KR101488691B1 - 비페닐-2-일카르밤산 1-〔2-（2-클로로-4-｛〔（ｒ）-2-히드록시-2-（8-히드록시-2-옥소-1,2-디히드로퀴놀린-5-일）에틸아미노〕메틸｝-5-메톡시페닐카르바모일）에틸〕피페리딘-4-일 에스테르의 석신산 염 및 이의 폐질환 치료를 위한 용도 - Google Patents

비페닐-2-일카르밤산 1-〔2-（2-클로로-4-｛〔（ｒ）-2-히드록시-2-（8-히드록시-2-옥소-1,2-디히드로퀴놀린-5-일）에틸아미노〕메틸｝-5-메톡시페닐카르바모일）에틸〕피페리딘-4-일 에스테르의 석신산 염 및 이의 폐질환 치료를 위한 용도 Download PDF

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KR101488691B1
KR101488691B1 KR20087022160A KR20087022160A KR101488691B1 KR 101488691 B1 KR101488691 B1 KR 101488691B1 KR 20087022160 A KR20087022160 A KR 20087022160A KR 20087022160 A KR20087022160 A KR 20087022160A KR 101488691 B1 KR101488691 B1 KR 101488691B1
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ethyl
delete delete
salt
piperidin
ester
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Korean (ko)
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KR20080114723A (ko
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레시마 추다사마
앤드류 케네디
린다 제인 킨돈
프랭크 패트릭 말렛
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글락소 그룹 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR20087022160A 2006-02-10 2007-02-08 비페닐-2-일카르밤산 1-〔2-（2-클로로-4-｛〔（ｒ）-2-히드록시-2-（8-히드록시-2-옥소-1,2-디히드로퀴놀린-5-일）에틸아미노〕메틸｝-5-메톡시페닐카르바모일）에틸〕피페리딘-4-일 에스테르의 석신산 염 및 이의 폐질환 치료를 위한 용도 Expired - Fee Related KR101488691B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0602778.3A GB0602778D0 (en) 2006-02-10 2006-02-10 Novel compound
GB0602778.3 2006-02-10
PCT/EP2007/051196 WO2007090859A1 (en) 2006-02-10 2007-02-08 Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders

Publications (2)

Publication Number Publication Date
KR20080114723A KR20080114723A (ko) 2008-12-31
KR101488691B1 true KR101488691B1 (ko) 2015-02-02

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ID=36119909

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KR20087022160A Expired - Fee Related KR101488691B1 (ko) 2006-02-10 2007-02-08 비페닐-2-일카르밤산 1-〔2-（2-클로로-4-｛〔（ｒ）-2-히드록시-2-（8-히드록시-2-옥소-1,2-디히드로퀴놀린-5-일）에틸아미노〕메틸｝-5-메톡시페닐카르바모일）에틸〕피페리딘-4-일 에스테르의 석신산 염 및 이의 폐질환 치료를 위한 용도

Country Status (33)

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US (1) US7960551B2 (enExample)
EP (1) EP1981872B1 (enExample)
JP (1) JP5616021B2 (enExample)
KR (1) KR101488691B1 (enExample)
CN (1) CN101379057B (enExample)
AR (2) AR059409A1 (enExample)
AU (1) AU2007213767B2 (enExample)
BR (1) BRPI0707559B8 (enExample)
CA (1) CA2641769C (enExample)
CR (1) CR10227A (enExample)
CY (1) CY1119238T1 (enExample)
DK (1) DK1981872T3 (enExample)
EA (1) EA016580B1 (enExample)
ES (1) ES2640226T3 (enExample)
GB (1) GB0602778D0 (enExample)
HR (1) HRP20171304T1 (enExample)
HU (1) HUE034315T2 (enExample)
IL (1) IL193103A (enExample)
JO (1) JO3389B1 (enExample)
LT (1) LT1981872T (enExample)
MA (1) MA30273B1 (enExample)
MY (1) MY153656A (enExample)
NO (1) NO341343B1 (enExample)
NZ (1) NZ570242A (enExample)
PE (2) PE20110120A1 (enExample)
PL (1) PL1981872T3 (enExample)
PT (1) PT1981872T (enExample)
SG (1) SG169404A1 (enExample)
SI (1) SI1981872T1 (enExample)
TW (1) TWI401251B (enExample)
UA (1) UA100364C2 (enExample)
WO (1) WO2007090859A1 (enExample)
ZA (1) ZA200806782B (enExample)

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AU2015234331B2 (en) * 2009-04-23 2017-08-03 Theravance Biopharma R&D Ip, Llc Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
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AR083115A1 (es) * 2010-09-30 2013-01-30 Theravance Inc Sales oxalato cristalinas de un compuesto diamida
CN103717239B (zh) * 2011-08-02 2017-08-01 希格马托制药工业公司 适合于吸入的氧化抗生物素蛋白的药物组合物
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2934594B1 (en) * 2012-12-18 2019-09-04 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities .
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
GB201500447D0 (en) * 2015-01-12 2015-02-25 Glaxosmithkline Ip Dev Ltd Novel Combination Product
CN106632257B (zh) * 2016-12-15 2019-02-12 上海市奉贤区中心医院 Gsk961081及其中间体的合成方法
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Also Published As

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JO3389B1 (ar) 2019-03-13
CN101379057A (zh) 2009-03-04
CN101379057B (zh) 2013-02-13
JP2009526018A (ja) 2009-07-16
WO2007090859A1 (en) 2007-08-16
US7960551B2 (en) 2011-06-14
CA2641769A1 (en) 2007-08-16
TW200800948A (en) 2008-01-01
AU2007213767A1 (en) 2007-08-16
SI1981872T1 (sl) 2017-10-30
UA100364C2 (xx) 2012-12-25
MY153656A (en) 2015-03-13
AU2007213767B2 (en) 2012-04-26
HUE034315T2 (en) 2018-02-28
ES2640226T3 (es) 2017-11-02
BRPI0707559B8 (pt) 2021-05-25
NO20083425L (no) 2008-09-09
JP5616021B2 (ja) 2014-10-29
DK1981872T3 (en) 2017-09-11
MA30273B1 (fr) 2009-03-02
PL1981872T3 (pl) 2017-11-30
EP1981872A1 (en) 2008-10-22
IL193103A (en) 2013-06-27
US20070281971A1 (en) 2007-12-06
SG169404A1 (en) 2011-03-30
KR20080114723A (ko) 2008-12-31
CA2641769C (en) 2014-02-04
CY1119238T1 (el) 2018-02-14
GB0602778D0 (en) 2006-03-22
AR104288A2 (es) 2017-07-12
BRPI0707559B1 (pt) 2021-01-12
NO341343B1 (no) 2017-10-16
CR10227A (es) 2008-10-29
EA200801691A1 (ru) 2009-02-27
EA016580B1 (ru) 2012-06-29
EP1981872B1 (en) 2017-06-21
LT1981872T (lt) 2017-09-11
TWI401251B (zh) 2013-07-11
BRPI0707559A2 (pt) 2011-05-10
IL193103A0 (en) 2009-02-11
PE20110120A1 (es) 2011-03-08
PE20071249A1 (es) 2008-01-16
PT1981872T (pt) 2017-09-13
NZ570242A (en) 2011-09-30
AR059409A1 (es) 2008-04-09
ZA200806782B (en) 2009-10-28
BRPI0707559A8 (pt) 2019-01-29
HRP20171304T1 (hr) 2017-10-20

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