GB1474377A - Naphthalene derivatives - Google Patents

Naphthalene derivatives

Info

Publication number
GB1474377A
GB1474377A GB4255073A GB4255073A GB1474377A GB 1474377 A GB1474377 A GB 1474377A GB 4255073 A GB4255073 A GB 4255073A GB 4255073 A GB4255073 A GB 4255073A GB 1474377 A GB1474377 A GB 1474377A
Authority
GB
United Kingdom
Prior art keywords
naphthyl
methoxy
group
compound
choh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4255073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB4255073A priority Critical patent/GB1474377A/en
Priority to CY1083A priority patent/CY1083A/en
Priority to CY1082A priority patent/CY1082A/en
Priority to IE1644/77A priority patent/IE40002B1/en
Priority to IE1740/74A priority patent/IE40001B1/en
Priority to ZA00745441A priority patent/ZA745441B/en
Priority to DE2463219A priority patent/DE2463219C2/de
Priority to DE2442305A priority patent/DE2442305C2/en
Priority to SE7411261A priority patent/SE420598B/en
Priority to FR7430151A priority patent/FR2242972B1/fr
Priority to AU73136/74A priority patent/AU488262B2/en
Priority to JP49103764A priority patent/JPS5920655B2/en
Priority to DK477674A priority patent/DK156642C/en
Priority to NLAANVRAGE7412060,A priority patent/NL175812C/en
Priority to CH999677A priority patent/CH603524A5/xx
Priority to CH1236974A priority patent/CH599090A5/xx
Priority to CH999477A priority patent/CH613932A5/xx
Priority to CH999877A priority patent/CH603526A5/xx
Priority to CH999377A priority patent/CH603523A5/xx
Priority to CH999977A priority patent/CH603527A5/xx
Priority to BE148417A priority patent/BE819794A/en
Priority to CH999577A priority patent/CH603543A5/xx
Priority to CH999777A priority patent/CH603525A5/xx
Priority to US05/748,676 priority patent/US4061779A/en
Publication of GB1474377A publication Critical patent/GB1474377A/en
Priority to SE7907064A priority patent/SE7907064A0/en
Priority to DK236080A priority patent/DK236080A/en
Priority to KE3081A priority patent/KE3081A/en
Priority to KE3082A priority patent/KE3082A/en
Priority to HK561/80A priority patent/HK56180A/en
Priority to HK562/80A priority patent/HK56280A/en
Priority to US06320190 priority patent/US4420639C1/en
Priority to MY197/81A priority patent/MY8100197A/en
Priority to MY198/81A priority patent/MY8100198A/en
Priority to JP57190679A priority patent/JPS6033818B2/en
Priority to JP57190681A priority patent/JPS605580B2/en
Priority to JP57190680A priority patent/JPS5921850B2/en
Priority to DK119384A priority patent/DK156562C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/26—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydration of carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1474377 Naphthalene derivatives BEECHAM GROUP Ltd 20 Aug 1974 [11 Sept 1973] 42550/73 Heading C2C [Also in Division A5] Novel compounds II in which X is Cl, Br, OCH 3 , SCH 3 , or 1-4C alkyl; Y is -CHR 1 -CH 2 - or R 1 is H or CH 3 and A is -CO- or -CHOH-; excepting the known compound 4-(61-methoxy- 21-naphthyl)butan-2-one; are prepared by methylation of a compound VI with MeLi, followed where necessary by reduction of the -CO- group to a -CHOH- group or by base catalysed reaction of acetone with a compound VII to give a compound II where Y is -CH = CH- followed where necessary by reduction of the -CO- group to a -CHOH- group. 3 - (6<SP>1</SP> - Methoxy - 2<SP>1</SP> - naphthyl) - butyric acid is prepared by reaction of triethylphosphonoacetate with 2-acetyl-6-methoxynaphthalene to give ethyl 3-(6<SP>1</SP>-methoxy-2<SP>1</SP>-naphthyl)-2-butenoate; reduction of this with H 2 over Pd/C to give ethyl 3 - (6<SP>1</SP> - methoxy - 2<SP>1</SP> - naphthyl) - butyrate and hydrolysis with NaOH. Trans - 3 - (6<SP>1</SP> - methoxy - 2<SP>1</SP> - naphthyl) - 2- butenoic acid is prepared by hydrolysis of its ethyl ester with NaOH.
GB4255073A 1973-09-11 1973-09-11 Naphthalene derivatives Expired GB1474377A (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
GB4255073A GB1474377A (en) 1973-09-11 1973-09-11 Naphthalene derivatives
CY1083A CY1083A (en) 1973-09-11 1974-08-20 4-(6'-methoxy-2'-naphthyl)-butan-2-one
CY1082A CY1082A (en) 1973-09-11 1974-08-20 Naphthalene derivatives
IE1644/77A IE40002B1 (en) 1973-09-11 1974-08-21 4-(6'-methoxy-2'-naphthyl)-butan-2-one
IE1740/74A IE40001B1 (en) 1973-09-11 1974-08-21 Naphthalene derivatives
ZA00745441A ZA745441B (en) 1973-09-11 1974-08-26 Aromatic compounds
DE2463219A DE2463219C2 (en) 1973-09-11 1974-09-04
DE2442305A DE2442305C2 (en) 1973-09-11 1974-09-04 Naphthalene derivatives, processes for their production and medicinal preparations containing these compounds
SE7411261A SE420598B (en) 1973-09-11 1974-09-05 ANALOGY PROCEDURE FOR THE PREPARATION OF Naphthalene derivatives
FR7430151A FR2242972B1 (en) 1973-09-11 1974-09-05
AU73136/74A AU488262B2 (en) 1973-09-11 1974-09-08 Naphthaline derivatives and their use as pharmaceuticals
JP49103764A JPS5920655B2 (en) 1973-09-11 1974-09-09 Manufacturing method for new naphthalene derivatives
DK477674A DK156642C (en) 1973-09-11 1974-09-10 ANALOGY PROCEDURE FOR THE PREPARATION OF NAPTHALEND DERIVATIVES
CH999977A CH603527A5 (en) 1973-09-11 1974-09-11
BE148417A BE819794A (en) 1973-09-11 1974-09-11 NAPHTHYLONES
CH1236974A CH599090A5 (en) 1973-09-11 1974-09-11
CH999477A CH613932A5 (en) 1973-09-11 1974-09-11
CH999877A CH603526A5 (en) 1973-09-11 1974-09-11
CH999377A CH603523A5 (en) 1973-09-11 1974-09-11
NLAANVRAGE7412060,A NL175812C (en) 1973-09-11 1974-09-11 PROCESS FOR PREPARING AND / OR MANUFACTURING A MEDICINAL PRODUCT WITH ANTI-INFLAMMATORY EFFECT, AND METHOD FOR PREPARING A 2,6-SUBSTITUTED SUBSTITUTED DERIVATIVE DERIVATIVE THEREOF.
CH999677A CH603524A5 (en) 1973-09-11 1974-09-11
CH999577A CH603543A5 (en) 1973-09-11 1974-09-11
CH999777A CH603525A5 (en) 1973-09-11 1974-09-11
US05/748,676 US4061779A (en) 1973-09-11 1976-12-08 Naphthalene derivatives having anti-inflammatory activity
SE7907064A SE7907064A0 (en) 1973-09-11 1979-08-23 Process for the preparation of naphthalene derivatives
DK236080A DK236080A (en) 1973-09-11 1980-05-30 ANALOGY PROCEDURE FOR PREPARING 4- (6-METHOXY-2-NAPHTHYL) BUTAN-2-ON.
KE3081A KE3081A (en) 1973-09-11 1980-09-06 Naphtalene derivatives
KE3082A KE3082A (en) 1973-09-11 1980-09-06 4-(6'-methoxy-2'-naphthyl)-butan-2-one
HK561/80A HK56180A (en) 1973-09-11 1980-10-02 Naphthalene derivatives
HK562/80A HK56280A (en) 1973-09-11 1980-10-02 4-(6'-methoxy-2'-naphthyl)-butan-2-one
US06320190 US4420639C1 (en) 1973-09-11 1981-11-12 Aromatic compounds
MY197/81A MY8100197A (en) 1973-09-11 1981-12-30 Naphthalene derivatives
MY198/81A MY8100198A (en) 1973-09-11 1981-12-30 4-(6'-methoxy-2'-naphthyl)-butan-2-one
JP57190679A JPS6033818B2 (en) 1973-09-11 1982-10-29 Manufacturing method for new naphthalene derivatives
JP57190681A JPS605580B2 (en) 1973-09-11 1982-10-29 Manufacturing method for new naphthalene derivatives
JP57190680A JPS5921850B2 (en) 1973-09-11 1982-10-29 Manufacturing method for new naphthalene derivatives
DK119384A DK156562C (en) 1973-09-11 1984-02-28 NAPHTHALENDER DERIVATIVES FOR USING INTERMEDIATES IN THE PREPARATION OF PHARMACEUTICAL ACTIVE NAPHTHALENDER DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4255073A GB1474377A (en) 1973-09-11 1973-09-11 Naphthalene derivatives

Publications (1)

Publication Number Publication Date
GB1474377A true GB1474377A (en) 1977-05-25

Family

ID=10424914

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4255073A Expired GB1474377A (en) 1973-09-11 1973-09-11 Naphthalene derivatives

Country Status (15)

Country Link
JP (4) JPS5920655B2 (en)
BE (1) BE819794A (en)
CH (8) CH603524A5 (en)
CY (2) CY1082A (en)
DE (2) DE2463219C2 (en)
DK (1) DK156642C (en)
FR (1) FR2242972B1 (en)
GB (1) GB1474377A (en)
HK (2) HK56180A (en)
IE (1) IE40001B1 (en)
KE (2) KE3081A (en)
MY (2) MY8100198A (en)
NL (1) NL175812C (en)
SE (2) SE420598B (en)
ZA (1) ZA745441B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407907A1 (en) * 1977-11-03 1979-06-01 Beecham Group Ltd NAPHTHALENE DERIVATIVES FOR USE AS A MEDICINAL PRODUCT
EP0021587A1 (en) * 1979-06-08 1981-01-07 Beecham Group Plc Substituted decalins, their preparation and use
US4270004A (en) * 1978-01-07 1981-05-26 Beecham Group Limited Chemical process for the preparation of 4-(61 -methoxy-21 -naphthyl)butan-2-one
WO1993014747A1 (en) 1992-01-29 1993-08-05 Smithkline Beecham Plc Spray-chilled nabumetone
WO1994009767A1 (en) * 1992-10-31 1994-05-11 Smithkline Beecham Plc Novel use of pharmaceutical compositions

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL52006A0 (en) * 1976-05-13 1977-07-31 Beecham Group Ltd Novel nephthalene derivatives their preparation and pharmaceutical compositions containing them
GB8416638D0 (en) * 1984-06-29 1984-08-01 Beecham Group Plc Topical treatment and composition
GB8607119D0 (en) * 1986-03-21 1986-04-30 Beecham Group Plc Process
EP0477098B1 (en) * 1990-09-18 1996-06-26 Fujitsu Limited Cursor displacement control device for a computer display
GB9108128D0 (en) * 1991-04-15 1991-06-05 Zambeletti Spa L Novel formulation
WO1997032837A1 (en) * 1996-03-06 1997-09-12 Sumitomo Pharmaceuticals Co., Ltd. Nonsteroidal estrogen derivatives
US5861538A (en) * 1997-08-04 1999-01-19 Albemarle Corporation Production of alkoxynaphthyl-substituted ketones from naphthaldehydes
AU2003229142A1 (en) * 2002-06-07 2003-12-22 Cortical Pty Ltd Naphthalene derivatives which inhibit the cytokine or biological activity of macrophage inhibitory factor (MIF)
EP2123621A1 (en) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft New [F-18]-marked L-glutamic acids and L-glutamic acid derivatives (1), application thereof and method for their manufacture
EP2123619A1 (en) 2008-05-20 2009-11-25 Bayer Schering Pharma AG New [F-18]-marked L-glutamic acids and L-glutamic acid derivatives (II), application thereof and method for their manufacture

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO125971B (en) * 1969-05-22 1972-12-04 Syntex Corp
BR6915468D0 (en) * 1969-10-09 1973-03-13 Syntex Corp PROCESS FOR THE PREPARATION OF D 2- (6-REPLACED-2-NAFTIL) -PROPANAL

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407907A1 (en) * 1977-11-03 1979-06-01 Beecham Group Ltd NAPHTHALENE DERIVATIVES FOR USE AS A MEDICINAL PRODUCT
US4243682A (en) * 1977-11-03 1981-01-06 Beecham Group Limited Fluoronaphthylones
US4270004A (en) * 1978-01-07 1981-05-26 Beecham Group Limited Chemical process for the preparation of 4-(61 -methoxy-21 -naphthyl)butan-2-one
EP0021587A1 (en) * 1979-06-08 1981-01-07 Beecham Group Plc Substituted decalins, their preparation and use
WO1993014747A1 (en) 1992-01-29 1993-08-05 Smithkline Beecham Plc Spray-chilled nabumetone
WO1994009767A1 (en) * 1992-10-31 1994-05-11 Smithkline Beecham Plc Novel use of pharmaceutical compositions

Also Published As

Publication number Publication date
IE40001B1 (en) 1979-02-14
CH603525A5 (en) 1978-08-15
ZA745441B (en) 1975-08-27
MY8100198A (en) 1981-12-31
CH603524A5 (en) 1978-08-15
SE7907064L (en) 1979-08-23
BE819794A (en) 1975-03-11
JPS5890526A (en) 1983-05-30
DK156642B (en) 1989-09-18
DE2442305A1 (en) 1975-03-13
FR2242972A1 (en) 1975-04-04
AU7313674A (en) 1976-03-11
MY8100197A (en) 1981-12-31
DK477674A (en) 1975-05-12
SE7411261L (en) 1975-03-12
JPS605580B2 (en) 1985-02-12
IE40001L (en) 1975-03-11
CH599090A5 (en) 1978-05-12
JPS5920655B2 (en) 1984-05-15
KE3082A (en) 1980-10-03
JPS5053359A (en) 1975-05-12
CY1083A (en) 1980-12-27
CH603523A5 (en) 1978-08-15
SE7907064A0 (en) 1979-08-23
HK56280A (en) 1980-10-10
CY1082A (en) 1980-12-27
CH603527A5 (en) 1978-08-15
DE2463219C2 (en) 1988-02-04
NL175812B (en) 1984-08-01
JPS5896036A (en) 1983-06-07
NL7412060A (en) 1975-03-13
KE3081A (en) 1980-10-03
JPS5921850B2 (en) 1984-05-22
JPS6033818B2 (en) 1985-08-05
CH613932A5 (en) 1979-10-31
CH603543A5 (en) 1978-08-31
JPS58113142A (en) 1983-07-05
CH603526A5 (en) 1978-08-15
NL175812C (en) 1985-01-02
DK156642C (en) 1990-01-29
SE420598B (en) 1981-10-19
DE2442305C2 (en) 1986-04-03
HK56180A (en) 1980-10-10
FR2242972B1 (en) 1978-07-21

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Effective date: 19940819