PE20091956A1 - Derivados de acido l-glutamico y l-glutamina marcados con [f-18] - Google Patents

Derivados de acido l-glutamico y l-glutamina marcados con [f-18]

Info

Publication number
PE20091956A1
PE20091956A1 PE2009000704A PE2009000704A PE20091956A1 PE 20091956 A1 PE20091956 A1 PE 20091956A1 PE 2009000704 A PE2009000704 A PE 2009000704A PE 2009000704 A PE2009000704 A PE 2009000704A PE 20091956 A1 PE20091956 A1 PE 20091956A1
Authority
PE
Peru
Prior art keywords
amino
glutamic acid
acid
derivatives
glutamine
Prior art date
Application number
PE2009000704A
Other languages
English (en)
Inventor
Ludger Dinkelborg
Mathias Berndt
Matthias Friebe
Heribert Schmitt-Willich
Detlev Sulzle
Norman Koglin
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39970942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091956(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20091956A1 publication Critical patent/PE20091956A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ACIDO L-GLUTAMICO Y L-GLUTAMINA MARCADOS CON [F-18] DE FORMULA (I) DONDE A ES HIDROXILO, ALCOXILO(C1-C5), HIDROXIALCOXILO(C1-C5), ENTRE OTROS; G ES HIDROXILO, O-ALQUILO(C1-C5), O-ALQUENILO(C2-C5), ENTRE OTROS; R1 Y R2 SON CADA UNO H, F18-ALCOXILO(C1-C5), F18-ALQUILO(C1-C5), F18-ALQUENILO(C2-C5), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (2S,4S)-2-AMINO-4-(3-FLUOROPROPIL)-PENTANODIOICO, ACIDO (2S,4S)-2-AMINO-4-(4-FLUOROBUTIL)-PENTANODIOICO, ACIDO (2S,4S)-2-AMINO-4-(2-FLUOROETOXI)-PENTANODIOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MARCADOS CON [F-18] SON UTILES PARA EL DIAGNOSTICO PRECOZ DE ENFERMEDADES TUMORALES BASADO EN PET (TOMOGRAFIA DE EMISION DE POSITRONES)
PE2009000704A 2008-05-20 2009-05-20 Derivados de acido l-glutamico y l-glutamina marcados con [f-18] PE20091956A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08075510A EP2123621A1 (de) 2008-05-20 2008-05-20 Neue {F-18}-markierte L-Glutaminsäure- und L-Glutaminderivate (I), ihre Verwendung sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
PE20091956A1 true PE20091956A1 (es) 2010-02-05

Family

ID=39970942

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000704A PE20091956A1 (es) 2008-05-20 2009-05-20 Derivados de acido l-glutamico y l-glutamina marcados con [f-18]

Country Status (25)

Country Link
US (3) US20110165076A1 (es)
EP (2) EP2123621A1 (es)
JP (2) JP2011520932A (es)
KR (1) KR101636245B1 (es)
CN (2) CN104356019A (es)
AR (1) AR073845A1 (es)
AU (1) AU2009250130B2 (es)
BR (1) BRPI0913128A2 (es)
CA (1) CA2723596C (es)
CL (1) CL2009001240A1 (es)
CO (1) CO6331330A2 (es)
CR (1) CR11800A (es)
DO (1) DOP2010000358A (es)
EA (1) EA025217B1 (es)
EC (1) ECSP10010617A (es)
HK (1) HK1205099A1 (es)
IL (1) IL208662A0 (es)
MX (1) MX2010012636A (es)
NZ (1) NZ589350A (es)
PA (1) PA8827401A1 (es)
PE (1) PE20091956A1 (es)
SV (1) SV2010003739A (es)
TW (2) TW201439043A (es)
UY (1) UY31835A (es)
WO (1) WO2009141091A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017713B1 (ru) 2006-11-01 2013-02-28 Байер Шеринг Фарма Акциенгезельшафт [f-18]-меченая l-глутаминовая кислота, [f-18]-меченый l-глутамин, их производные и их применение, а также способ их получения
EP2123621A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Neue {F-18}-markierte L-Glutaminsäure- und L-Glutaminderivate (I), ihre Verwendung sowie Verfahren zu ihrer Herstellung
US20130149243A1 (en) * 2009-11-17 2013-06-13 Bayer Intellectual Property Gmbh Method for production of f-18 labeled glutamic acid derivatives
DE102010036356A1 (de) * 2010-07-12 2012-01-12 Abx Advanced Biochemical Compounds Gmbh Vorrichtung zur Synthese radioaktiv markierter Verbindungen
DE102010063974B4 (de) * 2010-12-22 2021-10-07 Thomas Rühl Pharmakologische Wirkstoffe und Radiodiagnostika mit 18F-markierter 3-Aryl- oder 3-Heteroaryl-1,2,4-oxadiazoleinheit und Verfahren zu deren Herstellung
EP2520556A1 (en) 2011-05-03 2012-11-07 Bayer Pharma Aktiengesellschaft Radiolabeled amino acids for diagnostic imaging
EP2520557A1 (en) 2011-05-03 2012-11-07 Bayer Pharma Aktiengesellschaft Novel precursors of glutamate derivatives
US8784774B2 (en) * 2011-09-16 2014-07-22 General Electric Company Labeled molecular imaging agents and methods of use
CN103333079B (zh) * 2013-07-03 2016-08-17 广东回旋医药科技股份有限公司 亚氨基酸类pet显像剂及其制备方法与应用
US9468693B2 (en) 2014-01-23 2016-10-18 General Electric Company Labeled molecular imaging agents and methods of use
US9468692B2 (en) 2014-01-23 2016-10-18 General Electric Company Labeled molecular imaging agents and methods of use
CN106631863B (zh) * 2016-09-06 2018-08-17 中山大学附属第一医院 亚谷氨酸类pet显像剂的放射合成方法
CN109369445B (zh) * 2018-11-20 2021-10-15 首都医科大学 用于诊断和治疗的放射性谷氨酰胺衍生物及其制备方法
WO2023229997A1 (en) * 2022-05-23 2023-11-30 Board Of Regents, The University Of Texas System Cgmp-compliant automated [18f]fspg production for clinical examination

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EA017713B1 (ru) * 2006-11-01 2013-02-28 Байер Шеринг Фарма Акциенгезельшафт [f-18]-меченая l-глутаминовая кислота, [f-18]-меченый l-глутамин, их производные и их применение, а также способ их получения
EP2123621A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Neue {F-18}-markierte L-Glutaminsäure- und L-Glutaminderivate (I), ihre Verwendung sowie Verfahren zu ihrer Herstellung
EP1923382A1 (de) * 2006-11-18 2008-05-21 Bayer Schering Pharma Aktiengesellschaft [F-18] markierte L-Glutaminsäure, [F-18] markiertes Glutamin, ihre Derivate und ihre Verwendung sowie Verfahren zu ihrer Herstellung
EP2123620A1 (en) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft {F-19}-labeled L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them

Also Published As

Publication number Publication date
US9308282B2 (en) 2016-04-12
EP2123621A1 (de) 2009-11-25
TW201008585A (en) 2010-03-01
US20100290991A1 (en) 2010-11-18
CA2723596C (en) 2016-08-02
EA201001766A1 (ru) 2011-12-30
JP2015042671A (ja) 2015-03-05
CN104356019A (zh) 2015-02-18
TW201439043A (zh) 2014-10-16
ECSP10010617A (es) 2010-12-30
AU2009250130A1 (en) 2009-11-26
IL208662A0 (en) 2010-12-30
CO6331330A2 (es) 2011-10-20
CA2723596A1 (en) 2009-11-26
KR101636245B1 (ko) 2016-07-07
AR073845A1 (es) 2010-12-09
AU2009250130B2 (en) 2014-08-21
US20110165076A1 (en) 2011-07-07
SV2010003739A (es) 2011-04-06
JP2011520932A (ja) 2011-07-21
HK1205099A1 (en) 2015-12-11
EA025217B1 (ru) 2016-12-30
CL2009001240A1 (es) 2010-07-19
CR11800A (es) 2011-01-12
WO2009141091A8 (de) 2010-11-11
US20140154183A1 (en) 2014-06-05
EP2282982A1 (de) 2011-02-16
UY31835A (es) 2010-01-05
PA8827401A1 (es) 2009-12-16
KR20110009165A (ko) 2011-01-27
CN102083772A (zh) 2011-06-01
DOP2010000358A (es) 2010-12-31
NZ589350A (en) 2012-08-31
BRPI0913128A2 (pt) 2016-01-05
MX2010012636A (es) 2010-12-06
WO2009141091A1 (de) 2009-11-26

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