PE20121476A1 - Composicion para el tratamiento de trastornos proliferativos y otras condiciones patologicas mediadas por la actividad de cinasa de bcr-abl, c-kit, ddr1, ddr2 o pdgf-r - Google Patents

Composicion para el tratamiento de trastornos proliferativos y otras condiciones patologicas mediadas por la actividad de cinasa de bcr-abl, c-kit, ddr1, ddr2 o pdgf-r

Info

Publication number
PE20121476A1
PE20121476A1 PE2012000667A PE2012000667A PE20121476A1 PE 20121476 A1 PE20121476 A1 PE 20121476A1 PE 2012000667 A PE2012000667 A PE 2012000667A PE 2012000667 A PE2012000667 A PE 2012000667A PE 20121476 A1 PE20121476 A1 PE 20121476A1
Authority
PE
Peru
Prior art keywords
ddr1
ddr2
bcr
abl
pdgf
Prior art date
Application number
PE2012000667A
Other languages
English (en)
Inventor
Neil Gallagher
Ophelia Yin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43513643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121476(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20121476A1 publication Critical patent/PE20121476A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69Benzenesulfonamido-pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE PY ES 3-PIRIDILO; R1 ES H, ALQUILO INFERIOR, ALCOXILO INFERIOR-ALQUILO, ENTRE OTROS; R2 ES H, ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, CICLOALQUILO, BENZO-CICLOALQUILO, ENTRE OTROS; R4 ES H, ALQUILO INFERIOR O HALOGENO. ES COMPUESTO PREFERIDO: 4-METIL-3-[[4-(3-PIRIDINIL)-2-PIRIMIDINIL]-AMINO]-N-[5-(4-METIL-1H-IMIDAZOL-1-IL)-3-(TRIFLUORO-METIL)-FENIL]-BENZAMIDA. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS O CONDICIONES PATOLOGICAS MEDIADAS POR LA ACTIVIDAD CINASA DE Bcr-Abl, c-KIT, DDR1, DDR2 O PDGF-R
PE2012000667A 2009-11-17 2010-11-17 Composicion para el tratamiento de trastornos proliferativos y otras condiciones patologicas mediadas por la actividad de cinasa de bcr-abl, c-kit, ddr1, ddr2 o pdgf-r PE20121476A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26181209P 2009-11-17 2009-11-17

Publications (1)

Publication Number Publication Date
PE20121476A1 true PE20121476A1 (es) 2012-11-14

Family

ID=43513643

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000667A PE20121476A1 (es) 2009-11-17 2010-11-17 Composicion para el tratamiento de trastornos proliferativos y otras condiciones patologicas mediadas por la actividad de cinasa de bcr-abl, c-kit, ddr1, ddr2 o pdgf-r

Country Status (37)

Country Link
US (1) US9061029B2 (es)
EP (1) EP2501384B2 (es)
JP (2) JP5829615B2 (es)
KR (1) KR101743315B1 (es)
CN (1) CN102612368B (es)
AR (1) AR079029A1 (es)
AU (1) AU2010322102B2 (es)
BR (1) BR112012011693A2 (es)
CA (1) CA2779490C (es)
CL (1) CL2012001270A1 (es)
CO (1) CO6551690A2 (es)
DK (1) DK2501384T4 (es)
EC (1) ECSP12011903A (es)
ES (1) ES2572128T5 (es)
FI (1) FI2501384T4 (es)
GT (1) GT201200150A (es)
HR (1) HRP20160472T4 (es)
HU (1) HUE027307T2 (es)
IL (1) IL219727A (es)
JO (1) JO3634B1 (es)
MA (1) MA33738B1 (es)
ME (1) ME02413B (es)
MX (1) MX2012005694A (es)
MY (1) MY169956A (es)
NZ (1) NZ599968A (es)
PE (1) PE20121476A1 (es)
PH (1) PH12012500965A1 (es)
PL (1) PL2501384T5 (es)
RS (1) RS54747B2 (es)
RU (1) RU2625835C2 (es)
SG (1) SG10201501169VA (es)
SI (1) SI2501384T2 (es)
SM (1) SMT201600143B (es)
TN (1) TN2012000206A1 (es)
TW (1) TWI498116B (es)
WO (1) WO2011062927A1 (es)
ZA (1) ZA201203328B (es)

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EP2776130A1 (en) 2011-11-07 2014-09-17 Institut National de la Sante et de la Recherche Medicale (INSERM) A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis
US9695118B2 (en) 2012-04-24 2017-07-04 Chugai Seiyaku Kabushiki Kaisha Benzamide derivative
KR20150003849A (ko) * 2012-04-24 2015-01-09 추가이 세이야쿠 가부시키가이샤 퀴나졸린디온 유도체
AU2013256227B2 (en) 2012-05-02 2017-06-15 Georgetown University Treating neural disease with tyrosine kinase inhibitors
JP6078639B2 (ja) * 2012-05-15 2017-02-08 ノバルティス アーゲー Abl1、abl2およびbcr−abl1の活性を阻害するためのベンズアミド誘導体
US9561245B2 (en) 2012-09-06 2017-02-07 The Board Of Regents Of The University Of Texas System Combination treatments for melanoma
US20140080772A1 (en) * 2012-09-06 2014-03-20 The Board Of Regents Of The University Of Texas System Treatments for melanoma
US9572828B2 (en) 2013-07-18 2017-02-21 The Board Of Regents Of The University Of Texas System Treatment for melanoma
KR20160073413A (ko) 2013-10-23 2016-06-24 추가이 세이야쿠 가부시키가이샤 퀴나졸리논 및 이소퀴놀리논 유도체
TW201718474A (zh) * 2015-08-31 2017-06-01 東麗股份有限公司 尿素衍生物及其用途
CN108103186B (zh) * 2018-02-28 2021-07-02 固安博健生物技术有限公司 诊断类风湿性关节炎和骨关节炎的分子标志物
AU2019285066B2 (en) 2018-06-15 2024-06-13 Handa Pharmaceuticals, Inc. Kinase inhibitor salts and compositions thereof
EP3883935A4 (en) 2018-11-20 2022-08-10 Georgetown University COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE, MYODEGENERATIVE AND LYSOSOMA STORAGE DISEASES
WO2020144649A1 (en) * 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Pharmaceutical composition comprising enzalutamide dispersed in apple sauce
EP4096791A1 (en) 2020-01-31 2022-12-07 Nanocopoeia LLC Amorphous nilotinib microparticles and uses thereof
IL297776A (en) 2020-04-30 2022-12-01 Nanocopoeia Llc Orally disintegrating tablets containing an amorphous solid dispersion of nalotinib
MX2023003556A (es) 2020-09-29 2023-06-13 Shenzhen Pharmacin Co Ltd Composiciones farmaceuticas.

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EP1533304B1 (en) 2002-06-28 2009-11-04 Nippon Shinyaku Co., Ltd. Amide derivative
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
ES2405287T3 (es) 2002-08-01 2013-05-30 Eisai Inc. Tratamiento mejorado del cáncer con glutamina
CN101171013A (zh) * 2005-05-02 2008-04-30 诺瓦提斯公司 嘧啶基氨基苯甲酰胺衍生物用于治疗全身性肥大细胞增多症的应用
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
EP1923053A1 (en) 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
KR100925559B1 (ko) 2007-10-26 2009-11-05 한국과학기술연구원 악티노마이신 d를 유효성분으로 하는 ddr과 콜라겐결합 저해제

Also Published As

Publication number Publication date
TN2012000206A1 (en) 2013-12-12
FI2501384T4 (fi) 2024-01-11
HK1169950A1 (zh) 2013-02-15
CA2779490A1 (en) 2011-05-26
AU2010322102B2 (en) 2014-08-28
EP2501384B1 (en) 2016-02-17
TW201141481A (en) 2011-12-01
WO2011062927A1 (en) 2011-05-26
IL219727A0 (en) 2012-07-31
JP2013511524A (ja) 2013-04-04
NZ599968A (en) 2014-09-26
EP2501384B2 (en) 2023-11-01
DK2501384T4 (da) 2024-01-02
RU2625835C2 (ru) 2017-07-19
US20120289528A1 (en) 2012-11-15
AU2010322102A1 (en) 2012-05-24
MX2012005694A (es) 2012-06-13
AR079029A1 (es) 2011-12-21
RS54747B2 (sr) 2024-02-29
SI2501384T2 (sl) 2024-02-29
ES2572128T5 (es) 2024-05-17
ME02413B (me) 2016-09-20
CN102612368A (zh) 2012-07-25
CN102612368B (zh) 2014-03-05
ES2572128T3 (es) 2016-05-30
HUE027307T2 (hu) 2016-10-28
PH12012500965A1 (en) 2016-10-05
PL2501384T3 (pl) 2016-08-31
CO6551690A2 (es) 2012-10-31
US9061029B2 (en) 2015-06-23
SMT201600143B (it) 2016-07-01
ZA201203328B (en) 2013-02-27
HRP20160472T4 (hr) 2024-02-02
BR112012011693A2 (pt) 2016-03-01
IL219727A (en) 2016-07-31
CA2779490C (en) 2019-02-12
SG10201501169VA (en) 2015-04-29
JO3634B1 (ar) 2020-08-27
GT201200150A (es) 2014-08-11
RU2012124811A (ru) 2013-12-27
ECSP12011903A (es) 2012-09-28
PL2501384T5 (pl) 2024-01-29
HRP20160472T1 (hr) 2016-06-03
SI2501384T1 (sl) 2016-06-30
MA33738B1 (fr) 2012-11-01
KR101743315B1 (ko) 2017-06-15
JP2015180636A (ja) 2015-10-15
RS54747B1 (sr) 2016-10-31
MY169956A (en) 2019-06-19
DK2501384T3 (en) 2016-05-17
JP5829615B2 (ja) 2015-12-09
TWI498116B (zh) 2015-09-01
KR20120102635A (ko) 2012-09-18
CL2012001270A1 (es) 2012-10-12
EP2501384A1 (en) 2012-09-26

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