ME02413B - Postupak lečenja proliferativnih oboljenja i drugih patoloških stanja posredovanih aktivnoscu bcr-abl, c-kit, ddr1, ddr2 ili pdgf-r kinaze - Google Patents
Postupak lečenja proliferativnih oboljenja i drugih patoloških stanja posredovanih aktivnoscu bcr-abl, c-kit, ddr1, ddr2 ili pdgf-r kinazeInfo
- Publication number
- ME02413B ME02413B MEP-2016-89A MEP8916A ME02413B ME 02413 B ME02413 B ME 02413B ME P8916 A MEP8916 A ME P8916A ME 02413 B ME02413 B ME 02413B
- Authority
- ME
- Montenegro
- Prior art keywords
- formula
- pyrimidylaminobenzamide
- pharmaceutically acceptable
- kinase activity
- kit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (3)
1. Pirimidilaminobenzamid formule (I)u kojojPy označava 3-piridil,R1 predstavlja vodonik,R2 predstavlja 5-(4-metil-1H-imidazol-1-il)-3-(trifluorometil)-fenil; iR4 predstavlja metil;ili njegova farmaceutski prihvatljiva so, za lečenje proliferativnog oboljenja ili drugih patoloških stanja odabranih iz grupe koju čine melanom, posebno melanom koji u svom sastavu ima skrivene c-KIT mutacije, karcinom dojke, kancer debelog creva, kancer pluća, kancer prostate ili Kapošijev sarkom, gastrointestinalni stromalni tumori (GIST), akutna mijeloidna leukemija (AML), leukemija koja odgovara na inhibiciju aktivnosti Abl tirozin kinaze, hronična mijeloidna leukemija (CML), Filadelfija hromozom pozitivna akutna limfoblastna leukemija (Ph+ ALL), mezoteliom, sistemska mastocitoza, hipereozinofilni sindrom (HES), fibroza, hepatska fibroza, renalna fibroza, reumatoidni artritis, poliartritis, skleroderma, lupus eritematozus, bolest kalema protiv domaćina, neurofibromatoza, pulmonarna hipertenzija, pulmonarna arterijska hipertenzija, Alchajmerova bolest, seminom, disgerminom i psorijaza, gde se jedinjenje formule (I) ili njena farmaceutski prihvatljiva so i, po slobodnom izboru, farmaceutski prihvatljivi nosači, oralno primenjuju pomešani sa pireom od jabuke.
2.Pirimidilaminobenzamid formule (I) za upotrebu prema patentnom zahtevu 1 u obliku njegove monohidrohloridne monohidratne soli.
3. Pirimidilaminobenzamid formule (I) ili pirimidilaminobenzamid formule (I) u obliku njegove monohidrohloridne monohidratne soli za upotrebu prema patentnom zahtevu 1, naznačen time, što je patološko stanje odabrano od CML i Ph+ ALL. 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26181209P | 2009-11-17 | 2009-11-17 | |
| EP10781781.9A EP2501384B2 (en) | 2009-11-17 | 2010-11-17 | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
| PCT/US2010/056926 WO2011062927A1 (en) | 2009-11-17 | 2010-11-17 | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02413B true ME02413B (me) | 2016-09-20 |
Family
ID=43513643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-89A ME02413B (me) | 2009-11-17 | 2010-11-17 | Postupak lečenja proliferativnih oboljenja i drugih patoloških stanja posredovanih aktivnoscu bcr-abl, c-kit, ddr1, ddr2 ili pdgf-r kinaze |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9061029B2 (me) |
| EP (1) | EP2501384B2 (me) |
| JP (2) | JP5829615B2 (me) |
| KR (1) | KR101743315B1 (me) |
| CN (1) | CN102612368B (me) |
| AR (1) | AR079029A1 (me) |
| AU (1) | AU2010322102B2 (me) |
| BR (1) | BR112012011693A2 (me) |
| CA (1) | CA2779490C (me) |
| CL (1) | CL2012001270A1 (me) |
| CO (1) | CO6551690A2 (me) |
| DK (1) | DK2501384T4 (me) |
| EC (1) | ECSP12011903A (me) |
| ES (1) | ES2572128T5 (me) |
| FI (1) | FI2501384T4 (me) |
| GT (1) | GT201200150A (me) |
| HR (1) | HRP20160472T4 (me) |
| HU (1) | HUE027307T2 (me) |
| IL (1) | IL219727A (me) |
| JO (1) | JO3634B1 (me) |
| MA (1) | MA33738B1 (me) |
| ME (1) | ME02413B (me) |
| MX (1) | MX2012005694A (me) |
| MY (1) | MY169956A (me) |
| NZ (1) | NZ599968A (me) |
| PE (1) | PE20121476A1 (me) |
| PH (1) | PH12012500965A1 (me) |
| PL (1) | PL2501384T5 (me) |
| RS (1) | RS54747B2 (me) |
| RU (1) | RU2625835C2 (me) |
| SG (1) | SG10201501169VA (me) |
| SI (1) | SI2501384T2 (me) |
| SM (1) | SMT201600143B (me) |
| TN (1) | TN2012000206A1 (me) |
| TW (1) | TWI498116B (me) |
| WO (1) | WO2011062927A1 (me) |
| ZA (1) | ZA201203328B (me) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013068836A1 (en) | 2011-11-07 | 2013-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis |
| JP6130828B2 (ja) * | 2012-04-24 | 2017-05-17 | 中外製薬株式会社 | キナゾリンジオン誘導体 |
| WO2013161851A1 (ja) | 2012-04-24 | 2013-10-31 | 中外製薬株式会社 | ベンズアミド誘導体 |
| EP2844256B1 (en) * | 2012-05-02 | 2023-02-22 | Georgetown University | Treating amyotrophic lateral sclerosis with tyrosine kinase inhibitors |
| TR201807023T4 (tr) * | 2012-05-15 | 2018-06-21 | Novartis Ag | Abl1, abl2 ve bcr- abl1 aktivitesinin inhibe edilmesi için benzamid türevleri. |
| US20140080772A1 (en) * | 2012-09-06 | 2014-03-20 | The Board Of Regents Of The University Of Texas System | Treatments for melanoma |
| US9561245B2 (en) | 2012-09-06 | 2017-02-07 | The Board Of Regents Of The University Of Texas System | Combination treatments for melanoma |
| US9572828B2 (en) | 2013-07-18 | 2017-02-21 | The Board Of Regents Of The University Of Texas System | Treatment for melanoma |
| AU2014338070A1 (en) | 2013-10-23 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| BR112018002118A2 (pt) * | 2015-08-31 | 2018-09-18 | Toray Industries, Inc. | ?derivado de ureia, e, inibidor de receptor de domínio de discoidina 1? |
| CN108103186B (zh) * | 2018-02-28 | 2021-07-02 | 固安博健生物技术有限公司 | 诊断类风湿性关节炎和骨关节炎的分子标志物 |
| TWI787523B (zh) | 2018-06-15 | 2022-12-21 | 漢達生技醫藥股份有限公司 | 達沙替尼十二烷基硫酸鹽之結晶 |
| EP3883935A4 (en) | 2018-11-20 | 2022-08-10 | Georgetown University | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE, MYODEGENERATIVE AND LYSOSOMA STORAGE DISEASES |
| WO2020144650A1 (en) * | 2019-01-10 | 2020-07-16 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of prostate cancer |
| EP4096791A1 (en) | 2020-01-31 | 2022-12-07 | Nanocopoeia LLC | Amorphous nilotinib microparticles and uses thereof |
| WO2021222739A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
| KR20230097021A (ko) | 2020-09-29 | 2023-06-30 | 선전 파마신 컴퍼니 리미티드 | 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04012845A (es) | 2002-06-28 | 2005-02-24 | Nippon Shinyaku Co Ltd | Derivado de amida. |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| CA2493764C (en) | 2002-08-01 | 2011-05-24 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
| CN103638028A (zh) * | 2005-05-02 | 2014-03-19 | 诺瓦提斯公司 | 嘧啶基氨基苯甲酰胺衍生物用于治疗全身性肥大细胞增多症的应用 |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| KR100925559B1 (ko) | 2007-10-26 | 2009-11-05 | 한국과학기술연구원 | 악티노마이신 ｄ를 유효성분으로 하는 ｄｄｒ과 콜라겐결합 저해제 |
-
2010
- 2010-11-14 JO JOP/2010/0396A patent/JO3634B1/ar active
- 2010-11-15 AR ARP100104212A patent/AR079029A1/es not_active Application Discontinuation
- 2010-11-16 TW TW099139425A patent/TWI498116B/zh active
- 2010-11-17 US US13/509,626 patent/US9061029B2/en active Active
- 2010-11-17 SG SG10201501169VA patent/SG10201501169VA/en unknown
- 2010-11-17 WO PCT/US2010/056926 patent/WO2011062927A1/en not_active Ceased
- 2010-11-17 PE PE2012000667A patent/PE20121476A1/es not_active Application Discontinuation
- 2010-11-17 PL PL10781781.9T patent/PL2501384T5/pl unknown
- 2010-11-17 JP JP2012539982A patent/JP5829615B2/ja active Active
- 2010-11-17 CA CA2779490A patent/CA2779490C/en active Active
- 2010-11-17 KR KR1020127012603A patent/KR101743315B1/ko active Active
- 2010-11-17 FI FIEP10781781.9T patent/FI2501384T4/fi active
- 2010-11-17 DK DK10781781.9T patent/DK2501384T4/da active
- 2010-11-17 NZ NZ599968A patent/NZ599968A/en not_active IP Right Cessation
- 2010-11-17 AU AU2010322102A patent/AU2010322102B2/en active Active
- 2010-11-17 BR BR112012011693A patent/BR112012011693A2/pt not_active Application Discontinuation
- 2010-11-17 CN CN201080051819.0A patent/CN102612368B/zh not_active Ceased
- 2010-11-17 RU RU2012124811A patent/RU2625835C2/ru active
- 2010-11-17 MX MX2012005694A patent/MX2012005694A/es active IP Right Grant
- 2010-11-17 HU HUE10781781A patent/HUE027307T2/hu unknown
- 2010-11-17 EP EP10781781.9A patent/EP2501384B2/en active Active
- 2010-11-17 PH PH1/2012/500965A patent/PH12012500965A1/en unknown
- 2010-11-17 MY MYPI2012001993A patent/MY169956A/en unknown
- 2010-11-17 RS RS20160303A patent/RS54747B2/sr unknown
- 2010-11-17 ME MEP-2016-89A patent/ME02413B/me unknown
- 2010-11-17 HR HRP20160472TT patent/HRP20160472T4/hr unknown
- 2010-11-17 SI SI201031172T patent/SI2501384T2/sl unknown
- 2010-11-17 ES ES10781781T patent/ES2572128T5/es active Active
-
2012
- 2012-05-07 TN TNP2012000206A patent/TN2012000206A1/en unknown
- 2012-05-08 ZA ZA2012/03328A patent/ZA201203328B/en unknown
- 2012-05-10 IL IL219727A patent/IL219727A/en active IP Right Grant
- 2012-05-11 MA MA34855A patent/MA33738B1/fr unknown
- 2012-05-16 EC ECSP12011903 patent/ECSP12011903A/es unknown
- 2012-05-16 CL CL2012001270A patent/CL2012001270A1/es unknown
- 2012-05-17 GT GT201200150A patent/GT201200150A/es unknown
- 2012-05-17 CO CO12081907A patent/CO6551690A2/es not_active Application Discontinuation
-
2015
- 2015-04-28 JP JP2015091857A patent/JP2015180636A/ja active Pending
-
2016
- 2016-05-23 SM SM201600143T patent/SMT201600143B/it unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02413B (me) | Postupak lečenja proliferativnih oboljenja i drugih patoloških stanja posredovanih aktivnoscu bcr-abl, c-kit, ddr1, ddr2 ili pdgf-r kinaze | |
| CN109715626A (zh) | 作为fgfr抑制剂的杂环化合物 | |
| JP2017511311A5 (me) | ||
| JP2015529235A5 (me) | ||
| Mao et al. | Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors | |
| CN110382499A (zh) | Fgfr抑制剂及其应用 | |
| JP2017530176A5 (me) | ||
| RU2018100142A (ru) | Гетероциклические соединения, эффективные для ингибирования киназы | |
| JP2017088633A5 (me) | ||
| JP2008519790A5 (me) | ||
| RU2017125025A (ru) | Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk | |
| EA201391470A1 (ru) | Замещенные соли 2,3-дигидроимидазо[1,2-c]хиназолина | |
| RU2012120901A (ru) | Способ лечения пролиферативных расстройств и других патологических состояний, опосредованных действием киназ bcr-abl, c-kit, ddr1, ddr2 или pdgf-r | |
| RU2022100782A (ru) | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью | |
| JP2012526766A5 (me) | ||
| EA201690012A1 (ru) | Карбазолкарбоксамидные соединения | |
| CN110891950A (zh) | 一种三嗪化合物及其药学上可接受的盐 | |
| RU2015153319A (ru) | Гетероциклическое соединение бензимидазол-2-пиперазин, его фармацевтическая композиция, а также препаративные методы и назначение | |
| NZ590177A (en) | Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis | |
| JP6719451B2 (ja) | キナゾリン誘導体 | |
| WO2007042465A2 (en) | Combinati0n of nilotinib with farnesyl transferase inhibitors | |
| CN106957242A (zh) | 一种希夫碱类化合物及其制备方法和制药用途 | |
| Wang et al. | Discovery of 4-((N-(2-(dimethylamino) ethyl) acrylamido) methyl)-N-(4-methyl-3-((4-(pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia | |
| RU2011153613A (ru) | Аминопиразол триазолотиадиазольные ингибиторы протеинкиназы с-мет | |
| JP2024125139A5 (me) |