SMT201600143B - Metodo di trattamento di disturbi proliferativi e altre condizioni patologiche mediate dalla attività chinasica di bcr-abl, c-kit, ddr1, ddr2 o pdgf-r - Google Patents

Metodo di trattamento di disturbi proliferativi e altre condizioni patologiche mediate dalla attività chinasica di bcr-abl, c-kit, ddr1, ddr2 o pdgf-r

Info

Publication number
SMT201600143B
SMT201600143B SM201600143T SM201600143T SMT201600143B SM T201600143 B SMT201600143 B SM T201600143B SM 201600143 T SM201600143 T SM 201600143T SM 201600143 T SM201600143 T SM 201600143T SM T201600143 B SMT201600143 B SM T201600143B
Authority
SM
San Marino
Prior art keywords
kinasic
ddr1
ddr2
bcr
abl
Prior art date
Application number
SM201600143T
Other languages
English (en)
Inventor
Neil Gallagher
Ophelia Yin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43513643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201600143(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SMT201600143B publication Critical patent/SMT201600143B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SM201600143T 2009-11-17 2016-05-23 Metodo di trattamento di disturbi proliferativi e altre condizioni patologiche mediate dalla attività chinasica di bcr-abl, c-kit, ddr1, ddr2 o pdgf-r SMT201600143B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26181209P 2009-11-17 2009-11-17
PCT/US2010/056926 WO2011062927A1 (en) 2009-11-17 2010-11-17 Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity

Publications (1)

Publication Number Publication Date
SMT201600143B true SMT201600143B (it) 2016-07-01

Family

ID=43513643

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600143T SMT201600143B (it) 2009-11-17 2016-05-23 Metodo di trattamento di disturbi proliferativi e altre condizioni patologiche mediate dalla attività chinasica di bcr-abl, c-kit, ddr1, ddr2 o pdgf-r

Country Status (37)

Country Link
US (1) US9061029B2 (it)
EP (1) EP2501384B2 (it)
JP (2) JP5829615B2 (it)
KR (1) KR101743315B1 (it)
CN (1) CN102612368B (it)
AR (1) AR079029A1 (it)
AU (1) AU2010322102B2 (it)
BR (1) BR112012011693A2 (it)
CA (1) CA2779490C (it)
CL (1) CL2012001270A1 (it)
CO (1) CO6551690A2 (it)
DK (1) DK2501384T4 (it)
EC (1) ECSP12011903A (it)
ES (1) ES2572128T5 (it)
FI (1) FI2501384T4 (it)
GT (1) GT201200150A (it)
HK (1) HK1169950A1 (it)
HR (1) HRP20160472T4 (it)
HU (1) HUE027307T2 (it)
IL (1) IL219727A (it)
JO (1) JO3634B1 (it)
MA (1) MA33738B1 (it)
ME (1) ME02413B (it)
MX (1) MX2012005694A (it)
MY (1) MY169956A (it)
NZ (1) NZ599968A (it)
PE (1) PE20121476A1 (it)
PL (1) PL2501384T5 (it)
RS (1) RS54747B2 (it)
RU (1) RU2625835C2 (it)
SG (1) SG10201501169VA (it)
SI (1) SI2501384T2 (it)
SM (1) SMT201600143B (it)
TN (1) TN2012000206A1 (it)
TW (1) TWI498116B (it)
WO (1) WO2011062927A1 (it)
ZA (1) ZA201203328B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013068836A1 (en) 2011-11-07 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis
AR090836A1 (es) 2012-04-24 2014-12-10 Chugai Pharmaceutical Co Ltd Derivados de benzamida
CA2871453A1 (en) * 2012-04-24 2013-10-31 Chugai Seiyaku Kabushiki Kaisha Quinazolinedione derivative
DK2844256T3 (da) 2012-05-02 2023-03-27 Univ Georgetown Behandling af amyotrofisk lateral sklerose med tyrosinkinase-inhibitorer
PT2861579T (pt) * 2012-05-15 2018-04-27 Novartis Ag Derivados de benzamida para inibir a atividade de abl1, abl2 e bcr-abl
US9561245B2 (en) 2012-09-06 2017-02-07 The Board Of Regents Of The University Of Texas System Combination treatments for melanoma
US20140080772A1 (en) * 2012-09-06 2014-03-20 The Board Of Regents Of The University Of Texas System Treatments for melanoma
US9572828B2 (en) 2013-07-18 2017-02-21 The Board Of Regents Of The University Of Texas System Treatment for melanoma
CA2927830A1 (en) 2013-10-23 2015-04-30 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
TW201718474A (zh) * 2015-08-31 2017-06-01 東麗股份有限公司 尿素衍生物及其用途
CN108103186B (zh) * 2018-02-28 2021-07-02 固安博健生物技术有限公司 诊断类风湿性关节炎和骨关节炎的分子标志物
WO2019241504A1 (en) 2018-06-15 2019-12-19 Handa Pharmaceuticals, Llc Kinase inhibitor salts and compositions thereof
WO2020144646A1 (en) * 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Apalutamide dispersed in applesauce for treating prostate cancer
IL295007A (en) 2020-01-31 2022-09-01 Nanocopoeia Llc Amorphous nilotinib microparticles and uses thereof
WO2021222739A1 (en) 2020-04-30 2021-11-04 Nanocopoeia, Llc Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002963A1 (ja) 2002-06-28 2004-01-08 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
WO2004012662A2 (en) * 2002-08-01 2004-02-12 Aesgen, Inc. Improved treatment of cancer with glutamine
MX2007013741A (es) * 2005-05-02 2008-01-21 Novartis Ag Uso de derivados de pirimidilaminobenzamida para el tratamiento de mastocitosis sistemica.
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1923053A1 (en) 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
KR100925559B1 (ko) * 2007-10-26 2009-11-05 한국과학기술연구원 악티노마이신 ｄ를 유효성분으로 하는 ｄｄｒ과 콜라겐결합 저해제

Also Published As

Publication number Publication date
IL219727A (en) 2016-07-31
FI2501384T4 (fi) 2024-01-11
HRP20160472T1 (hr) 2016-06-03
RS54747B2 (sr) 2024-02-29
ES2572128T5 (es) 2024-05-17
ECSP12011903A (es) 2012-09-28
MA33738B1 (fr) 2012-11-01
AR079029A1 (es) 2011-12-21
HRP20160472T4 (hr) 2024-02-02
HK1169950A1 (zh) 2013-02-15
GT201200150A (es) 2014-08-11
CL2012001270A1 (es) 2012-10-12
CO6551690A2 (es) 2012-10-31
JP5829615B2 (ja) 2015-12-09
WO2011062927A1 (en) 2011-05-26
IL219727A0 (en) 2012-07-31
KR101743315B1 (ko) 2017-06-15
CA2779490C (en) 2019-02-12
US9061029B2 (en) 2015-06-23
PL2501384T5 (pl) 2024-01-29
DK2501384T3 (en) 2016-05-17
SI2501384T1 (sl) 2016-06-30
NZ599968A (en) 2014-09-26
PE20121476A1 (es) 2012-11-14
ZA201203328B (en) 2013-02-27
SG10201501169VA (en) 2015-04-29
CN102612368B (zh) 2014-03-05
EP2501384B1 (en) 2016-02-17
MY169956A (en) 2019-06-19
US20120289528A1 (en) 2012-11-15
AU2010322102B2 (en) 2014-08-28
KR20120102635A (ko) 2012-09-18
ME02413B (me) 2016-09-20
AU2010322102A1 (en) 2012-05-24
JP2015180636A (ja) 2015-10-15
JO3634B1 (ar) 2020-08-27
BR112012011693A2 (pt) 2016-03-01
CN102612368A (zh) 2012-07-25
PL2501384T3 (pl) 2016-08-31
RU2012124811A (ru) 2013-12-27
SI2501384T2 (sl) 2024-02-29
TN2012000206A1 (en) 2013-12-12
TW201141481A (en) 2011-12-01
HUE027307T2 (hu) 2016-10-28
RS54747B1 (sr) 2016-10-31
TWI498116B (zh) 2015-09-01
EP2501384B2 (en) 2023-11-01
EP2501384A1 (en) 2012-09-26
RU2625835C2 (ru) 2017-07-19
JP2013511524A (ja) 2013-04-04
ES2572128T3 (es) 2016-05-30
DK2501384T4 (da) 2024-01-02
CA2779490A1 (en) 2011-05-26
MX2012005694A (es) 2012-06-13

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