MA28428B1 - FORMES SALINES DE 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-n-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO) PHENYL]-BENZAMIDE - Google Patents
FORMES SALINES DE 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-n-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO) PHENYL]-BENZAMIDEInfo
- Publication number
- MA28428B1 MA28428B1 MA29225A MA29225A MA28428B1 MA 28428 B1 MA28428 B1 MA 28428B1 MA 29225 A MA29225 A MA 29225A MA 29225 A MA29225 A MA 29225A MA 28428 B1 MA28428 B1 MA 28428B1
- Authority
- MA
- Morocco
- Prior art keywords
- salt
- methyl
- benzamide
- phenyl
- tartrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La présente invention concerne des sels d'addition d'acides de 4-[(4-méthyl-1-pipérazinyl)méthyl]-N-[4-méthyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phényl]-benzamide, qui sont choisis dans le groupe constitué par un sel de tartrate, tel qu'un sel de (D)(-)-tartrate ou un sel de (L)(+)-tartrate, un sel de chlorhydrate, un sel de citrate, un sel de malate, un sel de fumarate, un sel de succinate, un sel de benzoate, un sel de benzènesulfonate, un sel de pamoate, un sel de formiate, un sel de malonate, un sel de 1,5-naphtalènedisulfonate, un sel de salicylate, un sel de cyclohexanesulfamate, un sel de lactate, un sel de mandélate, un sel de glutarate, un sel d'adipate, un sel de squarate, un sel de vanillate, un sel d'oxaloacétate, un sel d'ascorbate et un sel de sulfate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54181704P | 2004-02-04 | 2004-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28428B1 true MA28428B1 (fr) | 2007-02-01 |
Family
ID=34837520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29225A MA28428B1 (fr) | 2004-02-04 | 2006-08-01 | FORMES SALINES DE 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-n-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO) PHENYL]-BENZAMIDE |
Country Status (22)
Country | Link |
---|---|
US (3) | US20080249104A1 (fr) |
EP (1) | EP1713792B1 (fr) |
JP (1) | JP4937760B2 (fr) |
KR (2) | KR20060135735A (fr) |
CN (1) | CN100558723C (fr) |
AR (1) | AR047530A1 (fr) |
AU (1) | AU2005211514B2 (fr) |
BR (1) | BRPI0507464A (fr) |
CA (1) | CA2553887C (fr) |
EC (1) | ECSP066752A (fr) |
IL (1) | IL177005A (fr) |
MA (1) | MA28428B1 (fr) |
MY (1) | MY144177A (fr) |
NO (1) | NO20063942L (fr) |
NZ (1) | NZ548714A (fr) |
PE (1) | PE20051096A1 (fr) |
PH (1) | PH12013500157A1 (fr) |
RU (1) | RU2375355C2 (fr) |
TN (1) | TNSN06243A1 (fr) |
TW (1) | TWI347186B (fr) |
WO (1) | WO2005075454A2 (fr) |
ZA (1) | ZA200605972B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060235006A1 (en) * | 2005-04-13 | 2006-10-19 | Lee Francis Y | Combinations, methods and compositions for treating cancer |
GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
CA2824301C (fr) | 2005-11-25 | 2016-01-12 | Novartis Ag | Formes cristallines f, g, h, i et k du mesylate d'imatinib |
KR100799821B1 (ko) * | 2007-02-05 | 2008-01-31 | 동화약품공업주식회사 | 신규한 이마티닙 캠실레이트 및 그의 제조방법 |
US7550591B2 (en) | 2007-05-02 | 2009-06-23 | Chemagis Ltd. | Imatinib production process |
WO2008136010A1 (fr) * | 2007-05-07 | 2008-11-13 | Natco Pharma Limited | Procédé de préparation de l'imatinib base hautement pure |
WO2009036753A2 (fr) * | 2007-09-20 | 2009-03-26 | Schebo Biotech Ag | Nouveaux produits pharmaceutiques, procédés de fabrication de ceux-ci et utilisation de ceux-ci en thérapie médicale |
BRPI0817946A2 (pt) | 2007-09-25 | 2015-05-05 | Teva Pharma | Composições de imatinibe estável |
EP2062885A1 (fr) * | 2007-11-21 | 2009-05-27 | Eczacibasi-Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. | Sels d'addition d'acide d'imatinib et formules les comportant |
TW201920110A (zh) | 2009-01-16 | 2019-06-01 | 美商艾克塞里克斯公司 | 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途 |
US20100189790A1 (en) | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline formulation |
US20100330130A1 (en) * | 2009-05-22 | 2010-12-30 | Actavis Group Ptc Ehf | Substantially pure imatinib or a pharmaceutically acceptable salt thereof |
DK2445502T4 (da) | 2009-06-25 | 2022-11-28 | Alkermes Pharma Ireland Ltd | Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser |
EP2482820A2 (fr) | 2009-09-28 | 2012-08-08 | Medizinische Universität Wien | Nouvelle utilisation des inhibiteurs de pdgf-bêta |
PL389357A1 (pl) | 2009-10-22 | 2011-04-26 | Tomasz Koźluk | Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania |
KR101138840B1 (ko) * | 2009-12-28 | 2012-05-10 | 주식회사 셀트리온화학연구소 | 이마티닙 다이클로로아세트산염 및 이를 포함하는 항암제 조성물 |
EP2547671A1 (fr) | 2010-03-15 | 2013-01-23 | Natco Pharma Limited | Procédé de préparation d'une base imatinib cristalline très pure |
EP2582689B1 (fr) | 2010-06-18 | 2017-03-01 | KRKA, D.D., Novo Mesto | Nouvelle forme polymorphique d'imatinib base et préparation de ses sels |
WO2012090221A1 (fr) | 2010-12-29 | 2012-07-05 | Cadila Healthcare Limited | Nouveaux sels d'imatinib |
RU2646483C2 (ru) | 2012-04-04 | 2018-03-05 | Интервет Интернэшнл Б.В. | Твердые фармацевтические композиции для перорального введения на основе изоксазолиновых соединений |
WO2014016848A2 (fr) | 2012-07-24 | 2014-01-30 | Laurus Labs Private Limited | Formes solides d'inhibiteurs de tyrosine kinase, procédé pour leur préparation et leur composition pharmaceutique |
CA3172586A1 (fr) | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Composes d'imatinib en aerosol et utilisations connexes |
WO2017129624A1 (fr) | 2016-01-25 | 2017-08-03 | Krka, D.D., Novo Mesto | Composition pharmaceutique à dispersion rapide comprenant un inhibiteur de la tyrosine kinase |
CN112423754A (zh) | 2018-03-05 | 2021-02-26 | 奥克梅斯制药爱尔兰有限公司 | 阿立哌唑的给药策略 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
TW225528B (fr) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
JP3691861B2 (ja) * | 1994-09-14 | 2005-09-07 | 株式会社東芝 | 光ディスク用光パルス幅制御装置 |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
US6448293B1 (en) * | 2000-03-31 | 2002-09-10 | Pfizer Inc. | Diphenyl ether compounds useful in therapy |
GB0019228D0 (en) * | 2000-08-04 | 2000-09-27 | Smithkline Beecham Plc | Novel pharmaceutical |
GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
US6479692B1 (en) * | 2001-05-02 | 2002-11-12 | Nobex Corporation | Methods of synthesizing acylanilides including bicalutamide and derivatives thereof |
GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
DE60308337T2 (de) * | 2002-03-15 | 2007-09-20 | Novartis Ag | 4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen |
GB2398565A (en) * | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
CA2824301C (fr) * | 2005-11-25 | 2016-01-12 | Novartis Ag | Formes cristallines f, g, h, i et k du mesylate d'imatinib |
-
2005
- 2005-02-02 AR ARP050100395A patent/AR047530A1/es not_active Application Discontinuation
- 2005-02-02 MY MYPI20050400A patent/MY144177A/en unknown
- 2005-02-02 PE PE2005000124A patent/PE20051096A1/es not_active Application Discontinuation
- 2005-02-03 JP JP2006551802A patent/JP4937760B2/ja not_active Expired - Fee Related
- 2005-02-03 WO PCT/EP2005/001077 patent/WO2005075454A2/fr active Application Filing
- 2005-02-03 CN CNB2005800032177A patent/CN100558723C/zh not_active Expired - Fee Related
- 2005-02-03 CA CA2553887A patent/CA2553887C/fr not_active Expired - Fee Related
- 2005-02-03 KR KR1020067015707A patent/KR20060135735A/ko active Application Filing
- 2005-02-03 AU AU2005211514A patent/AU2005211514B2/en not_active Ceased
- 2005-02-03 KR KR1020127025616A patent/KR20120127525A/ko not_active Application Discontinuation
- 2005-02-03 US US10/597,287 patent/US20080249104A1/en not_active Abandoned
- 2005-02-03 BR BRPI0507464-9A patent/BRPI0507464A/pt not_active IP Right Cessation
- 2005-02-03 NZ NZ548714A patent/NZ548714A/xx not_active IP Right Cessation
- 2005-02-03 EP EP05707165.6A patent/EP1713792B1/fr active Active
- 2005-02-03 RU RU2006131548/04A patent/RU2375355C2/ru not_active IP Right Cessation
- 2005-02-03 TW TW094103446A patent/TWI347186B/zh not_active IP Right Cessation
-
2006
- 2006-07-19 ZA ZA200605972A patent/ZA200605972B/en unknown
- 2006-07-20 IL IL177005A patent/IL177005A/en unknown
- 2006-08-01 MA MA29225A patent/MA28428B1/fr unknown
- 2006-08-03 EC EC2006006752A patent/ECSP066752A/es unknown
- 2006-08-03 TN TNP2006000243A patent/TNSN06243A1/en unknown
- 2006-09-04 NO NO20063942A patent/NO20063942L/no not_active Application Discontinuation
-
2012
- 2012-02-08 US US13/368,811 patent/US8513256B2/en not_active Expired - Fee Related
-
2013
- 2013-01-22 PH PH12013500157A patent/PH12013500157A1/en unknown
- 2013-07-19 US US13/946,000 patent/US20140051853A1/en not_active Abandoned
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