - Anticuerpos anti notch-1 - Google Patents

Anticuerpos anti notch-1

Info

Publication number
PE20121494A1
PE20121494A1 PE2011002114A PE2011002114A PE20121494A1 PE 20121494 A1 PE20121494 A1 PE 20121494A1 PE 2011002114 A PE2011002114 A PE 2011002114A PE 2011002114 A PE2011002114 A PE 2011002114A PE 20121494 A1 PE20121494 A1 PE 20121494A1
Authority
PE
Peru
Prior art keywords
seq
sequence
amino acids
variable region
variable
Prior art date
Application number
PE2011002114A
Other languages
English (en)
Spanish (es)
Inventor
Zdenek Hostomsky
Kang Li
John Andrew Lippincott
Qinghai Peng
Donna Marie Stone
Ping Wei
Original Assignee
Pfizer
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121494(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Rinat Neuroscience Corp filed Critical Pfizer
Publication of PE20121494A1 publication Critical patent/PE20121494A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PE2011002114A 2009-06-18 2010-06-16 Anticuerpos anti notch-1 PE20121494A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18

Publications (1)

Publication Number Publication Date
PE20121494A1 true PE20121494A1 (es) 2012-11-01

Family

ID=42575817

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011002114A PE20121494A1 (es) 2009-06-18 2010-06-16 Anticuerpos anti notch-1

Country Status (18)

Country Link
US (1) US9090690B2 (cg-RX-API-DMAC7.html)
EP (2) EP2443151A1 (cg-RX-API-DMAC7.html)
JP (2) JP6059985B2 (cg-RX-API-DMAC7.html)
KR (1) KR101570898B1 (cg-RX-API-DMAC7.html)
CN (1) CN102686610A (cg-RX-API-DMAC7.html)
AU (1) AU2010261364B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1011805A2 (cg-RX-API-DMAC7.html)
CA (1) CA2765989C (cg-RX-API-DMAC7.html)
CO (1) CO6480924A2 (cg-RX-API-DMAC7.html)
IL (1) IL217066A0 (cg-RX-API-DMAC7.html)
MX (1) MX337468B (cg-RX-API-DMAC7.html)
NZ (1) NZ597611A (cg-RX-API-DMAC7.html)
PE (1) PE20121494A1 (cg-RX-API-DMAC7.html)
PH (1) PH12011502609B1 (cg-RX-API-DMAC7.html)
RU (1) RU2011151287A (cg-RX-API-DMAC7.html)
SG (1) SG176731A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010146550A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201109282B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8404239B2 (en) * 2008-10-01 2013-03-26 Genentech, Inc. Anti-Notch2 NRR antibodies
EP2443151A1 (en) 2009-06-18 2012-04-25 Pfizer Inc. Anti notch-1 antibodies
EP2483311B1 (en) * 2009-09-30 2016-05-18 F.Hoffmann-La Roche Ag Anti-Notch3 antagonistic antibodies for treating of a gamma-secretase inhibitor positive T-cell leukemia that does not respond to an anti-Notch1 antagonistic antibody.
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
AU2011342799B2 (en) 2010-12-15 2016-06-09 Wyeth Llc Anti-Notch1 antibodies
MX2015005810A (es) 2012-11-07 2015-09-23 Pfizer Anticuerpos anti-notch y conjugados de anticuerpo-farmaco.
JP2017510626A (ja) * 2014-03-07 2017-04-13 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ１抗体によって癌を治療するための方法
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
US11026996B2 (en) * 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
WO2018081648A2 (en) * 2016-10-29 2018-05-03 Genentech, Inc. Anti-mic antibidies and methods of use
JP7525160B2 (ja) 2018-08-31 2024-07-30 Ｂｌｏｏｍ Ｔｅｃｈｎｏｌｏｇｙ 株式会社 終末糖化産物に対する抗体およびその使用
JPWO2024053742A1 (cg-RX-API-DMAC7.html) 2022-09-09 2024-03-14

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Also Published As

Publication number Publication date
CN102686610A (zh) 2012-09-19
SG176731A1 (en) 2012-01-30
CA2765989C (en) 2016-11-29
EP2443151A1 (en) 2012-04-25
US9090690B2 (en) 2015-07-28
JP2016121162A (ja) 2016-07-07
MX337468B (es) 2016-03-02
BRPI1011805A2 (pt) 2016-10-11
KR101570898B1 (ko) 2015-11-23
AU2010261364B2 (en) 2015-05-07
JP6059985B2 (ja) 2017-01-11
AU2010261364A1 (en) 2012-01-19
WO2010146550A1 (en) 2010-12-23
IL217066A0 (en) 2012-02-29
NZ597611A (en) 2014-03-28
RU2011151287A (ru) 2013-07-27
US20120093813A1 (en) 2012-04-19
ZA201109282B (en) 2012-08-29
MX2011013717A (es) 2012-05-29
KR20120071379A (ko) 2012-07-02
EP3431501A1 (en) 2019-01-23
CA2765989A1 (en) 2010-12-23
PH12011502609A1 (en) 2012-11-12
CO6480924A2 (es) 2012-07-16
JP2012530487A (ja) 2012-12-06
PH12011502609B1 (en) 2018-11-07

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