SI2501384T2 - Postopek zdravljenja proliferativnih motenj in drugih patoloških stanj, posredovanih z Bcr-Abl, c-Kit, DDR1, DDR2 ali PDGF-R kinazno aktivnostjo - Google Patents
Postopek zdravljenja proliferativnih motenj in drugih patoloških stanj, posredovanih z Bcr-Abl, c-Kit, DDR1, DDR2 ali PDGF-R kinazno aktivnostjoInfo
- Publication number
- SI2501384T2 SI2501384T2 SI201031172T SI201031172T SI2501384T2 SI 2501384 T2 SI2501384 T2 SI 2501384T2 SI 201031172 T SI201031172 T SI 201031172T SI 201031172 T SI201031172 T SI 201031172T SI 2501384 T2 SI2501384 T2 SI 2501384T2
- Authority
- SI
- Slovenia
- Prior art keywords
- ddr1
- ddr2
- bcr
- abl
- pdgf
- Prior art date
Links
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 title 1
- 101100498819 Caenorhabditis elegans ddr-1 gene Proteins 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 title 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 230000001575 pathological effect Effects 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26181209P | 2009-11-17 | 2009-11-17 | |
| EP10781781.9A EP2501384B2 (en) | 2009-11-17 | 2010-11-17 | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
| PCT/US2010/056926 WO2011062927A1 (en) | 2009-11-17 | 2010-11-17 | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI2501384T1 SI2501384T1 (sl) | 2016-06-30 |
| SI2501384T2 true SI2501384T2 (sl) | 2024-02-29 |
Family
ID=43513643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201031172T SI2501384T2 (sl) | 2009-11-17 | 2010-11-17 | Postopek zdravljenja proliferativnih motenj in drugih patoloških stanj, posredovanih z Bcr-Abl, c-Kit, DDR1, DDR2 ali PDGF-R kinazno aktivnostjo |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9061029B2 (sl) |
| EP (1) | EP2501384B2 (sl) |
| JP (2) | JP5829615B2 (sl) |
| KR (1) | KR101743315B1 (sl) |
| CN (1) | CN102612368B (sl) |
| AR (1) | AR079029A1 (sl) |
| AU (1) | AU2010322102B2 (sl) |
| BR (1) | BR112012011693A2 (sl) |
| CA (1) | CA2779490C (sl) |
| CL (1) | CL2012001270A1 (sl) |
| CO (1) | CO6551690A2 (sl) |
| DK (1) | DK2501384T4 (sl) |
| EC (1) | ECSP12011903A (sl) |
| ES (1) | ES2572128T5 (sl) |
| FI (1) | FI2501384T4 (sl) |
| GT (1) | GT201200150A (sl) |
| HK (1) | HK1169950A1 (sl) |
| HR (1) | HRP20160472T4 (sl) |
| HU (1) | HUE027307T2 (sl) |
| IL (1) | IL219727A (sl) |
| JO (1) | JO3634B1 (sl) |
| MA (1) | MA33738B1 (sl) |
| ME (1) | ME02413B (sl) |
| MX (1) | MX2012005694A (sl) |
| MY (1) | MY169956A (sl) |
| NZ (1) | NZ599968A (sl) |
| PE (1) | PE20121476A1 (sl) |
| PL (1) | PL2501384T5 (sl) |
| RS (1) | RS54747B2 (sl) |
| RU (1) | RU2625835C2 (sl) |
| SG (1) | SG10201501169VA (sl) |
| SI (1) | SI2501384T2 (sl) |
| SM (1) | SMT201600143B (sl) |
| TN (1) | TN2012000206A1 (sl) |
| TW (1) | TWI498116B (sl) |
| WO (1) | WO2011062927A1 (sl) |
| ZA (1) | ZA201203328B (sl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2776130A1 (en) | 2011-11-07 | 2014-09-17 | Institut National de la Sante et de la Recherche Medicale (INSERM) | A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis |
| AR090835A1 (es) * | 2012-04-24 | 2014-12-10 | Chugai Pharmaceutical Co Ltd | Derivados de quinazolindiona |
| CN104379560A (zh) | 2012-04-24 | 2015-02-25 | 中外制药株式会社 | 苯甲酰胺衍生物 |
| CA2911040C (en) | 2012-05-02 | 2021-11-16 | Georgetown University | Treating an .alpha.-synucleinopathy with tyrosine kinase inhibitors |
| JP6078639B2 (ja) * | 2012-05-15 | 2017-02-08 | ノバルティス アーゲー | Ａｂｌ１、ａｂｌ２およびｂｃｒ−ａｂｌ１の活性を阻害するためのベンズアミド誘導体 |
| US20140080772A1 (en) * | 2012-09-06 | 2014-03-20 | The Board Of Regents Of The University Of Texas System | Treatments for melanoma |
| US9561245B2 (en) | 2012-09-06 | 2017-02-07 | The Board Of Regents Of The University Of Texas System | Combination treatments for melanoma |
| US9572828B2 (en) | 2013-07-18 | 2017-02-21 | The Board Of Regents Of The University Of Texas System | Treatment for melanoma |
| AU2014338070A1 (en) | 2013-10-23 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| BR112018002118A2 (pt) * | 2015-08-31 | 2018-09-18 | Toray Industries, Inc. | ?derivado de ureia, e, inibidor de receptor de domínio de discoidina 1? |
| CN108103186B (zh) * | 2018-02-28 | 2021-07-02 | 固安博健生物技术有限公司 | 诊断类风湿性关节炎和骨关节炎的分子标志物 |
| EP3806858A4 (en) | 2018-06-15 | 2022-03-09 | Handa Pharmaceuticals, Inc. | SALTS OF KINASE INHIBITORS AND ASSOCIATED COMPOSITIONS |
| WO2020144647A1 (en) * | 2019-01-10 | 2020-07-16 | Aragon Pharmaceuticals, Inc. | Pharmaceutical composition comprising apalutamide dispersed in apple sauce |
| AU2021212258A1 (en) | 2020-01-31 | 2022-09-29 | Nanocopoeia, Llc | Amorphous nilotinib microparticles and uses thereof |
| CA3181361A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2315043C2 (ru) | 2002-06-28 | 2008-01-20 | Ниппон Синяку Ко., Лтд. | Амидное производное, фармацевтическая композиция и терапевтические средства на его основе |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1572093B1 (en) * | 2002-08-01 | 2013-04-17 | Eisai Inc. | Prevention of cancer with glutamine |
| JP5129123B2 (ja) | 2005-05-02 | 2013-01-23 | ノバルティス アーゲー | 全身性肥満細胞症の処置のためのピリミジルアミノベンズアミド誘導体の使用 |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| KR100925559B1 (ko) * | 2007-10-26 | 2009-11-05 | 한국과학기술연구원 | 악티노마이신 ｄ를 유효성분으로 하는 ｄｄｒ과 콜라겐결합 저해제 |
-
2010
- 2010-11-14 JO JOP/2010/0396A patent/JO3634B1/ar active
- 2010-11-15 AR ARP100104212A patent/AR079029A1/es not_active Application Discontinuation
- 2010-11-16 TW TW099139425A patent/TWI498116B/zh active
- 2010-11-17 WO PCT/US2010/056926 patent/WO2011062927A1/en active Application Filing
- 2010-11-17 DK DK10781781.9T patent/DK2501384T4/da active
- 2010-11-17 CA CA2779490A patent/CA2779490C/en active Active
- 2010-11-17 HU HUE10781781A patent/HUE027307T2/hu unknown
- 2010-11-17 HR HRP20160472TT patent/HRP20160472T4/hr unknown
- 2010-11-17 US US13/509,626 patent/US9061029B2/en active Active
- 2010-11-17 AU AU2010322102A patent/AU2010322102B2/en active Active
- 2010-11-17 PE PE2012000667A patent/PE20121476A1/es not_active Application Discontinuation
- 2010-11-17 MY MYPI2012001993A patent/MY169956A/en unknown
- 2010-11-17 ES ES10781781T patent/ES2572128T5/es active Active
- 2010-11-17 JP JP2012539982A patent/JP5829615B2/ja active Active
- 2010-11-17 RS RS20160303A patent/RS54747B2/sr unknown
- 2010-11-17 BR BR112012011693A patent/BR112012011693A2/pt not_active Application Discontinuation
- 2010-11-17 FI FIEP10781781.9T patent/FI2501384T4/fi active
- 2010-11-17 SI SI201031172T patent/SI2501384T2/sl unknown
- 2010-11-17 SG SG10201501169VA patent/SG10201501169VA/en unknown
- 2010-11-17 EP EP10781781.9A patent/EP2501384B2/en active Active
- 2010-11-17 PL PL10781781.9T patent/PL2501384T5/pl unknown
- 2010-11-17 CN CN201080051819.0A patent/CN102612368B/zh active Active
- 2010-11-17 MX MX2012005694A patent/MX2012005694A/es active IP Right Grant
- 2010-11-17 ME MEP-2016-89A patent/ME02413B/me unknown
- 2010-11-17 KR KR1020127012603A patent/KR101743315B1/ko active IP Right Grant
- 2010-11-17 NZ NZ599968A patent/NZ599968A/en unknown
- 2010-11-17 RU RU2012124811A patent/RU2625835C2/ru active
-
2012
- 2012-05-07 TN TNP2012000206A patent/TN2012000206A1/en unknown
- 2012-05-08 ZA ZA2012/03328A patent/ZA201203328B/en unknown
- 2012-05-10 IL IL219727A patent/IL219727A/en active IP Right Grant
- 2012-05-11 MA MA34855A patent/MA33738B1/fr unknown
- 2012-05-16 EC ECSP12011903 patent/ECSP12011903A/es unknown
- 2012-05-16 CL CL2012001270A patent/CL2012001270A1/es unknown
- 2012-05-17 CO CO12081907A patent/CO6551690A2/es not_active Application Discontinuation
- 2012-05-17 GT GT201200150A patent/GT201200150A/es unknown
- 2012-10-26 HK HK12110734.6A patent/HK1169950A1/zh unknown
-
2015
- 2015-04-28 JP JP2015091857A patent/JP2015180636A/ja active Pending
-
2016
- 2016-05-23 SM SM201600143T patent/SMT201600143B/it unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1169950A1 (zh) | 治療增殖性障礙和其它由 激酶活性介導的病理學病症的方法 | |
| IL219109A0 (en) | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity | |
| IL216140A0 (en) | Egfr inhibitors and methods of treating disorders | |
| WO2011090738A3 (en) | Type ii raf kinase inhibitors | |
| EP2379559A4 (en) | PYRIMIDO DIAZEPINONE KINASE FERTILIZERS AND METHOD FOR THE TREATMENT OF ILLNESSES | |
| HK1166314A1 (en) | Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders bace | |
| IL226401A0 (en) | Methods for treating disorders related to @fgfBA | |
| FI20100385A (fi) | Menetelmä ja tuotantolaitos hienojakoisten, mineraalipitoisten kiintoaineiden lämpökäsittelyä varten | |
| ZA201405478B (en) | Method and composition for enzymatic treatment of fiber for papermaking, and paper products made therewith | |
| WO2012135641A3 (en) | Aurora kinase inhibitors and methods of making and using thereof | |
| HK1204474A1 (en) | Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders | |
| EP2903619A4 (en) | PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND ODORAT DISORDERS | |
| ZA201107773B (en) | Method of treating disorders associated with protein kinase ck2 activity | |
| EP2739637A4 (en) | DOUBLE-STRONG OLIGONUCLEOTIDE COMPOUNDS FOR THE TREATMENT OF HEARING AND BALANCE OF IMPAIRMENT | |
| WO2011085351A9 (en) | Method of treating kcnq related disorders | |
| EP2819587A4 (en) | METHODS, APPARATUSES AND SYSTEMS FOR DIAGNOSING AND TREATING MOOD DISORDERS | |
| EP2896694A4 (en) | GLUCIDE OXIDASE AND METHOD FOR PRODUCTION AND USE | |
| GB2455585B (en) | Capsicum seeds for the treatment of eczema and dermatitis | |
| EP2512468A4 (en) | PROCESS FOR TREATING SCARS AND CATENIN MEDIATION DISORDERS USING NEFOPAM COMPOUNDS | |
| EP2528612A4 (en) | METHODS OF TREATING GLUCOSE METABOLISM DISORDERS | |
| EP2528614A4 (en) | METHODS OF TREATING GLUCOSE METABOLISM DISORDERS | |
| EP2523730A4 (en) | METHOD FOR THE TREATMENT OF GLUCOSE TISSUE CHANGES | |
| WO2011026912A3 (en) | Retinoic acid receptor antagonists, mir-10a inhibitors and inhibitors of hoxb1 or hoxb3 repressors for treating pancreatic cancer | |
| AU2012902788A0 (en) | Method of treating glucose metabolism disorders |