BRPI0507464A - formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n[4-metil-3-((4-piridin-3-il) pirimidin-2-ilamino)fenil]-benzamida - Google Patents
formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n[4-metil-3-((4-piridin-3-il) pirimidin-2-ilamino)fenil]-benzamidaInfo
- Publication number
- BRPI0507464A BRPI0507464A BRPI0507464-9A BRPI0507464A BRPI0507464A BR PI0507464 A BRPI0507464 A BR PI0507464A BR PI0507464 A BRPI0507464 A BR PI0507464A BR PI0507464 A BRPI0507464 A BR PI0507464A
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- methyl
- phenyl
- methylpiperazin
- ylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
FORMAS DE SAL DE 4-(4-METILPIPERAZIN-1-ILMETIL)-N-¢4-METIL-3-((-PIRIDIN-3-IL)P IRIMIDIN-2-ILAMINO)FENIL!-BENZAMIDA. A presente invenção refere-se a sais de adição de ácido de 4-¢(4-metil-1-piperazinil)metil!-N-¢4-metil-3-¢¢4-(3-piridinil)-2-pirimidinil!a mino!fenil!-benzamida, selecionados do grupo consistindo em um sal tartarato, tal como (D)(-) ou um sal tartarato (L) (+), um sal cloridrato, um sal citrato, um sal maleato, um sal fumarato, um sal succinato, um sal benzoato, um sal benzenossulfonato, um sal pamoato, um sal formiato, um salmalonato, um sal 1,5-naftalenodissulfonato, um sal salicilato, um sal cicloexanodisulfamato,um sal, lactato um sal mandelato, um sal glutarato aquoso, um sal adipato, um sal esquarato, um sal vanilato, um sal oxaloacetato, um sal ascorbatoe um sal sulfato.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54181704P | 2004-02-04 | 2004-02-04 | |
PCT/EP2005/001077 WO2005075454A2 (en) | 2004-02-04 | 2005-02-03 | SALT FORMS OF 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-n-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO)PHENYL]-BENZAMIDE |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507464A true BRPI0507464A (pt) | 2007-07-10 |
Family
ID=34837520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507464-9A BRPI0507464A (pt) | 2004-02-04 | 2005-02-03 | formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n[4-metil-3-((4-piridin-3-il) pirimidin-2-ilamino)fenil]-benzamida |
Country Status (22)
Country | Link |
---|---|
US (3) | US20080249104A1 (pt) |
EP (1) | EP1713792B1 (pt) |
JP (1) | JP4937760B2 (pt) |
KR (2) | KR20060135735A (pt) |
CN (1) | CN100558723C (pt) |
AR (1) | AR047530A1 (pt) |
AU (1) | AU2005211514B2 (pt) |
BR (1) | BRPI0507464A (pt) |
CA (1) | CA2553887C (pt) |
EC (1) | ECSP066752A (pt) |
IL (1) | IL177005A (pt) |
MA (1) | MA28428B1 (pt) |
MY (1) | MY144177A (pt) |
NO (1) | NO20063942L (pt) |
NZ (1) | NZ548714A (pt) |
PE (1) | PE20051096A1 (pt) |
PH (1) | PH12013500157A1 (pt) |
RU (1) | RU2375355C2 (pt) |
TN (1) | TNSN06243A1 (pt) |
TW (1) | TWI347186B (pt) |
WO (1) | WO2005075454A2 (pt) |
ZA (1) | ZA200605972B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060235006A1 (en) * | 2005-04-13 | 2006-10-19 | Lee Francis Y | Combinations, methods and compositions for treating cancer |
GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
EP1960380A1 (en) | 2005-11-25 | 2008-08-27 | Novartis AG | F,g,h,i and k crystal forms of imatinib mesylate |
KR100799821B1 (ko) * | 2007-02-05 | 2008-01-31 | 동화약품공업주식회사 | 신규한 이마티닙 캠실레이트 및 그의 제조방법 |
US7550591B2 (en) | 2007-05-02 | 2009-06-23 | Chemagis Ltd. | Imatinib production process |
WO2008136010A1 (en) * | 2007-05-07 | 2008-11-13 | Natco Pharma Limited | A process for the preparation of highly pure imatinib base |
WO2009036753A2 (de) * | 2007-09-20 | 2009-03-26 | Schebo Biotech Ag | Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie |
KR101041203B1 (ko) | 2007-09-25 | 2011-06-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 이매티닙 조성물 |
EP2062885A1 (en) * | 2007-11-21 | 2009-05-27 | Eczacibasi-Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. | Acid addition salts of imatinib and formulations comprising the same |
TW202241853A (zh) | 2009-01-16 | 2022-11-01 | 美商艾克塞里克斯公司 | 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途 |
US20100189791A1 (en) | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline malate formulation |
US20100330130A1 (en) * | 2009-05-22 | 2010-12-30 | Actavis Group Ptc Ehf | Substantially pure imatinib or a pharmaceutically acceptable salt thereof |
EP4124616A1 (en) | 2009-06-25 | 2023-02-01 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
WO2011036305A2 (en) | 2009-09-28 | 2011-03-31 | Medizinische Universität Wien | New use of pdgfrbeta inhibitors |
PL389357A1 (pl) | 2009-10-22 | 2011-04-26 | Tomasz Koźluk | Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania |
KR101138840B1 (ko) * | 2009-12-28 | 2012-05-10 | 주식회사 셀트리온화학연구소 | 이마티닙 다이클로로아세트산염 및 이를 포함하는 항암제 조성물 |
CA2792472A1 (en) | 2010-03-15 | 2011-09-22 | Natco Pharma Limited | Process for the preparation of highly pure crystalline imatinib base |
EA024088B1 (ru) | 2010-06-18 | 2016-08-31 | КРКА, д.д., НОВО МЕСТО | α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
WO2012090221A1 (en) | 2010-12-29 | 2012-07-05 | Cadila Healthcare Limited | Novel salts of imatinib |
US20150057321A1 (en) | 2012-04-04 | 2015-02-26 | Intervet Inc. | Soft chewable pharmaceutical products |
WO2014016848A2 (en) | 2012-07-24 | 2014-01-30 | Laurus Labs Private Limited | Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof |
JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
EA035891B1 (ru) | 2016-01-25 | 2020-08-27 | КРКА, д.д., НОВО МЕСТО | Быстродиспергируемая фармацевтическая композиция, включающая ингибитор тирозинкиназы |
EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
TW225528B (pt) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
JP3691861B2 (ja) * | 1994-09-14 | 2005-09-07 | 株式会社東芝 | 光ディスク用光パルス幅制御装置 |
CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
US6448293B1 (en) * | 2000-03-31 | 2002-09-10 | Pfizer Inc. | Diphenyl ether compounds useful in therapy |
GB0019228D0 (en) * | 2000-08-04 | 2000-09-27 | Smithkline Beecham Plc | Novel pharmaceutical |
GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
US6479692B1 (en) * | 2001-05-02 | 2002-11-12 | Nobex Corporation | Methods of synthesizing acylanilides including bicalutamide and derivatives thereof |
GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
PT1487424E (pt) * | 2002-03-15 | 2007-01-31 | Novartis Ag | 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-il-amino)fenil]-benzamida para o tratamento doenças mediadas por ang ii |
GB2398565A (en) * | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
EP1960380A1 (en) * | 2005-11-25 | 2008-08-27 | Novartis AG | F,g,h,i and k crystal forms of imatinib mesylate |
-
2005
- 2005-02-02 MY MYPI20050400A patent/MY144177A/en unknown
- 2005-02-02 PE PE2005000124A patent/PE20051096A1/es not_active Application Discontinuation
- 2005-02-02 AR ARP050100395A patent/AR047530A1/es not_active Application Discontinuation
- 2005-02-03 CN CNB2005800032177A patent/CN100558723C/zh not_active Expired - Fee Related
- 2005-02-03 EP EP05707165.6A patent/EP1713792B1/en active Active
- 2005-02-03 CA CA2553887A patent/CA2553887C/en not_active Expired - Fee Related
- 2005-02-03 WO PCT/EP2005/001077 patent/WO2005075454A2/en active Application Filing
- 2005-02-03 AU AU2005211514A patent/AU2005211514B2/en not_active Ceased
- 2005-02-03 TW TW094103446A patent/TWI347186B/zh not_active IP Right Cessation
- 2005-02-03 KR KR1020067015707A patent/KR20060135735A/ko active Application Filing
- 2005-02-03 NZ NZ548714A patent/NZ548714A/xx not_active IP Right Cessation
- 2005-02-03 JP JP2006551802A patent/JP4937760B2/ja not_active Expired - Fee Related
- 2005-02-03 RU RU2006131548/04A patent/RU2375355C2/ru not_active IP Right Cessation
- 2005-02-03 KR KR1020127025616A patent/KR20120127525A/ko not_active Application Discontinuation
- 2005-02-03 US US10/597,287 patent/US20080249104A1/en not_active Abandoned
- 2005-02-03 BR BRPI0507464-9A patent/BRPI0507464A/pt not_active IP Right Cessation
-
2006
- 2006-07-19 ZA ZA200605972A patent/ZA200605972B/en unknown
- 2006-07-20 IL IL177005A patent/IL177005A/en unknown
- 2006-08-01 MA MA29225A patent/MA28428B1/fr unknown
- 2006-08-03 EC EC2006006752A patent/ECSP066752A/es unknown
- 2006-08-03 TN TNP2006000243A patent/TNSN06243A1/en unknown
- 2006-09-04 NO NO20063942A patent/NO20063942L/no not_active Application Discontinuation
-
2012
- 2012-02-08 US US13/368,811 patent/US8513256B2/en not_active Expired - Fee Related
-
2013
- 2013-01-22 PH PH12013500157A patent/PH12013500157A1/en unknown
- 2013-07-19 US US13/946,000 patent/US20140051853A1/en not_active Abandoned
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2363 DE 19-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |