PE20091787A1 - Agentes antiparasitarios derivados de indolinona - Google Patents

Agentes antiparasitarios derivados de indolinona

Info

Publication number
PE20091787A1
PE20091787A1 PE2009000577A PE2009000577A PE20091787A1 PE 20091787 A1 PE20091787 A1 PE 20091787A1 PE 2009000577 A PE2009000577 A PE 2009000577A PE 2009000577 A PE2009000577 A PE 2009000577A PE 20091787 A1 PE20091787 A1 PE 20091787A1
Authority
PE
Peru
Prior art keywords
alkyl
indolinone
floro
carbolin
indol
Prior art date
Application number
PE2009000577A
Other languages
English (en)
Spanish (es)
Inventor
Shi Hua Ang
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Bryan Ks Yeung
Bin Zou
Philipp Krastel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091787(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091787A1 publication Critical patent/PE20091787A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PE2009000577A 2008-04-29 2009-04-28 Agentes antiparasitarios derivados de indolinona PE20091787A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22

Publications (1)

Publication Number Publication Date
PE20091787A1 true PE20091787A1 (es) 2009-12-14

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000577A PE20091787A1 (es) 2008-04-29 2009-04-28 Agentes antiparasitarios derivados de indolinona

Country Status (31)

Country Link
US (2) US8053442B2 (zh)
EP (2) EP2722333A1 (zh)
JP (2) JP5438098B2 (zh)
KR (1) KR101390081B1 (zh)
CN (1) CN102015711B (zh)
AR (1) AR071222A1 (zh)
AU (1) AU2009242279B2 (zh)
BR (1) BRPI0911577B8 (zh)
CA (1) CA2719365C (zh)
CL (1) CL2009001007A1 (zh)
CO (1) CO6300940A2 (zh)
CY (1) CY1114874T1 (zh)
DK (1) DK2285808T3 (zh)
EA (1) EA019601B1 (zh)
EC (2) ECSP10010646A (zh)
ES (1) ES2447590T3 (zh)
HK (1) HK1149935A1 (zh)
HR (1) HRP20140151T1 (zh)
IL (1) IL208357A (zh)
JO (1) JO2904B1 (zh)
MA (1) MA32316B1 (zh)
MX (1) MX2010011868A (zh)
MY (2) MY152021A (zh)
NZ (1) NZ588217A (zh)
PE (1) PE20091787A1 (zh)
PL (1) PL2285808T3 (zh)
PT (1) PT2285808E (zh)
SI (1) SI2285808T1 (zh)
TW (1) TWI442921B (zh)
WO (1) WO2009132921A1 (zh)
ZA (1) ZA201006752B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2285808T3 (pl) * 2008-04-29 2014-04-30 Novartis Ag Spiro-indolowe pochodne do leczenia chorób pasożytniczych
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
PT2828256T (pt) 2012-03-23 2019-10-18 Novartis Ag Processo químico para a preparação de espiroindolonas e dos seus intermediários
EP2828385B1 (en) 2012-03-23 2018-02-07 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
HUE053379T2 (hu) 2013-11-13 2021-06-28 Codexis Inc Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN118005631A (zh) 2014-12-18 2024-05-10 豪夫迈·罗氏有限公司 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
EP3247713B1 (en) * 2015-01-23 2019-08-28 GlaxoSmithKline Intellectual Property Development Limited Pyrazolo[3,4-d]pyrimidin derivative and its use for the treatment of leishmaniasis
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
PL3810283T3 (pl) 2018-06-21 2023-10-16 F. Hoffmann-La Roche Ag Postacie stałe soli winianowej 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropylo)azetydyn-3-ylo)amino)fenylo)-3-metylo-1,3,4,9-tetrahydro-2H-pirydo[3,4-b]indol-2-ilo)-2,2-difluoropropan-1-olu, sposób ich otrzymywania i sposoby ich zastosowania w leczeniu nowotworów
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (en) * 2020-03-17 2021-09-23 The University Of Buea Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones as antimalarial agents
CN116273188B (zh) * 2023-03-01 2024-06-25 岭南师范学院 一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
JP2002520416A (ja) * 1998-07-14 2002-07-09 バイエル アクチェンゲゼルシャフト 寄生虫に作用するアルテミシニン誘導体（エンドペルオキシド類）
WO2000037470A1 (en) 1998-12-19 2000-06-29 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
US20050143371A1 (en) 2003-07-23 2005-06-30 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
EP2102207B1 (en) 2006-12-07 2010-06-02 F.Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
JP5512545B2 (ja) 2008-01-09 2014-06-04 アレイ バイオファーマ、インコーポレイテッド Ａｋｔタンパク質キナーゼ阻害剤としてのピリミジルシクロペンタン類
PL2285808T3 (pl) * 2008-04-29 2014-04-30 Novartis Ag Spiro-indolowe pochodne do leczenia chorób pasożytniczych

Also Published As

Publication number Publication date
CY1114874T1 (el) 2016-12-14
ES2447590T3 (es) 2014-03-12
MX2010011868A (es) 2010-11-26
BRPI0911577B8 (pt) 2021-05-25
PL2285808T3 (pl) 2014-04-30
US20110275613A1 (en) 2011-11-10
CA2719365C (en) 2017-03-07
JP2011518852A (ja) 2011-06-30
AU2009242279A1 (en) 2009-11-05
ECSP17068127A (es) 2017-10-31
BRPI0911577A8 (pt) 2018-03-06
WO2009132921A1 (en) 2009-11-05
CN102015711A (zh) 2011-04-13
AU2009242279B2 (en) 2012-08-30
SI2285808T1 (sl) 2014-03-31
ECSP10010646A (es) 2010-12-30
KR101390081B1 (ko) 2014-04-29
PT2285808E (pt) 2014-02-24
TW200948357A (en) 2009-12-01
JO2904B1 (en) 2015-09-15
BRPI0911577B1 (pt) 2021-02-23
KR20100135320A (ko) 2010-12-24
MY156601A (en) 2016-03-15
EP2722333A1 (en) 2014-04-23
ZA201006752B (en) 2011-05-25
AR071222A1 (es) 2010-06-02
CN102015711B (zh) 2013-05-01
JP5438098B2 (ja) 2014-03-12
US20090275560A1 (en) 2009-11-05
TWI442921B (zh) 2014-07-01
HK1149935A1 (zh) 2011-10-21
JP2014065729A (ja) 2014-04-17
HRP20140151T1 (hr) 2014-03-28
EA019601B1 (ru) 2014-04-30
CO6300940A2 (es) 2011-07-21
EP2285808A1 (en) 2011-02-23
IL208357A0 (en) 2010-12-30
US8399453B2 (en) 2013-03-19
BRPI0911577A2 (pt) 2016-01-05
CL2009001007A1 (es) 2010-06-11
DK2285808T3 (da) 2014-02-03
EP2285808B1 (en) 2013-11-20
EA201001689A1 (ru) 2011-08-30
NZ588217A (en) 2012-10-26
MA32316B1 (fr) 2011-05-02
US8053442B2 (en) 2011-11-08
IL208357A (en) 2014-11-30
MY152021A (en) 2014-08-15
CA2719365A1 (en) 2009-11-05

Similar Documents

Publication Publication Date Title
PE20091787A1 (es) Agentes antiparasitarios derivados de indolinona
PE20121118A1 (es) Compuestos de haloalquil heteroaril benzamida
PE20090189A1 (es) Derivados de aza-piridopirimidinona como agonistas de hm74a
PE20121500A1 (es) 2-amino-5,5-difluor-5,6-dihidro-4h-oxazinas como inhibidores de bace 1 y/o bace 2
PE20120031A1 (es) Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1
PH12015500347A1 (en) 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
EA200970047A1 (ru) Водные суспензии тмс278
BR112015005878A2 (pt) nanopartículas terapêuticas compreendendo agente terapêutico e métodos de preparar e usar as mesmas
PE20110153A1 (es) Derivados de piridazina como inhibidores de smo
EA200970510A1 (ru) Гетеромоноциклическое соединение и его применение
PE20070983A1 (es) COMPUESTOS DERIVADOS DE 3-DESAZAPURINA COMO AGONISTAS DEL RECEPTOR Toll-LIKE (TLR7)
EA201592082A1 (ru) 3,4-дигидроизохинолин-2(1h)-ильные соединения
ECSP11010898A (es) Pirrolidina-2-carboxamidas sustituidas
PE20121180A1 (es) (heteroarilmetil) tiohidantoinas sustituidas como drogas anticancer
PE20110419A1 (es) Compuestos de pirrolo-pirimidina como inhibidores de cdk
PE20070041A1 (es) Amidas de acido pirazolcarboxilico
NI201200089A (es) INHIBIDORES DE N1 - PIRAZOLOESPIROCETONA ACETIL - CoA CARBOXILASA.
PE20142456A1 (es) COMPUESTOS DE OXAZOLIDIN-2-ONA Y USOS DE LOS MISMOS COMO INHIBIDORES DE LA PI3Ks
PE20160664A1 (es) Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina
AR085037A1 (es) Acidos 6-amino-2-sustituido-5-vinilsililpirimidin-4-carboxilicos y esteres y acidos 4-amino-6-sustituido-3-vinilsililpiridin-picolinicos y esteres como herbicidas
PE20140934A1 (es) Derivados de pirazol
TW201144306A (en) Bicyclic heteroaryl analogues as GPR119 modulators
PE20151060A1 (es) Nuevos derivados de pirazina como agonistas del receptor cb2
PE20142450A1 (es) Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de bace1
PE20141553A1 (es) Compuestos de triazolopiridina como inhibidores de la ped10a

Legal Events

Date Code Title Description
FG Grant, registration