TWI347186B - Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide - Google Patents

Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide

Info

Publication number
TWI347186B
TWI347186B TW094103446A TW94103446A TWI347186B TW I347186 B TWI347186 B TW I347186B TW 094103446 A TW094103446 A TW 094103446A TW 94103446 A TW94103446 A TW 94103446A TW I347186 B TWI347186 B TW I347186B
Authority
TW
Taiwan
Prior art keywords
methylpiperazin
ylamino
benzamide
pyrimidin
ylmethyl
Prior art date
Application number
TW094103446A
Other languages
English (en)
Other versions
TW200529854A (en
Inventor
Hans Michael Burger
Paul William Manley
Michael Mutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34837520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI347186(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW200529854A publication Critical patent/TW200529854A/zh
Application granted granted Critical
Publication of TWI347186B publication Critical patent/TWI347186B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
TW094103446A 2004-02-04 2005-02-03 Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide TWI347186B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54181704P 2004-02-04 2004-02-04

Publications (2)

Publication Number Publication Date
TW200529854A TW200529854A (en) 2005-09-16
TWI347186B true TWI347186B (en) 2011-08-21

Family

ID=34837520

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094103446A TWI347186B (en) 2004-02-04 2005-02-03 Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide

Country Status (22)

Country Link
US (3) US20080249104A1 (zh)
EP (1) EP1713792B1 (zh)
JP (1) JP4937760B2 (zh)
KR (2) KR20060135735A (zh)
CN (1) CN100558723C (zh)
AR (1) AR047530A1 (zh)
AU (1) AU2005211514B2 (zh)
BR (1) BRPI0507464A (zh)
CA (1) CA2553887C (zh)
EC (1) ECSP066752A (zh)
IL (1) IL177005A (zh)
MA (1) MA28428B1 (zh)
MY (1) MY144177A (zh)
NO (1) NO20063942L (zh)
NZ (1) NZ548714A (zh)
PE (1) PE20051096A1 (zh)
PH (1) PH12013500157A1 (zh)
RU (1) RU2375355C2 (zh)
TN (1) TNSN06243A1 (zh)
TW (1) TWI347186B (zh)
WO (1) WO2005075454A2 (zh)
ZA (1) ZA200605972B (zh)

Families Citing this family (24)

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US20060235006A1 (en) * 2005-04-13 2006-10-19 Lee Francis Y Combinations, methods and compositions for treating cancer
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
CA2824301C (en) 2005-11-25 2016-01-12 Novartis Ag F, g, h, i and k crystal forms of imatinib mesylate
KR100799821B1 (ko) * 2007-02-05 2008-01-31 동화약품공업주식회사 신규한 이마티닙 캠실레이트 및 그의 제조방법
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
WO2008136010A1 (en) * 2007-05-07 2008-11-13 Natco Pharma Limited A process for the preparation of highly pure imatinib base
WO2009036753A2 (de) * 2007-09-20 2009-03-26 Schebo Biotech Ag Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie
BRPI0817946A2 (pt) 2007-09-25 2015-05-05 Teva Pharma Composições de imatinibe estável
EP2062885A1 (en) * 2007-11-21 2009-05-27 Eczacibasi-Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. Acid addition salts of imatinib and formulations comprising the same
TW201920110A (zh) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
US20100189790A1 (en) 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline formulation
US20100330130A1 (en) * 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
DK2445502T4 (da) 2009-06-25 2022-11-28 Alkermes Pharma Ireland Ltd Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser
EP2482820A2 (en) 2009-09-28 2012-08-08 Medizinische Universität Wien New use of pdgfrbeta inhibitors
PL389357A1 (pl) 2009-10-22 2011-04-26 Tomasz Koźluk Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania
KR101138840B1 (ko) * 2009-12-28 2012-05-10 주식회사 셀트리온화학연구소 이마티닙 다이클로로아세트산염 및 이를 포함하는 항암제 조성물
EP2547671A1 (en) 2010-03-15 2013-01-23 Natco Pharma Limited Process for the preparation of highly pure crystalline imatinib base
EP2582689B1 (en) 2010-06-18 2017-03-01 KRKA, D.D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
WO2012090221A1 (en) 2010-12-29 2012-07-05 Cadila Healthcare Limited Novel salts of imatinib
RU2646483C2 (ru) 2012-04-04 2018-03-05 Интервет Интернэшнл Б.В. Твердые фармацевтические композиции для перорального введения на основе изоксазолиновых соединений
WO2014016848A2 (en) 2012-07-24 2014-01-30 Laurus Labs Private Limited Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof
CA3172586A1 (en) 2013-07-31 2015-02-05 Avalyn Pharma Inc. Aerosol imatininb compounds and uses thereof
WO2017129624A1 (en) 2016-01-25 2017-08-03 Krka, D.D., Novo Mesto Fast dispersible pharmaceutical composition comprising tyrosine-kinase inhibitor
CN112423754A (zh) 2018-03-05 2021-02-26 奥克梅斯制药爱尔兰有限公司 阿立哌唑的给药策略

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (zh) 1992-04-03 1994-06-21 Ciba Geigy Ag
JP3691861B2 (ja) * 1994-09-14 2005-09-07 株式会社東芝 光ディスク用光パルス幅制御装置
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6448293B1 (en) * 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
GB0019228D0 (en) * 2000-08-04 2000-09-27 Smithkline Beecham Plc Novel pharmaceutical
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
US6479692B1 (en) * 2001-05-02 2002-11-12 Nobex Corporation Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
DE60308337T2 (de) * 2002-03-15 2007-09-20 Novartis Ag 4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
CA2824301C (en) * 2005-11-25 2016-01-12 Novartis Ag F, g, h, i and k crystal forms of imatinib mesylate

Also Published As

Publication number Publication date
NO20063942L (no) 2006-11-02
US8513256B2 (en) 2013-08-20
AU2005211514A1 (en) 2005-08-18
TW200529854A (en) 2005-09-16
ECSP066752A (es) 2006-11-16
CN100558723C (zh) 2009-11-11
IL177005A (en) 2014-05-28
WO2005075454A2 (en) 2005-08-18
IL177005A0 (en) 2006-12-10
NZ548714A (en) 2009-08-28
EP1713792B1 (en) 2014-04-30
WO2005075454A3 (en) 2006-07-27
PH12013500157A1 (en) 2014-09-08
MY144177A (en) 2011-08-15
KR20120127525A (ko) 2012-11-21
BRPI0507464A (pt) 2007-07-10
RU2375355C2 (ru) 2009-12-10
US20080249104A1 (en) 2008-10-09
JP4937760B2 (ja) 2012-05-23
MA28428B1 (fr) 2007-02-01
RU2006131548A (ru) 2008-03-10
US20140051853A1 (en) 2014-02-20
ZA200605972B (en) 2007-11-28
CA2553887A1 (en) 2005-08-18
PE20051096A1 (es) 2006-01-23
TNSN06243A1 (en) 2007-12-03
EP1713792A2 (en) 2006-10-25
JP2007520518A (ja) 2007-07-26
KR20060135735A (ko) 2006-12-29
AU2005211514B2 (en) 2009-09-10
AR047530A1 (es) 2006-01-25
CA2553887C (en) 2013-04-16
US20120142697A1 (en) 2012-06-07
CN1914191A (zh) 2007-02-14

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Legal Events

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