SG176731A1 - Anti notch-1 antibodies - Google Patents

Anti notch-1 antibodies Download PDF

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Publication number
SG176731A1
SG176731A1 SG2011090800A SG2011090800A SG176731A1 SG 176731 A1 SG176731 A1 SG 176731A1 SG 2011090800 A SG2011090800 A SG 2011090800A SG 2011090800 A SG2011090800 A SG 2011090800A SG 176731 A1 SG176731 A1 SG 176731A1
Authority
SG
Singapore
Prior art keywords
antibody
antigen binding
binding portion
amino acid
seq
Prior art date
Application number
SG2011090800A
Other languages
English (en)
Inventor
Zdenek Hostomsky
Kang Li
John Andrew Lippincott
Qinghai Peng
Donna Marie Stone
Ping Wei
Original Assignee
Pfizer
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG176731(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Rinat Neuroscience Corp filed Critical Pfizer
Publication of SG176731A1 publication Critical patent/SG176731A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG2011090800A 2009-06-18 2010-06-16 Anti notch-1 antibodies SG176731A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18
PCT/IB2010/052711 WO2010146550A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Publications (1)

Publication Number Publication Date
SG176731A1 true SG176731A1 (en) 2012-01-30

Family

ID=42575817

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2011090800A SG176731A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Country Status (18)

Country Link
US (1) US9090690B2 (cg-RX-API-DMAC7.html)
EP (2) EP2443151A1 (cg-RX-API-DMAC7.html)
JP (2) JP6059985B2 (cg-RX-API-DMAC7.html)
KR (1) KR101570898B1 (cg-RX-API-DMAC7.html)
CN (1) CN102686610A (cg-RX-API-DMAC7.html)
AU (1) AU2010261364B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1011805A2 (cg-RX-API-DMAC7.html)
CA (1) CA2765989C (cg-RX-API-DMAC7.html)
CO (1) CO6480924A2 (cg-RX-API-DMAC7.html)
IL (1) IL217066A0 (cg-RX-API-DMAC7.html)
MX (1) MX337468B (cg-RX-API-DMAC7.html)
NZ (1) NZ597611A (cg-RX-API-DMAC7.html)
PE (1) PE20121494A1 (cg-RX-API-DMAC7.html)
PH (1) PH12011502609B1 (cg-RX-API-DMAC7.html)
RU (1) RU2011151287A (cg-RX-API-DMAC7.html)
SG (1) SG176731A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010146550A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201109282B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8404239B2 (en) * 2008-10-01 2013-03-26 Genentech, Inc. Anti-Notch2 NRR antibodies
EP2443151A1 (en) 2009-06-18 2012-04-25 Pfizer Inc. Anti notch-1 antibodies
EP2483311B1 (en) * 2009-09-30 2016-05-18 F.Hoffmann-La Roche Ag Anti-Notch3 antagonistic antibodies for treating of a gamma-secretase inhibitor positive T-cell leukemia that does not respond to an anti-Notch1 antagonistic antibody.
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
AU2011342799B2 (en) 2010-12-15 2016-06-09 Wyeth Llc Anti-Notch1 antibodies
MX2015005810A (es) 2012-11-07 2015-09-23 Pfizer Anticuerpos anti-notch y conjugados de anticuerpo-farmaco.
JP2017510626A (ja) * 2014-03-07 2017-04-13 オンコメッド ファーマシューティカルズ インコーポレイテッド Notch1抗体によって癌を治療するための方法
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
US11026996B2 (en) * 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
WO2018081648A2 (en) * 2016-10-29 2018-05-03 Genentech, Inc. Anti-mic antibidies and methods of use
JP7525160B2 (ja) 2018-08-31 2024-07-30 Bloom Technology 株式会社 終末糖化産物に対する抗体およびその使用
JPWO2024053742A1 (cg-RX-API-DMAC7.html) 2022-09-09 2024-03-14

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Also Published As

Publication number Publication date
CN102686610A (zh) 2012-09-19
CA2765989C (en) 2016-11-29
EP2443151A1 (en) 2012-04-25
US9090690B2 (en) 2015-07-28
JP2016121162A (ja) 2016-07-07
MX337468B (es) 2016-03-02
BRPI1011805A2 (pt) 2016-10-11
KR101570898B1 (ko) 2015-11-23
AU2010261364B2 (en) 2015-05-07
PE20121494A1 (es) 2012-11-01
JP6059985B2 (ja) 2017-01-11
AU2010261364A1 (en) 2012-01-19
WO2010146550A1 (en) 2010-12-23
IL217066A0 (en) 2012-02-29
NZ597611A (en) 2014-03-28
RU2011151287A (ru) 2013-07-27
US20120093813A1 (en) 2012-04-19
ZA201109282B (en) 2012-08-29
MX2011013717A (es) 2012-05-29
KR20120071379A (ko) 2012-07-02
EP3431501A1 (en) 2019-01-23
CA2765989A1 (en) 2010-12-23
PH12011502609A1 (en) 2012-11-12
CO6480924A2 (es) 2012-07-16
JP2012530487A (ja) 2012-12-06
PH12011502609B1 (en) 2018-11-07

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