CN101379057B - 联苯-2-基氨基甲酸1-[2-(2-氯-4-{[(r)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基)乙基氨基]甲基}-5-甲氧基苯基氨甲酰基)乙基]哌啶-4-基酯的琥珀酸盐及其治疗肺疾病的用途 - Google Patents

联苯-2-基氨基甲酸1-[2-(2-氯-4-{[(r)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基)乙基氨基]甲基}-5-甲氧基苯基氨甲酰基)乙基]哌啶-4-基酯的琥珀酸盐及其治疗肺疾病的用途 Download PDF

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Publication number
CN101379057B
CN101379057B CN2007800050282A CN200780005028A CN101379057B CN 101379057 B CN101379057 B CN 101379057B CN 2007800050282 A CN2007800050282 A CN 2007800050282A CN 200780005028 A CN200780005028 A CN 200780005028A CN 101379057 B CN101379057 B CN 101379057B
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hydroxyl
succinate
oxo
ester
chloro
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Expired - Fee Related
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Chinese (zh)
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CN101379057A (zh
Inventor
R·查达萨玛
A·肯尼迪
L·J·金登
F·P·马利特
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GlaxoSmithKline Intellectual Property Development Ltd
Theravance Biopharma R&D IP LLC
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2007800050282A 2006-02-10 2007-02-08 联苯-2-基氨基甲酸1-[2-(2-氯-4-{[(r)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基)乙基氨基]甲基}-5-甲氧基苯基氨甲酰基)乙基]哌啶-4-基酯的琥珀酸盐及其治疗肺疾病的用途 Expired - Fee Related CN101379057B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0602778.3 2006-02-10
GBGB0602778.3A GB0602778D0 (en) 2006-02-10 2006-02-10 Novel compound
PCT/EP2007/051196 WO2007090859A1 (en) 2006-02-10 2007-02-08 Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders

Publications (2)

Publication Number Publication Date
CN101379057A CN101379057A (zh) 2009-03-04
CN101379057B true CN101379057B (zh) 2013-02-13

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CN2007800050282A Expired - Fee Related CN101379057B (zh) 2006-02-10 2007-02-08 联苯-2-基氨基甲酸1-[2-(2-氯-4-{[(r)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基)乙基氨基]甲基}-5-甲氧基苯基氨甲酰基)乙基]哌啶-4-基酯的琥珀酸盐及其治疗肺疾病的用途

Country Status (33)

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US (1) US7960551B2 (enExample)
EP (1) EP1981872B1 (enExample)
JP (1) JP5616021B2 (enExample)
KR (1) KR101488691B1 (enExample)
CN (1) CN101379057B (enExample)
AR (2) AR059409A1 (enExample)
AU (1) AU2007213767B2 (enExample)
BR (1) BRPI0707559B8 (enExample)
CA (1) CA2641769C (enExample)
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DK (1) DK1981872T3 (enExample)
EA (1) EA016580B1 (enExample)
ES (1) ES2640226T3 (enExample)
GB (1) GB0602778D0 (enExample)
HR (1) HRP20171304T1 (enExample)
HU (1) HUE034315T2 (enExample)
IL (1) IL193103A (enExample)
JO (1) JO3389B1 (enExample)
LT (1) LT1981872T (enExample)
MA (1) MA30273B1 (enExample)
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NZ (1) NZ570242A (enExample)
PE (2) PE20110120A1 (enExample)
PL (1) PL1981872T3 (enExample)
PT (1) PT1981872T (enExample)
SG (1) SG169404A1 (enExample)
SI (1) SI1981872T1 (enExample)
TW (1) TWI401251B (enExample)
UA (1) UA100364C2 (enExample)
WO (1) WO2007090859A1 (enExample)
ZA (1) ZA200806782B (enExample)

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TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
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AU2007213767A1 (en) 2007-08-16
SI1981872T1 (sl) 2017-10-30
BRPI0707559B1 (pt) 2021-01-12
CA2641769A1 (en) 2007-08-16
US20070281971A1 (en) 2007-12-06
KR101488691B1 (ko) 2015-02-02
AR059409A1 (es) 2008-04-09
ES2640226T3 (es) 2017-11-02
EP1981872A1 (en) 2008-10-22
WO2007090859A1 (en) 2007-08-16
TW200800948A (en) 2008-01-01
EA200801691A1 (ru) 2009-02-27
HRP20171304T1 (hr) 2017-10-20
IL193103A0 (en) 2009-02-11
EP1981872B1 (en) 2017-06-21
JP5616021B2 (ja) 2014-10-29
GB0602778D0 (en) 2006-03-22
DK1981872T3 (en) 2017-09-11
SG169404A1 (en) 2011-03-30
JO3389B1 (ar) 2019-03-13
MY153656A (en) 2015-03-13
LT1981872T (lt) 2017-09-11
CR10227A (es) 2008-10-29
AU2007213767B2 (en) 2012-04-26
CN101379057A (zh) 2009-03-04
BRPI0707559A8 (pt) 2019-01-29
NO20083425L (no) 2008-09-09
AR104288A2 (es) 2017-07-12
CY1119238T1 (el) 2018-02-14
NO341343B1 (no) 2017-10-16
CA2641769C (en) 2014-02-04
ZA200806782B (en) 2009-10-28
MA30273B1 (fr) 2009-03-02
US7960551B2 (en) 2011-06-14
EA016580B1 (ru) 2012-06-29
UA100364C2 (xx) 2012-12-25
HUE034315T2 (en) 2018-02-28
JP2009526018A (ja) 2009-07-16
IL193103A (en) 2013-06-27
NZ570242A (en) 2011-09-30
BRPI0707559B8 (pt) 2021-05-25
PE20110120A1 (es) 2011-03-08
PE20071249A1 (es) 2008-01-16
BRPI0707559A2 (pt) 2011-05-10
TWI401251B (zh) 2013-07-11
KR20080114723A (ko) 2008-12-31
PT1981872T (pt) 2017-09-13
PL1981872T3 (pl) 2017-11-30

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