CL2009001238A1 - Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales. - Google Patents
Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales.Info
- Publication number
- CL2009001238A1 CL2009001238A1 CL2009001238A CL2009001238A CL2009001238A1 CL 2009001238 A1 CL2009001238 A1 CL 2009001238A1 CL 2009001238 A CL2009001238 A CL 2009001238A CL 2009001238 A CL2009001238 A CL 2009001238A CL 2009001238 A1 CL2009001238 A1 CL 2009001238A1
- Authority
- CL
- Chile
- Prior art keywords
- labeled
- imaging
- pharmaceutical compositions
- glutamic acid
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compuestos derivados de ácido l-glutámico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparación; conjunto de diagnóstico por imágenes; composiciones farmacéuticas; y uso para el diagnóstico por imágenes de enfermedades tumorales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08075508A EP2123619A1 (de) | 2008-05-20 | 2008-05-20 | Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009001238A1 true CL2009001238A1 (es) | 2010-06-04 |
Family
ID=39767162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009001238A CL2009001238A1 (es) | 2008-05-20 | 2009-05-20 | Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20110104057A1 (es) |
EP (2) | EP2123619A1 (es) |
JP (1) | JP2011522799A (es) |
KR (1) | KR20110009166A (es) |
CN (1) | CN102036936A (es) |
AR (1) | AR073843A1 (es) |
CA (1) | CA2723459A1 (es) |
CL (1) | CL2009001238A1 (es) |
PA (1) | PA8827201A1 (es) |
PE (1) | PE20100140A1 (es) |
TW (1) | TW201008586A (es) |
UY (1) | UY31836A (es) |
WO (1) | WO2009141079A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100217011A1 (en) * | 2006-11-01 | 2010-08-26 | Bayer Schering Pharma Aktiengesellschaft | [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation |
CN102471235A (zh) * | 2009-07-11 | 2012-05-23 | 拜耳医药股份有限公司 | 利用环烷基的放射性标记方法 |
MX2012005733A (es) * | 2009-11-17 | 2013-01-22 | Bayer Ip Gmbh | Metodo de produccion de derivados de acido glutamico marcados con f-18. |
EP2520556A1 (en) * | 2011-05-03 | 2012-11-07 | Bayer Pharma Aktiengesellschaft | Radiolabeled amino acids for diagnostic imaging |
CN103333079B (zh) * | 2013-07-03 | 2016-08-17 | 广东回旋医药科技股份有限公司 | 亚氨基酸类pet显像剂及其制备方法与应用 |
CN106631863B (zh) * | 2016-09-06 | 2018-08-17 | 中山大学附属第一医院 | 亚谷氨酸类pet显像剂的放射合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1461184A (fr) | 1964-12-23 | 1966-01-07 | Takeda Chemical Industries Ltd | Procédé de préparation d'isoxazolidones substituées en position 5 |
GB1474377A (en) | 1973-09-11 | 1977-05-25 | Beecham Group Ltd | Naphthalene derivatives |
PL341652A1 (en) | 1998-01-21 | 2001-04-23 | Merck Sharp & Dohme | Derivatives of triazolopyridazine as ligands for gaba receptors |
WO2002014261A2 (en) * | 2000-08-10 | 2002-02-21 | Eli Lilly And Company | 4-substituted d-glutamic acid derivatives for use as antibiotic |
CA2494704A1 (en) * | 2002-08-02 | 2004-12-23 | Mallinckrodt Inc. | Radioactively labelled amino acid analogues, their preparation and use |
US20100217011A1 (en) * | 2006-11-01 | 2010-08-26 | Bayer Schering Pharma Aktiengesellschaft | [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation |
-
2008
- 2008-05-20 EP EP08075508A patent/EP2123619A1/de active Pending
-
2009
- 2009-05-13 CN CN2009801185341A patent/CN102036936A/zh active Pending
- 2009-05-13 WO PCT/EP2009/003384 patent/WO2009141079A1/de active Application Filing
- 2009-05-13 EP EP09749569A patent/EP2280915A1/de not_active Withdrawn
- 2009-05-13 JP JP2011509877A patent/JP2011522799A/ja active Pending
- 2009-05-13 KR KR1020107025997A patent/KR20110009166A/ko not_active Application Discontinuation
- 2009-05-13 CA CA2723459A patent/CA2723459A1/en not_active Abandoned
- 2009-05-13 US US12/993,289 patent/US20110104057A1/en not_active Abandoned
- 2009-05-20 PA PA20098827201A patent/PA8827201A1/es unknown
- 2009-05-20 TW TW098116763A patent/TW201008586A/zh unknown
- 2009-05-20 AR ARP090101803A patent/AR073843A1/es unknown
- 2009-05-20 CL CL2009001238A patent/CL2009001238A1/es unknown
- 2009-05-20 UY UY0001031836A patent/UY31836A/es not_active Application Discontinuation
- 2009-05-20 PE PE2009000707A patent/PE20100140A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20110104057A1 (en) | 2011-05-05 |
EP2280915A1 (de) | 2011-02-09 |
KR20110009166A (ko) | 2011-01-27 |
UY31836A (es) | 2010-01-05 |
PE20100140A1 (es) | 2010-03-21 |
WO2009141079A8 (de) | 2010-11-18 |
WO2009141079A1 (de) | 2009-11-26 |
CA2723459A1 (en) | 2009-11-26 |
TW201008586A (en) | 2010-03-01 |
AR073843A1 (es) | 2010-12-09 |
PA8827201A1 (es) | 2009-12-16 |
CN102036936A (zh) | 2011-04-27 |
JP2011522799A (ja) | 2011-08-04 |
EP2123619A1 (de) | 2009-11-25 |
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