PE20110120A1 - Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico - Google Patents
Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamicoInfo
- Publication number
- PE20110120A1 PE20110120A1 PE2010000996A PE2010000996A PE20110120A1 PE 20110120 A1 PE20110120 A1 PE 20110120A1 PE 2010000996 A PE2010000996 A PE 2010000996A PE 2010000996 A PE2010000996 A PE 2010000996A PE 20110120 A1 PE20110120 A1 PE 20110120A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- methyl
- ester
- metoxyphenylcarbamoyl
- piperidin
- Prior art date
Links
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 title abstract 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 4
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000001384 succinic acid Substances 0.000 abstract 2
- -1 2-FURANYLCARBONYL Chemical class 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 229960000289 fluticasone propionate Drugs 0.000 abstract 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602778.3A GB0602778D0 (en) | 2006-02-10 | 2006-02-10 | Novel compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110120A1 true PE20110120A1 (es) | 2011-03-08 |
Family
ID=36119909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000996A PE20110120A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
| PE2007000135A PE20071249A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000135A PE20071249A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
Country Status (33)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5540075B2 (ja) * | 2009-04-14 | 2014-07-02 | グラクソ グループ リミテッド | ビフェニル−２−イルカルバミン酸エステルの調製方法 |
| AU2015234331B2 (en) * | 2009-04-23 | 2017-08-03 | Theravance Biopharma R&D Ip, Llc | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
| EP2421849B1 (en) * | 2009-04-23 | 2013-04-03 | Theravance, Inc. | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| AR083115A1 (es) | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
| PH12014500193A1 (en) * | 2011-08-02 | 2014-03-24 | Alfasigma Spa | Pharmaceutical composition of oxidised avidin suitable for inhalation |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| EA201500651A1 (ru) * | 2012-12-18 | 2015-11-30 | Альмираль, С.А. | НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛ- И ХИНУКЛИДИНИЛКАРБАМАТА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| GB201500447D0 (en) * | 2015-01-12 | 2015-02-25 | Glaxosmithkline Ip Dev Ltd | Novel Combination Product |
| CN106632257B (zh) * | 2016-12-15 | 2019-02-12 | 上海市奉贤区中心医院 | Gsk961081及其中间体的合成方法 |
| WO2020047225A1 (en) | 2018-08-30 | 2020-03-05 | Theravance Biopharma R&D Ip, Llc | Methods for treating chronic obstructive pulmonary disease |
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| DE3134590A1 (de) | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
| US4460581A (en) * | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| US4894219A (en) * | 1988-03-29 | 1990-01-16 | University Of Florida | Beta-agonist carbostyril derivatives, assay method and pharmacological composition |
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| JP2008510014A (ja) * | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
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2006
- 2006-02-10 GB GBGB0602778.3A patent/GB0602778D0/en not_active Ceased
-
2007
- 2007-02-08 AR ARP070100537A patent/AR059409A1/es not_active Application Discontinuation
- 2007-02-08 PE PE2010000996A patent/PE20110120A1/es active IP Right Grant
- 2007-02-08 KR KR20087022160A patent/KR101488691B1/ko not_active Expired - Fee Related
- 2007-02-08 WO PCT/EP2007/051196 patent/WO2007090859A1/en not_active Ceased
- 2007-02-08 CA CA2641769A patent/CA2641769C/en active Active
- 2007-02-08 SG SG201100933-9A patent/SG169404A1/en unknown
- 2007-02-08 NZ NZ570242A patent/NZ570242A/en not_active IP Right Cessation
- 2007-02-08 ES ES07704449.3T patent/ES2640226T3/es active Active
- 2007-02-08 DK DK07704449.3T patent/DK1981872T3/en active
- 2007-02-08 EP EP07704449.3A patent/EP1981872B1/en active Active
- 2007-02-08 SI SI200731963T patent/SI1981872T1/sl unknown
- 2007-02-08 TW TW096104636A patent/TWI401251B/zh not_active IP Right Cessation
- 2007-02-08 AU AU2007213767A patent/AU2007213767B2/en not_active Ceased
- 2007-02-08 JO JOP/2007/0037A patent/JO3389B1/ar active
- 2007-02-08 JP JP2008553758A patent/JP5616021B2/ja not_active Expired - Fee Related
- 2007-02-08 PE PE2007000135A patent/PE20071249A1/es not_active Application Discontinuation
- 2007-02-08 EA EA200801691A patent/EA016580B1/ru unknown
- 2007-02-08 HU HUE07704449A patent/HUE034315T2/en unknown
- 2007-02-08 CN CN2007800050282A patent/CN101379057B/zh not_active Expired - Fee Related
- 2007-02-08 BR BRPI0707559A patent/BRPI0707559B8/pt not_active IP Right Cessation
- 2007-02-08 PL PL07704449T patent/PL1981872T3/pl unknown
- 2007-02-08 LT LTEP07704449.3T patent/LT1981872T/lt unknown
- 2007-02-08 US US11/672,536 patent/US7960551B2/en active Active
- 2007-02-08 HR HRP20171304TT patent/HRP20171304T1/hr unknown
- 2007-02-08 PT PT77044493T patent/PT1981872T/pt unknown
- 2007-08-02 UA UAA200809940A patent/UA100364C2/ru unknown
-
2008
- 2008-07-29 IL IL193103A patent/IL193103A/en active IP Right Grant
- 2008-08-05 ZA ZA200806782A patent/ZA200806782B/xx unknown
- 2008-08-05 NO NO20083425A patent/NO341343B1/no unknown
- 2008-08-08 MY MYPI20083025A patent/MY153656A/en unknown
- 2008-08-20 CR CR10227A patent/CR10227A/es not_active Application Discontinuation
- 2008-09-10 MA MA31228A patent/MA30273B1/fr unknown
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2016
- 2016-04-15 AR ARP160101036A patent/AR104288A2/es not_active Application Discontinuation
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2017
- 2017-08-22 CY CY20171100887T patent/CY1119238T1/el unknown
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